Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

Furue, Masutaka; Hashimoto-Hachiya, Akiko; Tsuji, Gaku

doi:10.3390/ijms20215424

Cited by 216Dermatology and Skin DiseasesPsoriasis: Treatment and PathogenesisToxic Organic Pollutants Impact

Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

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Furue, Masutaka, Hashimoto-Hachiya, Akiko, Tsuji, Gaku·2019·International Journal of Molecular Sciences

DOI 10.3390/ijms20215424PMC PMC6862295

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Abstract

The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. The immunoregulatory system governing T-helper 17/22 (Th17/22) and T regulatory cells (Treg) is also regulated by the AHR system. Notably, AHR agonists, such as tapinarof, are currently used as therapeutic agents in psoriasis and atopic dermatitis. In this review, we summarize recent topics on AHR related to atopic dermatitis and psoriasis.

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Ahr null mice have increased susceptibility to psoriasis, experimental colitis, colorectal cancer, and infections by Citrobacter rodentium and Toxoplasma gondii.
“Subsequent examination of this mouse has revealed significant defects in resident immune cell populations in the gut, lung, and skin as well as increased susceptibility to certain diseases including psoriasis, experiment colitis and colorectal cancer, and infections of microorganisms like Citrobacter rodentium and Toxoplasma gondii (Díaz-Díaz et al., 2016; Furue et al., 2019; H. R. Kim et al., 202”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Furue et al., 2019
Section 4, “AHR and Immune Modulation” (page unavailable), says C. rodentium-induced colitis becomes life-threatening in Ahr-deficient mice. Section 6, “AHR and Psoriasis” (page unavailable), reports exacerbated inflammation in an imiquimod-induced psoriasis model. The copy does not establish increased susceptibility to experimental colitis as a separate condition, colorectal cancer, or Toxoplasma gondii infection. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Ahr null mice have significant defects in resident immune cell populations in the gut, lung, and skin.
“Subsequent examination of this mouse has revealed significant defects in resident immune cell populations in the gut, lung, and skin as well as increased susceptibility to certain diseases including psoriasis, experiment colitis and colorectal cancer, and infections of microorganisms like Citrobacter rodentium and Toxoplasma gondii (Díaz-Díaz et al., 2016; Furue et al., 2019; H. R. Kim et al., 202”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Furue et al., 2019
Section 4 (AHR and Immune Modulation; page unavailable) reports losses of intestinal ILC3 cells and decreases in specific gut Treg subpopulations with Ahr deficiency. Section 6 (AHR and Psoriasis; page unavailable) describes altered skin inflammation and IL-22 production, but does not establish defects in skin-resident immune cell populations; the searched passages also do not establish defects in lung-resident populations. The claim extends the documented gut findings to the lung and skin. (LLM, conf=0.86)
Experimental — accuracy not yet measured
AHR is a ligand-dependent transcription factor activated by multiple compounds that can induce either epidermal differentiation or oxidative stress.
“AHR, a ligand-dependent transcription factor, is activated by multiple compounds that can induce either epidermal differentiation or oxidative stress (43, 44).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [44]

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Atopic Dermatitis: Global Epidemiology and Risk Factors
Nutten, S. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000370220 · Cited by 3,077 · see citing works
Psoriasis
Boehncke, W., & Schön, M. P. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61909-7 · Cited by 2,609 · see citing works
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Liu, J. Z., van Sommeren, S., Huang, H., Ng, S. C., Alberts, R., Takahashi, A., Ripke, S., Lee, J. C., Jostins, L., Shah, T., et al. (2015) · Nature Genetics · doi:10.1038/ng.3359 · Cited by 2,603 · see citing works
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110 · see citing works
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634 · see citing works
The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909 · see citing works
The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells
Qiu, J., Heller, J. J., Guo, X., Chen, Z. E., Fish, K., Fu, Y., & Zhou, L. (2011) · Immunity · doi:10.1016/j.immuni.2011.11.011 · Cited by 860 · see citing works
Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
Kiss, E. A., Vonarbourg, C., Kopfmann, S., Hobeika, E., Finke, D., Esser, C., & Diefenbach, A. (2011) · Science · doi:10.1126/science.1214914 · Cited by 801 · see citing works
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
Lee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D., et al. (2012) · Nature Immunology · doi:10.1038/ni.2187 · Cited by 777 · see citing works
Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr218 · Cited by 748 · see citing works
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii‐Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 746 · see citing works
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract
Monteleone, I., Rizzo, A., Sarra, M., Sica, G., Sileri, P., Biancone, L., MacDonald, T. T., Pallone, F., & Monteleone, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.007 · Cited by 656 · see citing works
Transcriptional Regulation of NF-E2 p45-related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway
Miao, W., Hu, L., Scrivens, P. J., & Batist, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412081200 · Cited by 541 · see citing works
Feedback control of AHR signalling regulates intestinal immunity
Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W., et al. (2017) · Nature · doi:10.1038/nature21080 · Cited by 537 · see citing works
Is eczema really on the increase worldwide?
Williams, H. C., Stewart, A. W., von Mutius, E., Cookson, W., & Anderson, H. R. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.11.004 · Cited by 530 · see citing works
The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology
Esser, C., & Rannug, A. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009001 · Cited by 501 · see citing works
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Tsoi, L. C., Rodriguez, E., Degenhardt, F., Baurecht, H., Wehkamp, U., Volks, N., Szymczak, S., Swindell, W. R., Sarkar, M. K., Raja, K., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.12.018 · Cited by 469 · see citing works
Pathogenesis of psoriasis and development of treatment
Ogawa, E., Sato, Y., Minagawa, A., & Okuyama, R. (2017) · The Journal of Dermatology · doi:10.1111/1346-8138.14139 · Cited by 464 · see citing works
Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation
Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701764104 · Cited by 437 · see citing works
Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora
Qiu, J., Guo, X., Chen, Z. E., He, L., Sonnenberg, G. F., Artis, D., Fu, Y., & Zhou, L. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.002 · Cited by 415 · see citing works
Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.
