The DOI matches its Crossref record; 293 of the 294 references it cites were found in a registry or an index.
Signaling pathways in Th2 development
Abstract
In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.
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“The STAT6 signaling pathway is mainly induced by IL-4, which induces the expression of GATA3 [31, 40].”
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Metadata
- Authors
- Mowen, K. A., & Glimcher, L. H.
- Affiliations
- Harvard University (US)
- Corresponding author
- Mowen, Kerri A.
- ORCID
- Glimcher, Laurie H.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2004-11-11
- Volume
- 202
- Issue
- 1
- Pages
- 203-222
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2023488690
- Cited by
- 255
- References
- 294
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 10 · 2018: 3 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 11 · 2013: 12 · 2012: 11
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- Th2 cells, T helper cell differentiation, signal transduction, Th1 cells, cell-mediated immunity, humoral immunity, intracellular pathogens, extracellular pathogens
- MeSH terms
- Animals, Cell Differentiation, Dendritic Cells, Digestive System, Humans, Transcription Factors, Signal Transduction, T-Lymphocyte Subsets, Cytokines, Th2 Cells, Mice
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