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Cited by 137Gastrointestinal motility and disordersPsychosomatic Disorders and Their TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study

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LEE, S., WU, J., MA, Y. L., TSANG, A., GUO, W.‐J., SUNG, J.·2009·Alimentary Pharmacology & Therapeutics
DOI 10.1111/j.1365-2036.2009.04074.x
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Abstract

Summary: Background No previous study has examined the comorbidity of Irritable Bowel Syndrome (IBS) and Generalized Anxiety Disorder (GAD) in a general population using standardized diagnostic methods. Aim To examine the prevalence, comorbidity and risk correlates of IBS and GAD in a general population. Methods A random community‐based telephone survey was conducted. The questionnaire covered symptoms of IBS, GAD, core depressive symptoms, help‐seeking behaviour and functional impairment on the Sheehan Disability Scale. Results A total of 2005 participants completed the interview. The current prevalence of IBS was 5.4% and the 12‐month prevalence of GAD was 4%. GAD was five times more common among IBS respondents than non‐IBS respondents (OR: 5.84, P < 0.001), whereas IBS was 4.7 times more common among GAD respondents than among non‐GAD respondents (OR: 6.32, P < 0.001). Core depressive symptoms (OR: 6.25, P < 0.01) and education level (OR: 5.918, P = 0.021) were risk correlates of GAD among IBS respondents. Comorbid respondents were more impaired than respondents having either disorder alone, but were not more likely to seek professional help than IBS‐only respondents. Conclusion Irritable Bowel Syndrome and GAD comorbidity was common and added to impairment in the community. The strong association between psychiatric morbidity and IBS observed in referral centres was not a consequence of increased help‐seeking behaviour.

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  • The OR for IBS was 5.84 among respondents with GAD compared to those without GAD and the OR for GAD was 6.32 for respondents with IBS compared to those without it (both, p < 0.001).

    “The OR for IBS was 5.84 among respondents with GAD compared to those without GAD and the OR for GAD was 6.32 for respondents with IBS compared to those without it (both, p < 0.001), showing considerable co-morbidity between these disorders.”

    From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [52]

    The “Comorbidity of GAD and IBS” section assigns the figures in the opposite direction: 5.84 is the relative risk of GAD among respondents with IBS, while 6.32 is the OR for IBS among respondents with GAD. Both are reported with P < 0.001, but the citing sentence reverses which figure applies to which comparison. (LLM, conf=0.92)

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  • In a community-based sample of 2,005 adolescents and adults from Hong Kong, the overall prevalence was 5.4% for IBS using the Rome III diagnostic criteria and 4.0% for GAD.

    “Lee et al.52 studied the co-morbidity of IBS and GAD in a community-based sample of 2,005 adolescents and adults from Hong Kong. They showed an overall prevalence of 5.4% for IBS using the Rome III diagnostic criteria and 4.0% for GAD.52”

    From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [52]

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  1. American Psychiatric Association. Diag- nostic and Statistical Manual of Mental Disorders, 3rd edn Revision. Washington, DC: American Psychiatric Press, Inc., 1987.

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Authors
LEE, S., WU, J., MA, Y. L., TSANG, A., GUO, W. ‐., & SUNG, J.
Affiliations
Chinese University of Hong Kong (HK)
Corresponding author
LEE, S.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2009-08-18
Volume
30
Issue
6
Pages
643-651
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/j.1365-2036.2009.04074.x
OpenAlex
W2021246452
Cited by
136
References
38
Citations by year
2026: 1 · 2025: 6 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 6 · 2020: 11 · 2019: 12 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 18 · 2013: 6 · 2012: 15
FWCI
11.69
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
irritable bowel syndrome, generalized anxiety disorder, comorbidities, prevalence, depressive symptoms, help-seeking, functional disability, Sheehan Disability Scale, risk factors, educational attainment, community survey
MeSH terms
Adolescent, Adult, Depressive Disorder, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Surveys and Questionnaires, Risk Factors, Socioeconomic Factors, Comorbidity, Prevalence, Irritable Bowel Syndrome, Young Adult

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