Cited by 176Pain Mechanisms and TreatmentsIon Channels and ReceptorsTactile and Sensory Interactions

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Influence of aging on thermal and vibratory thresholds of quantitative sensory testing

Lin, Yea‐Huey, Hsieh, Song‐Chou, Chao, Chi‐Chao, Chang, Yang‐Chyuan, Hsieh, Sung‐Tsang·2005·Journal of the Peripheral Nervous System

DOI 10.1111/j.1085-9489.2005.10305.x

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Abstract

Abstract Quantitative sensory testing has become a common approach to evaluate thermal and vibratory thresholds in various types of neuropathies. To understand the effect of aging on sensory perception, we measured warm, cold, and vibratory thresholds by performing quantitative sensory testing on a population of 484 normal subjects (175 males and 309 females), aged 48.61 ± 14.10 (range 20–86) years. Sensory thresholds of the hand and foot were measured with two algorithms: the method of limits (Limits) and the method of level (Level). Thresholds measured by Limits are reaction‐time‐dependent, while those measured by Level are independent of reaction time. In addition, we explored (1) the correlations of thresholds between these two algorithms, (2) the effect of age on differences in thresholds between algorithms, and (3) differences in sensory thresholds between the two test sites. Age was consistently and significantly correlated with sensory thresholds of all tested modalities measured by both algorithms on multivariate regression analysis compared with other factors, including gender, body height, body weight, and body mass index. When thresholds were plotted against age, slopes differed between sensory thresholds of the hand and those of the foot: for the foot, slopes were steeper compared with those for the hand for each sensory modality. Sensory thresholds of both test sites measured by Level were highly correlated with those measured by Limits, and thresholds measured by Limits were higher than those measured by Level. Differences in sensory thresholds between the two algorithms were also correlated with age: thresholds of the foot were higher than those of the hand for each sensory modality. This difference in thresholds (measured with both Level and Limits) between the hand and foot was also correlated with age. These findings suggest that age is the most significant factor in determining sensory thresholds compared with the other factors of gender and anthropometric parameters, and this provides a foundation for investigating the neurobiologic significance of aging on the processing of sensory stimuli.

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Authors: Lin, Y., Hsieh, S., Chao, C., Chang, Y., & Hsieh, S.
Affiliations: National Taiwan University Hospital (TW)
National Taiwan University (TW)
Corresponding author: Hsieh, Sung‐Tsang
ORCID: Hsieh, Song‐Chou
Chao, Chi‐Chao
Chang, Yang‐Chyuan
Venue: Journal of the Peripheral Nervous System
Publisher: Wiley
Published: 2005-09
Volume: 10
Issue: 3
Pages: 269-281
ISSN: 1085-9489 (ISSN-L)
1529-8027
DOI: 10.1111/j.1085-9489.2005.10305.x
OpenAlex: W2100986954
Cited by: 176
References: 65
Citations by year: 2026: 4 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 9 · 2013: 11 · 2012: 11
FWCI: 4.01
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 36 d)
Locations: Journal of the Peripheral Nervous System (publishedVersion)
PubMed (publishedVersion)
Funders: National Health Research Institutes
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords: aging, temperature thresholds, vibratory threshold, quantitative sensory testing, method of limits, reaction time, age-related sensory decline, neuropathy
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Aging, Algorithms, Analysis of Variance, Body Weight, Differential Threshold, Female, Foot, Hand, Humans, Male, Middle Aged, Reference Values, Sensory Thresholds, Sex Factors, Statistics as Topic, Thermosensing, Vibration, Pain Threshold

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Influence of aging on thermal and vibratory thresholds of quantitative sensory testing

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