The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System
Abstract
The effect of L‐DOPA and the dopamine (DA) receptor stimulating drug apomorphine was studied in rats after unilateral degeneration of the nigrostriatal DA system by intracerebral injection of 6‐hydroxydopamine. Both apomorphine and L‐DOPA induced a strong rotational behaviour which was registered in a specially designed “rotameter”. The direction of the rotation indicated that the denervated striatum was more sensitive to DA receptor stimulating drugs than the innervated striatum. This supersensitivity probably corresponded to the decentralisation type of supersensitivity in the peripheral nervous system although it developed faster. The action of L‐DOPA was inhibited by pretreatment with the DOPA‐decarboxylase inhibitor Ro4–4602 which indicated that L‐DOPA must be converted to DA in order to stimulate the supersensitive postsynaptic cells. Pretreatment with a single dose of reserpine also induced supersentitivity to apomorphine which reached its maximum on the 3rd day and then decreased on the 4th day. Postsynaptic supersensitivity after degeneration of the nigro‐striatal DA system is probably an important reason for the effectiveness of the L‐DOPA therapy against Parkinson's disease.
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Citations
Cites
Stereotaxic mapping of the monoamine pathways in the rat brain
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10998.x · Cited by 3,819
Self-citationFLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE
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Self-citation6-hydroxy-dopamine induced degeneration of central monoamine neurons
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Self-citationAscending Monoamine Neurons to the Telencephalon and Diencephalon
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Self-citationCellular localization of brain monoamines.
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Self-citationAmphetamines and related compounds
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Striatal Dopamine Release after Amphetamine or Nerve Degeneration Revealed by Rotational Behaviour
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Self-citation
Cited by
Oxidative Stress in Neurodegenerative Diseases
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Oxidative Stress in Neurodegenerative Diseases
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Caffeine as a psychomotor stimulant: mechanism of action
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Pharmacology and behavioral pharmacology of the mesocortical dopamine system
Tzschentke, T. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00033-2 · Cited by 481
Metadata
- Authors
- Ungerstedt, U.
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 1971-12
- Volume
- 82
- Issue
- S367
- Pages
- 69-93
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W2050709677
- Cited by
- 1,922
- References
- 29
- FWCI
- 56.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ungerstedt, U. (1971). Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System. Acta Physiologica Scandinavica. https://doi.org/10.1111/j.1365-201x.1971.tb11000.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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