Pharmacology and behavioral pharmacology of the mesocortical dopamine system

Tzschentke, T.M.

doi:10.1016/s0301-0082(00)00033-2

Cited by 483Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Pharmacology and behavioral pharmacology of the mesocortical dopamine system

Tzschentke, T.M.·2001·Progress in Neurobiology

DOI 10.1016/s0301-0082(00)00033-2

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Abstract

The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex behavioral responses. Considerable research efforts are directed towards refining the knowledge about the function of this brain area and the role it plays in cognitive performance and behavioral output. In the first part, this review provides, from a pharmacological perspective, an overview of anatomical, electrophysiological and neurochemical aspects of the function of the PFC, with an emphasis on the mesocortical dopamine system. Anatomy of the mesocortical system, basic physiological and pharmacological properties of neurotransmission within the PFC, and interactions between dopamine and glutamate as well as other transmitters within the mesocorticolimbic circuit are included. The coverage of these data is largely restricted to what is relevant for the second part of the review which focuses on behavioral studies that have examined the role of the PFC in a variety of phenomena, behaviors and paradigms. These include reward and addiction, locomotor activity and sensitization, learning, cognition, and schizophrenia. Although the focus of this review is on the mesocortical dopamine system, given the intricate interactions of dopamine with other transmitter systems within the PFC and the importance of the PFC as a source of glutamate in subcortical areas, these aspects are also covered in some detail where appropriate. Naturally, a topic as complex as this cannot be covered comprehensively in its entirety. Therefore this review is largely limited to data derived from studies using rats, and it is also specifically restricted to data concerning the medial PFC (mPFC). Since in several fields of research the findings concerning the function or role of the mPFC are relatively inconsistent, the question is addressed whether these inconsistencies might, at least in part, be related to the anatomical and functional heterogeneity of this brain area.

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In frontal cortex, because of low concentrations of the dopamine reuptake molecule DAT, it takes much longer to clear dopamine from synapses.
“In contrast, in frontal cortex, because of low concentrations of the dopamine reuptake molecule DAT, it takes much longer to clear dopamine from synapses (for reviews, see, e.g., [72–74]).”
From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [72]

Handbook of Physiology.
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388 · see citing works
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,159 · see citing works
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724 · see citing works
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640 · see citing works
Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans: Psychotomimetic, Perceptual, Cognitive, and Neuroendocrine Responses
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330 · see citing works
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985 · see citing works
Recent advances in the phencyclidine model of schizophrenia
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works
The somatic marker hypothesis and the possible functions of the prefrontal cortex
Damasio, A. R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0125 · Cited by 2,847 · see citing works
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747 · see citing works
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
Sokoloff, P., Bruno Giros, A., Martres, M., Bouthenet, M.-L., & Schwartz, J. (1990) · Nature · doi:10.1038/347146a0 · Cited by 2,608 · see citing works
Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990) · PubMed · Cited by 2,422 · see citing works
Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262 · see citing works
Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes
MILNER, B. (1963) · Archives of Neurology · doi:10.1001/archneur.1963.00460070100010 · Cited by 2,217 · see citing works
Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
Parent, A., & Hazrati, L.-N. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00007-c · Cited by 2,161 · see citing works
Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain
Carlsson, A., & Lindqvist, M. (1963) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1963.tb01730.x · Cited by 2,156 · see citing works
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Robinson, T. G., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,110 · see citing works
The prefrontal cortex
Fuster, J. M. (1997) · Cited by 2,095 · see citing works
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works
Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity
Kalivas, P. W., & Stewart, J. (1991) · Brain Research Reviews · doi:10.1016/0165-0173(91)90007-u · Cited by 2,021 · see citing works
Dopamine in schizophrenia: a review and reconceptualization
Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1474 · Cited by 2,021 · see citing works
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,019 · see citing works
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
Tol, H. H. M. V., Bunzow, J. R., Guan, H., Sunahara, R. K., Seeman, P. M., Niznik, H. B., & Civelli, O. (1991) · Nature · doi:10.1038/350610a0 · Cited by 2,015 · see citing works
Glutamate: A Neurotransmitter in Mammalian Brain
Fonnum, F. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb09689.x · Cited by 2,003 · see citing works
Chapter 6 Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62678-3 · Cited by 1,961 · see citing works
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick, D. A., Connors, B. W., Lighthall, J. W., & Prince, D. A. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.782 · Cited by 1,935 · see citing works
Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb11000.x · Cited by 1,926 · see citing works
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901 · see citing works
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831 · see citing works
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Robinson, T. E., & Becker, J. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90002-0 · Cited by 1,796 · see citing works
Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum
Kelly, P. H., Seviour, P. W., & Iversen, S. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90233-4 · Cited by 1,740 · see citing works
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718 · see citing works
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685 · see citing works
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593 · see citing works
Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin
Sesack, S. R., Deutch, A. Y., Roth, R. H., & Bunney, B. S. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902900205 · Cited by 1,568 · see citing works
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545 · see citing works
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527 · see citing works
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513 · see citing works
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500 · see citing works
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450 · see citing works
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364 · see citing works
Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy
Richardson, N. R., & Roberts, D. C. S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00153-0 · Cited by 1,357 · see citing works
The neuropsychology of schizophrenia
Gray, J. A., Feldon, J., Rawlins, J. N. P., Hemsley, D. R., & Smith, A. D. (1991) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00065055 · Cited by 1,350 · see citing works
The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia
Jentsch, J., & Roth, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00060-8 · Cited by 1,349 · see citing works
The control of firing pattern in nigral dopamine neurons: burst firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02877.1984 · Cited by 1,346 · see citing works
Sensorimotor Gating and Schizophrenia
Braff, D. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810140081011 · Cited by 1,312 · see citing works
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
Mansour, A., Fox, C. A., Akil, H., & Watson, S. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93946-u · Cited by 1,297 · see citing works
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain
Monaghan, D., & Cotman, C. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-11-02909.1985 · Cited by 1,294 · see citing works
Efferent connections of the substantia nigra and ventral tegmental area in the rat
Beckstead, R. M., Domesick, V. B., & Nauta, W. J. H. (1979) · Brain Research · doi:10.1016/0006-8993(79)91001-1 · Cited by 1,293 · see citing works
Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task
Schultz, W., Apicella, P., & Ljungberg, T. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00900.1993 · Cited by 1,291 · see citing works
Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
The neurobiology of startle
Koch, M. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00098-7 · Cited by 1,287 · see citing works
