Effects of probiotics on the gastrointestinal tract
Abstract
PURPOSE OF REVIEW: This review summarizes recent developments in our understanding of what gastrointestinal disorders probiotics can be of benefit for, focussing on conditions associated with infection or disruption of the normal gut flora. New insights into the effects administered strains can have in the gut, their safety, and potential for future development, will also be discussed. RECENT FINDINGS: Recent clinical studies have shown that probiotics can protect young children from diarrhoeal illness, including antibiotic-associated diarrhoea. They may also protect neonates from necrotizing enterocolitis. In adults, they can help prevent or reduce the severity of diarrhoeal illness, and ameliorate side-effects for those undergoing antibiotic therapy for infection. Researchers are looking at combining probiotics with prebiotics to enhance anti-inflammatory effects and restore colonization resistance of the commensal flora. New technologies are elucidating complex effects on gene expression in the gut, the probiotic, and bacterial pathogens. Recombinant strains capable of binding bacterial toxins are being developed as novel therapeutics against gastrointestinal infection. SUMMARY: Considering the clinical trial evidence of therapeutic benefit, probiotics are an underused treatment modality for prevention and amelioration of diarrhoeal illness. Better understanding of strain-specific effects, dosing regimens and any contraindications should help resolve this.
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The human gastrointestinal tract is where most probiotic actions occur and where colon cancer originates.
“The human gastrointestinal tract is where most probiotic actions [47,48] occur and where colon cancer originates.”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [47]
Cites
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Kruis, W., Frič, P., Pokrotnieks, J., Lukáš, M., Fixa, B., Kaščák, M., Kamm, M. A., Weismueller, J., Beglinger, C., Stolte, M., et al. (2004) · Gut · doi:10.1136/gut.2003.037747 · Cited by 1,285 · see citing works
Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
Servin, A. L. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.01.003 · Cited by 1,234 · see citing works
Potential Uses of Probiotics in Clinical Practice
Reid, G., Jaß, J., Sebulsky, M. T., & McCormick, J. K. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.4.658-672.2003 · Cited by 918 · see citing works
Rachmilewitz, D., Katakura, K., Karmeli, F., Hayashi, T., Reinus, C., Rudensky, B., Akira, S., Takeda, K., Lee, J., Takabayashi, K., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.019 · Cited by 859 · see citing works
Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T. (2005) · Gut · doi:10.1136/gut.2004.044834 · Cited by 766 · see citing works
Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis
D'Souza, A. L., Rajkumar, C., Cooke, J., & Bulpitt, C. J. (2002) · BMJ · doi:10.1136/bmj.324.7350.1361 · Cited by 664 · see citing works
Lin, H.-C., Su, B.-H., Chen, A.-C., Lin, T.-W., Tsai, C.-H., Yeh, T.-F., & Oh, W. (2005) · Pediatrics · doi:10.1542/peds.2004-1463 · Cited by 660 · see citing works
Resta-Lenert, S., & Barrett, K. E. (2003) · Gut · doi:10.1136/gut.52.7.988 · Cited by 642 · see citing works
Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM
Altermann, E., Russell, W. M., Azcárate-Peril, M. A., Barrangou, R., Buck, B. L., McAuliffe, O. E., Souther, N. E., Dobson, A., Duong, T., Callanan, M. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409188102 · Cited by 594 · see citing works
