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Significance of nitroimidazole compounds and hypoxia‐inducible factor‐1 for imaging tumor hypoxia

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Kizaka‐Kondoh, Shinae, Konse‐Nagasawa, Hideko·2009·Cancer Science
DOI 10.1111/j.1349-7006.2009.01195.x
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Abstract

A tumor‐specific microenvironment is characterized by hypoxia, in which oxygen tension is considerably lower than in normal tissues. The hypoxic status of various solid tumors has been attributed as an indicator of adverse prognosis due to tumor progression toward a more malignant phenotype with increased metastatic potential and resistance to treatment. Various exogenous and endogenous markers for hypoxia are currently available and studied in relation to each other, tumor architecture, and tumor microenvironment. Over the last few decades, various methods have been suggested to assess the level of oxygenation in solid tumors. Among them, nitroimidazole compounds have provided promising information on tumor hypoxia. To quantify the extent of hypoxia requires that nitroimidazole binding be primarily dependent on oxygen concentration as well as nitroreductase levels in the tumor cells. Furthermore, recent progress in molecular biology has highlighted a transcription factor, hypoxia‐inducible factor (HIF)‐1, whose activity is induced by hypoxia. HIF‐1 plays a central role in malignant progression by inducing the expression of various genes, whose functions are strongly associated with malignant alteration of the entire tumor. The cellular changes induced by HIF‐1 are extremely important therapeutic targets of cancer therapy, particularly in the therapy against refractory cancers. In this review, we will discuss the significance of pimonidazole and HIF‐1 as exogenous and endogenous hypoxia markers, respectively, as well as their evaluation and imaging of tumor hypoxia. (Cancer Sci 2009)

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Research works printed but not linked: 72

