Cited by 2,721Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyGastrointestinal motility and disorders

The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.

Review article: the role of butyrate on colonic function

Open access

HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., BRUMMER, R.‐J.·2008·Alimentary Pharmacology & Therapeutics

DOI 10.1111/j.1365-2036.2007.03562.x

Open this paper in CoChat — free account

Abstract

Summary: Background Butyrate, a short‐chain fatty acid, is a main end‐product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. Aim To provide an overview on the present knowledge of the bioactivity of butyrate, emphasizing effects and possible mechanisms of action in relation to human colonic function. Methods A PubMed search was performed to select relevant publications using the search terms: ‘butyrate, short‐chain fatty acid, fibre, colon, inflammation, carcinogenesis, barrier, oxidative stress, permeability and satiety’. Results Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. In addition, butyrate may promote satiety. Two important mechanisms include the inhibition of nuclear factor kappa B activation and histone deacetylation. However, the observed effects of butyrate largely depend on concentrations and models used and human data are still limited. Conclusion Although most studies point towards beneficial effects of butyrate, more human in vivo studies are needed to contribute to our current understanding of butyrate‐mediated effects on colonic function in health and disease.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2036.2007.03562.x

Cites

213 of 213 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,357
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study
Bingham, S. A., Day, N., Luben, R., Ferrari, P., Slimani, N., Norat, T., Clavel‐Chapelon, F., Kesse‐Guyot, E., Nieters, A., Boeing, H., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13174-1 · Cited by 1,123
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012
Epithelial Mucin Genes
Gendler, S. J., & Spicer, A. P. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003135 · Cited by 1,001
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 751
Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis
Scheppach, W. M., Sommer, H., Kirchner, T., Paganelli, G.-M., Bartram, P., Christl, S. U., Richter, F., Dusel, G., & Kasper, H. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91094-k · Cited by 740
Comparison of fermentation reactions in different regions of the human colon
Macfarlane, G. T., Gibson, G. R., & Cummings, J. H. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb04882.x · Cited by 676
Oxidative Stress and Pathogenesis of Inflammatory Bowel Disease: An Epiphenomenon or the Cause?
Rezaie, A. R., Parker, R. D., & Abdollahi, M. R. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9622-2 · Cited by 591
Butyrate production from dietary fibre and protection against large bowel cancer in a rat model.
McIntyre, A., Gibson, P. R., & Young, G. P. (1993) · Gut · doi:10.1136/gut.34.3.386 · Cited by 555
Dietary Fiber, Vegetables, and Colon Cancer: Critical Review and Meta-analyses of the Epidemiologic Evidence
Trock, B. J., Lanza, E., & Greenwald, P. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.8.650 · Cited by 548
The Effects of Short-Chain Fatty Acids on Human Colon Cancer Cell Phenotype Are Associated with Histone Hyperacetylation
Hinnebusch, B. F., Meng, S., Wu, J. T., Archer, S. Y., & Hodin, R. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.1012 · Cited by 546
Nondigestible Oligo‐ and Polysaccharides (Dietary Fiber): Their Physiology and Role in Human Health and Food
Tungland, B. C., & Meyer, D. (2002) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2002.tb00009.x · Cited by 525
Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier
Peng, L., He, Z., Chen, W., Holzman, I. R., & Lin, J. (2007) · Pediatric Research · doi:10.1203/01.pdr.0000250014.92242.f3 · Cited by 518
Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E 1 and E 2 production by intestinal myofibroblasts
Willemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518
Dietary Intake of Fiber and Decreased Risk of Cancers of the Colon and Rectum: Evidence From the Combined Analysis of 13 Case-Control Studies
Howe, G. R., Benito, E., Castelleto, R., Cornée, J., Estève, J., Gallagher, R. P., Iscovich, J., Deng-ao, J., Kaaks, R., Kune, G. A., et al. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.24.1887 · Cited by 504
The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line
Inan, M. S., Rasoulpour, R. J., Yin, L., Hubbard, A. K., Rosenberg, D. W., & Giardina, C. A. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70142-9 · Cited by 502
Dietary Fiber Intake and Risk of Colorectal Cancer
Park, Y., Hunter, D. J., Spiegelman, D. L., Bergkvist, L., Berrino, F., van den Brandt, P. A., Buring, J. E., Colditz, G. A., Freudenheim, J. L., Fuchs, C. S., et al. (2005) · JAMA · doi:10.1001/jama.294.22.2849 · Cited by 489
Butyrate Inhibits NF-κB Activation in Lamina Propria Macrophages of Patients with Ulcerative Colitis
Lührs, H., Gerke, T., Müller, J. G., Melcher, R., Schauber, J., Boxberger, F., Scheppach, W. M., & Menzel, T. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202317316105 · Cited by 480
Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
Karaki, S.-I., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J. B., & Kuwahara, A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-005-0140-x · Cited by 473
PPARγ as a new therapeutic target in inflammatory bowel diseases
Dubuquoy, L., Rousseaux, C., Thuru, X., Peyrin-Biroulet, L., Romano, O., Chavatte, P., Chamaillard, M., & Desreumaux, P. (2006) · Gut · doi:10.1136/gut.2006.093484 · Cited by 450
Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis
Dubuquoy, L., Jansson, E. Å., Deeb, S. S., Rakotobé, S., Karoui, M., Colombel, J., Auwerx, J. H., Pettersson, S., & Desreumaux, P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00271-3 · Cited by 448
Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis
Poritz, L. S., Garver, K. I., Green, C., Fitzpatrick, L. R., Ruggiero, F. M., & Koltun, W. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.07.050 · Cited by 414
Oligofructose Promotes Satiety in Rats Fed a High‐Fat Diet: Involvement of Glucagon‐Like Peptide‐1
Cani, P. D., Neyrinck, A. M., Maton, N., & Delzenne, N. M. (2005) · Obesity Research · doi:10.1038/oby.2005.117 · Cited by 390