Modulation of human dendritic cell phenotype and function by probiotic bacteria
Hart, A. L., Lammers, K., Brigidi, P., Vitali, B., Rizzello, F., Gionchetti, P., Campieri, M., Kamm, M. A., Knight, S. C., & Stagg, A. J. (2004) · Gut · doi:10.1136/gut.2003.037325 · Cited by 555 · see citing works
Weizman, Z., Asli, G., & Alsheikh, A. (2005) · Pediatrics · doi:10.1542/peds.2004-1815 · Cited by 548 · see citing works
Mack, D., Michail, S., Wei, S., McDougall, L., & Hollingsworth, M. (1999) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g941 · Cited by 544 · see citing works
Wehkamp, J., Harder, J., Wehkamp, K., Meissner, B. W.-V., Schlee, M., Enders, C., Sonnenborn, U., Nuding, S., Bengmark, S., Fellermann, K., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5750-5758.2004 · Cited by 471 · see citing works
Saccharomyces cerevisiae Fungemia: An Emerging Infectious Disease
Munoz, P., Bouza, E., Cuenca-Estrella, M., Eiros, J. M., Perez, M. J., Sanchez-Somolinos, M., Rincon, C., Hortal, J., & Pelaez, T. (2005) · Clinical Infectious Diseases · doi:10.1086/429916 · Cited by 462 · see citing works
Dani, C., Biadaioli, R., Bertini, G., Martelli, E., & Rubaltelli, F. F. (2002) · Neonatology · doi:10.1159/000063096 · Cited by 446 · see citing works
Characterization of Bacillus Probiotics Available for Human Use
Duc, L. H., Hong, H. A., Barbosa, T. M., Henriques, A. O., & Cutting, S. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.4.2161-2171.2004 · Cited by 434 · see citing works
Kato, K., Mizuno, S., Umesaki, Y., Ishii, Y., Sugitani, M., Imaoka, A., Otsuka, M., Hasunuma, O., Kurihara, R., Iwasaki, A., et al. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02268.x · Cited by 397 · see citing works
Hoyos, A. B. (1999) · International Journal of Infectious Diseases · doi:10.1016/s1201-9712(99)90024-3 · Cited by 385 · see citing works
Quantitative Analysis of Diverse Lactobacillus Species Present in Advanced Dental Caries
Byun, R., Nadkarni, M. A., Chhour, K.-L., Martin, F. E., Jacques, N. A., & Hunter, N. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.7.3128-3136.2004 · Cited by 382 · see citing works
Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
Rachmilewitz, D., Karmeli, F., Takabayashi, K., Hayashi, T., Leider–Trejo, L., Lee, J., Leoni, L. M., & Raz, E. (2002) · Gastroenterology · doi:10.1053/gast.2002.32994 · Cited by 380 · see citing works
Analysis of the Genome Structure of the Nonpathogenic Probiotic Escherichia coli Strain Nissle 1917
Grozdanov, L., Raasch, C., Schulze, J., Sonnenborn, U., Gottschalk, G., Hacker, J. H., & Dobrindt, U. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.16.5432-5441.2004 · Cited by 368 · see citing works
Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel
Langlands, S. J. (2004) · Gut · doi:10.1136/gut.2003.037580 · Cited by 359 · see citing works
Getting better with bifidobacteria
Leahy, S. C., Higgins, D. G., Fitzgerald, G. F., & van Sinderen, D. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02600.x · Cited by 331 · see citing works
Kotowska, M., Albrecht, P., & Szajewska, H. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02356.x · Cited by 288 · see citing works
Lammers, K. M., Brigidi, P., Vitali, B., Gionchetti, P., Rizzello, F., Caramelli, E., Matteuzzi, D., & Campieri, M. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00144-5 · Cited by 282 · see citing works
Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety
Saavedra, J. M., Abi‐Hanna, A., Moore, N. D., & Yolken, R. H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.2.261 · Cited by 278 · see citing works
Major depressive disorder: probiotics may be an adjuvant therapy.
