The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Influence of aging on thermal and vibratory thresholds of quantitative sensory testing
Abstract
Abstract Quantitative sensory testing has become a common approach to evaluate thermal and vibratory thresholds in various types of neuropathies. To understand the effect of aging on sensory perception, we measured warm, cold, and vibratory thresholds by performing quantitative sensory testing on a population of 484 normal subjects (175 males and 309 females), aged 48.61 ± 14.10 (range 20–86) years. Sensory thresholds of the hand and foot were measured with two algorithms: the method of limits (Limits) and the method of level (Level). Thresholds measured by Limits are reaction‐time‐dependent, while those measured by Level are independent of reaction time. In addition, we explored (1) the correlations of thresholds between these two algorithms, (2) the effect of age on differences in thresholds between algorithms, and (3) differences in sensory thresholds between the two test sites. Age was consistently and significantly correlated with sensory thresholds of all tested modalities measured by both algorithms on multivariate regression analysis compared with other factors, including gender, body height, body weight, and body mass index. When thresholds were plotted against age, slopes differed between sensory thresholds of the hand and those of the foot: for the foot, slopes were steeper compared with those for the hand for each sensory modality. Sensory thresholds of both test sites measured by Level were highly correlated with those measured by Limits, and thresholds measured by Limits were higher than those measured by Level. Differences in sensory thresholds between the two algorithms were also correlated with age: thresholds of the foot were higher than those of the hand for each sensory modality. This difference in thresholds (measured with both Level and Limits) between the hand and foot was also correlated with age. These findings suggest that age is the most significant factor in determining sensory thresholds compared with the other factors of gender and anthropometric parameters, and this provides a foundation for investigating the neurobiologic significance of aging on the processing of sensory stimuli.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“this decline is more severe for the lower extremities (Kenshalo, 1986; Lin et al., 2005)”
From Design Principles to Accommodate Older Adults (2012) · cites this paper as Lin et al., 2005
Citations
Cites
Mapping cortical change across the human life span
Sowell, E. R., Peterson, B. S., Thompson, P. M., Welcome, S. E., Henkenius, A. L., & Toga, A. W. (2003) · Nature Neuroscience · doi:10.1038/nn1008 · Cited by 2,328
The physiological basis of transcranial motor cortex stimulation in conscious humans
Lazzaro, V. D., Oliviero, A., Pilato, F., Saturno, E., Dileone, M., Mazzone, P., Insola, A., Tonali, P. A., & Rothwell, J. C. (2003) · Clinical Neurophysiology · doi:10.1016/j.clinph.2003.10.009 · Cited by 583
Rowland, L. P. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62285-x · Cited by 581
Epidermal Nerve Fiber Density: Normative Reference Range and Diagnostic Efficiency
McArthur, J. C., Stocks, E. A., Hauer, P., Cornblath, D. R., & Griffin, J. W. (1998) · Archives of Neurology · doi:10.1001/archneur.55.12.1513 · Cited by 560
Neural Events and the Psychophysical Law
Stevens, S. S. (1970) · Science · doi:10.1126/science.170.3962.1043 · Cited by 551
Shy, M. E., Frohman, E. M., So, Y. T., Arezzo, J. C., Cornblath, D. R., Giuliani, M. J., Kincaid, J. C., Ochoa, J. L., Parry, G. J., & Weimer, L. H. (2003) · Neurology · doi:10.1212/01.wnl.0000058546.16985.11 · Cited by 515
fMRI of Thermal Pain: Effects of Stimulus Laterality and Attention
Brooks, J. C. W., Nurmikko, T. J., Bimson, W. E., Singh, K. D., & Roberts, N. (2002) · NeuroImage · doi:10.1006/nimg.2001.0974 · Cited by 416
Periquet, M. I., Novak, V., Collins, M. P., Nagaraja, H. N., Erdem‐Özdamar, S., Nash, S. M., Freimer, M. L., Sahenk, Z., Kissel, J. T., & Mendell, J. R. (1999) · Neurology · doi:10.1212/wnl.53.8.1641 · Cited by 375
Edwards, R. R., Fillingim, R. B., & Ness, T. J. (2002) · Pain · doi:10.1016/s0304-3959(02)00324-x · Cited by 356
Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments
Shun, C., Chang, Y., Wu, H., Hsieh, S., Lin, W., Lin, Y., Tai, T., & Hsieh, S. (2004) · Brain · doi:10.1093/brain/awh180 · Cited by 356
Self-citationNational Cancer Institute (2020) · Definitions · doi:10.32388/jzk490 · Cited by 356
Thermal testing: normative data and repeatability for various test algorithms
Yarnitsky, D., & Sprecher, E. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90239-9 · Cited by 303
Bell-Krotoski, J. A., Weinstein, S., & Weinstein, C. D. (1993) · Journal of Hand Therapy · doi:10.1016/s0894-1130(12)80292-4 · Cited by 299
Quantitative measurement of pain sensation in patients with Parkinson disease
Djaldetti, R., Shifrin, A., Rogowski, Z., Sprecher, E., Melamed, E., & Yarnitsky, D. (2004) · Neurology · doi:10.1212/01.wnl.0000130455.38550.9d · Cited by 290
The innervation of human epidermis
Kennedy, W. R., & Wendelschafer‐Crabb, G. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90223-l · Cited by 277
Variables influencing neuropathic endpoints
Dyck, P. J. B., Litchy, W. J., Lehman, K. A., Hokanson, J. L., Low, P. A., & O’Brien, P. C. (1995) · Neurology · doi:10.1212/wnl.45.6.1115 · Cited by 274
What does chronic electrical stimulation teach us about muscle plasticity?
