Cited by 46Probiotics and Fermented FoodsGut microbiota and healthGastrointestinal motility and disorders

Effects of probiotics on the gastrointestinal tract

Snelling, Anna M·2005·Current Opinion in Infectious Diseases

Abstract

PURPOSE OF REVIEW: This review summarizes recent developments in our understanding of what gastrointestinal disorders probiotics can be of benefit for, focussing on conditions associated with infection or disruption of the normal gut flora. New insights into the effects administered strains can have in the gut, their safety, and potential for future development, will also be discussed. RECENT FINDINGS: Recent clinical studies have shown that probiotics can protect young children from diarrhoeal illness, including antibiotic-associated diarrhoea. They may also protect neonates from necrotizing enterocolitis. In adults, they can help prevent or reduce the severity of diarrhoeal illness, and ameliorate side-effects for those undergoing antibiotic therapy for infection. Researchers are looking at combining probiotics with prebiotics to enhance anti-inflammatory effects and restore colonization resistance of the commensal flora. New technologies are elucidating complex effects on gene expression in the gut, the probiotic, and bacterial pathogens. Recombinant strains capable of binding bacterial toxins are being developed as novel therapeutics against gastrointestinal infection. SUMMARY: Considering the clinical trial evidence of therapeutic benefit, probiotics are an underused treatment modality for prevention and amelioration of diarrhoeal illness. Better understanding of strain-specific effects, dosing regimens and any contraindications should help resolve this.

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Crossref · 10.1097/01.qco.0000182103.32504.e3

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Authors
Snelling, A. M.
Affiliations
University of Bradford (GB)
Corresponding author
Snelling, Anna M
Venue
Current Opinion in Infectious Diseases
Published
2005-10
Volume
18
Issue
5
Pages
420-426
ISSN
0951-7375 (ISSN-L)
OpenAlex
W2046258788
Cited by
46
References
77
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2013: 3 · 2012: 4
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
probiotics, gastrointestinal diseases, diarrhea, antibiotic-associated diarrhea, necrotizing enterocolitis, prebiotics, colonization resistance, gut microbiota, probiotic safety, neonates, children
MeSH terms
Gastrointestinal Diseases, Humans, Infections, Probiotics, Gastrointestinal Tract

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