The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Systematic review: the model for end‐stage liver disease – should it replace Child‐Pugh's classification for assessing prognosis in cirrhosis?
Open accessAbstract
Summary: Background: Prognosis in cirrhotic patients has had a resurgence of interest because of liver transplantation and new therapies for complications of end‐stage cirrhosis. The model for end‐stage liver disease score is now used for allocation in liver transplantation waiting lists, replacing Child‐Turcotte‐Pugh score. However, there is debate as whether it is better in other settings of cirrhosis. Aim: To review studies comparing the accuracy of model for end‐stage liver disease score vs. Child‐Turcotte‐Pugh score in non‐transplant settings. Results: Transjugular intrahepatic portosystemic shunt studies (with 1360 cirrhotics) only one of five, showed model for end‐stage liver disease to be superior to Child‐Turcotte‐Pugh to predict 3‐month mortality, but not for 12‐month mortality. Prognosis of cirrhosis studies (with 2569 patients) none of four showed significant differences between the two scores for either short‐ or long‐term prognosis whereas no differences for variceal bleeding studies (with 411 cirrhotics). Modified Child‐Turcotte‐Pugh score, by adding creatinine, performed similarly to model for end‐stage liver disease score. Hepatic encephalopathy and hyponatraemia (as an index of ascites), both components of Child‐Turcotte‐Pugh score, add to the prognostic performance of model for end‐stage liver disease score. Conclusions: Based on current literature, model for end‐stage liver disease score does not perform better than Child‐Turcotte‐Pugh score in non‐transplant settings. Modified Child‐Turcotte‐Pugh and model for end‐stage liver disease scores need further evaluation.
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Cites
Transection of the oesophagus for bleeding oesophageal varices
Pugh, R. N. H., Murray-Lyon, I. M., Dawson, J. L., Pietroni, M. C., & Williams, R. (1973) · Journal of British Surgery · doi:10.1002/bjs.1800600817 · Cited by 7,941
A Model to Predict Survival in Patients With End–Stage Liver Disease
Kamath, P. S., Wiesner, R. H., Malinchoc, M., Kremers, W., Therneau, T. M., Kosberg, C. L., D'Amico, G., Dickson, R. E., & Kim, R. W. (2001) · Hepatology · doi:10.1053/jhep.2001.22172 · Cited by 4,975
Malinchoc, M., Kamath, P. S., Gordon, F. D., Peine, C. J., Rank, J., & ter Borg, P. C. J. (2000) · Hepatology · doi:10.1053/he.2000.5852 · Cited by 2,893
Model for end-stage liver disease (MELD) and allocation of donor livers
Wiesner, R., Edwards, E., Freeman, R., Harper, A., Kim, R., Kamath, P., Kremers, W., Lake, J., Howard, T., Merion, R. M., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50016 · Cited by 2,528
Surgery and portal hypertension.
Child, C. G., & Turcotte, J. (1964) · PubMed · Cited by 1,933
Serum Creatinine as an Index of Renal Function: New Insights into Old Concepts
Perrone, R. D., Madias, N. E., & Levey, A. S. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.10.1933 · Cited by 1,581
The Liver and Portal Hypertension.
(1964) · Annals of Internal Medicine · doi:10.7326/0003-4819-61-6-1206_2 · Cited by 1,033
MELD and PELD: Application of survival models to liver allocation
Wiesner, R. H., McDiarmid, S. V., Kamath, P. S., Edwards, E. B., Malinchoc, M., Kremers, W. K., Krom, R. A. F., & Kim, R. W. (2001) · Liver Transplantation · doi:10.1053/jlts.2001.25879 · Cited by 864
The new liver allocation system: Moving toward evidence-based transplantation policy
Freeman, R. B., Wiesner, R. H., Harper, A., McDiarmid, S. V., Lake, J., Edwards, E., Merion, R., Wolfe, R., Turcotte, J., & Teperman, L. (2002) · Liver Transplantation · doi:10.1053/jlts.2002.35927 · Cited by 724
Assessment of the prognosis of cirrhosis: Child–Pugh versus MELD
Durand, F., & Valla, D. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2004.11.015 · Cited by 656
Cited by
The model for end-stage liver disease (MELD)
Kamath, P. S., & Kim, R. W. (2007) · Hepatology · doi:10.1002/hep.21563 · Cited by 1,674
Kaplan, D. E., Dai, F., Aytaman, A., Baytarian, M., Fox, R., Hunt, K., Knott, A., Pedrosa, M., Pocha, C., Mehta, R., et al. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.07.010 · Cited by 139
Botella-Carretero, J. I., Iglesias, B., Balsa, J. A., Arrieta, F., Zamarrón, I., & Vázquez, C. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.01.012 · Cited by 116
Metadata
- Authors
- CHOLONGITAS, E., PAPATHEODORIDIS, G. V., VANGELI, M., TERRENI, N., PATCH, D., & BURROUGHS, A. K.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2005-11-02
- Volume
- 22
- Issue
- 11-12
- Pages
- 1079-1089
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2139870153
- Cited by
- 420
- References
- 45
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CHOLONGITAS, E., PAPATHEODORIDIS, G. V., VANGELI, M., TERRENI, N., PATCH, D., & BURROUGHS, A. K. (2005). Systematic review: the model for end‐stage liver disease – should it replace Child‐Pugh's classification for assessing prognosis in cirrhosis? Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/j.1365-2036.2005.02691.x
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