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Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting

Vestergaard, M.E., Macaskill, P., Holt, P.E., Menzies, S.W.·2008·British Journal of Dermatology

Abstract

BACKGROUND: Dermoscopy is a noninvasive technique that enables the clinician to perform direct microscopic examination of diagnostic features, not seen by the naked eye, in pigmented skin lesions. Diagnostic accuracy of dermoscopy has previously been assessed in meta-analyses including studies performed in experimental and clinical settings. OBJECTIVES: To assess the diagnostic accuracy of dermoscopy for the diagnosis of melanoma compared with naked eye examination by performing a meta-analysis exclusively on studies performed in a clinical setting. METHODS: We searched for publications from 1987 to January 2008 and found nine eligible studies. The selected studies compare diagnostic accuracy of dermoscopy with naked eye examination using a valid reference test on consecutive patients with a defined clinical presentation, performed in a clinical setting. Hierarchical summary receiver operator curve analysis was used to estimate the relative diagnostic accuracy for clinical examination with, and without, the use of dermoscopy. RESULTS: We found the relative diagnostic odds ratio for melanoma, for dermoscopy compared with naked eye examination, to be 15.6 [95% confidence interval (CI) 2.9-83.7, P = 0.016]; removal of two outlier studies changed this to 9.0 (95% CI 1.5-54.6, P = 0.03). CONCLUSIONS: Dermoscopy is more accurate than naked eye examination for the diagnosis of cutaneous melanoma in suspicious skin lesions when performed in the clinical setting.

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Metadata

Authors
Vestergaard, M. E., Macaskill, P., Holt, P. E., & Menzies, S. W.
Venue
British Journal of Dermatology
Published
2008-06
Volume
159
Issue
3
Pages
???-???
ISSN
  • 0007-0963 (ISSN-L)
  • 1365-2133
OpenAlex
W2113790176
Cited by
862
References
1
FWCI
1.23
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2648 d)

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CoChat. (2026). Citation check: Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. https://app.cochat.ai/papers/10.1111/j.1365-2133.2008.08713.x
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Vestergaard, M. E., Macaskill, P., Holt, P. E., & Menzies, S. W. (2008). Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.2008.08713.x

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