The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat
Krettek, J. E., & Price, J. L. (1977) · The Journal of Comparative Neurology · doi:10.1002/cne.901710204 · Cited by 1,277 · see citing works
Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues
Tzschentke, T. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00060-4 · Cited by 1,254 · see citing works
Self-citation
A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
Pierce, R. C., & Kalivas, P. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00021-0 · Cited by 1,239 · see citing works
Specificity in the projection patterns of accumbal core and shell in the rat
Heimer, L., Zahm, D. S., Churchill, L., Kalivas, P. W., & Wohltmann, C. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90202-y · Cited by 1,219 · see citing works
Anatomy of CNS opioid receptors
Mansour, A., Khachaturian, H., Lewis, M. E., Akil, H., & Watson, S. J. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90093-8 · Cited by 1,197 · see citing works
Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics
BRAFF, D. L., Stone, C., Callaway, E., Geyer, M. A., Glick, I. D., & Bali, L. (1978) · Psychophysiology · doi:10.1111/j.1469-8986.1978.tb01390.x · Cited by 1,171 · see citing works
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
Schotte, A., Janssen, P. F. M., Gommeren, W., Luyten, W. H. M. L., Gompel, P. V., Lesage, A. S., Loore, K. D., & Leysen, J. E. (1996) · Psychopharmacology · doi:10.1007/bf02245606 · Cited by 1,167 · see citing works
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
Sunahara, R. K., Guan, H., O’Dowd, B. F., Seeman, P. M., Laurier, L. G., Ng, G., George, S. R., Torchia, J., Tol, H. H. M. V., & Niznik, H. B. (1991) · Nature · doi:10.1038/350614a0 · Cited by 1,166 · see citing works
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
Breier, A., Su, T.-P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2569 · Cited by 1,154 · see citing works
Information Processing and Attentional Functioning in the Developmental Course of Schizophrenic Disorders
Nuechterlein, K. H., & Dawson, M. E. (1984) · Schizophrenia Bulletin · doi:10.1093/schbul/10.2.160 · Cited by 1,141 · see citing works
Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex
Abercrombie, E. D., Keefe, K. A., DiFrischia, D. S., & Zigmond, M. J. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09224.x · Cited by 1,106 · see citing works
The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro‐gold
Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102 · see citing works
Dissociable Deficits in the Decision-Making Cognition of Chronic Amphetamine Abusers, Opiate Abusers, Patients with Focal Damage to Prefrontal Cortex, and Tryptophan-Depleted Normal Volunteers Evidence for Monoaminergic Mechanisms
Rogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101 · see citing works
Mesocorticolimbic dopaminergic network: functional and regulatory roles
Moal, M. L., & Simon, H. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.155 · Cited by 1,096 · see citing works
Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease
Carlsson, M. L., & Carlsson, A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90108-m · Cited by 1,086 · see citing works
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.
Pontieri, F. E., Tanda, G., Orzi, F., & Chiara, G. D. (1996) · Nature · doi:10.1038/382255a0 · Cited by 1,073 · see citing works
Neurobiology of addiction
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072 · see citing works
On the significance of subterritories in the “accumbens” part of the rat ventral striatum
Zahm, D. S., & Brog, J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90202-d · Cited by 1,040 · see citing works
Selective activation of the mesocortical DA system by stress
Thierry, A. M., Tassin, J., BLANC, G., & Glowinski, J. (1976) · Nature · doi:10.1038/263242a0 · Cited by 1,033 · see citing works
Gating and Habituation of the Startle Reflex in Schizophrenic Patients
Braff, D. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030038005 · Cited by 1,027 · see citing works
Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity
Oades, R. D., & Halliday, G. M. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90011-7 · Cited by 1,008 · see citing works
The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia
Gerfen, C. R. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.001441 · Cited by 1,004 · see citing works
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain
Petralia, R. S., & Wenthold, R. J. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903180309 · Cited by 999 · see citing works
Responses of monkey dopamine neurons during learning of behavioral reactions
Ljungberg, T., Apicella, P., & Schultz, W. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.1.145 · Cited by 987 · see citing works
The pyramidal neuron of the cerebral cortex: Morphological and chemical characteristics of the synaptic inputs
DeFelipe, J., & Fariñas, I. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90015-7 · Cited by 975 · see citing works
Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain
Mansour, A., Khachaturian, H., Lewis, M. E. S., Akil, H., & Watson, S. J. (1988) · Pain · doi:10.1016/0304-3959(88)90103-0 · Cited by 973 · see citing works
Dopamine receptor pharmacology
Seeman, P. M., & Tol, H. H. M. V. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90323-9 · Cited by 969 · see citing works
Discussion
Smith, Y., Bevan, M. D., Shink, É., & Bolam, J. P. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00004-9 · Cited by 948 · see citing works
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
Grace, A. A., & Bunney, B. S. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90135-5 · Cited by 937 · see citing works
Activation of memory circuits during cue-elicited cocaine craving.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.12040 · Cited by 936 · see citing works
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
Wolf, M. E. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00090-7 · Cited by 934 · see citing works
Central Catecholamine Neuron Systems: Anatomy and Physiology of the Dopamine Systems
Moore, R. Y., & Bloom, F. E. (1978) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.01.030178.001021 · Cited by 931 · see citing works
Extinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · see citing works
Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients
Benes, F. M. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350036005 · Cited by 894 · see citing works
Functions of the frontal cortex of the rat: A comparative review
Kolb, B. E. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90018-3 · Cited by 882 · see citing works
Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data
Parsons, C. G., Danysz, W., & Quack, G. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00019-2 · Cited by 881 · see citing works
Efferent connections and nigral afferents of the nucleus accumbens septi in the rat
Nauta, W. J. H., Smith, G. P., Faull, R. L. M., & Domesick, V. B. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90041-6 · Cited by 876 · see citing works
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study
Mansour, A., Fox, C. A., Burke, S., Meng, F., Thompson, R. C., Akil, H., & Watson, S. J. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500307 · Cited by 872 · see citing works
Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA
Bouthenet, M.-L., Souil, E., Martres, M., Sokoloff, P., Bruno Giros, A., & Schwartz, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91456-b · Cited by 868 · see citing works
Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines
Freund, T. F., Powell, J. F., & Smith, A. D. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90294-x · Cited by 867 · see citing works
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace, A., & Bunney, B. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-11-02866.1984 · Cited by 862 · see citing works
Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody
Petralia, R. S., Yokotani, N., & Wenthold, R. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00667.1994 · Cited by 850 · see citing works
The prefrontal cortex of the rat. I. cortical projection of the mediodorsal nucleus. II. efferent connections
Leonard, C. M. (1969) · Brain Research · doi:10.1016/0006-8993(69)90003-1 · Cited by 850 · see citing works
Glutamate‐ and GABA‐containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique
Ottersen, O. P., & Storm‐Mathisen, J. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902290308 · Cited by 848 · see citing works
Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat
Berendse, H. W., Graaf, Y. G.-D., & Groenewegen, H. J. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160305 · Cited by 847 · see citing works
Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area
Sesack, S. R., & Pickel, V. M. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903200202 · Cited by 820 · see citing works
The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data
Pennartz, C. M. A., Groenewegen, H. J., & LOPESDASILVA, F. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90025-6 · Cited by 802 · see citing works
Supranormal Stimulation of D1Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance
Zahrt, J., Taylor, J. R., Mathew, R. G., & Arnsten, A. F. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08528.1997 · Cited by 796 · see citing works
Latent inhibition.
