Psychological status and depression in patients with liver cirrhosis
Abstract
Background Previous studies reported an impairment of both the physical and mental dimensions of quality of life in patients with cirrhosis. Very few data are available on the psychological impact of the disease and its relation to liver function.Aim To measure the psychological status of patients with cirrhosis in relation to the severity of the liver impairment.Patients and methods One hundred and fifty-six patients with cirrhosis were studied. Two questionnaires (the Beck Depression Inventory and the Psychological General Well-Being Index) were self-administered in random order. Clinical and laboratory data were collected using standardised forms.Results The global score of Psychological General Well-Being Index was severely reduced compared to Italian population norm. Among individual domains, the more severely affected was General Health, the less compromised was Positive Well-Being. A negative relation was found between Child-Pugh score (a comprehensive measure of disease severity) and global Psychological General Well-Being Index and several individual subscales. The Beck Depression Inventory scores were indicative of a depressed mood in over 50% of patients, in relation to the presence of clinical symptoms.Conclusions Patients with cirrhosis have signs of psychological distress and depression, as assessed by Beck Depression Inventory and Psychological General Well-Being Index, in relation to the severity of liver disease. Accordingly, a non-negligible number of patients warrant treatment.
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Alcohol use disorder, substance abuse, and depression deteriorate the quality of life of patients with chronic liver disease.
“Alcohol use disorder, substance abuse, and depression are illnesses that deteriorate the quality of life (QOL) of patients with chronic liver disease (CLD).”
From A Behavioral Health Program for Alcohol Use Disorder, Substance Abuse, and Depression in Chronic Liver Disease (2019) · cites this paper as [9]
Chronic liver disease is uniquely associated with complex psychosocial comorbidities, including alcohol use disorder and substance abuse.
“Furthermore, CLD is uniquely associated with complex psychosocial comorbidities, including alcohol use disorder (increasingly among the young population)7, 8 and substance abuse, both of which occur more frequently and at a greater severity among patients with CLD than the general population.9”
From A Behavioral Health Program for Alcohol Use Disorder, Substance Abuse, and Depression in Chronic Liver Disease (2019) · cites this paper as [9]
Alcohol use disorder and substance abuse occur more frequently and at greater severity among patients with chronic liver disease than in the general population.
“Furthermore, CLD is uniquely associated with complex psychosocial comorbidities, including alcohol use disorder (increasingly among the young population)7, 8 and substance abuse, both of which occur more frequently and at a greater severity among patients with CLD than the general population.9”
From A Behavioral Health Program for Alcohol Use Disorder, Substance Abuse, and Depression in Chronic Liver Disease (2019) · cites this paper as [9]
Prior studies have reported depression and anxiety in 15% to >50% of patients with Child-Turcotte-Pugh class B or C and liver cancer.
“Prior studies have reported depression and anxiety in 15% to >50% of patients with Child-Turcotte-Pugh class B or C and liver cancer.”
From Depression and anxiety are common among patients with cirrhosis (2022) · cites this paper as [30]
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“(9) Depression remains under diagnosed and untreated in CLD(10) and is associated with worse clinical outcomes and higher mortality.”
BackgroundPatient-centered care: Key elements applicable to chronic liver disease
Verma, M., Brahmania, M., Fortune, B. E., Asrani, S. K., Fuchs, M., & Volk, M. L. (2023) · Hepatology · doi:10.1002/hep.32618 · Cited by 24 · see citing works
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- Authors
- Bianchi, G., Marchesini, G., Nicolino, F., Graziani, R., Sgarbi, D., Loguercio, C., Abbiati, R., & Zoli, M.
- Affiliations
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- University of Bologna (IT)
- Ospedale P. Pederzoli – Casa di Cura Privata S.p.a. (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Bracco (Italy) (IT)
- Corresponding author
- Bianchi, G.
- Venue
- Digestive and Liver Disease
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 37
- Issue
- 8
- Pages
- 593-600
- ISSN
- 1590-8658 (ISSN-L)
- OpenAlex
- W2042720628
- Cited by
- 187
- References
- 53
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 11 · 2021: 18 · 2020: 18 · 2019: 15 · 2018: 16 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 10 · 2012: 6
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestive and Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- liver cirrhosis, depression, psychological well-being, quality of life, psychological distress, Child-Pugh score, liver disease severity, Beck Depression Inventory, Psychological General Well-Being Index
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alcohol Drinking, Depression, Female, Humans, Liver Cirrhosis, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Sleep Wake Disorders, Stress, Psychological, Logistic Models
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