Smith, S. H., Jayawickreme, C., Rickard, D. J., Nicodeme, E., Bui, T., Simmons, C., Coquery, C. M., Neil, J., Pryor, W. M., Mayhew, D., et al. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.05.004 · Cited by 387 · see citing works
Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions
Di Meglio, P., Duarte, J. H., Ahlfors, H., Owens, N. D. L., Li, Y., Villanova, F., Tosi, I., Hirota, K., Nestle, F. O., Mrowietz, U., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.019 · Cited by 373 · see citing works
Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
van den Bogaard, E. H., Bergboer, J. G. M., Vonk-Bergers, M., van Vlijmen-Willems, I. M. J. J., Hato, S. V., van der Valk, P. G. M., Schröder, J. M., Joosten, I., Zeeuwen, P. L. J. M., & Schalkwijk, J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65642 · Cited by 373 · see citing works
Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities
Omiecinski, C. J., Heuvel, J. P. V., Perdew, G. H., & Peters, J. M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq338 · Cited by 368 · see citing works
Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.
Rannug, A., Rannug, U., Rosenkranz, H. S., Winqvist, L., Westerholm, R. N., Agurell, E., & Grafström, A.-K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47743-5 · Cited by 357 · see citing works
Lesions of Aryl-hydrocarbon Receptor–deficient Mice
Fernández‐Salguero, P. M., Ward, J. M., Sundberg, J. P., & Gonzalez, F. J. (1997) · Veterinary Pathology · doi:10.1177/030098589703400609 · Cited by 352 · see citing works
The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the ‘fused genes’ family
Kypriotou, M., Huber, M., & Hohl, D. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01472.x · Cited by 334 · see citing works
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
Furue, M., Chiba, T., Tsuji, G., Ulzii, D., Kido‐Nakahara, M., Nakahara, T., & Kadono, T. (2017) · Allergology International · doi:10.1016/j.alit.2016.12.002 · Cited by 324 · see citing works
Self-citation
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
Hayes, J. D. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00695-4 · Cited by 323 · see citing works
The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans
Wincent, E., Amini, N., Luecke-Johansson, S., Glatt, H. R., Bergman, J., Crescenzi, C., Rannug, A., & Rannug, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808321200 · Cited by 280 · see citing works
The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin
Hidaka, T., Ogawa, E., Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., Fujimura, T., Aiba, S., Nakayama, K., Okuyama, R., et al. (2017) · Nature Immunology · doi:10.1038/ni.3614 · Cited by 274 · see citing works
Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”
Yeager, R. L., Reisman, S. A., Aleksunes, L. M., & Klaassen, C. D. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp115 · Cited by 267 · see citing works
A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor
Yu, J., Luo, Y., Zhu, Z., Zhou, Y., Sun, L., Gao, J., Sun, J., Wang, G., Yao, X., & Li, W. S. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.11.036 · Cited by 257 · see citing works
Expression of Multiple Cytochrome P450 Enzymes and Multidrug Resistance-Associated Transport Proteins in Human Skin Keratinocytes
Baron, J. M., Holler, D. A., Schiffer, R., Frankenberg, S., Neis, M. M., Merk, H. F., & Jugert, F. K. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01298.x · Cited by 227 · see citing works
Cutting Edge: Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo- p -dioxin Generates a Population of CD4+CD25+ Cells with Characteristics of Regulatory T Cells
Funatake, C. J., Marshall, N. B., Steppan, L. B., Mourich, D. V., & Kerkvliet, N. I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4184 · Cited by 219 · see citing works
Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction
Ma, Q., Kinneer, K., Bi, Y., Chan, J. Y., & Kan, Y. W. (2004) · Biochemical Journal · doi:10.1042/bj20031123 · Cited by 217 · see citing works
An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway
Tsuji, G., Takahara, M., Uchi, H., Takeuchi, S., Mitoma, C., Moroi, Y., & Furue, M. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.10.017 · Cited by 209 · see citing works
Self-citation
The hsp90 Chaperone Complex Regulates Intracellular Localization of the Dioxin Receptor
Kazlauskas, A., Sundström, S., Poellinger, L., & Pongratz, I. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.7.2594-2607.2001 · Cited by 202 · see citing works
Functions of the aryl hydrocarbon receptor in the skin
Esser, C., Bargen, I., Weighardt, H., Haarmann-Stemmann, T., & Krutmann, J. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0394-4 · Cited by 187 · see citing works
The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells
Ye, J., Qiu, J., Bostick, J. W., Ueda, A., Schjerven, H., Li, S., Jobin, C., Chen, Z. E., & Zhou, L. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.114 · Cited by 180 · see citing works
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
Wang, K., Lv, Q., Miao, Y., Qiao, S., Dai, Y., & Wei, Z. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.039 · Cited by 179 · see citing works
Role of AhR/ARNT system in skin homeostasis
Furue, M., Takahara, M., Nakahara, T., & Uchi, H. (2014) · Archives of Dermatological Research · doi:10.1007/s00403-014-1481-7 · Cited by 175 · see citing works
Self-citation
Malassezia Yeasts Produce a Collection of Exceptionally Potent Activators of the Ah (Dioxin) Receptor Detected in Diseased Human Skin
Magiatis, P., Pappas, P., Gaitanis, G., Mexia, N., Melliou, E., Galanou, M., Vlachos, C., Stathopoulou, K., Skaltsounis, A., Μαρσέλος, Μ., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.92 · Cited by 171 · see citing works
Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect
Tsuji, G., Takahara, M., Uchi, H., Matsuda, T., Chiba, T., Takeuchi, S., Yasukawa, F., Moroi, Y., & Furue, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.194 · Cited by 169 · see citing works
Self-citation
Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions.