Randomized Clinical Trial of Plantago Ovata Seeds (Dietary Fiber) As Compared With Mesalamine in Maintaining Remission in Ulcerative Colitis
Fernández‐Bañares, F., Hinojosa, J., Sánchez-Lombraña, J. L., Navarro, E., Martínez-Salmerón, J. F., García-Pugés, A. M., Gónzalez‐Huix, F., Riera, J., González-Lara, V., Domínguez-Abascal, F., et al. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.872_a.x · Cited by 386
Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways
Schauber, J. (2003) · Gut · doi:10.1136/gut.52.5.735 · Cited by 383
The IκB/NF-κB system: a key determinant of mucosal inflammation and protection
Jobin, C., & Sartor, R. B. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.3.c451 · Cited by 382
Oligofructose promotes satiety in healthy human: a pilot study
Cani, P. D., Joly, E., Horsmans, Y., & Delzenne, N. M. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602350 · Cited by 381
Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon
Barcelo, A., Claustre, J., Moro, F., Chayvialle, J.-A., Cuber, J.-C., & Plaisancié, P. (2000) · Gut · doi:10.1136/gut.46.2.218 · Cited by 375
Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose
Gaudier, E., Jarry, A., Blottière, H. M., de Coppet, P., Buisine, M. P., Aubert, J. P., Laboisse, C., Cherbut, C., & Hoebler, C. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00219.2004 · Cited by 365
The immune system: a target for functional foods?
Calder, P. C., & Kew, S. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002682 · Cited by 359
Expression of the short-chain fatty acid receptor, GPR43, in the human colon
Karaki, S.-I., Tazoe, H., Hayashi, H., Kashiwabara, H., Tooyama, K., Suzuki, Y., & Kuwahara, A. (2007) · Journal of Molecular Histology · doi:10.1007/s10735-007-9145-y · Cited by 345
Inulin-type fructans of longer degree of polymerization exert more pronounced in vitro prebiotic effects
de Wiele, T. V., Boon, N., Possemiers, S., Jacobs, H., & Verstraete, W. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.03084.x · Cited by 333
Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease
Takaishi, H., Matsuki, T., Nakazawa, A., Takada, T., Kado, S., Asahara, T., Kamada, N., Sakuraba, A., Yajima, T., Higuchi, H., et al. (2007) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.07.016 · Cited by 325
Impact of inulin and oligofructose on gastrointestinal peptides
Delzenne, N. M., Cani, P. D., Daubioul, C., & Neyrinck, A. M. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041342 · Cited by 322
Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat
Cherbut, C., Ferrier, L., Rozé, C., Anini, Y., Blottière, H. M., Lecannu, G., & Galmiche, J. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.6.g1415 · Cited by 316
Physiological and Clinical Aspects of Short-Chain Fatty Acids
Cummings, J. H., Rombeau, J. L., & 坂田, 隆. (2004) · Medical Entomology and Zoology · Cited by 313
Starch intake and colorectal cancer risk: an international comparison
Cassidy, A., Bingham, S., & Cummings, J. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.181 · Cited by 308
Selective colonization of insoluble substrates by human faecal bacteria
Leitch, E. C. M., Walker, A. W., Duncan, S. H., Holtrop, G., & Flint, H. J. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01186.x · Cited by 297
The contribution of sulphate reducing bacteria and 5-aminosalicylic acid to faecal sulphide in patients with ulcerative colitis
Pitcher, M. (2000) · Gut · doi:10.1136/gut.46.1.64 · Cited by 297
SLC5A8 , a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
Li, H., Myeroff, L. L., Smiraglia, D. J., Romero, M. F., Pretlow, T. P., Kasturi, L., Lutterbaugh, J., Rerko, R. M., Casey, G., Issa, J. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1430846100 · Cited by 295
Effect of Dietary Inulin Supplementation on Inflammation of Pouch Mucosa in Patients With an Ileal Pouch-Anal Anastomosis
Welters, C. F. M., Heineman, E., Thunnissen, E., van den Bogaard, A. E. J. M., Soeters, P. B., & Baeten, C. G. M. I. (2002) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6257-2 · Cited by 294
Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial.
Breuer, R. I., Soergel, K. H., Lashner, B. A., Christ, M. L., Hanauer, S. B., Vanagunas, A., Harig, J. M., Keshavarzian, A., ROBINSON, M. G., Sellin, J. H., et al. (1997) · Gut · doi:10.1136/gut.40.4.485 · Cited by 282
Lipid peroxidation and antioxidant status in colorectal cancer
Skrzydlewska, E. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i3.403 · Cited by 277
Colonic Sulfide in Pathogenesis and Treatment of Ulcerative Colitis
Roediger, W. E. W., Moore, J., & Babidge, W. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018851723920 · Cited by 270
Control of the innate epithelial antimicrobial response is cell‐type specific and dependent on relevant microenvironmental stimuli
Schauber, J., Dorschner, R. A., Yamasaki, K., Brouha, B., & Gallo, R. L. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02399.x · Cited by 270
Oral oligofructose‐enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin
Casellas, F., Borruel, N., Torrejón, A., Varela, E., Antolı́n, M., Guarner, F., & Malagelada, J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03288.x · Cited by 260
Butyrate and the Colonocyte
Velazquez, O. C., Lederer, H. M., & Rombeau, J. L. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5967-2_14 · Cited by 259
Rationale for the luminal provision of butyrate in intestinal diseases
Wächtershäuser, A., & Stein, J. M. (2000) · European Journal of Nutrition · doi:10.1007/s003940070020 · Cited by 258
Immune dysfunction in inflammatory bowel disease
Neuman, M. G. (2007) · Translational research · doi:10.1016/j.trsl.2006.11.009 · Cited by 253
Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera
Ramakrishna, B., Venkataraman, S., Srinivasan, P., Dash, P., Young, G. P., & Binder, H. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002033420502 · Cited by 249
The butyrate story: old wine in new bottles?
Scheppach, W. M., & Weiler, F. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200409000-00009 · Cited by 246
Oral butyrate for mildly to moderately active Crohn's disease
Sabatino, A. D., Morera, R., Ciccocioppo, R., Cazzola, P., GOTTI, S., Tinozzi, F. P., Tinozzi, S., & Corazza, G. R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02639.x · Cited by 245
Effects of resistant starch on the colon in healthy volunteers: possible implications for cancer prevention
Hylla, S., Gostner, A., Dusel, G., Anger, H. J. W., Bartram, H.-P., Christl, S., Kasper, H., & Scheppach, W. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.1.136 · Cited by 241
