Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicentre, randomized, placebo-controlled double-blind trial: WBI-1001 as a novel topical treatment for atopic dermatitis
Abstract
Background There is a need for the development of novel nonsteroidal topical drugs for the treatment of atopic dermatitis (AD). Objectives The primary objective was to evaluate the efficacy of WBI-1001 over 6 weeks of treatment of mild to severe AD. Methods Patients with AD affecting 3-20% of their body surface area and with an Investigator's Global Assessment (IGA) of 2-4 were randomized (1 : 1 : 1) to receive placebo, WBI-1001 0·5% or WBI-1001 1·0% in a cream formulation applied twice daily for 6 weeks. At the end of this phase, patients receiving WBI-1001 continued the same treatment for an additional 6 weeks. Patients receiving placebo entered into a 6-week double-blind phase with re-randomization (1 : 1) to WBI-1001 0·5% or 1·0% cream. The primary objective was to evaluate the efficacy of WBI-1001 over 6 weeks of treatment of mild to severe AD. The primary endpoint was the mean change from baseline in IGA at day 42 (week 6). Results In total, 148 patients were randomized and analysed in the placebo (51), WBI-1001 0·5% (50) and WBI-1001 1·0% (47) groups. There was a decrease of 1·3 [43%; P Conclusions WBI-1001 is an efficacious novel topical anti-inflammatory molecule for the treatment of AD.
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Topical agent with AHR agonistic activity is beneficial for atopic dermatitis in clinical trial.
“Recently, topical agent with AHR agonistic activity has been reported to be beneficial for atopic dermatitis in clinical trial [36,37].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [36]
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- Authors
- Bissonnette, R., Poulin, Y., Zhou, Y., Tan, J., Hong, H. C., Webster, J., Ip, W., Tang, L., & Lyle, M.
- Affiliations
- Innovaderm (Canada) (CA)
- Centre de Recherche Dermatologique du Québec Métropolitain (CA)
- University of British Columbia (CA)
- Windsor Clinical Research (CA)
- Welichem Biotech (Canada) (CA)
- Corresponding author
- Bissonnette, R.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-14
- Volume
- 166
- Issue
- 4
- Pages
- 853-860
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W2117159275
- Cited by
- 92
- References
- 17
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 6
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- atopic dermatitis, topical treatment, Investigator's Global Assessment, treatment efficacy, drug safety, adverse drug reactions, folliculitis, contact dermatitis
- MeSH terms
- Administration, Cutaneous, Adult, Anti-Inflammatory Agents, Non-Steroidal, Chronic Disease, Dermatitis, Atopic, Dose-Response Relationship, Drug, Double-Blind Method, Eczema, Female, Humans, Male, Middle Aged, Ointments, Resorcinols, Severity of Illness Index, Stilbenes, Treatment Outcome, Young Adult
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