Tauchi, M., Hida, A., Negishi, T., Katsuoka, F., Noda, S., Mimura, J., Hosoya, T., Yanaka, A., Aburatani, H., Fujii-Kuriyama, Y., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9360-9368.2005 · Cited by 167 · see citing works
A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis
Peppers, J., Paller, A. S., Maeda-Chubachi, T., Wu, S., Robbins, K., Gallagher, K., & Kraus, J. E. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.06.047 · Cited by 165 · see citing works
Biopositive Effects of Low-Dose UVB on Epidermis: Coordinate Upregulation of Antimicrobial Peptides and Permeability Barrier Reinforcement
Hong, S. P., Kim, M. J., Jung, M.-Y., Jeon, H., Goo, J., Ahn, S. K., Lee, S. H., Elias, P. M., & Choi, E. H. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.169 · Cited by 157 · see citing works
Identification of an anthraquinone pigment and a hydroxystilbene antibiotic from Xenorhabdus luminescens
Richardson, W. H., Schmidt, T. M., & Nealson, K. H. (1988) · Applied and Environmental Microbiology · doi:10.1128/aem.54.6.1602-1605.1988 · Cited by 153 · see citing works
Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis
Tsuji, G., Hashimoto-Hachiya, A., Kiyomatsu-Oda, M., Takemura, M., Ohno, F., Ito, T., Morino-Koga, S., Mitoma, C., Nakahara, T., Uchi, H., et al. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.322 · Cited by 149 · see citing works
Self-citation
TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation
Ehrlich, A. K., Pennington, J. M., Bisson, W. H., Kolluri, S. K., & Kerkvliet, N. I. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx215 · Cited by 145 · see citing works
Safety of biologics in psoriasis
Kamata, M., & Tada, Y. (2017) · The Journal of Dermatology · doi:10.1111/1346-8138.14096 · Cited by 133 · see citing works
Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
Furue, M., Tsuji, G., Mitoma, C., Nakahara, T., Chiba, T., Morino-Koga, S., & Uchi, H. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.07.011 · Cited by 132 · see citing works
Self-citation
The IL ‐13/periostin/ IL ‐24 pathway causes epidermal barrier dysfunction in allergic skin inflammation
Mitamura, Y., Nunomura, S., Nanri, Y., Ogawa, M., Yoshihara, T., 増岡, 美., Tsuji, G., Nakahara, T., Hashimoto‐Hachiya, A., Conway, S. J., et al. (2018) · Allergy · doi:10.1111/all.13437 · Cited by 132 · see citing works
Self-citation
2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Induced Changes In Immunocompetence : Possible Mechanisms
Holsapple, M. P., Morris, D. L., Wood, S. C., & Snyder, N. K. (1991) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.31.040191.000445 · Cited by 129 · see citing works
2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1
Kopf, P. G., & Walker, M. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.02.007 · Cited by 127 · see citing works
Pathogenesis of Atopic Dermatitis: Current Paradigm.
Furue, M., Ulzii, D., Vu, Y. H., Tsuji, G., Kido‐Nakahara, M., & Nakahara, T. (2019) · PubMed · doi:10.22034/iji.2019.80253 · Cited by 123 · see citing works
Self-citation
The tryptophan derivative 6-formylindolo[3,2- b ]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and differentiation
Rannug, A., & Rannug, U. (2018) · Critical Reviews in Toxicology · doi:10.1080/10408444.2018.1493086 · Cited by 119 · see citing works
Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2
Furue, M., Uchi, H., Mitoma, C., Hashimoto-Hachiya, A., Chiba, T., Ito, T., Nakahara, T., & Tsuji, G. (2017) · Nutrients · doi:10.3390/nu9030223 · Cited by 113 · see citing works
Self-citation
Genetic and Pharmacological Analysis Identifies a Physiological Role for the AHR in Epidermal Differentiation
van den Bogaard, E. H. J., Podolsky, M. A., Smits, J. P. H., Cui, X., John, C., Gowda, K., Desai, D. H., Amin, S., Schalkwijk, J., Perdew, G. H., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.6 · Cited by 107 · see citing works
“Inflammatory skin march” in atopic dermatitis and psoriasis
Furue, M., & Kadono, T. (2017) · Inflammation Research · doi:10.1007/s00011-017-1065-z · Cited by 106 · see citing works
Self-citation
Staphylococcus aureus in atopic dermatitis: Strain-specific cell wall proteins and skin immunity
Iwamoto, K., Moriwaki, M., Miyake, R., & Hide, M. (2019) · Allergology International · doi:10.1016/j.alit.2019.02.006 · Cited by 104 · see citing works
Defining the Role for XAP2 in Stabilization of the Dioxin Receptor
Lees, M. J., Peet, D. J., & Whitelaw, M. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302430200 · Cited by 102 · see citing works
Anti-psoriatic effects of indigo naturalis on the proliferation and differentiation of keratinocytes with indirubin as the active component
Lin, Y., Leu, Y., Yang, S., Chen, H.-W., Wang, C.-T., & Pang, J. S. (2009) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.02.007 · Cited by 102 · see citing works
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation
Kennedy, L. H., Sutter, C. H., Leon Carrion, S., Tran, Q. T., Bodreddigari, S., Kensicki, E., Mohney, R. P., & Sutter, T. R. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kfs325 · Cited by 100 · see citing works
Current developments in phototherapy for psoriasis
Morita, A. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14213 · Cited by 99 · see citing works
2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation
Sutter, C. H., Bodreddigari, S., Campion, C., Wible, R. S., & Sutter, T. R. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr205 · Cited by 93 · see citing works
Phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of plaque psoriasis
Robbins, K., Bissonnette, R., Maeda‐Chubachi, T., Ye, L., Peppers, J., Gallagher, K., & Kraus, J. E. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.10.037 · Cited by 93 · see citing works
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Bissonnette, R., Poulin, Y., Zhou, Y., Tan, J., Hong, H. C., Webster, J., Ip, W., Tang, L., & Lyle, M. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10775.x · Cited by 92 · see citing works
Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin
Smith, S. H., Peredo, C. E., Takeda, Y., Bui, T. T., Neil, J. E., Rickard, D. J., Millerman, E., Therrien, J., Nicodème, E., Brusq, J.-M. G., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147979 · Cited by 92 · see citing works
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Takei, K., Hashimoto‐Hachiya, A., Takahara, M., Tsuji, G., Nakahara, T., & Furue, M. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.02.007 · Cited by 88 · see citing works
Self-citation
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Arima, K., Gupta, S., Gadkari, A. S., Hiragun, T., Kono, T., Katayama, I., Demiya, S., & Eckert, L. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14218 · Cited by 86 · see citing works
Psoriasis and the TNF/IL23/IL17 axis
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Self-citation
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Self-citation