Inflammatory bowel disease: past, present, and future
Sands, B. E. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-006-1995-7 · Cited by 239
Effect of Short‐Chain Fatty Acids on the Human Colonic Mucosa in Vitro
Scheppach, W. M., Bartram, P., Richter, A., Richter, F., Liepold, H., Dusel, G., Hofstetter, G., Rüthlein, J., & Kasper, H. (1992) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719201600143 · Cited by 234
Short‐chain fatty acid topical treatment in distal ulcerative colitis
Vernia, P., Marcheggiano, A., Caprilli, R., Frieri, G., Corrao, G., Valpiani, D., Paolo, M. C. D., Paoluzi, P., & Torsoli, A. (1995) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1995.tb00386.x · Cited by 232
Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease
Piche, T., Varannes, S. B. D., Sacher‐Huvelin, S., Holst, J. J., Cuber, J. C., & Galmiche, J. P. (2003) · Gastroenterology · doi:10.1053/gast.2003.50159 · Cited by 232
Colonic mucin synthesis is increased by sodium butyrate.
Finnie, I. A., Dwarakanath, A. D., Taylor, B. A., & Rhodes, J. M. (1995) · Gut · doi:10.1136/gut.36.1.93 · Cited by 231
Increasing Fecal Butyrate in Ulcerative Colitis Patients by Diet: Controlled Pilot Study
Hallert, C., Björck, I., NYMAN, M. E., Pousette, A., Grännö, C., & Svensson, H. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200303000-00005 · Cited by 228
Does butyrate protect from colorectal cancer?
Sengupta, S., Muir, J. G., & Gibson, P. R. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04213.x · Cited by 228
Colon carcinogens: Their metabolism and mode of action
Weisburger, J. H. (1971) · Cancer · doi:10.1002/1097-0142(197107)28:1 · Cited by 227
Treatment of left‐sided ulcerative colitis with butyrate enemas: a controlled trial
Steinhart, A. H., Hiruki, T., Brzezinski, A., & Baker, J. P. (1996) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1996.d01-509.x · Cited by 222
The starved colon—Diminished mucosal nutrition, diminished absorption, and colitis
Roediger, W. E. W. (1990) · Diseases of the Colon & Rectum · doi:10.1007/bf02051922 · Cited by 222
Topical butyrate improves efficacy of 5‐ASA in refractory distal ulcerative colitis: results of a multicentre trial
Vernia, P., Annese, V., Bresci, G., D'Albasio, G., Renata D'Incà, Giaccari, S., Ingrosso, M., Mansi, C., Riegler, G., Valpiani, D., et al. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01130.x · Cited by 217
Trefoil peptides: from structure to function
Thim, L. (1997) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050108 · Cited by 216
Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat.
Butzner, J. D., Parmar, R., Bell, C., & Dalal, V. (1996) · Gut · doi:10.1136/gut.38.4.568 · Cited by 213
Increasing butyrate concentration in the distal colon by accelerating intestinal transit
Lewis, S. J., & Heaton, K. W. (1997) · Gut · doi:10.1136/gut.41.2.245 · Cited by 211
The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype
Comalada, M., Bailón, E., de Haro, O., Lara‐Villoslada, F., Xaus, J., Zarzuelo, A., & Gálvez, J. (2006) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-006-0092-x · Cited by 207
Treatment of distal ulcerative colitis with short-chain fatty acid enemas a placebo-controlled trial
Scheppach, W. M., & German-Austrian Scfa Study Group (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02071409 · Cited by 204
Physiological and Clinical Aspects of Short-Chain Fatty Acids
Kris‐Etherton, P. M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1293a · Cited by 202
Butyrate reduces colonic paracellular permeability by enhancing PPARγ activation
Kinoshita, M., Suzuki, Y., & Saitō, Y. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00294-2 · Cited by 198
SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter
Gupta, N., Martin, P. M., Prasad, P. D., & Ganapathy, V. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.028 · Cited by 196
The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T
Hatayama, H., Iwashita, J., Kuwajima, A., & Abé, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.025 · Cited by 196
Organic anions and the diarrhea of inflammatory bowel disease
Vernia, P., Gnaedinger, A., Hauck, W., & Breuer, R. I. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01536987 · Cited by 194
Treatment of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial
Kanauchi, O., Suga, T., Tochihara, M., Hibi∥, T., Naganuma, M., Homma, T., Asakura, H., Nakano, H., Takahama, K., Fujiyama, Y., et al. (2002) · Journal of Gastroenterology · doi:10.1007/bf03326417 · Cited by 194
Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate?
Morrison, D. J., Mackay, W. G., Edwards, C. A., Preston, T., Dodson, B., & Weaver, L. T. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061853 · Cited by 194
HDAC inhibition prevents NF-κB activation by suppressing proteasome activity: Down-regulation of proteasome subunit expression stabilizes IκBα
Place, R. F., Noonan, E. J., & Giardina, C. A. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.030 · Cited by 189
Peptide YY and Proglucagon mRNA Expression Patterns and Regulation in the Gut
Zhou, J. F., Hegsted, M., McCutcheon, K. L., Keenan, M. J., Xi, X., Raggio, A. M., & Martin, R. J. (2006) · Obesity · doi:10.1038/oby.2006.77 · Cited by 188
Modulation of tight junction structure and function by cytokines
Walsh, S. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00048-x · Cited by 188
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
Dashwood, R. H., Myzak, M. C., & Ho, E. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi253 · Cited by 186
Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model
Mariadason, J. M., Barkla, D. H., & Gibson, P. R. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.4.g705 · Cited by 182
Influence of Dietary Fiber on Inflammatory Bowel Disease and Colon Cancer: Importance of Fermentation Pattern
Rose, D. J., DeMeo, M. T., Keshavarzian, A., & Hamaker, B. R. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00282.x · Cited by 181
Microarray Analysis of Butyrate Regulated Genes in Colonic Epithelial Cells
Daly, K., & Shirazi‐Beechey, S. P. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.49 · Cited by 178
Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats
Bourdu, S., Dapoigny, M., Chapuy, E., Artigue, F., Vasson, M.-P., Dechelotte, P., Bommelaer, G., Eschalier, A., & Ardid, D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.082 · Cited by 176
