HYPNOTIC EFFICACY OF TEMAZEPAM: A LONG‐TERM SLEEP LABORATORY EVALUATION
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Temazepam was evaluated in a strictly defined insomniac patient population under sleep laboratory conditions. Two protocols were used: a short‐term (26‐night) and a long‐term (54‐night) protocol evaluated the efficacy of the drug administered at night at 15 mg (short‐term study) and 30 mg (long‐term study), respectively. Temazepam seemed to be both safe and effective at doses of 15 and 30 mg with up to 5 weeks of ingestion. Suppression of slow wave sleep was observed at the high dose, but no suppression of REM sleep, found in studies with other benzodiazepines, was noted. No evidence was found for development of tolerance or rebound effects.
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Rebound insomnia upon abrupt cessation of benzodiazepines after short-term use was confirmed by other studies.
“This was confirmed by other studies [53-59].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [57]
The Discussion (page not specified in our copy) says the study found no evidence of rebound insomnia after abrupt withdrawal of temazepam. Although this paper evaluated a short-term protocol, it does not confirm the attributed finding; it reports the opposite for the benzodiazepine it studied. (LLM, conf=0.91)
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Cites
Statistical principles in experimental design.
Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137 · see citing works
The Effects of Coffee and Napping on Nighttime Highway Driving
Philip, P., Taillard, J., Moore, N. D., Delord, S., Valtat, C., Sagaspe, P., & Bioulac, B. H. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-11-200606060-00004 · Cited by 650 · see citing works
Rebound Insomnia: A New Clinical Syndrome
Kales, A., Scharf, M. B., & Kales, J. D. (1978) · Science · doi:10.1126/science.684426 · Cited by 200 · see citing works
Some Approximate Tests for Repeated Measurement Designs
Huynh, H. (1978) · Psychometrika · doi:10.1007/bf02293860 · Cited by 192 · see citing works
An ImprovedtTable for Simultaneous Control ongContrasts
Games, P. A. (1977) · Journal of the American Statistical Association · doi:10.1080/01621459.1977.10480607 · Cited by 118 · see citing works
Effectiveness of hypnotic drugs with prolonged use: Flurazepam and pentobarbital
Kales, A., Kales, J. D., Bixler, E. O., & Scharf, M. B. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1975183356 · Cited by 80 · see citing works
An Improved t Table for Simultaneous Control on g Contrasts
Games, P. A. (1977) · Journal of the American Statistical Association · doi:10.2307/2286211 · Cited by 63 · see citing works
Effects of placebo and flurazepam on sleep patterns in insomniac subjeets
Kaies, J., Kaies, A., Bixler, E. O., & Slye, E. S. (1971) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1971124691 · Cited by 49 · see citing works
Flurazepam Effects on Slow-Wave Sleep: Stage 4 Suppressed but Number of Delta Waves Constant
Feinberg, I., Fein, G., Walker, J. M., Price, L. J., Floyd, T. C., & March, J. D. (1977) · Science · doi:10.1126/science.21453 · Cited by 48 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [8]8. RECHTSCHAFFEN, A. & KALES, A. (ed.) (1968). A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Public Health Service Publication No. 204. Washington, DC: US Government Printing Office.
