The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Glycerol and the skin: holistic approach to its origin and functions
Abstract
Glycerol is a trihydroxy alcohol that has been included for many years in topical dermatological preparations. In addition, endogenous glycerol plays a role in skin hydration, cutaneous elasticity and epidermal barrier repair. The aquaporin-3 transport channel and lipid metabolism in the pilosebaceous unit have been evidenced as potential pathways for endogenous delivery of glycerol and for its metabolism in the skin. Multiple effects of glycerol on the skin have been reported. The diverse actions of the polyol glycerol on the epidermis include improvement of stratum corneum hydration, skin barrier function and skin mechanical properties, inhibition of the stratum corneum lipid phase transition, protection against irritating stimuli, enhancement of desmosomal degradation, and acceleration of wound-healing processes. Even an antimicrobial effect has been demonstrated. Topical application of glycerol-containing products improves skin properties in diseases characterized by xerosis and impaired epidermal barrier function, such as atopic dermatitis. The increase of epidermal hydration by glycerol is critical in skin conditions aggravated by dry and cold environmental conditions, e.g. winter xerosis. This paper provides a review on effects of glycerol on the skin, the mechanisms of its action, and the potential applications of glycerol in dermatology.
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Citations
Cites
The cornified envelope: a model of cell death in the skin
Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776
Moisturization and skin barrier function
Rawlings, A. V., & Harding, C. R. (2004) · Dermatologic Therapy · doi:10.1111/j.1396-0296.2004.04s1005.x · Cited by 924
Caspers, P. J., Bruining, H. A., Puppels, G. J., Lucassen, G. W., & Carter, E. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01258.x · Cited by 879
Feingold, K. R. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700013-jlr200 · Cited by 459
Fluhr, J. W., Kao, J., Ahn, S. K., Feingold, K. R., Elias, P. M., & Jain, M. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01399.x · Cited by 362
Self-citationStratum Corneum Moisturization at the Molecular Level: An Update in Relation to the Dry Skin Cycle
Rawlings, A. V., & Matts, P. J. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2005.23726.x · Cited by 362
Scott, I. R., & Harding, C. R. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90230-7 · Cited by 325
Use of an agent to reduce scattering in skin
Vargas, G., Chan, E. K., Barton, J. K., Rylander, H. G., & Welch, A. J. (1999) · Lasers in Surgery and Medicine · doi:10.1002/(sici)1096-9101(1999)24:2<133::aid-lsm9>3.0.co;2-x · Cited by 302
Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing
Hara-Chikuma, M., & Verkman, A. S. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0272-4 · Cited by 291
Dry skin, moisturization and corneodesmolysis
Harding, Watkinson, Rawlings, & Scott (2000) · International Journal of Cosmetic Science · doi:10.1046/j.1467-2494.2000.00001.x · Cited by 289
Cited by
Role of lipids in the formation and maintenance of the cutaneous permeability barrier
Feingold, K. R., & Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.007 · Cited by 383
Aquaporin-3 in keratinocytes and skin: Its role and interaction with phospholipase D2
Qin, H., Zheng, X., Zhong, X., Shetty, A. K., Elias, P. M., & Bollag, W. B. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.01.014 · Cited by 100
Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem
Chen, H., Zhao, Q., Zhong, Q., Duan, C., Krutmann, J., Wang, J., & Xia, J. (2022) · Phenomics · doi:10.1007/s43657-022-00073-y · Cited by 79
Souza, S. L., Graça, G., & Oliva, A. (2018) · Skin Research and Technology · doi:10.1111/srt.12412 · Cited by 34
Huygen, L., Thys, P. M., Wollenberg, A., Gutermuth, J., & Krohn, I. K. (2024) · Annals of Dermatology · doi:10.5021/ad.23.052 · Cited by 23
“This could be explained by the hydrating and moisturizing effect of the body cream due to the presence of substances, such as glycerol, white soft paraffin, liquid paraffin, and dimethicone 40,45-47 .”
BackgroundResult
Metadata
- Authors
- Fluhr, J. W., Darlenski, R., & Surber, C.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07
- Volume
- 159
- Issue
- 1
- Pages
- 23-34
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2100301990
- Cited by
- 332
- References
- 60
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.2008.08643.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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