Temazepam's efficacy in patients with sleep onset insomnia.
Open accessAbstract
The hypnotic efficacy of temazepam capsules (30 mg) was studied in twelve patients who had objective polysomnographic evidence of sleep onset insomnia. Patients slept in the laboratory, retiring at their usual bedtime after taking placebo or temazepam 30 min earlier, and were monitored for 8 h using standard polysomnographic techniques. Acute (nights 5‐7) and chronic (nights 11‐13) temazepam improved the sleep of these patients by reducing sleep latency and increasing sleep time compared to the placebo baseline (nights 2‐4). No detrimental effects on daytime function the following morning were observed using questionnaires and objective tests of performance. No consistent evidence of disturbed sleep after discontinuation of treatment was obtained over three recovery nights.
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Rebound insomnia upon abrupt cessation of benzodiazepines after short-term use was confirmed by other studies.
“This was confirmed by other studies [53-59].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [59]
The Design section describes nine nights of temazepam followed by three placebo recovery nights. Rather than confirming rebound insomnia after cessation, the Discussion (p. 695) says there was “no consistent disruption of sleep” and that mean sleep time during recovery was similar to baseline, although four of 12 patients had some disturbed recovery nights. (LLM, conf=0.89)
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HYPNOTIC EFFICACY OF TEMAZEPAM: A LONG‐TERM SLEEP LABORATORY EVALUATION
MITLER, M. M., CARSKADON, M. A., PHILLIPS, R. L., STERLING, W. R., ZARCONE, V. P., SPIEGEL, R., GUILLEMINAULT, C., & DEMENT, W. C. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb00459.x · Cited by 60 · see citing works
BIXLER, E. O., KALES, A., SOLDATOS, C. R., SCHARF, M. B., & KALES, J. D. (1978) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1978.tb02430.x · Cited by 60 · see citing works
EFFECT OF A METABOLITE OF DIAZEPAM, 3‐HYDROXYDIAZEPAM (TEMAZEPAM), ON SLEEP IN MAN
Nicholson, A. N., & Stone, B. M. (1976) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1976.tb04873.x · Cited by 47 · see citing works
Evaluation of Temazepam as a Hypnotic
Mitler, M. M. (1981) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1981.tb03546.x · Cited by 32 · see citing works
DOUBLE‐BLIND EVALUATION OF THE SAFETY AND HYPNOTIC EFFICACY OF TEMAZEPAM IN INSOMNIAC OUTPATIENTS
Heffron, W., & ROTH, P. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb00460.x · Cited by 22 · see citing works
DOUBLE‐BLIND EVALUATION OF THE EFFICACY AND SAFETY OF TEMAZEPAM IN OUTPATIENTS WITH INSOMNIA
Fillingim, J. M. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb00461.x · Cited by 21 · see citing works
Diazepam and 3‐hydroxydiazepam (temazepam) and sleep of middle age.
Nicholson, A., & Stone, B. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb00987.x · Cited by 17 · see citing works
Double-blind evaluation of temazepam, flurazepam, and placebo in geriatric insomniacs.
Fillingim, J. M. (1982) · PubMed · Cited by 15 · see citing works
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Sleep and Psychiatric Disorders: A Meta-analysis
Benca, R. M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080059010 · Cited by 1,468 · see citing works
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
Cosci, F., & Chouinard, G. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000506868 · Cited by 265 · see citing works
Ratti, E., Bettica, P., Alexander, R., Archer, G., Carpenter, D., Evoniuk, G., Gomeni, R., Lawson, E., Lopez, M., Millns, H., et al. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113480990 · Cited by 69 · see citing works
Watson, N. F., Benca, R. M., Krystal, A. D., McCall, W. V., & Neubauer, D. N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072493 · Cited by 59 · see citing works
A Guide to Benzodiazepine Selection. Part II: Clinical Aspects
Teboul, E., & Chouinard, G. (1991) · The Canadian Journal of Psychiatry · doi:10.1177/070674379103600117 · Cited by 25 · see citing works
- Authors
- Roehrs, T., Lamphere, J., Paxton, C., Wittig, R., Zorick, F., & Roth, T.
- Affiliations
- Henry Ford Hospital (US)
- Henry Ford Health (US)
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1984-06
- Volume
- 17
- Issue
- 6
- Pages
- 691-696
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC1463436
- OpenAlex
- W2017906291
- Semantic Scholar
- 057e1a51ac752249784b0f806b23f04219b42275
- Cited by
- 18
- References
- 8
- Citations by year
- 2023: 1 · 2020: 1 · 2014: 1 · 2013: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- temazepam, sleep onset insomnia, hypnotic efficacy, sleep latency, sleep duration, polysomnography, daytime functioning, withdrawal effects, benzodiazepines
- MeSH terms
- Adult, Clinical Trials as Topic, Double-Blind Method, Electroencephalography, Electromyography, Electrooculography, Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Random Allocation, Sleep, Temazepam, Time Factors, Anti-Anxiety Agents
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