PROMIS computerised adaptive tests are dynamic instruments to measure health-related quality of life in patients with cirrhosis: PROMIS tools for quality of life assessment in cirrhosis
Open accessAbstract
BACKGROUND: Cirrhotic patients have an impaired health-related quality of life (HRQOL), which is usually analysed using static paper-pencil questionnaires. The Patient Reported Outcomes Measurement Information System (PROMIS) computerised adaptive testing (CAT) are flexible, freely available, noncopyrighted, HRQOL instruments with US-based norms across 11 domains. CAT presents five to seven questions/domain depending on the patient's response, from large validated question banks. This provides brevity and precision equivalent to the entire question bank. AIM: To evaluate PROMIS CAT tools against 'legacy instruments' for cirrhotics and their informal caregivers. METHODS: A total of 200 subjects: 100 cirrhotics (70 men, 53% decompensated) and 100 caregivers were administered the PROMIS and legacy instruments [Sickness Impact Profile (SIP), Beck depression/anxiety inventories, Pittsburgh Sleep-Quality Index (PSQI) and Epworth Sleepiness scale (ESS)] concurrently. Both legacy and PROMIS results for patients were compared with caregivers and US norms. These were also compared between compensated and decompensated patients. Preference for SIP or PROMIS was inquired of a selected group (n = 70, 50% patients). Test - retest reliability was assessed in another group of 20 patients. RESULTS: Patients had significant impairment on all PROMIS domains apart from anger and anxiety compared with caregivers and US norms (P < 0.02 to <0.0001). Decompensated patients had significantly worse sleep, pain, social and physical function scores compared with compensated ones, similar to legacy instruments. There was a statistically significant correlation between PROMIS and their corresponding legacy instruments. The majority (71%) preferred PROMIS over SIP. PROMIS tools had significant test - retest reliability (ICC range 0.759-0.985) when administered 12 ± 6 days apart. CONCLUSION: PROMIS computerised adaptive testing tools had significant concurrent and discriminant validity, test - retest reliability and subject preference for assessing HRQOL in cirrhotic patients.
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Estimates for the prevalence of depression and anxiety are best known in patients with decompensated cirrhosis and liver transplant candidates.
“Estimates for the prevalence of depression and anxiety are best known in patients with decompensated cirrhosis and liver transplant candidates13,14”
From Depression and anxiety are common among patients with cirrhosis (2022) · cites this paper as [14]
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Depression and anxiety are common among patients with cirrhosis
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- Authors
- Bajaj, J. S., Thacker, L. R., Wade, J. B., Sanyal, A. J., Heuman, D. M., Sterling, R. K., Gibson, D. P., Stravitz, R. T., Puri, P., Fuchs, M., Luketic, V., Noble, N., White, M., Bell, D., & Revicki, D. A.
- Affiliations
- Virginia Commonwealth University (US)
- Georgetown University Medical Center (US)
- Corresponding author
- Bajaj, J. S.
- ORCID
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2011-09-19
- Volume
- 34
- Issue
- 9
- Pages
- 1123-1132
- ISSN
- 0269-2813 (ISSN-L)
- PMC
- PMC3989141
- OpenAlex
- W2099728097
- Cited by
- 83
- References
- 46
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 9 · 2016: 12 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 3
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK087913)
- National Center for Research Resources (UL1RR021990)
- National Center for Complementary and Integrative Health (UO1AT004428, U01AT004428)
- Topics
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Keywords
- PROMIS, computerized adaptive testing, health-related quality of life, liver cirrhosis, decompensated cirrhosis, patient-reported outcomes, informal caregivers, Sickness Impact Profile, sleep quality, test-retest reliability, concurrent validity, discriminant validity, patient preferences
- MeSH terms
- Adult, Depressive Disorder, Diagnosis, Computer-Assisted, Disability Evaluation, Female, Health Status Indicators, Health Surveys, Humans, Liver Cirrhosis, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Reproducibility of Results, Caregivers, Sickness Impact Profile
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