Pette, D., & Vrbov�, G. (1999) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199906)22:6 · Cited by 246
WARM AND COLD SPECIFIC SOMATOSENSORY SYSTEMS
Yarnitsky, D., & Ochoa, J. L. (1991) · Brain · doi:10.1093/brain/114.4.1819 · Cited by 229
Effects of age and sex on volumes of the thalamus, pons, and cortex
Sullivan, E. V., Rosenbloom, M. J., Serventi, K. L., & Adolf Pfefferbaum, A. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00044-7 · Cited by 227
Cool, warm, and heat‐pain detection thresholds
Dyck, P. J., Zimmerman, I. R., Gillen, D. A., Johnson, D. M., Karnes, J. L., & O’Brien, P. C. (1993) · Neurology · doi:10.1212/wnl.43.8.1500 · Cited by 209
Similarities between hearing and skin sensations.
von Békésy, G. (1959) · Psychological Review · doi:10.1037/h0046967 · Cited by 207
The effect of age and gender on epidermal nerve fiber density
Gøransson, L. G., Mellgren, S. I., Lindal, S., & Omdal, R. (2004) · Neurology · doi:10.1212/01.wnl.0000113732.41127.8f · Cited by 207
Quantification of myelinated endings and mechanoreceptors in human digital skin
Nolano, M., Provitera, V., Crisci, C., Stancanelli, A., Wendelschafer‐Crabb, G., Kennedy, W. R., & Santoro, L. (2003) · Annals of Neurology · doi:10.1002/ana.10615 · Cited by 201
Dyck, P. J., Dyck, P. J., Larson, T. S., O’Brien, P. C., & Velosa, J. A. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.510 · Cited by 190
Impact of Age, Gender and Cognitive Functioning on Pain Perception
Pickering, G. P., Jourdan, D., Eschalier, A., & Dubray, C. (2002) · Gerontology · doi:10.1159/000048937 · Cited by 185
Dyck, P. J. B., Bushek, W., Spring, E. M., Karnes, J. L., Litchy, W. J., O'Brien, P. C., & Service, F. J. (1987) · Diabetes Care · doi:10.2337/diacare.10.4.432 · Cited by 183
Gruener, G., & Dyck, P. J. (1994) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199411000-00004 · Cited by 174
Cutaneous innervation in Guillain-Barre syndrome: pathology and clinical correlations
Pan, C. (2003) · Brain · doi:10.1093/brain/awg039 · Cited by 170
Enzyme replacement therapy improves function of C-, Aδ-, and Aβ-nerve fibers in Fabry neuropathy
Hilz, M. J., Bryś, M., Marthol, H., Stemper, B., & Dütsch, M. (2004) · Neurology · doi:10.1212/01.wnl.0000118207.84514.40 · Cited by 168
Clinical applications of quantitative sensory testing (QST)
Zaslansky, R., & Yarnitsky, D. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00293-1 · Cited by 166
Peyron, R., Garcı́a-Larrea, L., Grégoire, M., Convers, P., Richard‐Mornas, A., Lavenne, F., Barral, F.-G., Mauguı̀ere, F., Michel, D., & Laurent, B. (2000) · Pain · doi:10.1016/s0304-3959(99)00190-6 · Cited by 162
Dyck, P. J. (1988) · Journal of Sound and Vibration · doi:10.1016/0022-460x(88)90273-8 · Cited by 156
Green, M. S., Kaye, J. A., & Ball, M. J. (2000) · Neurology · doi:10.1212/wnl.54.1.105 · Cited by 152
Meier, P. M., Berde, C. B., DiCanzio, J., Zurakowski, D., & Sethna, N. F. (2001) · Muscle & Nerve · doi:10.1002/mus.1153 · Cited by 148
Procedures for setting normal values
O’Brien, P. C., & Dyck, P. J. (1995) · Neurology · doi:10.1212/wnl.45.1.17 · Cited by 147
Age-Associated Differences in Responses to Noxious Stimuli
Edwards, R. R., & Fillingim, R. B. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.3.m180 · Cited by 144
Luebke, J. I., Chang, Y., Moore, T. L., & Rosene, D. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.035 · Cited by 144
Self-citationReview: Neural Coding and the Basic Law of Psychophysics
Johnson, K. O., Hsiao, S. S., & Yoshioka, T. (2002) · The Neuroscientist · doi:10.1177/107385840200800207 · Cited by 143
Quantitative sensory testing: effect of site and skin temperature on thermal thresholds
Hagander, L. G., Midani, H. A., Kuskowski, M. A., & Parry, G. J. G. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00192-3 · Cited by 133
(1993) · Neurology · doi:10.1212/wnl.43.5.1050 · Cited by 131
Simovic, D., Isner, J. M., Ropper, A. H., Pieczek, A., & Weinberg, D. H. (2001) · Archives of Neurology · doi:10.1001/archneur.58.5.761 · Cited by 118
A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain
Wallace, M. S., Rowbotham, M. C., Katz, N., Dworkin, R. H., Dotson, R. M., Galer, B. S., Rauck, R. L., Backonja, M. M., Quessy, S. N., & Meisner, P. D. (2002) · Neurology · doi:10.1212/01.wnl.0000036273.98213.34 · Cited by 115
Wellmer, A., Misra, V. P., Sharief, M. K., Kopelman, P. G., & Anand, P. (2001) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2001.01019.x · Cited by 110
Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy
Chiang, M., Lin, Y.-H., Pan, C., Tseng, T.-J., Lin, W. ‐., & Hsieh, S. (2002) · Neurology · doi:10.1212/wnl.59.7.1094 · Cited by 103
Self-citationQuantitative Thermal Perception Testing in Adults
Hilz, M. J., Stemper, B., Axelrod, F. B., Kolodny, E. H., & Neundörfer, B. (1999) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199909000-00008 · Cited by 100
A standard test of heat-pain responses using CASE IV
Dyck, P. J. B., Zimmerman, I. R., Johnson, D. M., Gillen, D. A., Hokanson, J. L., Karnes, J. L., Gruener, G., & O’Brien, P. C. (1996) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00277-9 · Cited by 96
Plastic Changes in Nociceptive Transmission of the Rat Spinal Cord With Advancing Age
Iwata, K., Fukuoka, T., Kondo, E., Tsuboi, Y., Tashiro, A., Noguchi, K., Masuda, Y., Morimoto, T., & Kanda, K. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00243.2001 · Cited by 94
Effects of aging on human skin innervation
Chang, Y., Lin, W., & Hsieh, S. (2003) · Neuroreport · doi:10.1097/00001756-200401190-00029 · Cited by 83
Self-citationResidual neuropathy in long-term population-based follow-up of Guillain–Barre syndrome
de la Cour, C. D., & Jakobsen, J. (2005) · Neurology · doi:10.1212/01.wnl.0000149521.65474.83 · Cited by 83
Effect of aging on sensory nerve conduction study parameters
Tong, H. C., Werner, R. A., & Franzblau, A. (2004) · Muscle & Nerve · doi:10.1002/mus.20026 · Cited by 81
Arnett, B. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.6.898 · Cited by 78
Altered Cutaneous Sensation in Trigeminal Neuralgia
Nurmikko, T. J. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530170087025 · Cited by 73
Degeneration of nociceptive nerve terminals in human peripheral neuropathy
Pan, C., Lin, Y.-H., Lin, W.-M., Tai, T., & Hsieh, S. (2001) · Neuroreport · doi:10.1097/00001756-200103260-00034 · Cited by 69
Self-citationQuantitative sensory testing: high sensitivity in small fiber neuropathy with normal NCS/EMG
Magda, P., Latov, N., Renard, M. V., & Sander, H. W. (2002) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2002.02029.x · Cited by 61
Comparison of algorithms of testing for use in automated evaluation of sensation
Dyck, P. J. B., Karnes, J. L., Gillen, D. A., O’Brien, P. C., Zimmerman, I. R., & Johnson, D. M. (1990) · Neurology · doi:10.1212/wnl.40.10.1607 · Cited by 54
Lipton, R. B., Galer, B. S., Dutcher, J. P., Portenoy, R. K., Berger, A., Arezzo, J. C., Mizruchi, M. S., Wiernik, P. H., & Schaumburg, H. H. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520210044017 · Cited by 35
Aging and quantitative sensory thresholds.