Cited by
Sorted by citations
Jerram, T. C. (1981) · Side effects of drugs annual · doi:10.1016/s0378-6080(81)80009-8 · Cited by 695 · see citing works
Fatigue Countermeasures in Aviation
Caldwell, J. A., Mallis, M. M., Caldwell, J. L., Paul, M. A., Miller, J. C., & Neri, D. F. (2009) · Aviation, Space, and Environmental Medicine · doi:10.3357/asem.2435.2009 · Cited by 295 · see citing works
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
Cosci, F., & Chouinard, G. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000506868 · Cited by 265 · see citing works
Diagnosis and Treatment of Chronic Insomnia: A Review
Benca, R. M. (2005) · Psychiatric Services · doi:10.1176/appi.ps.56.3.332 · Cited by 248 · see citing works
The Diagnosis and Management of Insomnia
Oates, J. A., Wood, A. J. J., Gillin, J. C., & Byerley, W. F. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220406 · Cited by 220 · see citing works
Heel, R. C., Brogden, R. N., Speight, T. M., & Avery, G. S. (1981) · Drugs · doi:10.2165/00003495-198121050-00001 · Cited by 203 · see citing works
Vinkers, C. H., & Olivier, B. (2012) · Advances in Pharmacological Sciences · doi:10.1155/2012/416864 · Cited by 195 · see citing works
Quazepam: Hypnotic Efficacy and Side Effects
Kales, A. (1990) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1990.tb02545.x · Cited by 188 · see citing works
Temazepam (Restoril, Sandoz Pharmaceuticals)
Jackson, E. A., Cardoni, A. A., McElnay, J. C., Jones, M. E., & ALEXANDER, B. K. (1982) · Annals of Pharmacotherapy · doi:10.1177/106002808201600902 · Cited by 165 · see citing works
Sleep Maintenance Insomnia: Strengths and Weaknesses of Current Pharmacologic Therapies
Rosenberg, R. P. (2006) · Annals of Clinical Psychiatry · doi:10.1080/10401230500464711 · Cited by 135 · see citing works
Nocturnal Myoclonus: Treatment Efficacy of Clonazepam and Temazepam
Mitler, M. M., Browman, C. P., Menn, S. J., Gujavarty, K. S., & Timms, R. M. (1986) · SLEEP · doi:10.1093/sleep/9.3.385 · Cited by 110 · see citing works
Self-citationObermeyer, W. H., & Benca, R. M. (1996) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70287-5 · Cited by 109 · see citing works
Polysomnographic effects of hypnotic drugs
Parrino, L., & Terzano, M. G. (1996) · Psychopharmacology · doi:10.1007/bf02246405 · Cited by 109 · see citing works
Correlates and consequences of chronic insomnia
Thase, M. E. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2004.09.006 · Cited by 104 · see citing works
Chronic benzodiazepine usage and withdrawal in insomnia patients
Poyares, D., Guilleminault, C., Ohayon, M. M., & Tufik, S. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2003.10.003 · Cited by 94 · see citing works
Self-citationSleep Disorders: Insomnia, Sleepwalking, Night Terrors, Nightmares, and Enuresis
Kales, A., SOLDATOS, C. R., & KALES, J. D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-4-582 · Cited by 77 · see citing works
Can valerian improve the sleep of insomniacs after benzodiazepine withdrawal?
Poyares, D. R., Guilleminault, C., Ohayon, M. M., & Tufik, S. B. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00305-0 · Cited by 76 · see citing works
Self-citationCeiling and floor effects in sleep research
Youngstedt, S. D. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0239 · Cited by 68 · see citing works
Rebound Insomnia and Elimination Half‐Life: Assessment of Individual Subject Response
Bixler, E. O., Kales, J. D., Kales, A., Jacoby, J. A., & Soldatos, C. R. (1985) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1985.tb02811.x · Cited by 49 · see citing works
Alprazolam: Effects on Sleep and Withdrawal Phenomena
Kales, A., Bixler, E. O., Vela‐Bueno, A., Soldatos, C. R., & Manfredi, R. L. (1987) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1987.tb03058.x · Cited by 46 · see citing works
Model insomnia by methylphenidate and caffeine and use in the evaluation of temazepam
Ōkuma, T., Matsuoka, H., Matsue, Y., & Toyomura, K. (1982) · Psychopharmacology · doi:10.1007/bf00432545 · Cited by 44 · see citing works
Dose—Response Studies of Lormetazepam: Efficacy, Side Effects, and Rebound Insomnia
Kales, A., Bixler, E. O., Soldatos, C. R., Mitsky, D. J., & Kales, J. D. (1982) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1982.tb02645.x · Cited by 40 · see citing works
The use of short‐ and long‐acting hypnotics in clinical medicine.
Nicholson, A. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01841.x · Cited by 38 · see citing works
Hypnotic medication in the treatment of chronic insomnia: non nocere! Doesn't anyone care?
