The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.
Review article: the role of butyrate on colonic function
Open accessAbstract
Summary: Background Butyrate, a short‐chain fatty acid, is a main end‐product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. Aim To provide an overview on the present knowledge of the bioactivity of butyrate, emphasizing effects and possible mechanisms of action in relation to human colonic function. Methods A PubMed search was performed to select relevant publications using the search terms: ‘butyrate, short‐chain fatty acid, fibre, colon, inflammation, carcinogenesis, barrier, oxidative stress, permeability and satiety’. Results Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. In addition, butyrate may promote satiety. Two important mechanisms include the inhibition of nuclear factor kappa B activation and histone deacetylation. However, the observed effects of butyrate largely depend on concentrations and models used and human data are still limited. Conclusion Although most studies point towards beneficial effects of butyrate, more human in vivo studies are needed to contribute to our current understanding of butyrate‐mediated effects on colonic function in health and disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Items 201–213 of 213
Tonelli, F., Dolara, P., Batignani, G., Monaci, I., Caderni, G., Spagnesi, M. T., Luceri, C., & Amorosi, A. (1995) · Diseases of the Colon & Rectum · doi:10.1007/bf02049735 · Cited by 24
Yano, S., & Tierney, D. F. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91788-9 · Cited by 24
Nancey, S., Moussata, D., Graber, I., Claudel, S., Saurin, J., & Flourié, B. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000161918.04760.f3 · Cited by 23
Rodríguez-Salvador, J., Armas-Pineda, C., Pérezpeña-Díazconti, M., Chico-Ponce de León, F., Sosa-Sáinz, G., Lezama, P., Targa, F. R., & Arenas‐Huertero, F. (2005) · PubMed · Cited by 23
Meijer, H. P., Welters, C. F. M., Heineman, E., Salomons, G. S., Büller, H. A., Dekker, J. P., & Einerhand, A. W. C. (2000) · Diseases of the Colon & Rectum · doi:10.1007/bf02236640 · Cited by 19
Kato, K., Ishii, Y., Mizuno, S., Sugitani, M., Asai, S., Kohno, T., Takahashi, K., Komuro, S., Iwamoto, M., Miyamoto, S., et al. (2006) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520600955070 · Cited by 19
Scalmati, A., & Lipkin, M. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.9399169 · Cited by 15
Human Faecal Microbiota Develops the Ability to Degrade Type 3 Resistant Starch During Weaning
Scheiwiller, J., Arrigoni, E., Brouns, F. J. P. H., & Amadò, R. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000237937.05050.0d · Cited by 15
Inhibitory effect of microfibril wheat bran on azoxymethane-induced colon carcinogenesis in CF1 mice
Takahashi, T., Satou, M., Watanabe, N., Sakaitani, Y., Takagi, A., Uchida, K., Ikeda, M., Moriyama-Ebina, R., Matsumoto, K., & Morotomi, M. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00096-8 · Cited by 15
Activation of PPARγ is not involved in butyrate-induced epithelial cell differentiation
Ulrich, S., Wächtershäuser, A., Loitsch, S. M., von Knethen, A., Brüne, B., & Stein, J. M. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.07.007 · Cited by 13
Kameue, C., Tsukahara, T., & Ushida, K. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.606 · Cited by 11
Mortensen, F. V., Jørgensen, B., Christiansen, H. M., Sloth-Nielsen, J., Wolff, B., & Hessov, I. (2000) · Thrombosis Research · doi:10.1016/s0049-3848(00)00194-8 · Cited by 10
Barrett, K. E. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00340.2005 · Cited by 10
Cited by
Sorted by citations
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Self-citationParada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925
Metadata
- Authors
- HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐.
- Affiliations
- Maastricht University (NL)
- TiFN (NL)
- Corresponding author
- HAMER, H. M.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-10-26
- Volume
- 27
- Issue
- 2
- Pages
- 104-119
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1934624334
- Cited by
- 2,721
- References
- 213
- Citations by year
- 2026: 116 · 2025: 195 · 2024: 203 · 2023: 203 · 2022: 207 · 2021: 238 · 2020: 201 · 2019: 196 · 2018: 176 · 2017: 147 · 2016: 159 · 2015: 134 · 2014: 124 · 2013: 113 · 2012: 78
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- butyrate, short-chain fatty acids, colonic function, colonic mucosa, intestinal epithelial cells, dietary fiber fermentation, colonic inflammation, colorectal carcinogenesis, intestinal barrier, oxidative stress, satiety, NF-κB inhibition, histone deacetylation
- MeSH terms
- Animals, Butyrates, Child, Preschool, Colon, Colonic Neoplasms, Dietary Fiber, Enema, Fatty Acids, Volatile, Humans, Infant, Newborn, Inflammation, Intestinal Mucosa, Rabbits, Satiation, Oxidative Stress, Carbohydrate Metabolism, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
