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Telogen skin contains an inhibitor of hair growth

PAUS, R., STENN, K.S., LINK, R.E.·1990·British Journal of Dermatology

Abstract

We have investigated whether C57B1-6 mouse skin with all its follicles in the telogen stage of the hair cycle contains a hair-growth inhibitory activity, as opposed to skin with anagen follicles. Crude aqueous extracts of whole telogen mouse skin (TE), anagen skin (AE) or vehicle alone (V) were injected intraperitoneally into mice in which anagen had previously been induced by plucking of telogen hair follicles. Injection of TE, but not AE or V, significantly retarded the development of anagen follicles, as measured by macroscopic and quantitative microscopic hair growth parameters (skin pigmentation and thickness, appearance of trichohyaline granules) and the incorporation of tritiated thymidine into mouse skin from animals previously treated with either TE or V (skin organ culture). This inhibitory activity seemed to be localized to the epidermis and was also present in rat epidermis. We suggest that this apparently non-species-specific inhibitor present in telogen skin may play a role in regulating the hair cycle in rodents.

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Metadata

Authors
PAUS, R., STENN, K. S., & LINK, R. E.
Venue
British Journal of Dermatology
Published
1990-06
Volume
122
Issue
6
Pages
777-784
ISSN
  • 0007-0963 (ISSN-L)
  • 1365-2133
OpenAlex
W2084368791
Cited by
235
References
0
FWCI
11.31
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Telogen skin contains an inhibitor of hair growth. https://app.cochat.ai/papers/10.1111/j.1365-2133.1990.tb06266.x
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PAUS, R., STENN, K. S., & LINK, R. E. (1990). Telogen skin contains an inhibitor of hair growth. British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.1990.tb06266.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.