Dietary Fructooligosaccharides Affect Intestinal Barrier Function in Healthy Men
ten Bruggencate, S., Bovee-Oudenhoven, I. M. J., Lettink-Wissink, M. L. G., Katan, M., & van der Meer, R. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.70 · Cited by 173
Inhibition of interferon gamma signaling by the short chain fatty acid butyrate.
Klampfer, L., Huang, J., Sasazuki, T., Shirasawa, S., & Augenlicht, L. H. (2003) · PubMed · Cited by 168
Histone Deacetylase Inhibitors Up-Regulate the Expression of Tight Junction Proteins
Bordin, M., D'Atri, F., Guillemot, L., & Citi, S. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.692.2.12 · Cited by 168
Germinated barley foodstuff prolongs remission in patients with ulcerative colitis
Hanai, H., Kanauchi, O., Mitsuyama, K., Andoh, A., Takeuchi, K., Iida, T., Araki, Y., Fujiyama, Y., Toyonaga, A., Sata, M., et al. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.13.5.643 · Cited by 166
Motor effects of short-chain fatty acids and lactate in the gastrointestinal tract
Cherbut, C. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002213 · Cited by 166
Colonic fermentation and proximal gastric tone in humans
Ropert, A., Cherbut, C., Rozé, C., Quellec, A. L., Holst, J. J., Fu–Cheng, X., Varannes, S. B. D., & Jp, G. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690193 · Cited by 165
Physiological and Anti‐Inflammatory Roles of Dietary Fiber and Butyrate in Intestinal Functions
Andoh, A., Bamba, T., & Sasaki, M. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300518 · Cited by 161
Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors.
Conley, B. A., Egorin, M. J., Tait, N. S., Rosen, D. M., Sausville, E. A., Dover, G. H., Fram, R. J., & Echo, D. A. V. (1998) · PubMed · Cited by 155
The G-protein-coupled receptor 40 family (GPR40–GPR43) and its role in nutrient sensing
Covington, D. K., Briscoe, C. A., Brown, A. J., & Jayawickreme, C. K. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340770 · Cited by 154
Short-chain fatty acids alter tight junction permeability in intestinal monolayer cells via lipoxygenase activation
Ohata, A., Usami, M., & Miyoshi, M. (2005) · Nutrition · doi:10.1016/j.nut.2004.12.004 · Cited by 150
AGA technical review: Impact of dietary fiber on colon cancer occurrence
Kim, Y. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70377-5 · Cited by 147
Dietary Fructooligosaccharides Increase Intestinal Permeability in Rats
ten Bruggencate, S. J. M., Bovee-Oudenhoven, I. M. J., Lettink-Wissink, M. L. G., & van der Meer, R. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.837 · Cited by 147
Protective activity of butyrate on hydrogen peroxide-induced DNA damage in isolated human colonocytes and HT29 tumour cells
Rosignoli, P. (2001) · Carcinogenesis · doi:10.1093/carcin/22.10.1675 · Cited by 147
Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies
Reddy, B. S. (1998) · British Journal Of Nutrition · doi:10.1017/s0007114500006061 · Cited by 147
Ispaghula Husk May Relieve Gastrointestinal Symptoms in Ulcerative Colitis in Remission
Hallert, C., Kaldma, M., & Petersson, B. G. (1991) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529108998594 · Cited by 146
Topical butyrate for acute radiation proctitis: randomised, crossover trial
Vernia, P., Fracasso, P., Casale, V., Villotti, G., Marcheggiano, A., Stigliano, V., Pinnarò, P., Bagnardi, V., & Caprilli, R. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02787-2 · Cited by 139
Combined Oral Sodium Butyrate and Mesalazine Treatment Compared to Oral Mesalazine Alone in Ulcerative Colitis
Vernia, P., Monteleone, G., Grandinetti, G., Villotti, G., Giulio, E. D., Frieri, G., Marcheggiano, A., Pallone, F., Caprilli, R., & Torsoli, A. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005537411244 · Cited by 138
Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-κB
Venkatraman, A., Ramakrishna, B., Velayudhan, S. R., Kumar, N. S. N., Pulimood, A. B., & Patra, S. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00307.2002 · Cited by 138
Treatment of diversion colitis by short-chain fatty acids
Guillemot, F., Colombel, J., Neut, C., Verplanck, N., Lecomte, M., Romond, C., Paris, J., & Cortot, A. (1991) · Diseases of the Colon & Rectum · doi:10.1007/bf02049697 · Cited by 138
Treatment of ulcerative colitis patients by long-term administration of germinated barley foodstuff: Multi-center open trial
Kanauchi, O., Mitsuyama, K., Homma, T., Takahama, K., Fujiyama, Y., Andoh, A., Araki, Y., Toshihiro, S., Hibi∥, T., Naganuma, M., et al. (2003) · International Journal of Molecular Medicine · doi:10.3892/ijmm.12.5.701 · Cited by 137
Role of mucins in inflammatory bowel disease: important lessons from experimental models
Einerhand, A. W. C., Renes, I. B., Makkink, M. K., van der Sluis, M., Büller, H. A., & Dekker, J. P. (2002) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200207000-00008 · Cited by 136
Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model
D’Argenio, G., Cosenza, V., Cave, M. D., Iovino, P., Valle, N. D., Lombardi, G., & Mazzacca, G. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8964397 · Cited by 136
Colonic fermentation of dietary fibre to short chain fatty acids in patients with adenomatous polyps and colonic cancer.
Clausen, M. R., Bonnén, H., & Mortensen, P. B. (1991) · Gut · doi:10.1136/gut.32.8.923 · Cited by 135
Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy
Lambert, D., Wood, I. S., Ellis, A., & Shirazi‐Beechey, S. P. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600264 · Cited by 135
Potential of short chain fatty acids to modulate the induction of DNA damage and changes in the intracellular calcium concentration by oxidative stress in isolated rat distal colon cells
Abrahamse, S. L., Pool-Zobel, B. L., & Rechkemmer, G. (1999) · Carcinogenesis · doi:10.1093/carcin/20.4.629 · Cited by 135
Essential Role of the JAK/STAT1 Signaling Pathway in the Expression of Inducible Nitric-oxide Synthase in Intestinal Epithelial Cells and Its Regulation by Butyrate
Stempelj, M., Kédinger, M., Augenlicht, L. H., & Klampfer, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609426200 · Cited by 134
Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NFκB signalling
Schwab, M., Reynders, V., Loitsch, S. M., Steinhilber, D., Stein, J. M., & Schröder, O. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.04.010 · Cited by 133
Effect of dietary resistant starch and protein on colonic fermentation and intestinal tumourigenesis in rats