Logan, A., & Katzman, M. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.019 · Cited by 277 · see citing works
Vandenbroucke, K., Hans, W., Van Huysse, J., Neirynck, S., Demetter, P., Remaut, E., Rottiers, P., & Steidler, L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.020 · Cited by 277 · see citing works
Asahara, T., Shimizu, K., Nomoto, K., Hamabata, T., Ozawa, A., & Takeda, Y. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2240-2247.2004 · Cited by 277 · see citing works
Prebiotics and resistance to gastrointestinal infections
Gibson, G. R., McCartney, A. L., & Rastall, R. A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041343 · Cited by 276 · see citing works
Plummer, S. F., Weaver, M. A., Harris, J. C., Dee, P., & Hunter, J. O. (2004) · PubMed · Cited by 251 · see citing works
Wang, K.-Y., Li, S.-N., Liu, C.-S., Perng, D., Su, Y.-C., Wu, D., Jan, C.-M., Lai, C.-H., Wang, T., & Wang, W.-M. (2004) · PubMed · doi:10.1093/ajcn/80.3.737 · Cited by 250 · see citing works
Identification ofLactobacillus plantarumGenes That Are Induced in the Gastrointestinal Tract of Mice
Bron, P. A., Grangette, C., Mercenier, A., de Vos, W. M., & Kleerebezem, M. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.17.5721-5729.2004 · Cited by 239 · see citing works
Lewis, S., Burmeister, S., & Brazier, J. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00677-9 · Cited by 226 · see citing works
Altenhoefer, A., Oswald, S., Sonnenborn, U., Enders, C., Schulze, J., Hacker, J., & Oelschlaeger, T. A. (2004) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00368-7 · Cited by 221 · see citing works
Nista, E. C., Candelli, M., Cremonini, F., Cazzato, I. A., Zocco, M. A., Franceschi, F., Cammarota, G., Gasbarrini, G., & Gasbarrini, A. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02274.x · Cited by 212 · see citing works
Jain, P. K., McNaught, C. E., Anderson, A. D. G., Macfie, J., & Mitchell, C. J. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2003.12.002 · Cited by 211 · see citing works
Myllyluoma, E., Veijola, L., Ahlroos, T., Tynkkynen, S., Kankuri, E. M., Vapaatalo, H., Rautelin, H. I. K., & Korpela, R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02448.x · Cited by 197 · see citing works
Thibault, H., Aubert‐Jacquin, C., & Goulet, O. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200408000-00004 · Cited by 195 · see citing works
Prebiotics and other microbial substrates for gut functionality
Ouwehand, A. C., Derrien, M., de Vos, W., Tiihonen, K., & Rautonen, N. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2005.01.007 · Cited by 192 · see citing works
Sheil, B., McCarthy, J., O’Mahony, L., Bennett, M. W., Ryan, P., Fitzgibbon, J. J., Kiely, B., Collins, J. K., & Shanahan, F. (2004) · Gut · doi:10.1136/gut.2003.027789 · Cited by 187 · see citing works
Patterns of cytokine induction by gram-positive and gram-negative probiotic bacteria
Cross, M. L., Ganner, A., Teilab, D., & Fray, L. M. (2004) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.04.001 · Cited by 184 · see citing works
Epithelia Under Metabolic Stress Perceive Commensal Bacteria as a Threat
Nazli, A., Yang, P., Jury, J., Howe, K. L., Watson, J. L., Söderholm, J. D., Sherman, P. M., Perdue, M. H., & McKay, D. M. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63182-3 · Cited by 183 · see citing works
Verdú, E. F., Bercík, P., Bergonzelli, G. E., Huang, X.-X., Blennerhasset, P., Rochat, F., Fiaux, M., Mansourian, R., Corthésy-Theulaz, I., & Collins, S. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.007 · Cited by 180 · see citing works
Effects of Saccharomyces boulardii in children with acute diarrhoea
Kurugöl, Z., & Koturoğlu, G. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb01786.x · Cited by 150 · see citing works
Parassol, N., Freitas, M., Thoreux, K., Dalmasso, G., Bourdet‐Sicard, R., & Rampal, P. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2004.09.013 · Cited by 146 · see citing works
Sturm, A., Rilling, K., Baumgart, D. C., Gargas, K., Abou-Ghazalé, T., Raupach, B., Eckert, J., Schumann, R. R., Enders, C., Sonnenborn, U., et al. (2005) · Infection and Immunity · doi:10.1128/iai.73.3.1452-1465.2005 · Cited by 145 · see citing works