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Takei, K., Mitoma, C., Hashimoto‐Hachiya, A., Uchi, H., Takahara, M., Tsuji, G., Kido‐Nakahara, M., Nakahara, T., & Furue, M. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12717 · Cited by 81 · see citing works
Self-citation
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Self-citation
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Hong, C., Lee, C., Yu, H., & Huang, S.-K. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.04.017 · Cited by 61 · see citing works
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Self-citation
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Self-citation
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Takagi, S., Tojo, H., Tomita, S., Sano, S., Itami, S., Hara, M., Inoue, S., Horie, K., Kondoh, G., Hosokawa, K., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318513 · Cited by 59 · see citing works
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Self-citation
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Ito, T., Takahashi, H., Kawada, A., Iizuka, H., & Nakagawa, H. (2017) · The Journal of Dermatology · doi:10.1111/1346-8138.14105 · Cited by 57 · see citing works
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Tanaka, G., Kanaji, S., Hirano, A., Arima, K., Shinagawa, A., Goda, C., Yasunaga, S., Ikizawa, K., Yanagihara, Y., Kubo, M., et al. (2005) · International Immunology · doi:10.1093/intimm/dxh260 · Cited by 53 · see citing works
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Mari, O. D. A., Uchi, H., Morino‐Koga, S., & Furue, M. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.02.014 · Cited by 53 · see citing works
Self-citation
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Noda, S., Harada, N., Hida, A., Fujii‐Kuriyama, Y., Motohashi, H., & Yamamoto, M. P. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00306-1 · Cited by 49 · see citing works
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Self-citation
Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function
Geng, S., Mezentsev, A., Kalachikov, S. M., Raith, K., Roop, D. R., & Panteleyev, A. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03282 · Cited by 48 · see citing works
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Esser, C. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3139-2_16 · Cited by 48 · see citing works
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Hirano, A., Goto, M., Mitsui, T., Hashimoto-Hachiya, A., Tsuji, G., & Furue, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091948 · Cited by 48 · see citing works
Self-citation
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Increased risk of psoriasis in subjects with abdominal obesity: A nationwide population‐based study
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Self-citation
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Self-citation
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Patient preference for biologic treatments of psoriasis in Japan
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Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis
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Self-citation
Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes
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Self-citation
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AhR mediates an anti‐inflammatory feedback mechanism in human Langerhans cells involving Fcε RI and IDO
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Phenotypes of atopic dermatitis identified by cluster analysis in early childhood
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Secukinumab decreased circulating anti‐ BP 180‐ NC 16a autoantibodies in a patient with coexisting psoriasis vulgaris and bullous pemphigoid
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Inhibition of AHR transcription by NF1C is affected by a single-nucleotide polymorphism, and is involved in suppression of human uterine endometrial cancer
Li, D., Takao, T., Tsunematsu, R., Morokuma, S., Fukushima, K., Kobayashi, H., Saito, T., Furue, M., Wake, N., & Asanoma, K. (2012) · Oncogene · doi:10.1038/onc.2012.509 · Cited by 31 · see citing works
Self-citation
Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne
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Self-citation
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Self-citation
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Self-citation
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Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression
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Self-citation
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Ichiyama, S., Ito, M., Funasaka, Y., Abe, M., Nishida, E., Muramatsu, S., Nishihara, H., Kato, H., Morita, A., Imafuku, S., et al. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14225 · Cited by 24 · see citing works
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The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver
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Serum Levels of Aryl Hydrocarbon Receptor, Cytochromes P450 1A1 and 1B1 in Patients with Exacerbated Psoriasis Vulgaris
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Ogawa, E., Okuyama, R., Seki, T., Kobayashi, A., Oiso, N., Muto, M., Nakagawa, H., & Kawada, A. (2017) · The Journal of Dermatology · doi:10.1111/1346-8138.14101 · Cited by 20 · see citing works
Antioxidant Houttuynia cordata extract upregulates filaggrin expression in an aryl hydrocarbon-dependent manner.
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Self-citation
Implications of tryptophan photoproduct FICZ in oxidative stress and terminal differentiation of keratinocytes
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Self-citation
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Expanded Genome-Wide Association Study Meta-Analysis of Psoriasis Expands the Catalog of Common Psoriasis-Associated Variants
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Cross‐sectional multicenter observational study of psoriatic arthritis in Japanese patients: Relationship between skin and joint symptoms and results of treatment with tumor necrosis factor‐α inhibitors
Tsuruta, N., NARISAWA, Y., Imafuku, S., Ito, K., Yamaguchi, K., Miyagi, T., Takahashi, K., Fukamatsu, H., Morizane, S., Koketsu, H., et al. (2019) · The Journal of Dermatology · doi:10.1111/1346-8138.14745 · Cited by 15 · see citing works
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Evaluation of epicardial adipose tissue volume and coronary artery calcification in Japanese patients with psoriasis vulgaris
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Aryl hydrocarbon receptor polymorphisms are associated with dry skin phenotypes in Chinese patients with atopic dermatitis
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Use of a dose-response model to guide future clinical trial of benvitimod cream to treat mild and moderate psoriasis