Mp, M., & Sc, T. (1990) · PubMed · Cited by 30
Clinical versus quantitative vibration assessment: improving clinical performance
Burns, T. M., Taly, A., O’Brien, P. C., & Dyck, P. J. B. (2002) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2002.02016.x · Cited by 28
Quantitative sensory testing: effect of site and pressure on vibration thresholds
Hagander, L. G., Midani, H. A., Kuskowski, M. A., & Parry, G. J. G. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00278-9 · Cited by 25
Sedehizade, F., Klocke, R., & Jockusch, H. (1997) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199702)20:2 · Cited by 23
Sensory Testing in Human Immunodeficiency Virus Type 1-Infected Men
Gulevich, S. J., Kalmijn, J. A., Thal, L. J., Iragui‐Madoz, V., McCutchan, J. A., Kennedy, C. J., & Grant, I. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530360083022 · Cited by 20
Quantitative sensation testing in small‐diameter sensory fiber neuropathy
Dyck, P. J., & O’Brien, P. C. (2002) · Muscle & Nerve · doi:10.1002/mus.10255 · Cited by 17
Role of insulin‐like growth factor‐I in the treatment of painful small fiber predominant neuropathy
Windebank, A. J., Sorenson, E. J., Civil, R. H., & O’Brien, P. C. (2004) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2004.09311.x · Cited by 16
Diagnostic yield by testing small fiber function in patients examined for polyneuropathy
Sindrup, S. H., Gaist, D., Johannsen, L. G., Havsager, A., Homburg, A.-M. F., Kjeldsen, M. J., Madsen, C., Dalsgaard, N. J., Ellemann, K., & Smith, T. (2001) · Journal of the Peripheral Nervous System · doi:10.1046/j.1529-8027.2001.01022.x · Cited by 12
Cited by
Sorted by citations
Magerl, W., Krumova, E. K., Baron, R., Tölle, T. R., Treede, R., & Maier, C. (2010) · Pain · doi:10.1016/j.pain.2010.07.026 · Cited by 612
Lautenbacher, S., Peters, J. H., Heesen, M., Scheel, J., & Kunz, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.039 · Cited by 536
Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study
Lauria, G., Bakkers, M., Schmitz, C., Lombardi, R., Penza, P., Devigili, G., Smith, A. G., Hsieh, S., Mellgren, S. I., Umapathi, T., et al. (2010) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2010.00271.x · Cited by 518
Self-citationMultisensory design: Reaching out to touch the consumer
Spence, C. J., & Gallace, A. (2011) · Psychology and Marketing · doi:10.1002/mar.20392 · Cited by 450
(2010) · PubMed Central · Cited by 267
Metadata
- Authors
- Lin, Y., Hsieh, S., Chao, C., Chang, Y., & Hsieh, S.
- Affiliations
- National Taiwan University Hospital (TW)
- National Taiwan University (TW)
- Corresponding author
- Hsieh, Sung‐Tsang
- Venue
- Journal of the Peripheral Nervous System
- Publisher
- Wiley
- Published
- 2005-09
- Volume
- 10
- Issue
- 3
- Pages
- 269-281
- ISSN
- 1085-9489 (ISSN-L)
- 1529-8027
- OpenAlex
- W2100986954
- Cited by
- 176
- References
- 65
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 11
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Peripheral Nervous System (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health Research Institutes
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- aging, temperature thresholds, vibratory threshold, quantitative sensory testing, method of limits, reaction time, age-related sensory decline, neuropathy
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aging, Algorithms, Analysis of Variance, Body Weight, Differential Threshold, Female, Foot, Hand, Humans, Male, Middle Aged, Reference Values, Sensory Thresholds, Sex Factors, Statistics as Topic, Thermosensing, Vibration, Pain Threshold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