Lubow, R. E. (1973) · Psychological Bulletin · doi:10.1037/h0034425 · Cited by 793 · see citing works
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792 · see citing works
An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal‐projection (prefrontal) cortex in the rat
Beckstead, R. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901840104 · Cited by 792 · see citing works
Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input.
Hoffman, H. S., & Ison, J. R. (1980) · Psychological Review · doi:10.1037/0033-295x.87.2.175 · Cited by 780 · see citing works
Efferent projections of the infralimbic cortex of the rat
Hurley, K. M., Herbert, H., Moga, M. M., & Saper, C. B. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903080210 · Cited by 777 · see citing works
Nicotine activates and desensitizes midbrain dopamine neurons
Pidoplichko, V. I., DeBiasi, M., Williams, J. T., & Dani, J. A. (1997) · Nature · doi:10.1038/37120 · Cited by 769 · see citing works
Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity
Iversen, S., & Mishkin, M. (1970) · Experimental Brain Research · doi:10.1007/bf00237911 · Cited by 765 · see citing works
Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760 · see citing works
Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain
Boyson, S., McGonigle, P., & Molinoff, P. B. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-11-03177.1986 · Cited by 749 · see citing works
Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area
Corrigall, W. A., Coen, K. M., & Adamson, K. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)90401-4 · Cited by 740 · see citing works
Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography
Groenewegen, H. J. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90339-9 · Cited by 732 · see citing works
Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine
Robinson, T. E., & Kolb, B. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00576.x · Cited by 726 · see citing works
Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro
Grace, A., & Onn, S. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03463.1989 · Cited by 720 · see citing works
Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.
Morgan, M. A., & LeDoux, J. E. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.681 · Cited by 717 · see citing works
Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
Okubo, Y., Suhara, T., Suzuki, K., Kobayashi, K., Inoue, O., Terasaki, O., Someya, Y., Sassa, T., Sudo, Y., Matsushima, E., et al. (1997) · Nature · doi:10.1038/385634a0 · Cited by 710 · see citing works
Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients
Swerdlow, N. R. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020063007 · Cited by 708 · see citing works
Neurotransmitter regulation of dopamine neurons in the ventral tegmental area
Kalivas, P. W. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90008-n · Cited by 704 · see citing works
Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine
Robinson, T. E., & Kolb, B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08491.1997 · Cited by 704 · see citing works
Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia
Kim, J. S., Kornhuber, H. H., Schmid‐Burgk, W., & Holzmüller, B. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90178-0 · Cited by 694 · see citing works
Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons
Piazza, P. V., & Le Moal, M. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.002043 · Cited by 690 · see citing works
Reward expectancy in primate prefrental neurons
Watanabe, M. (1996) · Nature · doi:10.1038/382629a0 · Cited by 684 · see citing works
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
Chiodo, L. A., & Bunney, B. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-08-01607.1983 · Cited by 680 · see citing works
NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers
Malhotra, A. K. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00137-3 · Cited by 680 · see citing works
Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry
Gonon, F. G. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90307-7 · Cited by 676 · see citing works
The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task
Sawaguchi, T., & Goldman‐Rakic, P. S. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.2.515 · Cited by 649 · see citing works
Self-inhibition by Dopaminergic Neurons
Groves, P. M., Wilson, C. J., Young, S. J., & Rebec, G. V. (1975) · Science · doi:10.1126/science.242074 · Cited by 642 · see citing works
Extrinsic connections of the basal ganglia
Parent, A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90105-j · Cited by 633 · see citing works
Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization
Pierce, R. C., Bell, K., Duffy, P., & Kalivas, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01550.1996 · Cited by 624 · see citing works
The role of dopamine in drug abuse viewed from the perspective of its role in motivation
Chiara, G. D. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01118-i · Cited by 624 · see citing works
Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia
Swerdlow, N. R., & Geyer, M. A. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033326 · Cited by 616 · see citing works
Differential Performance of Acute and Chronic Schizophrenics in a Latent Inhibition Task
Baruch, I., HEMSLEY, D. R., & Gray, J. A. (1988) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198810000-00004 · Cited by 612 · see citing works
Dopaminergic stimulation disrupts sensorimotor gating in the rat
Mansbach, R. S., Geyer, M. A., & BRAFF, D. L. (1988) · Psychopharmacology · doi:10.1007/bf00212846 · Cited by 608 · see citing works
The Left Striato-pallidal Hyperactivity Model of Schizophrenia
Early, T. S., Haller, J., Posner, M. I., & Raichle, M. (2019) · Psychology Press eBooks · doi:10.4324/9781315785004-2 · Cited by 598 · see citing works
Feature Article: Distributed Modular Architectures Linking Basal Ganglia, Cerebellum, and Cerebral Cortex: Their Role in Planning and Controlling Action
Houk, J. C., & Wise, S. P. (1995) · Cerebral Cortex · doi:10.1093/cercor/5.2.95 · Cited by 594 · see citing works
Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys
Murphy, B. L., Arnsten, A. F., Goldman-Rakic, P. S., & Roth, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1325 · Cited by 590 · see citing works
The dopamine transporter: immunochemical characterization and localization in brain
Ciliax, B. J., Heilman, C. J., Demchyshyn, L. L., Pristupa, Z. B., Ince, E., Hersch, S. M., Niznik, H. B., & Levey, A. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01714.1995 · Cited by 589 · see citing works
Dopaminergic innervation of the cerebral cortex: unexpected differences between rodents and primates
Berger, B., Gaspar, P., & Verney, C. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90179-x · Cited by 588 · see citing works
Dopamine Axon Varicosities in the Prelimbic Division of the Rat Prefrontal Cortex Exhibit Sparse Immunoreactivity for the Dopamine Transporter
Sesack, S. R., Hawrylak, V. A., Matus, C., Guido, M. A., & Levey, A. I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02697.1998 · Cited by 582 · see citing works
Nicotine maintains robust self-administration in rats on a limited-access schedule
Corrigall, W. A., & Coen, K. M. (1989) · Psychopharmacology · doi:10.1007/bf00589894 · Cited by 578 · see citing works
Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
Chesselet, M.-F. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90058-7 · Cited by 577 · see citing works
Dissociating executive functions of the prefrontal cortex.