Zang, Y., Jiang, D., Cai, L., Chen, X., Wang, Q., Xie, Z., Liu, Y., Zhang, C., Jing, S., Chen, G.-H., et al. (2015) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cp202486 · Cited by 11 · see citing works
Late‐onset psoriatic arthritis in Japanese patients
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Cost‐efficacy and pharmacoeconomics of psoriatic patients in Japan: Analysis from a single outpatient clinic
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Non‐corticosteroid adherence and itch severity influence perception of itch in atopic dermatitis
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New onset of psoriasis during nivolumab treatment for lung cancer
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Prevalence of inflammatory bowel disease in Japanese psoriatic patients
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Improvement in abnormal coronary arteries estimated by coronary computed tomography angiography after secukinumab treatment in a Japanese psoriatic patient
Yamazaki, F., Takehana, K., Tamashima, M., & Okamoto, H. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14545 · Cited by 8 · see citing works
Cutaneous permeability barrier function in signal transducer and activator of transcription 6-deficient mice is superior to that in wild-type mice
Zhang, W., Sakai, T., Matsuda‐Hirose, H., Goto, M., Yamate, T., & Hatano, Y. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.07.008 · Cited by 6 · see citing works
Improvement of nail lesions in a patient with psoriatic arthritis by switching the treatment from an anti‐interleukin‐17A antibody to an anti‐tumor necrosis factor‐α antibody
Komatsu‐Fujii, T., Honda, T., Otsuka, A., & Kabashima, K. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14700 · Cited by 5 · see citing works
Psoriasis vulgaris associated with systemic lupus erythematosus successfully treated with apremilast
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The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses
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Self-citation
Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor
Uberoi, A., Bartow‐McKenney, C., Zheng, Q., Flowers, L. J., Campbell, A. E., Knight, S. A. B., Chan, N., Wei, M. H., Lovins, V. M., Bugayev, J., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.05.011 · Cited by 325 · see citing works
New Treatment Addressing the Pathogenesis of Psoriasis
Tokuyama, M., & Mabuchi, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207488 · Cited by 291 · see citing works
The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
Facheris, P., Jeffery, J., DUCA, E. D., & Guttman‐Yassky, E. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00992-4 · Cited by 247 · see citing works
Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis
Lebwohl, M., Gold, L. S., Strober, B. E., Papp, K. A., Armstrong, A. W., Bagel, J., Kircik, L., Ehst, B. D., Hong, H., Soung, J., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2103629 · Cited by 199 · see citing works
Tapinarof in the treatment of psoriasis: A review of the unique mechanism of action of a novel therapeutic aryl hydrocarbon receptor-modulating agent
Bissonnette, R., Stein Gold, L., Rubenstein, D. S., Tallman, A. M., & Armstrong, A. (2021) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2020.10.085 · Cited by 181 · see citing works
Particulate matter causes skin barrier dysfunction.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., et al. (2021) · JCI insight · doi:10.1172/jci.insight.145185 · Cited by 173 · see citing works
“AHR, a ligand-dependent transcription factor, is activated by multiple compounds that can either induce epidermal differentiation or oxidative stress (43, 44).”
Background
Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
Fernández‐Gallego, N., Sánchez‐Madrid, F., & Cibrián, D. (2021) · Cells · doi:10.3390/cells10113176 · Cited by 135 · see citing works
Gut–X axis
Xu, L., Zhang, Y., Li, X., Li, C., Hu, H., Hu, J., Liu, M., Yang, Q. Z., Gu, P., Li, J., et al. (2025) · iMeta · doi:10.1002/imt2.270 · Cited by 138 · see citing works
Air pollution and skin disorders
Roberts, W. (2021) · International Journal of Women's Dermatology · doi:10.1016/j.ijwd.2020.11.001 · Cited by 111 · see citing works
Advances in psoriasis research: From pathogenesis to therapeutics
Sugumaran, D., Yong, A. C. H., & Stanslas, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122991 · Cited by 108 · see citing works
A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes
Szelest, M., Walczak, K., & Plech, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031104 · Cited by 98 · see citing works
Environmental Air Pollutants Affecting Skin Functions with Systemic Implications
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310502 · Cited by 94 · see citing works
Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation
Chen, Y., Wang, Y., Fu, Y., Yin, Y., & Xu, K. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01046-y · Cited by 91 · see citing works
Tapinarof validates the aryl hydrocarbon receptor as a therapeutic target: A clinical review
Silverberg, J. I., Boguniewicz, M., Quintana, F. J., Clark, R. A., Gross, L., Hirano, I., Tallman, A. M., Brown, P. M., Fredericks, D., Rubenstein, D. S., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.12.013 · Cited by 87 · see citing works
Aryl hydrocarbon receptor: Its roles in physiology
Kou, Z., & Dai, W. H. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114428 · Cited by 91 · see citing works
Molecular role of cytochrome P4501A enzymes in oxidative stress
Stading, R. E., Chu, C., Couroucli, X. I., Lingappan, K., & Moorthy, B. (2020) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2020.07.001 · Cited by 85 · see citing works
Skin barrier defects in atopic dermatitis: From old idea to new opportunity
Yoshida, T., Beck, L. A., & Benedetto, A. D. (2021) · Allergology International · doi:10.1016/j.alit.2021.11.006 · Cited by 88 · see citing works
Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases
Stec, A., Sikora, M., Maciejewska, M., Paralusz-Stec, K., Michalska, M. N., Sikorska, E., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043494 · Cited by 85 · see citing works
Itch in Atopic Dermatitis – What Is New?
Legat, F. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.644760 · Cited by 82 · see citing works
Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells
Bangert, C., Alkon, N., Chennareddy, S., Arnoldner, T., Levine, J. P., Pilz, M., Medjimorec, M. A., Ruggiero, J. R., Cohenour, E. R., Jonak, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46540-0 · Cited by 76 · see citing works
Autoimmunity and autoimmune co‐morbidities in psoriasis
Furue, K., Ito, T., Tsuji, G., Kadono, T., Nakahara, T., & Furue, M. (2018) · Immunology · doi:10.1111/imm.12891 · Cited by 76 · see citing works
Self-citation
Tapinarof Cream 1%: First Approval
Keam, S. J. (2022) · Drugs · doi:10.1007/s40265-022-01748-6 · Cited by 74 · see citing works
What’s New in Topicals for Atopic Dermatitis?
