The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Interaction of hREV1 with three human Y‐family DNA polymerases
Abstract
Polκ is one of many DNA polymerases involved in translesion DNA synthesis (TLS). It belongs to the Y‐family of polymerases along with Polη, Polι and hREV1. Unlike Polη encoded by the xeroderma pigmentosum variant (XPV) gene, Polκ is unable to bypass UV‐induced DNA damage in vitro, but it is able to bypass benzo[a]pyrene (B[a]P)‐adducted guanines accurately and efficiently. In an attempt to identify factor(s) targeting Polκ to its cognate DNA lesion(s), we searched for Polκ‐interacting proteins by using the yeast two‐hybrid assay. We found that Polκ interacts with a C‐terminal region of hREV1. Polη and Polι were also found to interact with the same region of hREV1. The interaction between Polκ and hREV1 was confirmed by pull‐down and co‐immunoprecipitation assays. The C‐terminal region of hREV1 is known to interact with hREV7, a non‐catalytic subunit of Polζ that is another structurally unrelated TLS enzyme, and we show that Polκ and hREV7 bind to the same C‐terminal region of hREV1. Thus, our results suggest that hREV1 plays a pivotal role in the multi‐enzyme, multi‐step process of translesion DNA synthesis.
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Cites
The BRCT Domain Is a Phospho-Protein Binding Domain
Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727
Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair
Prakash, S., & Prakash, L. (2002) · Genes & Development · doi:10.1101/gad.1009802 · Cited by 344
Cited by
Y-family DNA polymerases and their role in tolerance of cellular DNA damage
Sale, J. E., Lehmann, A. R., & Woodgate, R. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3289 · Cited by 665
Lange, S. S., Takata, K.-I., & Wood, R. D. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2998 · Cited by 615
Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance
Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591
Translesion synthesis: Y-family polymerases and the polymerase switch
LEHMANN, A., NIIMI, A., OGI, T., BROWN, S., SABBIONEDA, S., WING, J., KANNOUCHE, P., & GREEN, C. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.003 · Cited by 389
Goodman, M. F., & Woodgate, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a010363 · Cited by 317
“4) (Guo et al. 2003; Ohashi et al. 2004; Tissier et al. 2004) and targeting them to sites of DNA damage.”
Background
Metadata
- Authors
- Ohashi, E., Murakumo, Y., Kanjo, N., Akagi, J., Masutani, C., Hanaoka, F., & Ohmori, H.
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2004-06
- Volume
- 9
- Issue
- 6
- Pages
- 523-531
- ISSN
- 1356-9597 (ISSN-L)
- 1365-2443
- OpenAlex
- W1997803780
- Cited by
- 256
- References
- 3
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ohashi, E., Murakumo, Y., Kanjo, N., Akagi, J., Masutani, C., Hanaoka, F., & Ohmori, H. (2004). Interaction of hREV1 with three human Y‐family DNA polymerases. Genes to Cells. https://doi.org/10.1111/j.1356-9597.2004.00747.x
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