Robbins, T. W. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0131 · Cited by 574 · see citing works
AMPA glutamate receptor subunits are differentially distributed in rat brain
Martin, L. J., Blackstone, C. D., Levey, A. I., Huganir, R. L., & Price, D. L. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90199-p · Cited by 569 · see citing works
Stress Preferentially Increases Extraneuronal Levels of Excitatory Amino Acids in the Prefrontal Cortex: Comparison to Hippocampus and Basal Ganglia
Moghaddam, B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13387.x · Cited by 567 · see citing works
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys
Arnsten, A. F. T., Cai, J. X., Murphy, B. L., & Goldman-Rakic, P. S. (1994) · Psychopharmacology · doi:10.1007/bf02245056 · Cited by 566 · see citing works
Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats
Carboni, E., Impérato, A., Perezzani, L., & Chiara, G. D. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90012-2 · Cited by 560 · see citing works
Correlation of physiological subgroupings of nonpyramidal cells with parvalbumin- and calbindinD28k-immunoreactive neurons in layer V of rat frontal cortex
Kawaguchi, Y., & Kubota, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.387 · Cited by 558 · see citing works
Dissociable Forms of Inhibitory Control within Prefrontal Cortex with an Analog of the Wisconsin Card Sort Test: Restriction to Novel Situations and Independence from “On-Line” Processing
Dias, R., Robbins, T. W., & Roberts, A. C. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09285.1997 · Cited by 555 · see citing works
Involvement of the Prelimbic–Infralimbic Areas of the Rodent Prefrontal Cortex in Behavioral Flexibility for Place and Response Learning
Ragozzino, M. E., Detrick, S., & Kesner, R. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04585.1999 · Cited by 553 · see citing works
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity
Bunney, B. S., & Grace, A. A. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90471-x · Cited by 553 · see citing works
Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxidase study in the rat
Phillipson, O. T. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870108 · Cited by 553 · see citing works
Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats
PYCOCK, C., Kerwin, R. W., & Carter, C. J. (1980) · Nature · doi:10.1038/286074a0 · Cited by 550 · see citing works
Dopamine ?Autoreceptors?: Pharmacological characterization by microiontophoretic single cell recording studies
Aghajanian, G. K., & Bunney, B. S. (1977) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00508803 · Cited by 548 · see citing works
Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex
Granon, S., Passetti, F., Thomas, K. L., Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01208.2000 · Cited by 546 · see citing works
Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens
Kalivas, P. W., & Duffy, P. (1990) · Synapse · doi:10.1002/syn.890050104 · Cited by 544 · see citing works
Biochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibres in rat brain
Fonnum, F., Storm‐Mathisen, J., & Divac, I. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90168-8 · Cited by 543 · see citing works
5-Hydroxytryptamine 2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
Jakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536 · see citing works
Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex
Kawaguchi, Y. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02638.1995 · Cited by 533 · see citing works
Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons
Clarke, P. B. S., & Pert, A. (1985) · Brain Research · doi:10.1016/0006-8993(85)90456-1 · Cited by 527 · see citing works
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
Rossetti, Z. L., Hmaidan, Y., & GESSA, G. L. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90706-a · Cited by 526 · see citing works
Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.
Bals-Kubik, R., Ableitner, A., Herz, A., & Shippenberg, T. S. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10296-6 · Cited by 525 · see citing works
The acoustic startle response in rats—circuits mediating evocation, inhibition and potentiation
Koch, M., & Schnitzler, H. U. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)02296-1 · Cited by 521 · see citing works
Mismatches between neurotransmitter and receptor localizations in brain: observations and implications
Herkenham, M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90268-5 · Cited by 520 · see citing works
Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
Nisell, M., Nomikos, G. G., & Svensson, T. H. (1994) · Synapse · doi:10.1002/syn.890160105 · Cited by 510 · see citing works
Chapter 5 The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: evidence for a parallel organization
Groenewegen, H. J., Berendse, H. W., Wolters, J. G., & Lohman, A. H. M. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)62677-1 · Cited by 506 · see citing works
Mesencephalic dopamine neurons projecting to neocortex
Lindvall, O., Björklund, A., Moore, R. Y., & Stenevi, U. (1974) · Brain Research · doi:10.1016/0006-8993(74)90947-0 · Cited by 504 · see citing works
Dopaminergic Terminals in the Rat Cortex
Thierry, A. M., Blanc, G., Sobel, A., Stinus, L., & Glowinski, J. (1973) · Science · doi:10.1126/science.182.4111.499 · Cited by 503 · see citing works
The Cerebral Cortex of the Rat and Visual Attentional Function: Dissociable Effects of Mediofrontal, Cingulate, Anterior Dorsolateral, and Parietal Cortex Lesions on a Five-Choice Serial Reaction Time Task
Muir, J. L., Everitt, B. J., & Robbins, T. W. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.470 · Cited by 503 · see citing works
Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists
Skirboll, L. R., Grace, A. A., & Bunney, B. S. (1979) · Science · doi:10.1126/science.482929 · Cited by 501 · see citing works
D1Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+Conductance
Hernández‐López, S., Bargas, J., Surmeier, D. J., Reyes, A., & Galarraga, E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03334.1997 · Cited by 495 · see citing works
Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
Mrzljak, L., Bergson, C., Pappy, M., Huff, R., Levenson, R., & Goldman-Rakic, P. S. (1996) · Nature · doi:10.1038/381245a0 · Cited by 494 · see citing works
Afferent connections of the medial frontal cortex of the rat. II. Cortical and subcortical afferents
Condé, F., Maire-Lepoivre, E., Audinat, É., & Crépel, F. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903520407 · Cited by 494 · see citing works
Cortical Dopaminergic Involvement in Cocaine Reinforcement
Goeders, N. E., & Smith, J. E. (1983) · Science · doi:10.1126/science.6879176 · Cited by 490 · see citing works
Cholecystokinin innervation of the ventral striatum: A morphological and radioimmunological study
Záborszky, L., Alheid, G. F., Beinfeld, M. C., Eiden, L. E., Heimer, L., & Palkovits, M. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90302-1 · Cited by 489 · see citing works
Catecholamine regulation of the prefrontal cortex
Arnsten, A. F. T. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100208 · Cited by 489 · see citing works
Pharmacology of mesocortical dopamine neurons.
Bannon, M. J., & Roth, R. H. (1983) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06572-x · Cited by 488 · see citing works
A glutamatergic corticostriatal path?