Montalto, M., Vastola, M. E., Marigo, L., Covino, M., Graziosetto, R., Curigliano, V., Santoro, L., Cuoco, L., Manna, R., & Gasbarrini, A. (2004) · Digestion · doi:10.1159/000076559 · Cited by 141 · see citing works
Effects of on genes expression pattern in small bowel mucosa
Caro, S. D., TAO, H., Grillo, A., Elia, C., Gasbarrini, A., Sepulveda, A. R., & Gasbarrini, A. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2004.12.008 · Cited by 130 · see citing works
Genetically engineered probiotics
Steidler, L. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00072-6 · Cited by 120 · see citing works
Strain-Specific Effects of Probiotics on Gut Barrier Integrity following Hemorrhagic Shock
Luyer, M. D. P., Buurman, W. A., Hadfoune, M., Speelmans, G., Knol, J., Jacobs, J. A., Dejong, C. H. C., Vriesema, A. J. M., & Greve, J. W. M. (2005) · Infection and Immunity · doi:10.1128/iai.73.6.3686-3692.2005 · Cited by 119 · see citing works
Regulating the Safety of Probiotics - The European Approach
von Wright, A. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382322 · Cited by 117 · see citing works
Burton, J. P., Chilcott, C., & Tagg, J. R. (2005) · Oral Diseases · doi:10.1111/j.1601-0825.2005.01084.x · Cited by 113 · see citing works
Recombinant Probiotics for Treatment and Prevention of Enterotoxigenic Escherichia coli Diarrhea
Paton, A. W., Jennings, M. P., Morona, R., Wang, H., Focareta, A., Roddam, L. F., & Paton, J. C. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.01.050 · Cited by 107 · see citing works
Possible Confounding Factors in an Oral Probiotics Trial: Breast Milk: In Reply
Lin, H., Su, B., & Tsai, C. (2005) · PEDIATRICS · doi:10.1542/peds.2005-0245 · Cited by 95 · see citing works
Intestinal immunity ofEscherichia coliNISSLE 1917: a safe carrier for therapeutic molecules
Westendorf, A. M., Gunzer, F., Deppenmeier, S., Tapadar, D., Hunger, J. K., Schmidt, M. A., Buer, J., & Bruder, D. (2004) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.10.023 · Cited by 94 · see citing works
Tursi, A., Brandimarte, G., Giorgetti, G. M., & Modeo, M. E. (2004) · PubMed · Cited by 93 · see citing works
Ingrassia, I., Leplingard, A., & Darfeuille–Michaud, A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.6.2880-2887.2005 · Cited by 92 · see citing works
Herbrecht, R., & Nivoix, Y. (2005) · Clinical Infectious Diseases · doi:10.1086/429926 · Cited by 83 · see citing works
Are live saccharom yces yeasts harmful to patients?
Piarroux, R., Millon, L., Bardonnet, K., Vagner, O., & Koenig, H. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02001-2 · Cited by 77 · see citing works
Duodenal Microflora in Very-Low-Birth-Weight Neonates and Relation to Necrotizing Enterocolitis
Hoy, C. M., Wood, C. M., Hawkey, P. M., & Puntis, J. W. L. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.12.4539-4547.2000 · Cited by 76 · see citing works
The Probiotic Effect of Saccharomyces boulardii in a Pediatric Age Group
Erdeve, Ö. (2004) · Journal of Tropical Pediatrics · doi:10.1093/tropej/50.4.234 · Cited by 75 · see citing works
Nonpathogenic Escherichia coli Strain Nissle1917 Prevents Murine Acute and Chronic Colitis
Kamada, N., Inoue, N., Hisamatsu, T., Okamoto, S., Matsuoka, K., Sato, T., Chinen, H., Hong, K. S., Yamada, T., Suzuki, Y., et al. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000158158.55955.de · Cited by 74 · see citing works
Sullivan, Å. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg346 · Cited by 71 · see citing works
Kitazawa, H., Watanabe, H., Shimosato, T., Kawai, Y., Itoh, T., & Saito, T. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(02)00477-4 · Cited by 63 · see citing works
Farrar, M. D., Whitehead, T. R., Lan, J. Q., Dilger, P., Thorpe, R., Holland, K. T., & Carding, S. R. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02565.x · Cited by 51 · see citing works
SACCHAROMYCES CEREVISIAE FUNGEMIA IN AN ELDERLY PATIENT WITH CLOSTRIDIUM DIFFICILE COLITIS
