Cited by 94Neurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity DisorderNeuroscience and Neuropharmacology Research

Methylphenidate and cocaine: the same effects on gene regulation?

YANO, M, STEINER, H·2007·Trends in Pharmacological Sciences

Abstract

Methylphenidate (Ritalin), a psychostimulant used in the treatment of Attention-Deficit Hyperactivity Disorder, has pharmacological effects similar to cocaine and amphetamine. Clinical use of methylphenidate, as well as diversion and abuse, have significantly increased during the past 10-15 years, heightening concerns regarding the long-term effects of methylphenidate on the developing brain. Here we review the effects of acute and repeated methylphenidate treatment on molecules of neuronal signaling and neuroplasticity (including transcription factors, neuropeptides, and components of second messenger cascades) and compare these molecular effects with those produced by cocaine and amphetamine. Some molecular changes, such as altered transcription factor gene regulation, are similar to those of cocaine and amphetamine. Other effects, notably those on the expression of opioid peptides and postsynaptic density molecules (Homer 1a), differ between methylphenidate and cocaine or amphetamine treatment. These differences support the notion that methylphenidate produces less neuroadaptations than cocaine and amphetamine, and might provide a molecular basis for reduced addiction liability of methylphenidate compared with these other psychostimulants.

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Crossref · 10.1016/j.tips.2007.10.004

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Authors
YANO, M., & STEINER, H.
Affiliations
Rosalind Franklin University of Medicine and Science (US)
Corresponding author
STEINER, H
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2007-11
Volume
28
Issue
11
Pages
588-596
ISSN
0165-6147 (ISSN-L)
OpenAlex
W1979447206
Cited by
94
References
88
Citations by year
2025: 4 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 9 · 2013: 7 · 2012: 8
FWCI
4.11
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA011261, R01DA011261, F30DA017998, DA017998)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
methylphenidate, cocaine, amphetamine, psychostimulants, gene expression regulation, transcription factors, neuroplasticity, neuropeptides, opioid peptides, Homer1a, postsynaptic density, second messenger cascades, addiction liability, neural adaptation, attention deficit hyperactivity disorder, drug abuse
MeSH terms
Amphetamine, Central Nervous System Stimulants, Animals, Cocaine, Corpus Striatum, Gene Expression Regulation, Humans, Methylphenidate, Molecular Structure

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