McGeer, P. L., McGeer, E. G., Scherer, U., & Singh, K. (1977) · Brain Research · doi:10.1016/0006-8993(77)91003-4 · Cited by 486 · see citing works
The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1
Petralia, R., Wang, Y., & Wenthold, R. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06102.1994 · Cited by 481 · see citing works
Chronic Stress Induces Impairment of Spatial Working Memory Because of Prefrontal Dopaminergic Dysfunction
Mizoguchi, K., Yuzurihara, M., Ishige, A., Sasaki, H., Chui, D.-H., & Tabira, T. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01568.2000 · Cited by 481 · see citing works
Phencyclidine-induced psychosis
Rm, A., & Young, S. J. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.9.1081 · Cited by 478 · see citing works
High affinity uptake of glutamate in terminals of corticostriatal axons
Divac, I., Fonnum, F., & Storm‐Mathisen, J. (1977) · Nature · doi:10.1038/266377a0 · Cited by 478 · see citing works
Primate analogue of the Wisconsin card sorting test: Effects of excitotoxic lesions of the prefrontal cortex in the marmoset.
Dias, R. S., Robbins, T. W., & Roberts, A. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.5.872 · Cited by 476 · see citing works
Primate analogue of the Wisconsin Card Sorting Test: effects of excitotoxic lesions of the prefrontal cortex in the marmoset
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.5.872 · Cited by 476 · see citing works
Neuroleptics increase C-FOS expression in the forebrain: Contrasting effects of haloperidol and clozapine
Robertson, G. S., & Fibiger, H. C. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90054-6 · Cited by 474 · see citing works
Chemical and structural analysis of the relation between cortical inputs and tyrosine hydroxylase-containing terminals in rat neostriatum
Bouyer, J. J., Park, D. H., JOH, T. H., & Pickel, V. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90239-7 · Cited by 472 · see citing works
Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground
Weinberger, D. R., & Lipska, B. K. (1995) · Schizophrenia Research · doi:10.1016/0920-9964(95)00013-c · Cited by 468 · see citing works
Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization- receptor autoradiographic analysis
Mansour, A., Meador‐Woodruff, J. H., Bunzow, J., Civelli, O., Akil, H., & Watson, S. J. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02587.1990 · Cited by 467 · see citing works
Burst firing in midbrain dopaminergic neurons
Overton, P. G., & Clark, D. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00039-8 · Cited by 466 · see citing works
D 1 Dopamine Receptor Activation Required for Postsynaptic Expression of D 2 Agonist Effects
Walters, J. R., Bergstrom, D. A., Carlson, J. H., Chase, T. N., & Braun, A. R. (1987) · Science · doi:10.1126/science.2953072 · Cited by 465 · see citing works
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies
Laruelle, M., & Abi-Dargham, A. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300405 · Cited by 464 · see citing works
Persistent sensitization of dopamine neurotransmission in ventral striatum (nucleus accumbens) produced by prior experience with (+)-amphetamine: a microdialysis study in freely moving rats
Robinson, T. E., Jurson, P. A., Bennett, J. A., & Bentgen, K. M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90549-5 · Cited by 463 · see citing works
Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell
Deutch, A. Y., & Cameron, D. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90007-o · Cited by 461 · see citing works
Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task.
McCarthy, G., Blamire, A. M., Puce, A., Nobre, A. C., Bloch, G., Hyder, F., Goldman-Rakic, P., & Shulman, R. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8690 · Cited by 459 · see citing works
Chapter 3 Qualitative and quantitative comparison of the prefrontal cortex in rat and in primates, including humans
Uylings, H. B. M., & van Eden, C. G. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)62675-8 · Cited by 454 · see citing works
Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents
Fitzgerald, L., Ortiz, J., Hamedani, A., & Nestler, E. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00274.1996 · Cited by 450 · see citing works
NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine
Verma, A., & Moghaddam, B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00373.1996 · Cited by 449 · see citing works
Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system
Richfield, E. K., Penney, J. B., & Young, A. B. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90168-1 · Cited by 448 · see citing works

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The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592 · see citing works
Antidepressant Actions of Histone Deacetylase Inhibitors
Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works
Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective
Alcaro, A., Huber, R., & Panksepp, J. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.07.014 · Cited by 614 · see citing works
Dopamine: a potential substrate for synaptic plasticity and memory mechanisms
Jay, T. M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00085-6 · Cited by 576 · see citing works
Regulation of affect by the lateral septum: implications for neuropsychiatry
Sheehan, T. P., Chambers, R. A., & Russell, D. S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.04.009 · Cited by 514 · see citing works
Mesolimbic dopaminergic pathways in fear conditioning
Pezze, M. A., & Feldon, J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.004 · Cited by 510 · see citing works
Cortical and basal ganglia contributions to habit learning and automaticity
Ashby, F. G., Turner, B. O., & Horvitz, J. C. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.02.001 · Cited by 481 · see citing works
Mechanism of Action of Atypical Antipsychotic Drugs and the Neurobiology of Schizophrenia
Horáček, J., Bubeníková‐Valešová, V., Kopeček, M., Páleníček, T., Dockery, C. A., Mohr, P., & Höschl, C. (2006) · CNS Drugs · doi:10.2165/00023210-200620050-00004 · Cited by 462 · see citing works
Opponency revisited: competition and cooperation between dopamine and serotonin
Boureau, Y.-L., & Dayan, P. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.151 · Cited by 456 · see citing works
Cellular and synaptic mechanisms of nicotine addiction
Mansvelder, H. D., & McGehee, D. S. (2002) · Journal of Neurobiology · doi:10.1002/neu.10148 · Cited by 438 · see citing works
Cellular mechanisms of nicotine addiction
Dani, J. A., & De Biasi, M. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00652-9 · Cited by 408 · see citing works
I h Channels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain
Neuhoff, H., Neu, A. D., Liss, B., & Roeper, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01290.2002 · Cited by 400 · see citing works
The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment
Weiner, I. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1313-x · Cited by 387 · see citing works
Computational perspectives on dopamine function in prefrontal cortex
Cohen, J. D., Braver, T. S., & Brown, J. W. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00314-8 · Cited by 386 · see citing works
Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish?
Guo, S. (2003) · Genes Brain & Behavior · doi:10.1046/j.1601-183x.2003.00053.x · Cited by 369 · see citing works
Anatomical Substrates for Glutamate‐Dopamine Interactions
Sesack, S., Carr, D. B., Omelchenko, N., & Pinto, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.066 · Cited by 348 · see citing works
Neurobiology of Dopamine in Schizophrenia
Guillin, O., Abi‐Dargham, A., & Laruelle, M. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78001-1 · Cited by 365 · see citing works
Mood, food, and obesity
Singh, M. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00925 · Cited by 337 · see citing works
Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery
Goldwater, D. S., Pavlides, C., Hunter, R. G., Bloss, E. B., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.053 · Cited by 333 · see citing works
Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep–wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats
Léna, I., Parrot, S., Deschaux, O., Muffat‐Joly, S., Sauvinet, V., Renaud, B., Suaud‐Chagny, M. ‐., & Gottesmann, C. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20602 · Cited by 322 · see citing works
Human category learning 2.0
Ashby, F. G., & Maddox, W. T. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05874.x · Cited by 319 · see citing works
The many faces of fatigue in major depressive disorder
Demyttenaere, K., De Fruyt, J., & Stahl, S. M. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004729 · Cited by 288 · see citing works
Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia
Abi‐Dargham, A., & Moore, H. M. (2003) · The Neuroscientist · doi:10.1177/1073858403252674 · Cited by 275 · see citing works
Neuroactive steroid regulation of neurotransmitter release in the CNS: Action, mechanism and possible significance
Zheng, P. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.07.001 · Cited by 263 · see citing works
Glutamatergic mechanisms in addiction
Tzschentke, T., & Schmidt, W. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001269 · Cited by 265 · see citing works
Self-citation
Hippocampal modulation of sensorimotor processes.