Kleinman, E. P., Laborada, J., Metterle, L., & Eichenfield, L. F. (2022) · American Journal of Clinical Dermatology · doi:10.1007/s40257-022-00712-0 · Cited by 72 · see citing works
Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective
Hemrajani, C., Negi, P., Parashar, A., Gupta, G., Jha, N. K., Singh, S. K., Chellappan, D. K., & Dua, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112633 · Cited by 69 · see citing works
Targeting AhR as a Novel Therapeutic Modality against Inflammatory Diseases
Cannon, A. S., Nagarkatti, P. S., & Nagarkatti, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010288 · Cited by 67 · see citing works
Limosilactobacillus reuteri Attenuates Atopic Dermatitis via Changes in Gut Bacteria and Indole Derivatives from Tryptophan Metabolism
Fang, Z., Pan, T., Wang, H., Zhu, J., Zhang, H., Zhao, J., Chen, W., & Lu, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147735 · Cited by 65 · see citing works
Tissue-resident memory T cells in the skin
Khalil, S., Bardawil, T., Kurban, M., & Abbas, O. M. (2020) · Inflammation Research · doi:10.1007/s00011-020-01320-6 · Cited by 62 · see citing works
IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis
Miake, S., Tsuji, G., Takemura, M., Hashimoto‐Hachiya, A., Vu, Y. H., Furue, M., & Nakahara, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164053 · Cited by 61 · see citing works
Self-citation
Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives
Borgia, F., Pomi, F. L., Vaccaro, M., Alessandrello, C., Papa, V., & Gangemi, S. (2022) · Biomolecules · doi:10.3390/biom12121904 · Cited by 63 · see citing works
Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases
Napolitano, M., Fabbrocini, G., Martora, F., Picone, V., Morelli, P., & Patruno, C. (2021) · Cells · doi:10.3390/cells10123559 · Cited by 58 · see citing works
Tapinarof for the treatment of psoriasis
Nogueira, S., Rodrigues, M. A., Vender, R. B., & Torres, T. R. (2022) · Dermatologic Therapy · doi:10.1111/dth.15931 · Cited by 55 · see citing works
Pathogenesis of Inflammation in Skin Disease: From Molecular Mechanisms to Pathology
Shirley, S. N., Watson, A. E., & Yusuf, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810152 · Cited by 55 · see citing works
New Topical Therapies for Psoriasis
Lé, A. M., & Torres, T. R. (2021) · American Journal of Clinical Dermatology · doi:10.1007/s40257-021-00649-w · Cited by 54 · see citing works
Synthetic Approaches to the New Drugs Approved during 2019
Flick, A. C., Leverett, C. A., Ding, H. X., McInturff, E. L., Fink, S. J., Mahapatra, S., Carney, D. W., Lindsey, E. A., DeForest, J. C., France, S. P., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00208 · Cited by 53 · see citing works
IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis
Vu, Y. H., Hashimoto‐Hachiya, A., Takemura, M., Yumine, A., Mitamura, Y., Nakahara, T., Furue, M., & Tsuji, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249412 · Cited by 52 · see citing works
Self-citation
New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression
Dębińska, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112506 · Cited by 52 · see citing works
Air Pollution and Atopic Dermatitis (AD): The Impact of Particulate Matter (PM10) on an AD Mouse-Model
Woo, Y. R., Park, S., Choi, K., Hong, E. S., Kim, S., & Kim, H. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176079 · Cited by 50 · see citing works
New and Emerging Oral/Topical Small-Molecule Treatments for Psoriasis
Carmona‐Rocha, E., Rusiñol, L., & Puig, L. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020239 · Cited by 48 · see citing works
Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation
Landemaine, L., Costa, G. D., Fissier, E., Francis, C., Morand, S. C., Verbeke, J., Michel, M., Briandet, R., Sokol, H., Guéniche, A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098160 · Cited by 48 · see citing works
The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases?
Shivanna, B., Chu, C., & Moorthy, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031516 · Cited by 46 · see citing works
Aryl hydrocarbon receptor/nuclear factor E2‐related factor 2 (AHR/NRF2) signalling: A novel therapeutic target for atopic dermatitis
Hwang, J., Newton, E. M., Hsiao, J. L., & Shi, V. Y. (2022) · Experimental Dermatology · doi:10.1111/exd.14541 · Cited by 47 · see citing works
The role of the AHR in host–pathogen interactions
Barreira‐Silva, P., Lian, Y., Kaufmann, S. H. E., & Moura‐Alves, P. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01088-4 · Cited by 44 · see citing works
The roles of T cells in psoriasis
Zhang, P., Su, Y., Li, S., Chen, H., Wu, R., & Wu, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1081256 · Cited by 44 · see citing works
Atopic dermatitis: diagnosis, molecular pathogenesis, and therapeutics
Bai, R., Zheng, Y., & Dai, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00313-3 · Cited by 46 · see citing works
Tapinarof Cream 1% for Extensive Plaque Psoriasis: A Maximal Use Trial on Safety, Tolerability, and Pharmacokinetics
Jett, J. E., McLaughlin, M., Lee, M. S., Parish, L. C., DuBois, J. C., Raoof, T. J., Tabolt, G., Wilson, T., Somerville, M. C., DellaMaestra, W., et al. (2021) · American Journal of Clinical Dermatology · doi:10.1007/s40257-021-00641-4 · Cited by 40 · see citing works
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process
Salminen, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101928 · Cited by 38 · see citing works
Emerging Therapeutic Options for Chronic Pruritus
Reszke, R., Krajewski, P. K., & Szepietowski, J. C. (2020) · American Journal of Clinical Dermatology · doi:10.1007/s40257-020-00534-y · Cited by 38 · see citing works
Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards—Lessons from Yusho
Furue, M., Ishii, Y., Tsukimori, K., & Tsuji, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020708 · Cited by 39 · see citing works
Self-citation
Effect of allyl isothiocyanate on oxidative stress in COPD via the AhR / CYP1A1 and Nrf2 / NQO1 pathways and the underlying mechanism
Zhu, W.-T., Li, C., Dai, T.-T., Song, Q.-Q., Chen, Y., Han, Z., Sun, N., & Wang, D. L. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154774 · Cited by 36 · see citing works
The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects
Alves, L. D. F., Moore, J. B., & Kell, D. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169082 · Cited by 37 · see citing works
Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes
Tanaka, Y., Uchi, H., Hashimoto‐Hachiya, A., & Furue, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9298052 · Cited by 36 · see citing works
Self-citation
A double-blind, randomized, placebo- and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis
Cai, L., Chen, G.-H., Lu, Q., Zheng, M., Li, Y., Chen, J., Zheng, J., Zhang, F., Yu, J.-B., Yang, S., et al. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001221 · Cited by 35 · see citing works
The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury
Stading, R. E., Couroucli, X. I., Lingappan, K., & Moorthy, B. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1853705 · Cited by 35 · see citing works
Tapinarof cream for the treatment of atopic dermatitis: Efficacy and safety results from two Japanese phase 3 trials
Igarashi, A., Tsuji, G., Fukasawa, S., Murata, R., & Yamane, S. (2024) · The Journal of Dermatology · doi:10.1111/1346-8138.17451 · Cited by 35 · see citing works
Self-citation
The aryl hydrocarbon receptor at the forefront of host‐microbe interactions in the skin: A perspective on current knowledge gaps and directions for future research and therapeutic applications
van den Bogaard, E. H. J., Esser, C., & Perdew, G. H. (2021) · Experimental Dermatology · doi:10.1111/exd.14409 · Cited by 35 · see citing works
ZNF384: A Potential Therapeutic Target for Psoriasis and Alzheimer’s Disease Through Inflammation and Metabolism
Liu, S., Yuan, X., Su, H., Liu, F., Zhuang, Z., & Chen, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.892368 · Cited by 35 · see citing works
The Aryl Hydrocarbon Receptor (AHR): Peacekeeper of the Skin
Dawe, H. R., & Meglio, P. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041618 · Cited by 35 · see citing works
Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System
Tanaka, Y., Ito, T., Tsuji, G., & Furue, M. (2020) · Antioxidants · doi:10.3390/antiox9060507 · Cited by 30 · see citing works
Self-citation
Therapeutic potential of microneedles based delivery systems for the management of atopic dermatitis
Shukla, S., Mamale, K., Arya, R. K. K., Kaundal, R. K., & Shukla, R. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104493 · Cited by 30 · see citing works
Novel Therapeutic Targets for the Treatment of Atopic Dermatitis
Tsuji, G., Yamamura, K., Kawamura, K., Kido‐Nakahara, M., Ito, T., & Nakahara, T. (2023) · Biomedicines · doi:10.3390/biomedicines11051303 · Cited by 30 · see citing works
Self-citation
Experimental Pharmacological Management of Psoriasis
Campione, E., Cosio, T., Di Prete, M., Lanna, C., Dattola, A., & Bianchi, L. (2021) · Journal of Experimental Pharmacology · doi:10.2147/jep.s265632 · Cited by 27 · see citing works
The contribution of IL-17 to the development of autoimmunity in psoriasis
Furue, M., & Kadono, T. (2019) · Innate Immunity · doi:10.1177/1753425919852156 · Cited by 27 · see citing works
Self-citation
Aryl Hydrocarbon Receptors: Evidence of Therapeutic Targets in Chronic Inflammatory Skin Diseases
Kim, H.-B., Um, J., Chung, B. Y., Kim, J. C., Kang, S. Y., Park, C. W., & Kim, H. O. (2022) · Biomedicines · doi:10.3390/biomedicines10051087 · Cited by 27 · see citing works
Novel Therapeutic Strategies in the Topical Treatment of Atopic Dermatitis
Pinto, L. M., Chiricozzi, A., Calabrese, L., Mannino, M., & Peris, K. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122767 · Cited by 26 · see citing works
Natural Product-Derived Compounds Targeting Keratinocytes and Molecular Pathways in Psoriasis Therapeutics
Lee, Y. G., Jung, Y., Choi, H., Lee, J.-I., Lim, T., & Lee, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116068 · Cited by 25 · see citing works
Bacterial Autoimmune Drug Metabolism Transforms an Immunomodulator into Structurally and Functionally Divergent Antibiotics
Park, H. B., Goddard, T. N., Oh, J., Patel, J. R., Wei, Z., Perez, C. E., Mercado, B. Q., Wang, R., Wyche, T. P., Piizzi, G., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201916204 · Cited by 25 · see citing works
Epigenetic Regulations of AhR in the Aspect of Immunomodulation
Wajda, A., Łapczuk-Romańska, J., & Paradowska‐Gorycka, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176404 · Cited by 25 · see citing works
Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes
Tsuji, G., Hashimoto-Hachiya, A., Matsuda-Taniguchi, T., Takai-Yumine, A., Takemura, M., Yan, X., Furue, M., & Nakahara, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.745997 · Cited by 22 · see citing works
Self-citation
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Lie, E., Choi, M., Wang, S., & Eichenfield, L. F. (2023) · Pediatric Drugs · doi:10.1007/s40272-023-00592-9 · Cited by 23 · see citing works
The Effects of Environmental Pollutants and Exposures on Hair Follicle Pathophysiology
Samra, T., Lin, R. R., & Maderal, A. D. (2024) · Skin Appendage Disorders · doi:10.1159/000537745 · Cited by 23 · see citing works
A phase 2, randomized, double‐blind, vehicle‐controlled trial of tapinarof cream in Japanese pediatric patients with atopic dermatitis
Igarashi, A., Tsuji, G., Murata, R., Fukasawa, S., & Yamane, S. (2024) · The Journal of Dermatology · doi:10.1111/1346-8138.17587 · Cited by 22 · see citing works
Self-citation
Regulatory mechanism of the IL-33-IL-37 axis via aryl hydrocarbon receptor in atopic dermatitis and psoriasis
Tsuji, G., Yamamura, K., Kawamura, K., Kido-Nakahara, M., Ito, T., & Nakahara, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914633 · Cited by 21 · see citing works
Self-citation
Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 1
Tsuji, G., Hashimoto‐Hachiya, A., Vu, Y. H., Miake, S., Takemura, M., Mitamura, Y., Ito, T., Murata, M., Furue, M., & Nakahara, T. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030891 · Cited by 21 · see citing works
Self-citation
Chlorogenic acid attenuates pro-inflammatory response in the blood of streptozotocin-induced diabetic rats
Lee, Y., Bae, C., & Ahn, T. (2022) · Laboratory Animal Research · doi:10.1186/s42826-022-00148-x · Cited by 20 · see citing works
TDO2 and tryptophan metabolites promote kynurenine/AhR signals to facilitate glioma progression and immunosuppression.