  1. 10.1016/j.semradonc.2004.04.008 · DOI · Paper page
  2. 10.1111/j.1349-7006.2003.tb01395.x · DOI · Paper page
  3. 10.1016/S0092-8674(01)00507-4 · DOI · Paper page
  4. 10.1007/s00066-003-1150-9 · DOI
  5. 10.1016/j.molcel.2006.05.001 · DOI
  6. Hockel M, 1991, Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements, Cancer Res, 51, 6098
  7. 10.1259/bjr.72.859.10624317 · DOI · Paper page
  8. 10.1038/bjc.1995.429 · DOI · Paper page
  9. 10.1038/nrc2289 · DOI · Paper page
  10. 10.2307/3580034 · DOI · Paper page
  11. 10.1158/0008-5472.CAN-04-4480 · DOI
  12. 10.1002/hed.20223 · DOI · Paper page
  13. 10.1038/sj.bjc.6602219 · DOI
  14. 10.1158/0008-5472.CAN-08-0677 · DOI
  15. 10.1016/S0360-3016(02)03935-4 · DOI
  16. 10.1002/ijc.23449 · DOI
  17. Brown JM, 1979, Evidence for acutely hypoxic cells in mouse tumors and a possible mechanism of reoxygenation, Br, 52, 650
  18. 10.1007/BF01081524 · DOI · Paper page
  19. 10.2967/jnumed.107.045914 · DOI · Paper page
  20. 10.1161/STROKEAHA.107.485938 · DOI
  21. Maeda K, 1953, A new antibiotic, azomycin, J Antibiot (Tokyo), 6, 182
  22. Mohindra JK, 1976, Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells, Cancer Res, 36, 930
  23. 10.1093/jac/31.2.201 · DOI
  24. 10.1248/bpb.29.2335 · DOI
  25. 10.1016/j.clon.2007.03.010 · DOI · Paper page
  26. 10.1007/BF00689809 · DOI
  27. 10.1016/j.bmc.2004.06.039 · DOI
  28. Hodgkiss RJ, 1998, Use of 2‐nitroimidazoles as bioreductive markers for tumour hypoxia, Anticancer Drug Des, 13, 687
  29. 10.1021/ja00203a018 · doi:10.1021/ja00203a018
  30. Hori H, 1994, Environmental Oxidants, 425
  31. 10.3109/03602538809049618 · doi:10.3109/03602538809049618
  32. 10.1016/S0006-2952(00)00373-7 · doi:10.1016/s0006-2952(00)00373-7
  33. 10.1016/j.freeradbiomed.2007.12.013 · DOI
  34. 10.2174/1389557013406800 · doi:10.2174/1389557013406800
  35. 10.1016/j.radonc.2003.09.012 · DOI
  36. Azuma Y, 2003, Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin, Clin Cancer Res, 9, 4944
  37. 10.1016/0360-3016(92)90497-6 · DOI
  38. Orna MV, 1989, Correlation of kinetic parameters of nitroreductase enzymes with redox properties of nitroaromatic compounds, J Biol Chem, 264, 12 379, 10.1016/S0021-9258(18)63869-4 · doi:10.1016/s0021-9258(18)63869-4
  39. 10.2307/3574491 · DOI · Paper page
  40. 10.1289/ehp.8564309 · DOI · Paper page
  41. 10.1002/ijc.2910610422 · DOI · Paper page
  42. Franko AJ, 1987, Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro, Cancer Res, 47, 5367
  43. 10.1007/BF00253009 · doi:10.1007/bf00253009
  44. 10.2307/3575246 · DOI · Paper page
  45. 10.1080/09553008514550881 · doi:10.1080/09553008514550881
  46. 10.1016/j.ijrobp.2005.09.010 · doi:10.1016/j.ijrobp.2005.09.010
  47. Bennewith KL, 2002, Orally administered pimonidazole to label hypoxic tumor cells, Cancer Res, 62, 6827
  48. 10.1667/RR0719.1 · DOI · Paper page
  49. 10.1016/0360-3016(94)90190-2 · doi:10.1016/0360-3016(94)90190-2
  50. 10.2307/3579536 · DOI
  51. 10.1016/j.ijrobp.2005.03.049 · DOI
  52. 10.1016/0006-2952(90)90086-Z · DOI
  53. 10.1007/s00259-008-0772-7 · doi:10.1007/s00259-008-0772-7
  54. 10.2174/092986708783497391 · DOI
  55. 10.1016/j.ijrobp.2005.05.068 · DOI
  56. 10.2967/jnumed.108.053785 · DOI · Paper page
  57. 10.1111/j.1464-410X.2007.06761.x · DOI
  58. 10.1016/j.ijrobp.2007.11.034 · doi:10.1016/j.ijrobp.2007.11.034
  59. Engelhardt EL, 2002, The synthesis and radiolabeling of 2‐nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia, J Nucl Med, 43, 837
  60. Fujibayashi Y, 1997, Copper‐62‐ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential, J Nucl Med, 38, 1155
  61. 10.1102/1470-7330.2007.0001 · doi:10.1102/1470-7330.2007.0001
  62. 10.1053/j.semnuclmed.2007.07.001 · DOI · Paper page
  63. 10.1080/09553009014552331 · doi:10.1080/09553009014552331
  64. 10.1158/1078-0432.CCR-06-1563 · DOI
  65. 10.1016/j.radonc.2004.07.018 · DOI
  66. Harada H, 2002, Antitumor effect of TAT‐oxygen‐dependent degradation‐caspase‐3 fusion protein specifically stabilized and activated in hypoxic tumor cells, Cancer Res, 62, 2013
  67. 10.1162/15353500200505112 · DOI
  68. 10.1016/j.febslet.2006.09.025 · DOI
  69. 10.1038/sj.onc.1210556 · DOI
  70. 10.1016/j.ijrobp.2007.04.081 · DOI
  71. 10.1073/pnas.0701152104 · DOI · Paper page
  72. 10.1016/j.radonc.2006.01.002 · DOI

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Metadata

Authors
Kizaka‐Kondoh, S., & Konse‐Nagasawa, H.
Venue
Cancer Science
Publisher
Wiley
Published
2009-07-10
Volume
100
Issue
8
Pages
1366-1373
ISSN
  • 1347-9032 (ISSN-L)
  • 1349-7006
DOI
10.1111/j.1349-7006.2009.01195.x
OpenAlex
W1966798186
Cited by
255
References
9
FWCI
3.11
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Kizaka‐Kondoh, S., & Konse‐Nagasawa, H. (2009). Significance of nitroimidazole compounds and hypoxia‐inducible factor‐1 for imaging tumor hypoxia. Cancer Science. https://doi.org/10.1111/j.1349-7006.2009.01195.x

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