Bast, T., & Feldon, J. (2003) · Progress in neurobiology · doi:10.1016/s0301-0082(03)00112-6 · Cited by 267 · see citing works
Monoamine transporters and psychostimulant addiction
Howell, L. L., & Kimmel, H. L. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.003 · Cited by 249 · see citing works
The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders
Dobryakova, E., Genova, H. M., DeLuca, J., & Wylie, G. R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00052 · Cited by 242 · see citing works
Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia
Sesack, S. R., & CARR, D. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00931-9 · Cited by 238 · see citing works
Modulation of the Activity of Pyramidal Neurons in Rat Prefrontal Cortex by Raphe Stimulation In Vivo: Involvement of Serotonin and GABA
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh104 · Cited by 232 · see citing works
Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implications for impulsivity
Congdon, E., Lesch, K. P., & Canli, T. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30557 · Cited by 218 · see citing works
Relative Prenatal and Postnatal Maternal Contributions to Schizophrenia-Related Neurochemical Dysfunction after In Utero Immune Challenge
Meyer, U., Nyffeler, M., Schwendener, S., Knuesel, I., Yee, B. K., & Feldon, J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301413 · Cited by 215 · see citing works
Optogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications
Nimgampalle, M., Chakravarthy, H., Sharma, S., Shree, S., Bhat, A. R., Pradeepkiran, J. A., & Devanathan, V. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101994 · Cited by 207 · see citing works
Regional Differences in Extracellular Dopamine and Serotonin Assessed by In Vivo Microdialysis in Mice Lacking Dopamine and/or Serotonin Transporters
Shen, H., Hagino, Y., Kobayashi, H., Shinohara-Tanaka, K., Ikeda, K., Yamamoto, H., Yamamoto, T., Lesch, K., Murphy, D. L., Hall, F. S., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300476 · Cited by 204 · see citing works
Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites
Lindgren, N., Usiello, A., Goiny, M., Haycock, J. W., Erbs, E., Greengard, P., Hökfelt, T. G. M., Borrelli, E., & Fisone, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730708100 · Cited by 203 · see citing works
Brain circuits determine destiny in depression: a novel approach to the psychopharmacology of wakefulness, fatigue, and executive dysfunction in major depressive disorder.
Stahl, S. M., Zhang, L., Damatarca, C., & Grady, M. M. (2003) · PubMed · Cited by 202 · see citing works
Neurotransmitters and prefrontal cortex–limbic system interactions: implications for plasticity and psychiatric disorders
Arco, A. D., & Mora, F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0243-8 · Cited by 201 · see citing works
The WAG/Rij strain: A genetic animal model of absence epilepsy with comorbidity of depressiony
Sarkisova, K. Y., & van Luijtelaar, G. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.010 · Cited by 198 · see citing works
Alcohol and the prefrontal cortex
Abernathy, K., Chandler, L. J., & Woodward, J. J. (2010) · International Review of Neurobiology · doi:10.1016/s0074-7742(10)91009-x · Cited by 196 · see citing works
Development of alcohol-associated cues and cue-induced brain activation in alcoholics
Wrase, J., Grüsser, S. M., Vollstädt‐Klein, S., Diener, C., Hermann, D., Flor, H., Mann, K. F., Braus, D. F., & Heinz, A. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00676-4 · Cited by 192 · see citing works
Construct Validity of the Animal Latent Inhibition Model of Selective Attention Deficits in Schizophrenia
Lubow, R. E. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi005 · Cited by 191 · see citing works
Dopamine and Glutamate in Huntington's Disease: A Balancing Act
André, V. M., Cepeda, C., & Levine, M. S. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00134.x · Cited by 189 · see citing works
The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems
Adell, A., & Artigas, F. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.05.001 · Cited by 190 · see citing works
Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats
Shoblock, J. R., Sullivan, E. B., Maisonneuve, I. M., & Glick, S. D. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1288-7 · Cited by 181 · see citing works
A randomized controlled trial of targeted prefrontal cortex modulation with tDCS in patients with alcohol dependence
Klauss, J., Penido Pinheiro, L. C., Silva Merlo, B. L., Correia Santos, G. D. A., Fregni, F., Nitsche, M. A., & Miyuki Nakamura-Palacios, E. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000984 · Cited by 178 · see citing works
ΔFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment
Perrotti, L. I., Bolaños, C. A., Choi, K., Russo, S. J., Edwards, S., Ulery, P. G., Wallace, D. L., Self, D. W., Nestler, E. J., & Barrot, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04110.x · Cited by 178 · see citing works
Cannabinoids and prefrontal cortical function: Insights from preclinical studies
Egerton, A., Allison, C., Brett, R. R., & Pratt, J. A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.12.002 · Cited by 171 · see citing works
Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex
Del Arco, A., & Mora, F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.04.011 · Cited by 163 · see citing works
Prefrontal cortex plasticity mechanisms in drug seeking and relapse
van den Oever, M. C., Spijker, S., Smit, A. B., & Vries, T. J. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.016 · Cited by 163 · see citing works
The activation of interactive attentional networks
Xuan, B., Mackie, M., Spagna, A., Wu, T., Tian, Y., Hof, P. R., & Fan, J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.01.017 · Cited by 157 · see citing works
The influence of mental fatigue and motivation on neural network dynamics; an EEG coherence study
Lorist, M. M., Bezdan, E., ten Caat, M., Span, M. M., Roerdink, J. B. T. M., & Maurits, N. M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.015 · Cited by 158 · see citing works
The neurobiology of methamphetamine induced psychosis
Hsieh, J. H., Stein, D. J., & Howells, F. M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00537 · Cited by 158 · see citing works
Fatigue in Liver Disease: Pathophysiology and Clinical Management
Swain, M. G. (2006) · Canadian Journal of Gastroenterology · doi:10.1155/2006/624832 · Cited by 148 · see citing works