Zhong, C., Peng, L., Tao, B., Yin, S., Lyu, L., Ding, H., Yang, X., Peng, T., He, H., & Zhou, P. (2022) · PubMed Central · Cited by 19 · see citing works
Efficacy of the Radical Scavenger, Tempol, to Reduce Inflammation and Oxidative Stress in a Murine Model of Atopic Dermatitis
Ardizzone, A., Repici, A., Capra, A. P., Gaetano, F. D., Bova, V., Casili, G., Campolo, M., & Esposito, E. (2023) · Antioxidants · doi:10.3390/antiox12061278 · Cited by 20 · see citing works
Synthesis and clinical application of new drugs approved by FDA in 2022
Zhang, J., Wang, Y., Sun, L., Wang, S., & Chen, Z. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00138-y · Cited by 19 · see citing works
Oxidative stress products and managements in atopic dermatitis
Luo, Y., Hu, J., Zhou, Z., Zhang, Y., Wu, Y., & Sun, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1538194 · Cited by 18 · see citing works
Rodent Genetic Models of Ah Receptor Signaling
Wilson, R. H., & Bradfield, C. A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1955916 · Cited by 16 · see citing works
“…psoriasis, experiment colitis and colorectal cancer, and infections of microorganisms like Citrobacter rodentium and Toxoplasma gondii (D ıaz-D ıaz et al. 2016; Furue et al. 2019; H. R. Kim et al. 2020; Kim et al. 2012; Kiss et al. 2011; Qiu et al. 2012; Sanchez et al. 2010; Wagage et al. 2015).”
Background
Biomimetic Total Synthesis of (±)-Carbocyclinone-534 Reveals Its Biosynthetic Pathway
Qu, C., Long, X., Sang, Y., Zhang, M., Zhao, X., Xue, X., & Deng, J. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c02865 · Cited by 17 · see citing works
Short-term effect of NO2 on outpatient visits for dermatologic diseases in Xinxiang, China: a time-series study
Chao, L., Lu, M., An, Z., Li, J., Li, Y., Zhao, Q., Wang, Y., Liu, Y., Wu, W., & Song, J. (2021) · Environmental Geochemistry and Health · doi:10.1007/s10653-021-00831-3 · Cited by 17 · see citing works
Aryl hydrocarbon receptor role in chronic inflammatory skin diseases: a narrative review
Dec, M., & Arasiewicz, H. (2024) · Advances in Dermatology and Allergology · doi:10.5114/ada.2023.135617 · Cited by 18 · see citing works
The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis
Lee, Y., Lee, E. M., Yon, D. K., Jee, H. M., Baek, H., Lee, S. W., Cho, J., & Han, M. Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-83288-9 · Cited by 17 · see citing works
Staphylococcus aureus Activates the Aryl Hydrocarbon Receptor in Human Keratinocytes
Stange, E.-L., Rademacher, F., Drerup, K. A., Heinemann, N., Möbus, L., Gläser, R., & Harder, J. (2022) · Journal of Innate Immunity · doi:10.1159/000524033 · Cited by 16 · see citing works
The role of aryl hydrocarbon receptor in vitiligo: a review
Li, Y., Zeng, Y., Chen, Z., Tan, X., Mei, X., & Wu, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1291556 · Cited by 19 · see citing works
Nuclear receptors for epidermal lipid barrier: Advances in mechanisms and applications
Yin, X., Yan, Y., Li, J., Cao, Z., Shen, S., Chang, Q., Zhao, Y., Wang, X., & Wang, P. (2024) · Experimental Dermatology · doi:10.1111/exd.15107 · Cited by 17 · see citing works
Aryl Hydrocarbon Receptor Activation in Pulmonary Alveolar Epithelial Cells Limits Inflammation and Preserves Lung Epithelial Cell Integrity
Zimmerman, E., Sturrock, A., Reilly, C. A., Burrell, K. L., Warren, K. J., Mir-Kasimov, M., Zhang, M., Pierce, M. S., Helms, M. N., & Paine, R. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300325 · Cited by 16 · see citing works
Tapinarof cream for the treatment of plaque psoriasis: Efficacy and safety results from 2 Japanese phase 3 trials
Igarashi, A., Tsuji, G., Fukasawa, S., Murata, R., & Yamane, S. (2024) · The Journal of Dermatology · doi:10.1111/1346-8138.17423 · Cited by 16 · see citing works
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Authors: Furue, M., Hashimoto-Hachiya, A., & Tsuji, G.
Affiliations: Kyushu University (JP)
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan
Corresponding author: Furue, Masutaka
ORCID: Furue, Masutaka
Tsuji, Gaku
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2019-10-31
Volume: 20
Issue: 21
Pages: 5424
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms20215424
PMC: PMC6862295
OpenAlex: W2982429666
Cited by: 215
References: 144
Citations by year: 2026: 35 · 2025: 23 · 2024: 42 · 2023: 37 · 2022: 27 · 2021: 27 · 2020: 20 · 2019: 2 · 2018: 2
FWCI: 3.68
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: The Ministry of Health, Labour, and Welfare in Japan (H30-Shokuhin-Shitei-005)
The Leading Advanced Projects for Medical Innovation in Japan (The Leading Advanced Projects for Medical Innovation in Japan)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: aryl hydrocarbon receptor, ARNT, atopic dermatitis, psoriasis, skin barrier function, filaggrin, oxidative stress, Nrf2, tapinarof, AhR agonists, dioxins, tryptophan metabolites
MeSH terms: Filaggrin Proteins, Animals, Dermatitis, Atopic, T-Lymphocytes, Helper-Inducer, Humans, Psoriasis, Skin, Receptors, Aryl Hydrocarbon, Oxidative Stress, Polymorphism, Single Nucleotide, T-Lymphocytes, Regulatory

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Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

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