Cited by 212Helicobacter pylori-related gastroenterology studiesProbiotics and Fermented FoodsGastrointestinal motility and disorders

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Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial

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Nista, E. C., Candelli, M., Cremonini, F., Cazzato, I. A., Zocco, M. A., Franceschi, F., Cammarota, G., Gasbarrini, G., Gasbarrini, A·2004·Alimentary Pharmacology & Therapeutics

DOI 10.1111/j.1365-2036.2004.02274.x

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Abstract

Summary: Background : Helicobacter pylori eradication fails in about 10% of patients, particularly because of the occurrence of resistance to antibiotics and side‐effects. During anti‐H. pylori therapy, probiotics have been successfully used to reduce the incidence of side‐effects. Aim : To evaluate the effect of Bacillus clausii, a probiotic, on incidence (primary variable) and severity of antibiotic‐associated side‐effects during anti‐H. pylori therapy. Methods : One hundred and twenty H. pylori‐positive patients were randomly screened to receive: (i) a standard 7 days triple therapy with rabeprazole 20 mg b.d., clarithromycin 500 mg b.d. and amoxicillin 1 g b.d. and B. clausii t.d.s. (each preparation containing 2 × 10 9 spores) for 14 days starting from the first day of treatment. (ii) The same 7 days triple therapy and placebo t.d.s. for 14 days starting from the first day of treatment. Side‐effects were assessed using a validated questionnaire and were recorded for 4 weeks from the start of therapy. Results : The incidences of nausea, diarrhoea and epigastric pain in patients treated with B. clausii were significantly lower than in placebo group, in both PP and ITT analysis. Equally, intensity of nausea and diarrhoea in patients treated with B. clausii was significantly lower than in placebo group. There were no differences in adherence to treatment and H. pylori eradication rates between groups. Conclusion : In symptom‐free, H. pylori‐positive subjects B. clausii bacteriotherapy reduces the incidence of the most common side‐effects related to anti‐H. pylori antibiotic therapy compared with placebo.

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Authors: Nista, E. C., Candelli, M., Cremonini, F., Cazzato, I. A., Zocco, M. A., Franceschi, F., Cammarota, G., Gasbarrini, G., & Gasbarrini, A.
Affiliations: Università Cattolica del Sacro Cuore (IT)
ORCID: Nista, E. C.
Candelli, M.
Zocco, M. A.
Franceschi, F.
Cammarota, G.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2004-11
Volume: 20
Issue: 10
Pages: 1181-1188
ISSN: 0269-2813 (ISSN-L)
1365-2036
DOI: 10.1111/j.1365-2036.2004.02274.x
OpenAlex: W2120773585
Cited by: 212
References: 27
Citations by year: 2026: 4 · 2025: 2 · 2024: 12 · 2023: 15 · 2022: 29 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 2 · 2017: 9 · 2016: 11 · 2015: 9 · 2014: 8 · 2013: 16 · 2012: 11
FWCI: 11.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 28 d)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: Bacillus clausii, probiotics, Helicobacter pylori eradication, antibiotic adverse effects, triple therapy, clarithromycin, amoxicillin, rabeprazole, nausea, diarrhea, epigastric pain, Helicobacter pylori infection
MeSH terms: Adolescent, Adult, Aged, Amoxicillin, Anti-Ulcer Agents, Bacillus, Benzimidazoles, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Omeprazole, Prospective Studies, Helicobacter pylori, Helicobacter Infections, Clarithromycin, Probiotics, 2-Pyridinylmethylsulfinylbenzimidazoles, Rabeprazole

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Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial

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