Long-range projection neurons of the mouse ventral tegmental area: a single-cell axon tracing analysis
Aransay, A., Rodríguez-López, C., García‐Amado, M., Clascá, F., & Prensa, L. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00059 · Cited by 143 · see citing works
Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy
Cordato, N. J., Duggins, A., Halliday, G. M., Morris, J. G., & Pantelis, C. (2005) · Brain · doi:10.1093/brain/awh508 · Cited by 146 · see citing works
Effects of medial prefrontal cortex cytotoxic lesions in mice
Deacon, R. M. J., Penny, C., & Rawlins, J. N. P. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00225-5 · Cited by 143 · see citing works
Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions
Feduccia, A. A., Chatterjee, S., & Bartlett, S. E. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00083 · Cited by 142 · see citing works
Environmental enrichment, prefrontal cortex, stress, and aging of the brain
Segovia, G., Arco, A. D., & Mora, F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0214-0 · Cited by 130 · see citing works
Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents
Straub, C., Tritsch, N. X., Hagan, N. A., Gu, C., & Sabatini, B. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0589-14.2014 · Cited by 130 · see citing works
Cocaine-Induced Plasticity of Intrinsic Membrane Properties in Prefrontal Cortex Pyramidal Neurons: Adaptations in Potassium Currents
Dong, Y., Nasif, F. J., Tsui, J. J., Ju, W. Y. H., Cooper, D., Hu, X., Malenka, R. C., & White, F. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4715-04.2005 · Cited by 129 · see citing works
Neurotensin: Role in psychiatric and neurological diseases
Cáceda, R., Kinkead, B. L., & Nemeroff, C. B. (2006) · Peptides · doi:10.1016/j.peptides.2006.04.024 · Cited by 129 · see citing works
Cholinergic axons in the rat ventral tegmental area synapse preferentially onto mesoaccumbens dopamine neurons
Omelchenko, N., & Sesack, S. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20852 · Cited by 127 · see citing works
Novel Approaches to the Treatment of Cocaine Addiction
Sofuoglu, M., & Kosten, T. R. (2005) · CNS Drugs · doi:10.2165/00023210-200519010-00002 · Cited by 126 · see citing works
A SPECT study of apathy in Alzheimer's disease
Lanctôt, K. L., Moosa, S., Herrmann, N., Leibovitch, F. S., Rothenburg, L., Cotter, A., & Black, S. E. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000103633 · Cited by 126 · see citing works
Aripiprazole, A Drug that Displays Partial Agonism and Functional Selectivity
Tuplin, E. W. N., & Holahan, M. R. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170413115754 · Cited by 124 · see citing works
Sex differences in (+)-amphetamine- and (+)-methamphetamine-induced behavioral response in male and female Sprague–Dawley rats
Milesi‐Hallé, A., McMillan, D. E., Laurenzana, E. M., Byrnes-Blake, K. A., & Owens, S. M. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.018 · Cited by 124 · see citing works
The neural circuitry of reward and its relevance to psychiatric disorders
Chau, D. T., Roth, R. M., & Green, A. I. (2004) · Current Psychiatry Reports · doi:10.1007/s11920-004-0026-8 · Cited by 123 · see citing works
The thalamic nucleus submedius and ventrolateral orbital cortex are involved in nociceptive modulation: A novel pain modulation pathway
Tang, J., Qu, C., & Huo, F. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.002 · Cited by 121 · see citing works
Cholinergic connectivity: it's implications for psychiatric disorders
Scarr, E., Gibbons, A. S., Neo, J. H., Udawela, M., & Dean, B. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00055 · Cited by 117 · see citing works
Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia
Managò, F., Mereu, M., Mastwal, S. S., Mastrogiacomo, R., Scheggia, D., Emanuele, M., Luca, M. A. D., Weinberger, D. R., Wang, K. H., & Papaleo, F. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.044 · Cited by 117 · see citing works
Mixing pleasures: Review of the effects of drugs on sex behavior in humans and animal models
Frohmader, K. S., Pitchers, K. K., Balfour, M. E., & Coolen, L. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.11.009 · Cited by 117 · see citing works
Effects of orbital prefrontal cortex dopamine depletion on inter-temporal choice: a quantitative analysis
Kheramin, S., Body, S., Ho, M.-Y., Vel�zquez-Martinez, D. N., Bradshaw, C. M., Szabadi, E., Deakin, J. F. W., & Anderson, I. M. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1813-y · Cited by 117 · see citing works
Maternal high fat diet during the perinatal period alters mesocorticolimbic dopamine in the adult rat offspring: reduction in the behavioral responses to repeated amphetamine administration
Naef, L., Srivastava, L. K., Gratton, A. P., Hendrickson, H. P., Owens, S. M., & Walker, C. (2007) · Psychopharmacology · doi:10.1007/s00213-007-1008-4 · Cited by 116 · see citing works
Brain-Specific Overexpression of Trace Amine-Associated Receptor 1 Alters Monoaminergic Neurotransmission and Decreases Sensitivity to Amphetamine
Revel, F. G., Meyer, C. A., Bradaïa, A., Jeanneau, K., Calcagno, E., André, C. B., Hänggi, M., Miss, M.-T., Galley, G., Norcross, R. D., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.109 · Cited by 114 · see citing works
Clinical implications and electrochemical biosensing of monoamine neurotransmitters in body fluids, in vitro, in vivo, and ex vivo models
Baranwal, A., & Chandra, P. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.09.002 · Cited by 115 · see citing works
Role of the mesotelencephalic dopamine system in learning and memory processes in the rat
Hefco, V., Yamada, K., Hefco, A., Hriţcu, L., Tiron, A., & Nabeshima, T. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02115-0 · Cited by 115 · see citing works
Nicotinic, glutamatergic and dopaminergic synaptic transmission and plasticity in the mesocorticolimbic system: Focus on nicotine effects
Pistillo, F., Clementi, F., Zoli, M., & Gotti, C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.002 · Cited by 113 · see citing works
Dopamine D1-Class Receptors Selectively Modulate a Slowly Inactivating Potassium Current in Rat Medial Prefrontal Cortex Pyramidal Neurons
Dong, Y., & White, F. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02686.2003 · Cited by 114 · see citing works
The endophenotype of impulsivity: reaching consilience through behavioral, genetic, and neuroimaging approaches.