KRAMER, M. L. (2000) · Sleep Medicine Reviews · doi:10.1053/smrv.2000.0122 · Cited by 35 · see citing works
Temazepam as premedication in day surgery
Beechey, A. P. G., Eltringham, R., & STUDD, C. (1981) · Anaesthesia · doi:10.1111/j.1365-2044.1981.tb08593.x · Cited by 35 · see citing works
Nighttime and daytime efficacy of flurazepam and oxazepam in chronic insomnia
(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.2.191 · Cited by 33 · see citing works
Self-citationAdverse effects of temazepam in older adults with chronic insomnia
Morin, C. M., Bastien, C., Brink, D., & Brown, T. R. (2003) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.454 · Cited by 33 · see citing works
Evaluation of Temazepam as a Hypnotic
Mitler, M. M. (1981) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1981.tb03546.x · Cited by 32 · see citing works
Self-citationPharmacokinetics of temazepam after day-time and night-time oral administration
Müller, F. O., Dyk, M. V., Hundt, H. K. L., Joubert, A. L., Luus, H. G., Groenewoud, G., & Dunbar, G. C. (1987) · European Journal of Clinical Pharmacology · doi:10.1007/bf00544571 · Cited by 31 · see citing works
Timms, R. M. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380100049011 · Cited by 31 · see citing works
Hypnotics: rebound insomnia and residual sequelae.
Nicholson, A. (1980) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1980.tb04829.x · Cited by 29 · see citing works
A Guide to Benzodiazepine Selection. Part II: Clinical Aspects
Teboul, E., & Chouinard, G. (1991) · The Canadian Journal of Psychiatry · doi:10.1177/070674379103600117 · Cited by 25 · see citing works
Insomnia and Other Sleep Disorders
Kales, A., Kales, J. D., & Soldatos, C. R. (1982) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31374-8 · Cited by 25 · see citing works
Temazepam 7.5 mg: effects on sleep in elderly insomniacs
Vgontzas, A. N., Kales, A., Bixler, E. O., & Myers, D. C. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00192550 · Cited by 22 · see citing works
Benzodiazepine Hypnotics and Insomnia
Kales, A. (1990) · Hospital Practice · doi:10.1080/21548331.1990.11704103 · Cited by 22 · see citing works
Clinical Comparison of Benzodiazepine Hypnotics With Short and Long Elimination Half-Lives
Kales, A., Soldatos, C. R., & Vela‐Bueno, A. (1985) · Springer eBooks · doi:10.1007/978-94-009-4886-0_9 · Cited by 20 · see citing works
Divoll, M., & Greenblatt, D. J. (1981) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)81041-5 · Cited by 20 · see citing works
Brotizolam: A sleep laboratory evaluation
Vela‐Bueno, A., Oliveros, J. R. G., Dobladez-Blanco, B., Arrigain-Ijurra, S., Soldatos, C. R., & Kales, A. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00544014 · Cited by 19 · see citing works
Temazepam's efficacy in patients with sleep onset insomnia.
Roehrs, T., Lamphere, J., Paxton, C., Wittig, R., Zorick, F., & Roth, T. (1984) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1984.tb02405.x · Cited by 18 · see citing works
Wilson, S. J., Rich, A., Rich, N. C., Potokar, J. P., & Nutt, D. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00004 · Cited by 17 · see citing works
Tuk, B., Oberyé, J., Pieters, M. S. M., Schoemaker, R. C., Kemp, B., van Gerven, J., Danhof, M., KAMPHUISEN, H. A. C., Cohen, A. F., Breimer, D. D., et al. (1997) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(97)90123-5 · Cited by 16 · see citing works
Hauri, P., & Esther, M. S. (1990) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62578-6 · Cited by 16 · see citing works
The Nature and Extent of Benzodiazepine Abuse: An Overview of Recent Literature
Dietch, J. T. (1983) · Psychiatric Services · doi:10.1176/ps.34.12.1139 · Cited by 15 · see citing works
Obermeyer, W. H., & Benca, R. M. (1999) · Otolaryngologic Clinics of North America · doi:10.1016/s0030-6665(05)70131-6 · Cited by 14 · see citing works
