Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens
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Lesion or inactivation of the mesolimbic DA system in the VTA or NAc decreases cocaine, amphetamine, heroin, and nicotine self-administration in rats.
“In addition, lesion or inactivation of the mesolimbic DA system in the VTA [137,138] or in the NAc [139-143] decreases cocaine, amphetamine, heroin, and nicotine self-administration in rats.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [142]
Depletion of dopamine in the nucleus accumbens induced by local 6-hydroxydopamine injections severely attenuates the rewarding effects of cocaine or amphetamine, as assessed by instrumental responses or conditioned place preference.
“Depletion of dopamine in the nucleus accumbens induced by local 6-hydroxydopamine (6-OHDA) injections severely attenuates the rewarding effects of cocaine or amphetamine, as assessed by instrumental responses”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Roberts et al., 1980
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Self-citation
- Authors
- Roberts, D. C. S., Koob, G. F., Klonoff, P., & Fibiger, H. C.
- Affiliations
- Salk Institute for Biological Studies (US)
- University of British Columbia (CA)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1980-05
- Volume
- 12
- Issue
- 5
- Pages
- 781-787
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2005997674
- Cited by
- 730
- References
- 20
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 13 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 9
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cocaine self-administration, nucleus accumbens, 6-hydroxydopamine lesion, dopamine depletion, extinction, cocaine reward, desmethylimipramine, pargyline, continuous reinforcement
- MeSH terms
- Animals, Brain Chemistry, Cocaine, Dopamine, Hydroxydopamines, Male, Norepinephrine, Nucleus Accumbens, Reinforcement, Psychology, Self Administration, Septal Nuclei, Rats
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