Congdon, E., & Canli, T. (2005) · Behavioral & Cognitive Neuroscience Reviews · doi:10.1177/1534582305285980 · Cited by 110 · see citing works
Estrogen regulates responses of dopamine neurons in the ventral tegmental area to cocaine
Zhang, D., Yang, S., Yang, C., Jin, G.-Z., & Zhen, X. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1188-6 · Cited by 110 · see citing works
Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice
Takahashi, Y., Mizuo, K., Shinkai, Y., Oshio, S., & Takeda, K. (2010) · The Journal of Toxicological Sciences · doi:10.2131/jts.35.749 · Cited by 108 · see citing works
Repeated Cocaine Administration Increases Voltage-Sensitive Calcium Currents in Response to Membrane Depolarization in Medial Prefrontal Cortex Pyramidal Neurons
Nasif, F. J., Hu, X., & White, F. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0010-05.2005 · Cited by 107 · see citing works
Enhanced motivation to self‐administer cocaine is predicted by self‐grooming behaviour and relates to dopamine release in the rat medial prefrontal cortex and amygdala
Homberg, J. R., Akker, M. V. D., Raasø, H. S., Wardeh, G., Binnekade, R., Schoffelmeer, A. N. M., & Vries, T. J. D. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01976.x · Cited by 106 · see citing works
The Abused Inhalant Toluene Increases Dopamine Release in the Nucleus Accumbens by Directly Stimulating Ventral Tegmental Area Neurons
Riegel, A. C., Zapata, A. G., Shippenberg, T. S., & French, E. D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301273 · Cited by 105 · see citing works
Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
Möller, M., du Preez, J. L., Emsley, R. A., & Harvey, B. H. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.09.006 · Cited by 103 · see citing works
Prenatal exposure to infection: a primary mechanism for abnormal dopaminergic development in schizophrenia
Meyer, U., & Feldon, J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1504-9 · Cited by 109 · see citing works
Repeated Cocaine Administration Increases Membrane Excitability of Pyramidal Neurons in the Rat Medial Prefrontal Cortex
Nasif, F. J., Sidiropoulou, K., Hu, X., & White, F. J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.075184 · Cited by 100 · see citing works
Oxytocin Reverses Amphetamine-Induced Deficits in Social Bonding: Evidence for an Interaction with Nucleus Accumbens Dopamine
Young, K. A., Liu, Y., Gobrogge, K. L., Wang, H., & Wang, Z. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4275-13.2014 · Cited by 99 · see citing works
Estrous Cycle-Dependent Changes in Basal and Ethanol-Induced Activity of Cortical Dopaminergic Neurons in the Rat
Dazzi, L., Seu, E., Cherchi, G., Barbieri, P. P., Matzeu, A., & Biggio, G. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301150 · Cited by 98 · see citing works
Midbrain muscarinic receptor mechanisms underlying regulation of mesoaccumbens and nigrostriatal dopaminergic transmission in the rat
Miller, A. D., & Blaha, C. D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04017.x · Cited by 93 · see citing works
The basal ganglia: anatomy, physiology, and pharmacology
Tisch, S. H., Silberstein, P., Limousin, P. D., & Jahanshahi, M. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.06.004 · Cited by 92 · see citing works
Cannabis, Cannabinoids and Schizophrenia: Integration of the Evidence
Cohen, M. A., Solowij, N., & Carr, V. J. (2008) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670801961156 · Cited by 90 · see citing works
Associative deficit accounts of disrupted latent inhibition and blocking in schizophrenia
Escobar, M. E., Oberling, P., & Miller, R. R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00067-7 · Cited by 89 · see citing works
Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR
Schicknick, H., Schott, B. H., Budinger, E., Smalla, K., Riedel, A., Seidenbecher, C. I., Scheich, H., Gundelfinger, E. D., & Tischmeyer, W. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn026 · Cited by 88 · see citing works
Efficacy and Safety of Varenicline for Smoking Cessation
Hays, J. T., Ebbert, J. O., & Sood, A. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.01.017 · Cited by 84 · see citing works
Ventral medial prefrontal cortex (vmPFC) as a target of the dorsolateral prefrontal modulation by transcranial direct current stimulation (tDCS) in drug addiction
Nakamura-Palacios, E. M., Lopes, I. B. C., Souza, R. A., Klauss, J., Batista, E. K., Conti, C. L., Moscon, J. A., & de Souza, R. S. M. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1559-9 · Cited by 85 · see citing works
Environmental enrichment reduces the function of D1 dopamine receptors in the prefrontal cortex of the rat
Arco, A. D., Segovia, G., Canales, J. J., GARRIDO, P., de Blas, M., García‐Verdugo, J. M., & Mora, F. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0565-8 · Cited by 85 · see citing works
Long-term social isolation and medial prefrontal cortex: dopaminergic and cholinergic neurotransmission
Leng, A., Feldon, J., & Ferger, B. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.11.011 · Cited by 83 · see citing works
Repeated Cocaine Administration Promotes Long-Term Potentiation Induction in Rat Medial Prefrontal Cortex
Huang, C., Lin, H., & Hsu, K. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl096 · Cited by 84 · see citing works

Behavioral/Systems/Cognitive Mesocortical Dopamine Neurons Operate in Distinct Temporal Domains Using Multimodal Signaling
Lavı́n, A., Nogueira, L., Lapish, C. C., Wightman, R. M., Phillips, P. E. M., & Seamans, J. K. (2013)
Dopamine, the prefrontal cortex and schizophrenia
Knable, M. B., & Weinberger, D. R. (1997) · Journal of Psychopharmacology · doi:10.1177/026988119701100205 · Cited by 304 · see citing works
Dopamine tunes prefrontal outputs to orchestrate aversive processing
Weele, C. M. V., Siciliano, C. A., & Tye, K. M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.11.044 · Cited by 89 · see citing works
Dopamine Function in the Prefrontal Cortex
Thierry, A. M., Pirot, S., Gioanni, Y., & Glowinski, J. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60848-0 · Cited by 24 · see citing works
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592 · see citing works

Authors: Tzschentke, T. M.
Affiliations: Grünenthal Group (Germany) (DE)
Corresponding author: Tzschentke, T.M.
ORCID: Tzschentke, T.M.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2001-02
Volume: 63
Issue: 3
Pages: 241-320
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/s0301-0082(00)00033-2
OpenAlex: W2111304405
Semantic Scholar: 314205aef63746557803f0214ed764321bbe28dc
Cited by: 481
References: 1,268
Citations by year: 2026: 1 · 2025: 4 · 2024: 9 · 2023: 19 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 13 · 2018: 6 · 2017: 17 · 2016: 14 · 2015: 24 · 2014: 21 · 2013: 11 · 2012: 24
FWCI: 2.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: mesocortical dopamine system, prefrontal cortex, medial prefrontal cortex, glutamate, dopamine-glutamate interaction, mesocorticolimbic circuit, reward, addiction, locomotor activity, sensitization, learning, cognition, schizophrenia
MeSH terms: Animals, Behavior, Animal, Dopamine, Humans, Synaptic Transmission, Neurons, Prefrontal Cortex, Ventral Tegmental Area

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Pharmacology and behavioral pharmacology of the mesocortical dopamine system

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