The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets
Open accessAbstract
Summary: During evolution, vertebrates have developed an adaptive immune system able to cope with a variety of pathogens. Dendritic cells (DCs) are central to this process. DCs integrate information derived from pathogens or endogenous danger signals and convey them to T lymphocytes. Most of the present knowledge on DCs was generated in mice or by using human DCs differentiated in vitro from monocytes. In both species, several DC subsets have been identified in vivo based on differences in their phenotypes, anatomical locations or functions. In mice, protective immunity against intracellular pathogens or tumors can be induced most efficiently by targeting antigens to the CD8α+ DCs, a subset of DCs which resides in lymphoid tissues and is especially efficient at cross‐presenting exogenous antigens to CD8+ T lymphocytes. In contrary, harnessing human DC subsets for medical purposes is currently hampered by insufficient knowledge about these cells. To overcome this cognitive gap, we are using comparative genomics as a tool for designing hypotheses and experiments to further characterize DC subset functions and their molecular control, including the investigation of the functional equivalences that might exist between human and mouse DC subsets.
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Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
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“Moreover, Clec9a was demonstrated to specifically promote cross-presentation of exogenous antigens engulfed from dead cells (64).”
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Dendritic Cell Regulation of T Helper Cells
Yin, X., Chen, S., & Eisenbarth, S. C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-025146 · Cited by 447
Re(de)fining the dendritic cell lineage
Satpathy, A. T., Wu, X., Albring, J. C., & Murphy, K. M. (2012) · Nature Immunology · doi:10.1038/ni.2467 · Cited by 441
Personalized Dendritic Cell Vaccines‐Recent Breakthroughs and Encouraging Clinical Results
Mastelic-Gavillet, B., Balint, K., Boudousquie, C., Gannon, P. O., & Kandalaft, L. E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00766 · Cited by 189
Chougnet, C. A., Thacker, R. I., Shehata, H. M., Hennies, C. M., Lehn, M. A., Lages, C. S., & Janssen, E. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501006 · Cited by 187
Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells
Sawai, C. M., Sisirak, V., Ghosh, H. S., Hou, E. Z., Ceribelli, M., Staudt, L. M., & Reizis, B. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130443 · Cited by 133
Metadata
- Authors
- Crozat, K., Guiton, R., Guilliams, M., Henri, S., Baranek, T., Schwartz‐Cornil, I., Malissen, B., & Dalod, M.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2010-02-22
- Volume
- 234
- Issue
- 1
- Pages
- 177-198
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2105108488
- Cited by
- 186
- References
- 6
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Crozat, K., Guiton, R., Guilliams, M., Henri, S., Baranek, T., Schwartz‐Cornil, I., Malissen, B., & Dalod, M. (2010). Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets. Immunological Reviews. https://doi.org/10.1111/j.0105-2896.2009.00868.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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