Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

Getts, Daniel R.; Terry, Rachael L.; Getts, Meghann Teague; Müller, Marcus; Rana, Sabita; Shrestha, Bimmi; Radford, Jane; Van Rooijen, Nico; Campbell, Iain L.; King, Nicholas J.C.

doi:10.1084/jem.20080421

Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

In a lethal West Nile virus (WNV) model, central nervous system infection triggered a threefold increase in CD45int/CD11b+/CD11c− microglia at days 6–7 postinfection (p.i.). Few microglia were proliferating, suggesting that the increased numbers were derived from a migratory precursor cell. Deple…