Cherifi, S., Robberecht, J., & Miendje, Y. (2004) · Acta Clinica Belgica · doi:10.1179/acb.2004.033 · Cited by 49 · see citing works
Refinement of a Therapeutic Shiga Toxin–Binding Probiotic for Human Trials
Pinyon, R. A., Paton, J. C., Paton, A. W., Botten, J. A., & Morona, R. (2004) · The Journal of Infectious Diseases · doi:10.1086/383417 · Cited by 39 · see citing works
Synbiotics to strengthen gut barrier function and reduce morbidity in critically ill patients
Bengmark, S. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2004.01.005 · Cited by 36 · see citing works
Sullivan, Å., Johansson, A. V., Svenungsson, B., & Nord, C. E. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh406 · Cited by 33 · see citing works
Nishijima, K., Shukunami, K., & Kotsuji, F. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000159269.58480.4b · Cited by 30 · see citing works
Use of a Continuous-Flow Anaerobic Culture To Characterize Enteric Virulence Gene Expression
Ruı́z-Pérez, F., Sheikh, J., Davis, S., Boedeker, E. C., & Nataro, J. P. (2004) · Infection and Immunity · doi:10.1128/iai.72.7.3793-3802.2004 · Cited by 28 · see citing works
Reid, G., Guarner, F., Gibson, G. R., Tompkins, T. A., Gill, H., Rowland, I. R., Rastall, B., Pot, B., & Sanders, M. E. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.052 · Cited by 26 · see citing works
Enhancing immunogenicity by CpG DNA.
Jiang, W., & Pisetsky, D. S. (2003) · PubMed · Cited by 23 · see citing works
Making microbes work for mankind—clever trick or a glimpse of the future for IBD treatment?
Shanahan, F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.029 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 77 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The dual role of bacteriocins as anti- and probiotics
Gillor, O., Etzion, A., & Riley, M. A. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1726-5 · Cited by 418 · see citing works
Cross-Talk between Probiotic Bacteria and the Host Immune System1,
Corthésy, B., Gaskins, H. R., & Mercenier, A. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.781s · Cited by 351 · see citing works
Fungal—bacterial interactions: a mixed bag of mingling microbes
Wargo, M. J., & Hogan, D. A. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.06.001 · Cited by 286 · see citing works
Gianotti, L. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i2.167 · Cited by 209 · see citing works
Probiotic metabolites as epigenetic targets in the prevention of colon cancer
Kumar, M., Nagpal, R., Verma, V., Kumar, A., Kaur, N., Rajkumar, H., Gautam, S. K., & Singh, B. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00542.x · Cited by 183 · see citing works
BACTIBASE: a new web-accessible database for bacteriocin characterization
Hammami, R., Zouhir, A., Hamida, J. B., & Fliss, I. (2007) · BMC Microbiology · doi:10.1186/1471-2180-7-89 · Cited by 170 · see citing works
Fernández-Carrocera, L. A., Solis-Herrera, A., Cabanillas-Ayón, M., Gallardo-Sarmiento, R. B., García-Pérez, C. S., Montaño-Rodríguez, R., & Echániz-Aviles, M. O. L. (2012) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2011-300435 · Cited by 145 · see citing works
Medellin-Peña, M. J., & Griffiths, M. W. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01651-08 · Cited by 139 · see citing works
Reddy, B. S., Macfie, J. M., Gatt, M., Larsen, C. N., Jensen, S. S., & Leser, T. D. (2007) · British journal of surgery · doi:10.1002/bjs.5705 · Cited by 138 · see citing works
Selecting Lactic Acid Bacteria for Their Safety and Functionality by Use of a Mouse Colitis Model
Daniel, C., Poiret, S., Goudercourt, D., Dennin, V., Leyer, G. J., & Pot, B. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.00109-06 · Cited by 131 · see citing works
Bertino, E., Giuliani, F., Prandi, G., Coscia, A., Martano, C., & Fabris, C. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31817b6dbe · Cited by 117 · see citing works
Common occurrence of antibacterial agents in human intestinal microbiota
Drissi, F., Buffet, S., Raoult, D., & Merhej, V. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00441 · Cited by 108 · see citing works
Phylum XXVI. Actinobacteria phyl. nov.