Lamphere, J. K., Roehrs, T., Zorick, F. J., Koshorek, G., & Roth, T. G. (1989) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470040107 · Cited by 11 · see citing works
Erman, M. K., Loewy, D., & Scharf, M. B. (2005) · Current Medical Research and Opinion · doi:10.1185/030079905x25541 · Cited by 10 · see citing works
Chronic toxicity/carcinogenesis study of temazepam in mice and rats
Robison, R. L. (1984) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(84)90197-0 · Cited by 10 · see citing works
Beary, M., Lacey, J. H., Crutchfield, M., & Bhat, A. (1984) · Psychopharmacology · doi:10.1007/bf00427415 · Cited by 9 · see citing works
McLean, L. S. (2002) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v04n0109 · Cited by 8 · see citing works
Walsh, J. K., Hartman, P. G., & Kowall, J. P. (1994) · Elsevier eBooks · doi:10.1016/b978-0-7506-9002-7.50022-7 · Cited by 8 · see citing works
Temazepam as a hypnotic in osteoarthritic patients
Leigh, T. J., Hindmarch, I., Bird, H. A., & Wright, V. A. (1987) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470020107 · Cited by 6 · see citing works
An integrative approach to the management of insomnia
Soldatos, C. R., & Dikeos, D. G. (2003) · Current Opinion in Psychiatry · doi:10.1097/00001504-200304002-00014 · Cited by 5 · see citing works
Scharf, M. B. (1986) · Clinical Psychology Review · doi:10.1016/0272-7358(86)90017-6 · Cited by 4 · see citing works
The Treatment of Sleep Disorders
Cook, P. J. (1984) · Springer eBooks · doi:10.1007/978-1-4613-2791-2_7 · Cited by 3 · see citing works
Sleep Disturbances as Side Effects of Therapeutic Drugs
Kales, A., & Vgontzas, A. N. (1995) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57836-6_20 · Cited by 3 · see citing works
The efficacy of Temazepam for improving daytime sleep and night-time performance in Army aviators
Caldwell, J. L., Hall, K. K., Prazinko, B. F., Norman, D. N., Rowe, T. L., Erickson, B. S., Estrada, A., & Caldwell, J. A. (2001) · PsycEXTRA Dataset · doi:10.1037/e447412006-001 · Cited by 3 · see citing works
Weilburg, J. B., & Gelenberg, A. J. (1991) · Springer eBooks · doi:10.1007/978-1-4757-1137-0_6 · Cited by 2 · see citing works
Long-Term Use of Sleeping Pills in Chronic Insomnia
KRAMER, M. L. (2006) · Springer eBooks · doi:10.1007/0-387-27682-3_14 · Cited by 1 · see citing works
Psychopharmakotherapie bei Schlafstörungen
Spiegel, R. (1983) · Springer eBooks · doi:10.1007/978-3-7091-7645-0_16 · Cited by 1 · see citing works
Self-citationKales, A., Vgontzas, A. N., & Bixler, E. O. (1995) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57836-6_13 · Cited by 1 · see citing works
Insomnia Management and Hypnotic Benzodiazepine Therapeutics
Bond, W. S. (1990) · Journal of Pharmacy Technology · doi:10.1177/875512259000600606
- Authors
- MITLER, M. M., CARSKADON, M. A., PHILLIPS, R. L., STERLING, W. R., ZARCONE, V. P., SPIEGEL, R., GUILLEMINAULT, C., & DEMENT, W. C.
- Affiliations
- State University of New York (US)
- Stanford Medicine (US)
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1979-04
- Volume
- 8
- Issue
- Supplement s1
- Pages
- 63S-68S
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC1429637
- OpenAlex
- W1966581042
- Semantic Scholar
- fbc63bd78f0601b7f23917b8c33e6fe35d09f938
- Cited by
- 60
- References
- 9
- Citations by year
- 2020: 1 · 2012: 1
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- temazepam, hypnotic efficacy, insomnia, long-term drug use, REM sleep, benzodiazepines, drug tolerance, rebound effect, sleep laboratory
- MeSH terms
- Adult, Clinical Trials as Topic, Drug Tolerance, Electroencephalography, Humans, Hypnotics and Sedatives, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Sleep, REM, Temazepam, Time Factors, Anti-Anxiety Agents, Substance-Related Disorders
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