Leu, R. K. L., Brown, I. L., Hu, Y., Morita, T., Esterman, A., & Young, G. P. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl245 · Cited by 133
Short chain fatty acid distributions of enema samples from a sigmoidoscopy population: an association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer.
Weaver, G. A., Krause, J. A., Miller, T. L., & Wolin, M. J. (1988) · Gut · doi:10.1136/gut.29.11.1539 · Cited by 126
Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72
Arvans, D. L., Vavricka, S. R., Ren, H., Musch, M. W., Kang, L. H., Rocha, F. G., Lucioni, A., Turner, J. R., Alverdy, J. C., & Chang, E. B. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00206.2004 · Cited by 126
Increased butyrate formation in the pig colon by feeding raw potato starch leads to a reduction of colonocyte apoptosis and a shift to the stem cell compartment
Mentschel, J., & Claus, R. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00318-4 · Cited by 124
Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT.
Paroder, V., Spencer, S. R., Paroder, M., Arango, D., Schwartz, S., Mariadason, J., Augenlicht, L., Eskandari, S., & Carrasco, N. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0602365103 · Cited by 123
Short-chain fatty acids in the treatment of radiation proctitis
TALLEY, N., Chen, F., King, D. W., Jones, M., & Talley, N. J. (1997) · Diseases of the Colon & Rectum · doi:10.1007/bf02050927 · Cited by 121
In vivo butyrate metabolism and colonic permeability in extensive ulcerative colitis
Hond, E. D., Hiele, M. I., Evenepoel, P., Peeters, M., Ghoos, Y. F., & Rutgeerts, P. J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70137-4 · Cited by 121
Plasmin/Plasminogen System in Colorectal Cancer
Berger, D. H. (2002) · World Journal of Surgery · doi:10.1007/s00268-002-4050-8 · Cited by 118
Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon
Bauer‐Marinovic, M. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl025 · Cited by 115
Serum acetate:propionate ratio is related to serum cholesterol in men but not women.
Wolever, T., Fernandes, J., & Rao, A. (1996) · Journal of NutriLife · doi:10.1093/jn/126.11.2790 · Cited by 115
Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate
Ebert, M. N. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg122 · Cited by 112
Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells
Ren, H., Musch, M. W., Kojima, K., Boone, D. L., Ma, A. I., & Chang, E. B. (2001) · Gastroenterology · doi:10.1053/gast.2001.27028 · Cited by 112
Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice
Delmée, E., Cani, P. D., Gual, G., Knauf, C., Burcelin, R., Maton, N., & Delzenne, N. M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.05.013 · Cited by 111
An Investigation into the In Vivo Performance Variability of pH Responsive Polymers for Ileo-Colonic Drug Delivery Using Gamma Scintigraphy in Humans
Ibekwe, V. C., Liu, F., Fadda, H. M., Khela, M. K., Evans, D. F., Parsons, G. E., & Basit, A. W. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20742 · Cited by 111
Acarbose Enhances Human Colonic Butyrate Production
Weaver, G. A., Tangel, C. T., Krause, J. A., Parfitt, M. M., Jenkins, P., Rader, J. M., LEWIS, B. A., Miller, T. L., & Wolin, M. J. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.717 · Cited by 110
Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers
Gostner, A., Blaut, M., Schäffer, V., Kozianowski, G., Theis, S., Klingeberg, M., Dombrowski, Y., Martin, D., Ehrhardt, S., Taras, D., et al. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051589 · Cited by 108
Oral Administration of Butyrivibrio fibrisolvens, a Butyrate-Producing Bacterium, Decreases the Formation of Aberrant Crypt Foci in the Colon and Rectum of Mice
Ohkawara, S., Furuya, H., Nagashima, K., Asanuma, N., & Hino, T. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2878 · Cited by 108
Short-chain fatty acid formation in the hindgut of rats fed oligosaccharides varying in monomeric composition, degree of polymerisation and solubility
Nilsson, U. J., & NYMAN, M. E. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051531 · Cited by 105
Cellular growth state differentially regulates enterocyte gene expression in butyrate-treated HT-29 cells.
Hodin, R. A., Meng, S., Archer, S. Y., & Tang, R. (1996) · PubMed · Cited by 105
Stimulation of Butyrate Production in the Large Intestine of Weaning Piglets by Dietary Fructooligosaccharides and Its Influence on the Histological Variables of the Large Intestinal Mucosa
Tsukahara, T., IWASAKI, Y., Nakayama, K., & Ushida, K. (2003) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.49.414 · Cited by 105
Volatile fatty acids in human peripheral and portal blood: Quantitative determination by vacuum distillation and gas chromatography
Dankert, J., Zijlstra, J. B., & Wolthers, B. G. (1981) · Clinica Chimica Acta · doi:10.1016/0009-8981(81)90359-4 · Cited by 104
Time of day and glucose tolerance status affect serum short-chain fatty concentrations in humans
Wolever, T. M. S., Josse, R. G., Leiter, L. A., & Chiasson, J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90127-x · Cited by 103
Butyrate modulates TGF-β1 generation and function: Potential renal benefit for Acacia(sen) SUPERGUM™ (gum arabic)?
Matsumoto, N., Riley, S., Fraser, D. J., Al‐Assaf, S., Ishimura, E., Wolever, T. M. S., Phillips, G. O., & Phillips, A. O. (2006) · Kidney International · doi:10.1038/sj.ki.5000028 · Cited by 103
Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis
Pinto, A., Fidalgo, P. O., Cravo, M. L., Midões, J., Chaves, P. P., Rosa, J. C., Birto, M. D. A., & Leitão, C. N. (1999) · Diseases of the Colon & Rectum · doi:10.1007/bf02236937 · Cited by 101
Short-chain fatty acids promote the migration of colonic epithelial cells in vitro
Wilson, A., & Gibson, P. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9247468 · Cited by 101
PPAR-γ Is Selectively Upregulated in Caco-2 Cells by Butyrate
Wächtershäuser, A., Loitsch, S. M., & Stein, J. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2793 · Cited by 100
Short-chain fatty acid enemas
Senagore, A. J., MacKeigan, J. M., Scheider, M., & Ebrom, S. J. (1992) · Diseases of the Colon & Rectum · doi:10.1007/bf02253492 · Cited by 95
Sodium Butyrate Inhibits Carcinoma Development in a 1,2‐Dimethylhydrazine‐Induced Rat Colon Cancer
Medina, V., Afonso, J., Álvarez‐Argüelles, H., Hernández, C., & González, F. (1998) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719802200114 · Cited by 90
Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1β, and nuclear factor κB in trinitrobenzene sulphonic acid induced colitis in rats
Song, M., Xia, B., & Li, J. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2005.037945 · Cited by 90
Colonic epithelial cell activation and the paradoxical effects of butyrate
Gibson, P. R., Rosella, O., Wilson, A. J., Mariadason, J. M., Rickard, K., Byron, K., & Barkla, D. H. (1999) · Carcinogenesis · doi:10.1093/carcin/20.4.539 · Cited by 90
Counter-regulatory effect of sodium butyrate on tumour necrosis factor-alpha (TNF-α)-induced complement C3 and factor B biosynthesis in human intestinal epithelial cells
Andoh, A., Fujiyama, Y., Hata, K., Araki, Y., Takaya, H., Shimada, M., & Bamba, T. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01038.x · Cited by 89
Dose-dependent reduction of dietary protein-induced colonocyte DNA damage by resistant starch in rats correlates more highly with caecal butyrate than with other short chain fatty acids
Toden, S., Bird, A. R., Topping, D. L., & Conlon, M. A. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.2.3627 · Cited by 88
A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon
Roda, A. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i7.1079 · Cited by 86
Butyrate impairs intestinal tumor cell-induced angiogenesis by inhibiting HIF-1α nuclear translocation
Zgouras, D., Wächtershäuser, A., Frings, D., & Stein, J. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02916-9 · Cited by 84
The human colonic monocarboxylate transporter Isoform 1: Its potential importance to colonic tissue homeostasis
Cuff, M. A., Dyer, J., Jones, M., & Shirazi‐Beechey, S. P. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.12.003 · Cited by 83
Luminal peptide YY-releasing factors in the isolated vascularly perfused rat colon
Plaisancié, P., Dumoulin, V., Chayvialle, J. A., & Cuber, J.-C. (1996) · Journal of Endocrinology · doi:10.1677/joe.0.1510421 · Cited by 80
Luminal glucagon-like peptide-1(7–36) amide-releasing factors in the isolated vascularly perfused rat colon
Plaisancié, P., Dumoulin, V., Chayvialle, J. A., & Cuber, J.-C. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1450521 · Cited by 79
Variable Effects of Short Chain Fatty Acids and Lactic Acid in Inducing Intestinal Mucosal Injury in Newborn Rats
Lin, J., Nafday, S. M., Chauvin, S. N., Magid, M. S., Pabbatireddy, S., Holzman, I. R., & Babyatsky, M. W. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200210000-00016 · Cited by 79
Luminal ions and short chain fatty acids as markers of functional activity of the mucosa in ulcerative colitis.
Roediger, W. E. W., Heyworth, M. F., Willoughby, P. H., Piris, J., Moore, A., & Truelove, S. C. (1982) · Journal of Clinical Pathology · doi:10.1136/jcp.35.3.323 · Cited by 76
Microcirculatory and trophic effects of short chain fatty acids in the human rectum after Hartmann's procedure
Mortensen, F. V., Hessov, I., Birke, H., Korsgaard, N., & Nielsen, H. K. (1991) · British journal of surgery · doi:10.1002/bjs.1800781019 · Cited by 75
Short-Chain Fatty Acids Induce Colonic Mucosal Injury in Rats with Various Postnatal Ages
Nafday, S. M., Chen, W., Peng, L., Babyatsky, M. W., Holzman, I. R., & Lin, J. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000150721.83224.89 · Cited by 73
Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding
Chirakkal, H., Leech, S. H., Brookes, K. E., Prais, A. L., Waby, J. S., & Corfe, B. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209702 · Cited by 72
In vivo measurement of colonic butyrate metabolism in patients with quiescent ulcerative colitis
Simpson, E. J., Chapman, M. A. S., Dawson, J. M., Berry, D., Macdonald, I. A., & Cole, A. (2000) · Gut · doi:10.1136/gut.46.1.73 · Cited by 71
Tumour necrosis factor and nuclear factor B inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide
Lončar, M. B. (2003) · Gut · doi:10.1136/gut.52.9.1297 · Cited by 68
Prolonged Butyrate Treatment Inhibits the Migration and Invasion Potential of HT1080 Tumor Cells
Zeng, H., & Briske‐Anderson, M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.2.291 · Cited by 67
Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation
Augenlicht, L. H., Shi, L., Mariadason, J. M., LABOISSE, C. L., & Velcich, A. (2003) · Oncogene · doi:10.1038/sj.onc.1206521 · Cited by 67
Short-chain fatty acid enemas fail to decrease colonic hypersensitivity and inflammation in TNBS-induced colonic inflammation in rats
Tarrerias, L. A., Millecamps, M., Alloui, A., Beaughard, C., Kemeny, L. J., Bourdu, S., Bommelaer, G., Eschalier, A., Dapoigny, M. C., & Ardid, D. (2002) · Pain · doi:10.1016/s0304-3959(02)00234-8 · Cited by 66
Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans
Gee, J. M., & Johnson, I. T. (2005) · Nutrition · doi:10.1016/j.nut.2005.03.002 · Cited by 64
Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: Effects on transglutaminase activity
D’Argenio, G., Cosenza, V., Sorrentini, I., Ritis, F. D., Gatto, A., Cave, M. D., D’Armiento, F. P., & Mazzacca, G. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90598-3 · Cited by 63
A New Look at Crohn's Disease
Wehkamp, J., & Stange, E. F. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.030 · Cited by 63
Rectal cell proliferation and colon cancer risk in ulcerative colitis.
Biasco, G., Paganelli, G. M., Miglioli, M., Brillanti, S., Febo, G. D., Gizzi, G., de Leòn, M. P., Campieri, M., & Barbara, L. (1990) · PubMed · Cited by 62
Short-Chain Fatty Acid Release of Peptide YY in the Isolated Rabbit Distal Colon
Longo, W. E., Ballantyne, G. H., Savoca, P., Adrian, T. E., Bilchik, A. J., & Modlin, I. M. (1991) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529108996507 · Cited by 62
Acarbose raises serum butyrate in human subjects withimpaired glucose tolerance
Wolever, T. M. S., & Chiasson, J. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500001239 · Cited by 62
Histological changes in the colonic mucosa following irrigation with short-chain fatty acids
Scheppach, W., Müller, J. G., Boxberger, F., Dusel, G., Richter, F., Bartram, H.-P., Christl, S. U., Dempfle, C.-E. H., & Kasper, H. (1997) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199702000-00010 · Cited by 61
Butyrylated starch is less susceptible to enzymic hydrolysis and increases large-bowel butyrate more than high-amylose maize starch in the rat
Bajka, B. H., Topping, D. L., Cobiac, L., & Clarke, J. M. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061807 · Cited by 60
Dietary supplementation with β-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects
Nilsson, U. J., Johansson, M., Nilsson, Å., Björck, I., & NYMAN, M. E. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602816 · Cited by 59
Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells
Tran, C. P., Familari, M., Parker, L. M., Whitehead, R. H., & Giraud, A. S. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.1.g85 · Cited by 59
Effect of butyrate on paracellular permeability in rat distal colonic mucosa ex vivo
Mariadason, J. M., Kilias, D., Catto‐Smith, A. G., & Gibson, P. R. (1999) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.1999.01972.x · Cited by 58
Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids
Krishnan, S., Ramakrishna, B., & Binder, H. J. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1018871412748 · Cited by 57
Molecular weight of guar gum affects short‐chain fatty acid profile in model intestinal fermentation
Stewart, M., & Slavin, J. L. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600024 · Cited by 57
PPARγ is a key target of butyrate-induced caspase-3 activation in the colorectal cancer cell line Caco-2
Schwab, M., Reynders, V., Ulrich, S., Zahn, N., Stein, J. M., & Schröder, O. (2006) · APOPTOSIS · doi:10.1007/s10495-006-9788-2 · Cited by 56
Anti-inflammatory properties of heat shock protein 70 and butyrate on Salmonella-induced interleukin-8 secretion in enterocyte-like Caco-2 cells
Malago, J. J., Koninkx, J. F. J. G., Tooten, P. C. J., van Liere, E. A., & van Dijk, J. E. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02810.x · Cited by 55
Dietary Sodium Gluconate Protects Rats from Large Bowel Cancer by Stimulating Butyrate Production
Kameue, C., Tsukahara, T., Yamada, K., Koyama, H., Iwasaki, Y., Nakayama, K., & Ushida, K. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.940 · Cited by 53
Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis.
al-Sabbagh, R., Sinicrope, F. A., Sellin, J. H., Shen, Y., & Roubein, L. D. (1996) · PubMed · Cited by 53
Rectal absorption of short chain fatty acids in the absence of chloride.
McNeil, N. I., Cummings, J. H., & James, W. P. T. (1979) · Gut · doi:10.1136/gut.20.5.400 · Cited by 52
Defensin expression in chronic pouchitis in patients with ulcerative colitis or familial adenomatous polyposis coli
Kiehne, K. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i7.1056 · Cited by 51
The Dietary Combination of Germinated Barley Foodstuff plus Clostridium butyricum Suppresses the Dextran Sulfate Sodium-induced Experimental Colitis in Rats
Araki, Y. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200451180 · Cited by 50
Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats
Araki, Y., Andoh, A., Takizawa, J., Takizawa, W., & Fujiyama, Y. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.13.4.577 · Cited by 49
Volatile fatty acids in the human intestine: Studies in surgical patients
Mitchell, B. L., Lawson, M. J., Davies, M., Grant, A. K., Roediger, W. E. W., Illman, R. J., & Topping, D. L. (1985) · Nutrition Research · doi:10.1016/s0271-5317(85)80140-8 · Cited by 47
Colonic Luminal Hydrogen Sulfide Is Not Elevated in Ulcerative Colitis
Moore, J., Babidge, W., Millard, S. M., & Roediger, W. E. W. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018848709769 · Cited by 44
Apparent fiber digestibility and fecal short-chain fatty acid concentrations with ingestion of two types of dietary fiber.
Fredstrom, S., Lampe, J., Jung, H.-S., & Slavin, J. (1994) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719401800114 · Cited by 44
The Influence of Specific Luminal Factors on the Colonic Epithelium: High-Dose Butyrate and Physical Changes Suppress Early Carcinogenic Events in Rats
Wong, C. S., Sengupta, S., Tjandra, J. J., & Gibson, P. R. (2005) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-0810-x · Cited by 41
Probiotics, prebiotics, synbiotics: ecological treatment for inflammatory bowel disease?
Marteau, P. R. (2006) · Gut · doi:10.1136/gut.2004.051458 · Cited by 38
Dietary Fiber and Colorectal Cancer
Baron, J. A. (2005) · JAMA · doi:10.1001/jama.294.22.2904 · Cited by 36
Colonic Production of Butyrate in Patients with Previous Colonic Cancer during Long-Term Treatment with Dietary Fibre (Plantago ovataSeeds)
Nordgaard, I., Hove, H., Clausen, M. R., & Mortensen, P. B. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609003122 · Cited by 35
Sodium butyrate enhances complement-mediated cell injury via down-regulation of decay-accelerating factor expression in colonic cancer cells
Andoh, M. S. A. (2002) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-001-0239-1 · Cited by 35
Impaired Detoxication of Hydrogen Sulfide in Ulcerative Colitis?
Picton, R., Eggo, M. C., Langman, M. J. S., & Singh, S. V. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9529-y · Cited by 32
The intracellular target of butyrate's actions: HDAC or HDON'T?
Gibson, P. R. (2000) · Gut · doi:10.1136/gut.46.4.447 · Cited by 32
Differential expression of multiple transglutaminases in human colon: impaired keratinocyte transglutaminase expression in ulcerative colitis
D’Argenio, G., Calvani, M., Valle, N. D., Cosenza, V., Matteo, G. D., Giorgio, P., Margarucci, S., Petillo, O., Jori, F. P., Galderisi, U., et al. (2005) · Gut · doi:10.1136/gut.2004.049411 · Cited by 32
Short-chain fatty acids stimulate mucosal cell proliferation in the closed human rectum after Hartmann's procedure
Mortensen, F. V., Langkilde, N. C., Joergensen, J. C. R., & Hessov, I. (1999) · International Journal of Colorectal Disease · doi:10.1007/s003840050201 · Cited by 31
Butyrate is a potent inhibitor of urokinase secretion by normal colonic epithelium in vitro
Gibson, P. R., Rosella, O., Rosella, G., & Young, G. P. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90166-x · Cited by 30
Propionate absorption associated with bicarbonate secretion in vitro in the mouse cecum
Kawamata, K., Hayashi, H., & Suzuki, Y. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0200-4 · Cited by 29
Short‐Chain Fatty Acid Induces Intestinal Mucosal Injury in Newborn Rats and Down‐Regulates Intestinal Trefoil Factor Gene Expression In Vivo and In Vitro
Lin, J., Peng, L., Itzkowitz, S. H., Holzman, I. R., & Babyatsky, M. W. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000179659.09210.ff · Cited by 26
Effect of Topical Butyrate on Rectal Epithelial Kinetics and Mucosal Enzyme Activities
Gibson, P. R., Kilias, D., Rosella, O., Day, J. M., Abbott, M., Finch, C. F., & Young, G. P. (1998) · Clinical Science · doi:10.1042/cs0940671 · Cited by 25