Goodfellow, M. (2012) · Springer eBooks · doi:10.1007/978-0-387-68233-4_3 · Cited by 90 · see citing works
Modeling solubilities of sugars in alcohols based on original experimental data
Montañés, F., Olano, A., Ibáñez, E., & Fornari, T. (2007) · AIChE Journal · doi:10.1002/aic.11258 · Cited by 81 · see citing works
Sanz, M. L., Corzo‐Martínez, M., Rastall, R. A., Olano, A., & Moreno, F. J. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071111l · Cited by 75 · see citing works
Lin, D., & Medeiros, D. M. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.02.007 · Cited by 61 · see citing works
Endam, L. M., Alromaih, S., González, E., Madrenas, J., Cousineau, B., Renteria, A. E., & Desrosiers, M. Y. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00440 · Cited by 56 · see citing works
Innate and specific gut-associated immunity and microbial interference
Singh, V., Singh, K., Amdekar, S., Singh, D. D., Tripathi, P., Sharma, G. L., & Yadav, H. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2008.00497.x · Cited by 51 · see citing works
Hashem, M. A., & Mohamed, M. H. (2009) · PubMed · Cited by 49 · see citing works
Positive Interactions with the Microbiota: Probiotics
Kalliomäki, M. A., Salminen, S., & Isolauri, E. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09550-9_5 · Cited by 49 · see citing works
Binns, C. W., Lee, A. H., Harding, H., Gracey, M. S., & Barclay, D. (2007) · Acta Paediatrica · doi:10.1111/j.1651-2227.2007.00508.x · Cited by 43 · see citing works
Capodice, J. L., Gorroochurn, P., Cammack, A. S., Eric, G., McKiernan, J. M., Benson, M. C., Stone, B. A., & Katz, A. E. (2009) · PubMed · Cited by 42 · see citing works
Microbiota and pathogen ‘pas de deux’: setting up and breaking down barriers to intestinal infection
McKenney, E. S., & Kendall, M. M. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw051 · Cited by 39 · see citing works
Classification of antimicrobial peptide using diversity measure with quadratic discriminant analysis
Chen, W., & Luo, L. (2009) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2009.03.013 · Cited by 31 · see citing works
Isolation and characterisation of new putative probiotic bacteria from human colonic flora
Raz, I., Gollop, N., Polak‐Charcon, S., & Schwartz, B. (2007) · British Journal Of Nutrition · doi:10.1017/s000711450747249x · Cited by 31 · see citing works
Production of biologically active human interleukin-10 by Bifidobacterium bifidum BGN4
Hong, N., Ku, S., Yuk, K., Johnston, T. V., Ji, G. E., & Park, M. S. (2021) · Microbial Cell Factories · doi:10.1186/s12934-020-01505-y · Cited by 29 · see citing works
Potential role of probiotic bacteria in the treatment and prevention of localised candidosis
Mailänder‐Sánchez, D., Wagener, J., & Schaller, M. (2011) · Mycoses · doi:10.1111/j.1439-0507.2010.01967.x · Cited by 27 · see citing works
Feng, P., Wang, Z., & Yu, X. (2017) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2017.2669302 · Cited by 27 · see citing works
Huang, C., & Lee, F. (2009) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3658 · Cited by 23 · see citing works
Aplicação de bactérias probióticas para profilaxia e tratamento de doenças gastrointestinais
Varavallo, M. A., Thomé, J. N., & Teshima, E. (2008) · Semina Ciências Biológicas e da Saúde · doi:10.5433/1679-0367.2008v29n1p83 · Cited by 23 · see citing works
Srikham, K., & Thirabunyanon, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112871 · Cited by 24 · see citing works
Probiotic use in irritable bowel syndrome
Young, P., & Cash, B. D. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0053-1 · Cited by 22 · see citing works
In Vitro and In Vivo Gene Silencing by TransKingdom RNAi (tkRNAi)
Xiang, S., Keates, A. C., Fruehauf, J. H., Yang, Y., Guo, H., Nguyen, T. A., & Li, C. J. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-547-7_7 · Cited by 19 · see citing works
Ader, F., Faure, K., Guery, B. P., & Nseir, S. (2007) · Pathologie Biologie · doi:10.1016/j.patbio.2007.06.002 · Cited by 18 · see citing works
Lü (2010) · Open Access Bioinformatics · doi:10.2147/oab.s10782 · Cited by 14 · see citing works
Biavati, B., & Mattarelli, P. (2015) · Bergey's Manual of Systematics of Archaea and Bacteria · doi:10.1002/9781118960608.gbm00019 · Cited by 14 · see citing works
Potential of probiotics as pharmaceutical agent: a review
Sarkar, S. (2013) · British Food Journal · doi:10.1108/bfj-06-2011-0163 · Cited by 12 · see citing works
Zamri, H. F., Shamsudin, M. N., Rahim, R. A., & Neela, V. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.02.012 · Cited by 12 · see citing works
Kumar, M., Hemalatha, R., Kumar, R., Nagpal, R., Devraj, J. P., Verma, V., Behare, P. V., Mal, G., & Singh, B. (2013) · Medical Epigenetics · doi:10.1159/000354719 · Cited by 9 · see citing works
Brave New (Microbial) World: implications for nasal and sinus disorders
Desrosiers, M. Y., & Valera, F. C. P. (2019) · Brazilian Journal of Otorhinolaryngology · doi:10.1016/j.bjorl.2019.09.001 · Cited by 7 · see citing works
Integrated Approaches in the Management of Gastrointestinal Disorders: A Biopsychosocial Perspective
Chughtai, M. A., Kerimkulova, M. K., Mushtaq, O., Anand, V. H., Rehman, A., Shehryar, A., Hassan, B. D., Islam, R., Islam, H., Mansoor, M., et al. (2024) · Cureus · doi:10.7759/cureus.60962 · Cited by 6 · see citing works
Probiotic Therapy, What is the most Effective Method for Host Protection Against Enteric Pathogen
Ghaderian, S. M. H., Natanzi, M. M., Goudarzvand, M., & Khodaii, Z. (2013) · International Journal of Enteric Pathogens · doi:10.17795/ijep13289 · Cited by 2 · see citing works
Recursos naturais amazônicos como fontes potenciais de probióticos: uma revisão
da Silva, A. J. M., Feio, C. D. G. B., Marinho, P. S. B., Gaspar, D. P., & Ferreira, N. R. (2022) · Research Society and Development · doi:10.33448/rsd-v11i4.27496 · Cited by 1 · see citing works
Microbiologic evaluation of efficacy of probiotic for correction intestinal disbiosis
Bissenova, N., Yergaliyeva, A., Махамбетов, К. О., & Talgatbekova, N. (2016) · Journal of Clinical Medicine of Kazakhstan · doi:10.23950/1812-2892-2016-2-36-42
Greenfield, R. H. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-2954-0.50108-3
Greenfield, R. H. (2009) · Elsevier eBooks · doi:10.1016/b978-84-458-1911-1.50104-4
- Authors
- Snelling, A. M.
- Affiliations
- University of Bradford (GB)
- Corresponding author
- Snelling, Anna M
- Venue
- Current Opinion in Infectious Diseases
- Published
- 2005-10
- Volume
- 18
- Issue
- 5
- Pages
- 420-426
- ISSN
- 0951-7375 (ISSN-L)
- OpenAlex
- W2046258788
- Cited by
- 46
- References
- 77
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2013: 3 · 2012: 4
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, gastrointestinal diseases, diarrhea, antibiotic-associated diarrhea, necrotizing enterocolitis, prebiotics, colonization resistance, gut microbiota, probiotic safety, neonates, children
- MeSH terms
- Gastrointestinal Diseases, Humans, Infections, Probiotics, Gastrointestinal Tract
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