Sorted by citations

A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Self-citation
Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases
Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925

See all 2,721

Authors: HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐.
Affiliations: Maastricht University (NL)
TiFN (NL)
Corresponding author: HAMER, H. M.
ORCID: HAMER, H. M.
JONKERS, D.
VENEMA, K.
TROOST, F. J.
BRUMMER, R.‐J.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2007-10-26
Volume: 27
Issue: 2
Pages: 104-119
ISSN: 0269-2813 (ISSN-L)
1365-2036
DOI: 10.1111/j.1365-2036.2007.03562.x
OpenAlex: W1934624334
Cited by: 2,721
References: 213
Citations by year: 2026: 116 · 2025: 195 · 2024: 203 · 2023: 203 · 2022: 207 · 2021: 238 · 2020: 201 · 2019: 196 · 2018: 176 · 2017: 147 · 2016: 159 · 2015: 134 · 2014: 124 · 2013: 113 · 2012: 78
FWCI: 3.46
Type: journal article
Language: en
Open access: green
cris.maastrichtuniversity.nl
Licence: other-oa
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
TNO Repository (submittedVersion)
Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: butyrate, short-chain fatty acids, colonic function, colonic mucosa, intestinal epithelial cells, dietary fiber fermentation, colonic inflammation, colorectal carcinogenesis, intestinal barrier, oxidative stress, satiety, NF-κB inhibition, histone deacetylation
MeSH terms: Animals, Butyrates, Child, Preschool, Colon, Colonic Neoplasms, Dietary Fiber, Enema, Fatty Acids, Volatile, Humans, Infant, Newborn, Inflammation, Intestinal Mucosa, Rabbits, Satiation, Oxidative Stress, Carbohydrate Metabolism, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Review article: the role of butyrate on colonic function

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks