Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

Furue, Masutaka

doi:10.3390/ijms21155382

Cited by 424Dermatology and Skin DiseasesPsoriasis: Treatment and PathogenesisContact Dermatitis and Allergies

Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

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Furue, Masutaka·2020·International Journal of Molecular Sciences

DOI 10.3390/ijms21155382PMC PMC7432778

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Abstract

Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction correlates with the downregulation of barrier-related molecules such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL). IL-4 and IL-13 potently inhibit the expression of these molecules by activating signal transducer and activator of transcription (STAT)6 and STAT3. In addition to IL-4 and IL-13, IL-22 and IL-17A are probably involved in the barrier dysfunction by inhibiting the expression of these barrier-related molecules. In contrast, natural or medicinal ligands for aryl hydrocarbon receptor (AHR) are potent upregulators of FLG, LOR, and IVL expression. As IL-4, IL-13, IL-22, and IL-17A are all capable of inducing oxidative stress, antioxidative AHR agonists such as coal tar, glyteer, and tapinarof exert particular therapeutic efficacy for AD. These antioxidative AHR ligands are known to activate an antioxidative transcription factor, nuclear factor E2-related factor 2 (NRF2). This article focuses on the mechanisms by which FLG, LOR, and IVL expression is regulated by IL-4, IL-13, IL-22, and IL-17A. The author also summarizes how AHR and NRF2 dual activators exert their beneficial effects in the treatment of AD.

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Activation of NRF2 by AHR ligands such as coal tar abolishes IL-4/IL-13-mediated inhibition of epidermal barrier proteins such as FLG and LOR.
“Activation of NRF2 by AHR ligands such as coal tar abolished IL-4/IL-13–mediated inhibition of epidermal barrier proteins such as FLG and LOR (42, 56).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [42]
AhR ligands can also signal through Nrf2, a pleiotropic transcription factor involved in redox homeostasis, metabolism, and immune modulation.
“AhR ligands can also signal via Nuclear factor erythroid 2-related factor 2 (Nrf2)48–51, a pleiotropic transcription factor involved in redox homeostasis, metabolism, and immune modulation52.”
From Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy (2025) · cites this paper as [48]

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Zhang, J., Sun, L., Li, W., Wang, Y., Li, X., & Liu, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108844 · Cited by 15 · see citing works
Retracted
Diagnostic features of atopic dermatitis
Hanifin, J. M., & Rajka, G. (1980) · Acta Dermato-Venereologica · doi:10.2340/00015555924447 · Cited by 5,086 · see citing works
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978 · see citing works
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110 · see citing works
The skin: an indispensable barrier
Proksch, E., Brandner, J. M., & Jensen, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00786.x · Cited by 2,054 · see citing works
Secukinumab in plaque psoriasis—results of two phase 3 trials
Langley, R. G., Elewski, B. E., Lebwohl, M., Reich, K., Griffiths, C. E. M., Papp, K., Puig, L., Nakagawa, H., Spelman, L., Sigurgeirsson, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314258 · Cited by 1,997 · see citing works
The IL-17 Family of Cytokines in Health and Disease
McGeachy, M. J., Cua, D. J., & Gaffen, S. L. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.021 · Cited by 1,443 · see citing works
IL-22 Increases the Innate Immunity of Tissues
Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., & Sabat, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.007 · Cited by 1,362 · see citing works
Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084 · see citing works
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026 · see citing works
Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
Gittler, J. K., Shemer, A., Suárez-Fariñas, M., Fuentes-Duculan, J., Gulewicz, K. J., Wang, C. Q. F., Mitsui, H., Cardinale, I., de Guzman Strong, C., Krueger, J. G., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.012 · Cited by 981 · see citing works
IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes
Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., & Morel, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3695 · Cited by 864 · see citing works
Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis
Gordon, K. B., Blauvelt, A., Papp, K. A., Langley, R. G. B., Luger, T. A., Ohtsuki, M., Reich, K., Amato, D. A., Ball, S. G., Braun, D. K., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1512711 · Cited by 851 · see citing works
Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis
Lebwohl, M., Strober, B. E., Menter, A., Gordon, K. B., Węgłowska, J., Puig, L., Papp, K. A., Spelman, L. J., Toth, D. P., Kerdel, F. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503824 · Cited by 830 · see citing works
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
Nograles, K. E., Zaba, L. C., Guttman‐Yassky, E., Fuentes‐Duculan, J., Suárez‐Fariñas, M., Cardinale, I. R., Khatcherian, A., Gonzalez, J., Pierson, K. C., White, T. R., et al. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08769.x · Cited by 805 · see citing works
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
Lee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D., et al. (2012) · Nature Immunology · doi:10.1038/ni.2187 · Cited by 777 · see citing works
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii‐Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 746 · see citing works
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis
Guttman‐Yassky, E., Bissonnette, R., Ungar, B., Suárez‐Fariñas, M., Ardeleanu, M., Esaki, H., Suprun, M., Estrada, Y. D., Xu, H., Peng, X., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.08.022 · Cited by 706 · see citing works
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes
Junttila, I. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00888 · Cited by 687 · see citing works
Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
Chiricozzi, A., Guttman-Yassky, E., Suárez-Fariñas, M., Nograles, K. E., Tian, S., Cardinale, I., Chimenti, S., & Krueger, J. G. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.340 · Cited by 686 · see citing works
IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells
Nograles, K. E., Zaba, L. C., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Kikuchi, T., Ramon, M., Bergman, R., Krueger, J. G., & Guttman-Yassky, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.041 · Cited by 627 · see citing works
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Paternoster, L., Kemp, J. P., Zheng, J., Smith, G. D., Relton, C. L., Evans, D. M., McArdle, W. L., Henderson, A. J., Standl, M., Tiesler, C. M. T., et al. (2015) · Nature Genetics · doi:10.1038/ng.3424 · Cited by 614 · see citing works
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
Kim, B. E., Leung, D. Y. M., Boguniewicz, M., & Howell, M. D. (2008) · Clinical Immunology · doi:10.1016/j.clim.2007.11.006 · Cited by 538 · see citing works
The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses
Vogel, C. F. A., Winkle, L. S. V., Esser, C., & Haarmann‐Stemmann, T. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101530 · Cited by 515 · see citing works
The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis
Susan, M. L., Valdez, P. A., Wu, J., Jung, K., Zhong, F., Hall, L., Kasman, I. M., Winer, J., Modrusan, Z. D., Danilenko, D. M., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2229 · Cited by 509 · see citing works
Genes Encoding Structural Proteins of Epidermal Cornification and S100 Calcium-Binding Proteins Form a Gene Complex (“Epidermal Differentiation Complex”) on Human Chromosome 1q21
Mischke, D., Korge, B. P., Marenholz, I., Volz, A., & Ziegler, A. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12338501 · Cited by 505 · see citing works
The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology
Esser, C., & Rannug, A. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009001 · Cited by 501 · see citing works
Interleukin-22 (IL-22) Activates the JAK/STAT, ERK, JNK, and p38 MAP Kinase Pathways in a Rat Hepatoma Cell Line
Lejeune, D., Dumoutier, L., Constantinescu, S. N., Kruijer, W., Schuringa, J. J., & Renauld, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204204200 · Cited by 478 · see citing works
Basic biology and role of interleukin‐17 in immunity and inflammation
Zenobia, C., & Hajishengallis, G. (2015) · Periodontology 2000 · doi:10.1111/prd.12083 · Cited by 477 · see citing works
The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond
Brembilla, N. C., Senra, L., & Boehncke, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01682 · Cited by 477 · see citing works
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Tsoi, L. C., Rodriguez, E., Degenhardt, F., Baurecht, H., Wehkamp, U., Volks, N., Szymczak, S., Swindell, W. R., Sarkar, M. K., Raja, K., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.12.018 · Cited by 469 · see citing works
Pathogenesis of psoriasis and development of treatment
Ogawa, E., Sato, Y., Minagawa, A., & Okuyama, R. (2017) · The Journal of Dermatology · doi:10.1111/1346-8138.14139 · Cited by 464 · see citing works
Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation
Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701764104 · Cited by 437 · see citing works
Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin
Esaki, H., Brunner, P. M., Renert-Yuval, Y., Czarnowicki, T., Huynh, T., Tran, G., Lyon, S., Rodriguez, G., Immaneni, S., Johnson, D. B., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.07.013 · Cited by 428 · see citing works
Treatment of atopic dermatitis with tralokinumab, an anti–IL-13 mAb
Wollenberg, A., Howell, M. D., Guttman‐Yassky, E., Silverberg, J. I., Kell, C., Ranade, K., Moate, R., & van der Merwe, R. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.05.029 · Cited by 408 · see citing works
Significance of Skin Barrier Dysfunction in Atopic Dermatitis
Kim, B. E., & Leung, D. Y. M. (2018) · Allergy, Asthma & Immunology Research · doi:10.4168/aair.2018.10.3.207 · Cited by 393 · see citing works
Periostin promotes chronic allergic inflammation in response to Th2 cytokines
増岡, 美., Shiraishi, H., Ohta, S., Suzuki, S., Arima, K., Aoki, S., Toda, S., Inagaki, N., Kurihara, Y., Hayashida, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58978 · Cited by 389 · see citing works
Self-citation
Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.
Smith, S. H., Jayawickreme, C., Rickard, D. J., Nicodeme, E., Bui, T., Simmons, C., Coquery, C. M., Neil, J., Pryor, W. M., Mayhew, D., et al. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.05.004 · Cited by 387 · see citing works
Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
van den Bogaard, E. H., Bergboer, J. G. M., Vonk-Bergers, M., van Vlijmen-Willems, I. M. J. J., Hato, S. V., van der Valk, P. G. M., Schröder, J. M., Joosten, I., Zeeuwen, P. L. J. M., & Schalkwijk, J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65642 · Cited by 373 · see citing works
Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial
Guttman-Yassky, E., Brunner, P. M., Neumann, A. U., Khattri, S., Pavel, A. B., Malik, K., Singer, G. K., Baum, D., Gilleaudeau, P., Sullivan-Whalen, M., et al. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.01.016 · Cited by 343 · see citing works
The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the ‘fused genes’ family
Kypriotou, M., Huber, M., & Hohl, D. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01472.x · Cited by 334 · see citing works
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
Furue, M., Chiba, T., Tsuji, G., Ulzii, D., Kido‐Nakahara, M., Nakahara, T., & Kadono, T. (2017) · Allergology International · doi:10.1016/j.alit.2016.12.002 · Cited by 324 · see citing works
Self-citation
IL‐17 and IL‐22 in immunity: Driving protection and pathology
Eyerich, K., Dimartino, V., & Cavani, A. (2017) · European Journal of Immunology · doi:10.1002/eji.201646723 · Cited by 324 · see citing works
Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis
Jensen, J.-M., Fölster-Holst, R., Baranowsky, A., Schunck, M., Winoto-Morbach, S., Neumann, C., Schütze, S., & Proksch, E. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22621.x · Cited by 309 · see citing works
Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis
Nomura, T., Sandilands, A., Akiyama, M., Liao, H., Evans, A. T., Sakai, K., Ota, M., Sugiura, H., Yamamoto, K., Satō, H., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.646 · Cited by 272 · see citing works
The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling
Amano, W., Nakajima, S., Kunugi, H., Numata, Y., Kitoh, A., Egawa, G., Dainichi, T., Honda, T., Otsuka, A., Kimoto, Y., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.051 · Cited by 259 · see citing works
A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor
Yu, J., Luo, Y., Zhu, Z., Zhou, Y., Sun, L., Gao, J., Sun, J., Wang, G., Yao, X., & Li, W. S. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.11.036 · Cited by 257 · see citing works
Assembly of the epidermal cornified cell envelope
Kalinin, A., Marekov, L. N., & Steinert, P. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.17.3069 · Cited by 250 · see citing works
IL‐17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion
Gutowska‐Owsiak, D., Schaupp, A., Salimi, M., Selvakumar, T. A., McPherson, T., Taylor, S., & Ogg, G. S. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01412.x · Cited by 239 · see citing works
Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin
Pellerin, L., Henry, J., Hsu, C.-Y., Balica, S., Jean-Decoster, C., Méchin, M.-C., Hansmann, B., Rodriguez, E., Weindinger, S., Schmitt, A.-M., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1566 · Cited by 239 · see citing works
Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis
Furue, M., Hashimoto-Hachiya, A., & Tsuji, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215424 · Cited by 215 · see citing works
Self-citation
The Antimicrobial Protein Psoriasin (S100A7) Is Upregulated in Atopic Dermatitis and after Experimental Skin Barrier Disruption
Gläser, R., Meyer‐Hoffert, U., Harder, J., Cordes, J., Wittersheim, M., Kobliakova, J., Fölster‐Holst, R., Proksch, E., Schröder, J., & Schwarz, T. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.268 · Cited by 214 · see citing works
The hsp90 Chaperone Complex Regulates Intracellular Localization of the Dioxin Receptor
Kazlauskas, A., Sundström, S., Poellinger, L., & Pongratz, I. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.7.2594-2607.2001 · Cited by 211 · see citing works
Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)+ TH2/TH1 cell imbalance, whereas adults acquire CLA+ TH22/TC22 cell subsets
Czarnowicki, T., Esaki, H., Gonzalez, J., Malajian, D., Shemer, A., Noda, S., Talasila, S., Berry, A., Gray, J., Becker, L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.049 · Cited by 210 · see citing works
An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway
Tsuji, G., Takahara, M., Uchi, H., Takeuchi, S., Mitoma, C., Moroi, Y., & Furue, M. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.10.017 · Cited by 209 · see citing works
Self-citation
Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab
Brunner, P. M., Pavel, A. B., Khattri, S., Leonard, A., Malik, K., Rose, S., On, S. C. J., Vekaria, A. S., Traidl‐Hoffmann, C., Singer, G., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.07.028 · Cited by 200 · see citing works
Nrf2-A regulator of keratinocyte redox signaling
Schäfer, M., & Werner, S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.018 · Cited by 192 · see citing works
IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis
Krueger, J. G., Wharton, K. A., Schlitt, T., Suprun, M., Torene, R. I., Jiang, X., Wang, C. Q. F., Fuentes‐Duculan, J., Hartmann, N., Peters, T., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.04.029 · Cited by 190 · see citing works
Nrf2 links epidermal barrier function with antioxidant defense
Schäfer, M., Farwanah, H., Willrodt, A., Huebner, A. J., Sandhoff, K., Roop, D. R., Hohl, D., Bloch, W., & Werner, S. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200219 · Cited by 186 · see citing works
IL-17 Induces an Expanded Range of Downstream Genes in Reconstituted Human Epidermis Model
Chiricozzi, A., Nograles, K. E., Johnson-Huang, L. M., Fuentes‐Duculan, J., Cardinale, I. R., Bonifacio, K. M., Gulati, N., Mitsui, H., Guttman‐Yassky, E., Suárez‐Fariñas, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090284 · Cited by 180 · see citing works
Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain
Jones, B. C., Logsdon, N. J., & Walter, M. R. (2008) · Structure · doi:10.1016/j.str.2008.06.005 · Cited by 176 · see citing works
Decreased expression of filaggrin in atopic skin
Seguchi, T., Chang-Yi, C., Kusuda, S., Takahashi, M., Aisu, K., & Tezuka, T. (1996) · Archives of Dermatological Research · doi:10.1007/bf02505232 · Cited by 175 · see citing works
Role of AhR/ARNT system in skin homeostasis
Furue, M., Takahara, M., Nakahara, T., & Uchi, H. (2014) · Archives of Dermatological Research · doi:10.1007/s00403-014-1481-7 · Cited by 175 · see citing works
Self-citation
Chronic mucocutaneous candidiasis disease associated with inborn errors of IL‐17 immunity
Okada, S., Puel, A., Casanova, J., & Kobayashi, M. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.71 · Cited by 175 · see citing works
Malassezia Yeasts Produce a Collection of Exceptionally Potent Activators of the Ah (Dioxin) Receptor Detected in Diseased Human Skin
Magiatis, P., Pappas, P., Gaitanis, G., Mexia, N., Melliou, E., Galanou, M., Vlachos, C., Stathopoulou, K., Skaltsounis, A., Μαρσέλος, Μ., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.92 · Cited by 171 · see citing works
Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect
Tsuji, G., Takahara, M., Uchi, H., Matsuda, T., Chiba, T., Takeuchi, S., Yasukawa, F., Moroi, Y., & Furue, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.194 · Cited by 169 · see citing works
Self-citation
Nrf2 Promotes Keratinocyte Proliferation in Psoriasis through Up-Regulation of Keratin 6, Keratin 16, and Keratin 17
Yang, L., Fan, X., Cui, T., Dang, E., & Wang, G. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.05.015 · Cited by 169 · see citing works
Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes: IL-22 affects filaggrin expression at multiple levels
Gutowska-Owsiak, D., Schaupp, A. L., Salimi, M., Taylor, S., & Ogg, G. S. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10400.x · Cited by 168 · see citing works
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
Galbraith, G. M. P. (2009) · Yearbook of Dermatology and Dermatologic Surgery · doi:10.1016/s0093-3619(09)79289-5 · Cited by 167 · see citing works
IL-19 Is a Component of the Pathogenetic IL-23/IL-17 Cascade in Psoriasis
Witte, E., Kokolakis, G., Witte, K., Philipp, S., Doecke, W., Babel, N., Wittig, B. M., Warszawska, K., Kurek, A., Erdmann‐Keding, M., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.308 · Cited by 165 · see citing works
A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis
Peppers, J., Paller, A. S., Maeda-Chubachi, T., Wu, S., Robbins, K., Gallagher, K., & Kraus, J. E. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.06.047 · Cited by 165 · see citing works
Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Interaction of the Ah and hr loci
Knutson, J. C. (1982) · Cell · doi:10.1016/0092-8674(82)90028-9 · Cited by 156 · see citing works
Ultraviolet-B Exposure of Human Skin Induces Cytochromes P450 1A1 and 1B1
Katiyar, S. K., Mukhtar, H., & Matsui, M. S. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00876.x · Cited by 155 · see citing works
IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway
Cho, K., Suh, J. W., Lee, K. H., Kang, J. L., & Woo, S. (2011) · International Immunology · doi:10.1093/intimm/dxr110 · Cited by 154 · see citing works
Identification of an anthraquinone pigment and a hydroxystilbene antibiotic from Xenorhabdus luminescens
Richardson, W. H., Schmidt, T. M., & Nealson, K. H. (1988) · Applied and Environmental Microbiology · doi:10.1128/aem.54.6.1602-1605.1988 · Cited by 153 · see citing works
Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis
Tsuji, G., Hashimoto-Hachiya, A., Kiyomatsu-Oda, M., Takemura, M., Ohno, F., Ito, T., Morino-Koga, S., Mitoma, C., Nakahara, T., Uchi, H., et al. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.322 · Cited by 149 · see citing works
Self-citation
Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation
Su, Y., Huang, J., Zhao, X., Li, J., Wang, W., Yang, X. O., Shi, Y., Wang, X., Lai, Y., & Dong, C. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau9657 · Cited by 148 · see citing works
Fluorescence Excitation Spectroscopy Provides Information About Human Skin In Vivo
Gillies, R. J., Zonios, G. I., Anderson, R. R., & Kollias, N. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00091.x · Cited by 142 · see citing works
Safety of biologics in psoriasis
Kamata, M., & Tada, Y. (2017) · The Journal of Dermatology · doi:10.1111/1346-8138.14096 · Cited by 133 · see citing works
Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
Furue, M., Tsuji, G., Mitoma, C., Nakahara, T., Chiba, T., Morino-Koga, S., & Uchi, H. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.07.011 · Cited by 132 · see citing works
Self-citation
The IL ‐13/periostin/ IL ‐24 pathway causes epidermal barrier dysfunction in allergic skin inflammation
Mitamura, Y., Nunomura, S., Nanri, Y., Ogawa, M., Yoshihara, T., 増岡, 美., Tsuji, G., Nakahara, T., Hashimoto‐Hachiya, A., Conway, S. J., et al. (2018) · Allergy · doi:10.1111/all.13437 · Cited by 132 · see citing works
Self-citation
Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization
Broccardo, C. J., Mahaffey, S. B., Schwarz, J., Wruck, L. M., David, G. L., Schlievert, P. M., Reisdorph, N. A., & Leung, D. Y. M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.033 · Cited by 128 · see citing works
Molecular Identification and Expression Analysis of Filaggrin-2, a Member of the S100 Fused-Type Protein Family
Wu, Z., Hansmann, B., Meyer‐Hoffert, U., Gläser, R., & Schröder, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005227 · Cited by 128 · see citing works
2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1
Kopf, P. G., & Walker, M. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.02.007 · Cited by 127 · see citing works
Chloracne, "the hallmark of dioxin intoxication".
Suskind, R. R. (1985) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.2240 · Cited by 127 · see citing works
Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription
Nair, M., Teng, A., Bilanchone, V., Agrawal, A., Li, B., & Dai, X. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508196 · Cited by 125 · see citing works
Pathogenesis of Atopic Dermatitis: Current Paradigm.
Furue, M., Ulzii, D., Vu, Y. H., Tsuji, G., Kido‐Nakahara, M., & Nakahara, T. (2019) · PubMed · doi:10.22034/iji.2019.80253 · Cited by 123 · see citing works
Self-citation
PTP1B is a negative regulator of interleukin 4–induced STAT6 signaling
Lu, X., Malumbres, R., Shields, B., Jiang, X., Sarosiek, K. A., Natkunam, Y., Tiganis, T., & Lossos, I. S. (2008) · Blood · doi:10.1182/blood-2008-03-148726 · Cited by 122 · see citing works
Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways
Zissler, U. M., Chaker, A. M., Effner, R., Ulrich, M., Guerth, F. M., Piontek, G., Dietz, K., Regn, M., Knapp, B. L., Theis, F. J., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.110 · Cited by 121 · see citing works
Receptors for Interleukin (IL)-4 Do Not Associate with the Common γChain, and IL-4 Induces the Phosphorylation of JAK2 Tyrosine Kinase in Human Colon Carcinoma Cells
Murata, T., Noguchi, P. D., & Puri, R. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30829 · Cited by 115 · see citing works
Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2
Furue, M., Uchi, H., Mitoma, C., Hashimoto-Hachiya, A., Chiba, T., Ito, T., Nakahara, T., & Tsuji, G. (2017) · Nutrients · doi:10.3390/nu9030223 · Cited by 113 · see citing works
Self-citation
Interleukin‐17 alters the biology of many cell types involved in the genesis of psoriasis, systemic inflammation and associated comorbidities
Krueger, J. G., & Brunner, P. M. (2017) · Experimental Dermatology · doi:10.1111/exd.13467 · Cited by 113 · see citing works
Interleukin-22: A likely target for treatment of autoimmune diseases
Yang, X., & Zheng, S. G. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.11.008 · Cited by 110 · see citing works
Regulation of CYP1A1 Transcription via the Metabolism of the Tryptophan-Derived 6-Formylindolo[3,2-b]carbazole
Wei, Y., Bergander, L. V., Rannug, U., & Rannug, A. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2037 · Cited by 110 · see citing works
Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression
Otsuka, A., Doi, H., Egawa, G., Maekawa, A., Fujita, T., Nakamizo, S., Nakashima, C., Nakajima, S., Watanabe, T., Miyachi, Y., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.07.027 · Cited by 108 · see citing works
Genetic and Pharmacological Analysis Identifies a Physiological Role for the AHR in Epidermal Differentiation
van den Bogaard, E. H. J., Podolsky, M. A., Smits, J. P. H., Cui, X., John, C., Gowda, K., Desai, D. H., Amin, S., Schalkwijk, J., Perdew, G. H., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.6 · Cited by 107 · see citing works
Guselkumab Efficacy after Withdrawal Is Associated with Suppression of Serum IL-23-Regulated IL-17 and IL-22 in Psoriasis: VOYAGE 2 Study
Gordon, K. B., Armstrong, A. W., Foley, P. A., Song, M., Shen, Y., Li, S., Muñoz‐Elías, E. J., Branigan, P. J., Liu, X., & Reich, K. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.05.016 · Cited by 107 · see citing works
The IL ‐13– OVOL 1– FLG axis in atopic dermatitis
Furue, K., Ito, T., Tsuji, G., Ulzii, D., Vu, Y. H., Kido‐Nakahara, M., Nakahara, T., & Furue, M. (2019) · Immunology · doi:10.1111/imm.13120 · Cited by 107 · see citing works
Self-citation
Staphylococcus aureus in atopic dermatitis: Strain-specific cell wall proteins and skin immunity
Iwamoto, K., Moriwaki, M., Miyake, R., & Hide, M. (2019) · Allergology International · doi:10.1016/j.alit.2019.02.006 · Cited by 104 · see citing works
IL‐17 and IL‐22 mediate IL‐20 subfamily cytokine production in cultured keratinocytes via increased IL‐22 receptor expression
Tohyama, M., Hanakawa, Y., Shirakata, Y., Dai, X., Yang, L., Hirakawa, S., Tokumaru, S., Okazaki, H., Sayama, K., & Hashimoto, K. (2009) · European Journal of Immunology · doi:10.1002/eji.200939473 · Cited by 103 · see citing works
Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway
Murata, T. (1998) · International Immunology · doi:10.1093/intimm/10.8.1103 · Cited by 103 · see citing works
Defining the Role for XAP2 in Stabilization of the Dioxin Receptor
Lees, M. J., Peet, D. J., & Whitelaw, M. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302430200 · Cited by 102 · see citing works
Redox Regulation of Interleukin-4 Signaling
Sharma, P., Chakraborty, R., Wang, L., Min, B., Tremblay, M. L., Kawahara, T., Lambeth, J. D., & Haque, S. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.019 · Cited by 100 · see citing works
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation
Kennedy, L. H., Sutter, C. H., Leon Carrion, S., Tran, Q. T., Bodreddigari, S., Kensicki, E., Mohney, R. P., & Sutter, T. R. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kfs325 · Cited by 100 · see citing works
Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model
Palombo, R., Savini, I., Avigliano, L., Madonna, S., Cavani, A., Albanesi, C., Mauriello, A., Melino, G., & Terrinoni, A. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.201 · Cited by 99 · see citing works
Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice
Schäfer, M., Willrodt, A., Kurinna, S., Link, A. S., Farwanah, H., Geusau, A., Gruber, F., Sorg, O., Huebner, A. J., Roop, D. R., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303281 · Cited by 98 · see citing works
Signal Transduction Pathway of Interleukin-4 and Interleukin-13 in Human B Cells Derived from X-linked Severe Combined Immunodeficiency Patients
Izuhara, K., Heike, T., Otsuka, T., Yamaoka, K., Mayumi, M., Imamura, T., Niho, Y., & Harada, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.619 · Cited by 97 · see citing works
EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes
Sutter, T. R., Yin, H., Li, Y., Mammen, J. S., Bodreddigari, S., Stevens, G., Cole, J. A., & Sutter, T. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900874106 · Cited by 97 · see citing works
Transient Expression of Epidermal Filaggrin in Cultured Cells Causes Collapse of Intermediate Filament Networks with Alteration of Cell Shape and Nuclear Integrity.
Dale, B. A., Presland, R. B., Lewis, S. P., Underwood, R. A., & Fleckman, P. H. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12334205 · Cited by 94 · see citing works
UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan
Wei, Y., Rannug, U., & Rannug, A. (1999) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(98)00118-5 · Cited by 93 · see citing works
2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation
Sutter, C. H., Bodreddigari, S., Campion, C., Wible, R. S., & Sutter, T. R. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr205 · Cited by 93 · see citing works
Phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of plaque psoriasis
Robbins, K., Bissonnette, R., Maeda‐Chubachi, T., Ye, L., Peppers, J., Gallagher, K., & Kraus, J. E. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.10.037 · Cited by 93 · see citing works
Interleukin-22 Promotes Wound Repair in Diabetes by Improving Keratinocyte Pro-Healing Functions
Avitabile, S., Odorisio, T., Madonna, S., Eyerich, S., Guerra, L., Eyerich, K., Zambruno, G., Cavani, A., & Cianfarani, F. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.278 · Cited by 92 · see citing works
Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicentre, randomized, placebo-controlled double-blind trial: WBI-1001 as a novel topical treatment for atopic dermatitis
Bissonnette, R., Poulin, Y., Zhou, Y., Tan, J., Hong, H. C., Webster, J., Ip, W., Tang, L., & Lyle, M. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10775.x · Cited by 92 · see citing works
Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair
de Koning, H. D., van den Bogaard, E. H. J., Bergboer, J. G. M., Kamsteeg, M., van Vlijmen‐Willems, I. M. J. J., Hitomi, K., Henry, J., Simon, M., Takashita, N., Ishida‐Yamamoto, A., et al. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.10885.x · Cited by 91 · see citing works
Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond
McLean, W. H. I. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14997 · Cited by 91 · see citing works
Cynaropicrin attenuates UVB-induced oxidative stress via the AhR–Nrf2–Nqo1 pathway
Takei, K., Hashimoto‐Hachiya, A., Takahara, M., Tsuji, G., Nakahara, T., & Furue, M. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.02.007 · Cited by 88 · see citing works
Self-citation
Burden of atopic dermatitis in Japanese adults: Analysis of data from the 2013 National Health and Wellness Survey
Arima, K., Gupta, S., Gadkari, A. S., Hiragun, T., Kono, T., Katayama, I., Demiya, S., & Eckert, L. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14218 · Cited by 86 · see citing works
Functional Analysis of the Profilaggrin N-Terminal Peptide: Identification of Domains that Regulate Nuclear and Cytoplasmic Distribution
Pearton, D. J., Dale, B. A., & Presland, R. B. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01831.x · Cited by 85 · see citing works
Psoriasis and the TNF/IL23/IL17 axis
Furue, K., Ito, T., Tsuji, G., Kadono, T., & Furue, M. (2019) · Giornale Italiano di Dermatologia e Venereologia · doi:10.23736/s0392-0488.18.06202-8 · Cited by 84 · see citing works
Self-citation
Antioxidant cinnamaldehyde attenuates UVB-induced photoaging
Tanaka, Y., Uchi, H., & Furue, M. (2019) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2019.11.001 · Cited by 84 · see citing works
Self-citation
Evidence for Specific Proteolytic Cleavage of the N-Terminal Domain of Human Profilaggrin During Epidermal Differentiation
Presland, R. B., Kimball, J. R., Kautsky, M. B., Lewis, S. P., Lo, C. Y., & Dale, B. A. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12333356 · Cited by 82 · see citing works
Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes
Uchi, H., Yasumatsu, M., Morino-Koga, S., Mitoma, C., & Furue, M. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.10.003 · Cited by 82 · see citing works
Self-citation
Differential efficacy of biologic treatments targeting the TNF-α/IL-23/IL-17 axis in psoriasis and psoriatic arthritis
Furue, K., Ito, T., & Furue, M. (2018) · Cytokine · doi:10.1016/j.cyto.2018.08.025 · Cited by 82 · see citing works
Self-citation
Antioxidant soybean tar <scp>G</scp>lyteer rescues <scp>T</scp>‐helper‐mediated downregulation of filaggrin expression via aryl hydrocarbon receptor
Takei, K., Mitoma, C., Hashimoto‐Hachiya, A., Uchi, H., Takahara, M., Tsuji, G., Kido‐Nakahara, M., Nakahara, T., & Furue, M. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12717 · Cited by 81 · see citing works
Self-citation
South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin
Thawer-Esmail, F., Jakaša, I., Todd, G., Wen, Y., Brown, S., Kroboth, K., Campbell, L., O’Regan, G. M., McLean, W. H. I., Irvine, A. D., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.053 · Cited by 79 · see citing works
IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants
Ranasinghe, C., Trivedi, S., Wijesundara, D. K., & Jackson, R. J. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.010 · Cited by 79 · see citing works
Differences in Involucrin Immunolabeling Within Cornified Cell Envelopes in Normal and Psoriatic Epidermis
Ishida‐Yamamoto, A., & Iizuka, H. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12665870 · Cited by 77 · see citing works
An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells
Yasukawa, S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K.-I., Yasuda, T., Natsuaki, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms4755 · Cited by 77 · see citing works
Self-citation
2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro
Ju, Q., Fimmel, S., Hinz, N., Stahlmann, R., Xia, L., & Zouboulis, C. C. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01204.x · Cited by 74 · see citing works
In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification
Pendaries, V., Lamer, M. L., Cau, L., Hansmann, B., Malaisse, J., Kežić, S., Serre, G., & Simon, M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.29 · Cited by 74 · see citing works
2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Differentiation Pattern of Human Keratinocytes in Organotypic Culture
Loertscher, J. A., Sattler, C. A., & Allen‐Hoffmann, B. L. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9202 · Cited by 74 · see citing works
IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases
Mitamura, Y., Nunomura, S., Furue, M., & Izuhara, K. (2020) · Allergology International · doi:10.1016/j.alit.2019.12.003 · Cited by 72 · see citing works
Self-citation
Loricrin: Past, Present, and Future
Ishitsuka, Y., & Roop, D. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072271 · Cited by 71 · see citing works
Efficacy and safety of topical WBI‐1001 in patients with mild to moderate psoriasis: results from a randomized double‐blind placebo‐controlled, phase II trial
Bissonnette, R., Bolduc, C., Maari, C., Nigen, S., Webster, J. M., Tang, L. Y. W., & Lyle, M. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04332.x · Cited by 69 · see citing works
Sharing of receptor subunits and signal transduction pathway between the IL-4 and IL-13 receptor system.
Murata, T., Taguchi, J., Puri, R. K., & Mohri, H. (1999) · PubMed · Cited by 68 · see citing works
Molecular signatures order the potency of topically applied anti-inflammatory drugs in patients with atopic dermatitis
Guttman‐Yassky, E., Ungar, B., Malik, K., Dickstein, D. R., Suprun, M., Estrada, Y. D., Xu, H., Peng, X., Oliva, M., Todd, D., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.01.027 · Cited by 67 · see citing works
Perillaldehyde inhibits AHR signaling and activates NRF2 antioxidant pathway in human keratinocytes
Fuyuno, Y., Uchi, H., Yasumatsu, M., Morino-Koga, S., Tanaka, Y., Mitoma, C., & Furue, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9524657 · Cited by 65 · see citing works
Self-citation
JAK1/3 inhibition preserves epidermal morphology in full‐thickness 3D skin models of atopic dermatitis and psoriasis
Clarysse, K., Pfaff, C. M., Marquardt, Y., Huth, L., Krohn, I. K., Kluwig, D., Lüscher, B., Gutermuth, J., & Baron, J. M. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15301 · Cited by 65 · see citing works
Primary role of barrier dysfunction in the pathogenesis of atopic dermatitis
Elias, P. M. (2018) · Experimental Dermatology · doi:10.1111/exd.13693 · Cited by 64 · see citing works
Translocation of profilaggrin N-terminal domain into keratinocyte nuclei with fragmented DNA in normal human skin and loricrin keratoderma.
Ishida‐Yamamoto, A., Takahashi, H., Presland, R. B., Dale, B. A., & Iizuka, H. (1998) · PubMed · Cited by 62 · see citing works
Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors
Jin, S. H., Choi, D., Chun, Y.-J., & Noh, M. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.08.019 · Cited by 61 · see citing works
The role of the OVOL1–OVOL2 axis in normal and diseased human skin
Tsuji, G., Ito, T., Chiba, T., Mitoma, C., Nakahara, T., Uchi, H., & Furue, M. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.02.005 · Cited by 61 · see citing works
Self-citation
IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis
Miake, S., Tsuji, G., Takemura, M., Hashimoto‐Hachiya, A., Vu, Y. H., Furue, M., & Nakahara, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164053 · Cited by 61 · see citing works
Self-citation
Direct assessment of skin epithelial barrier by electrical impedance spectroscopy
Rinaldi, A. O., Morita, H., Wawrzyniak, P., Dreher, A., Grant, S., Svedenhag, P., & Akdiş, C. A. (2019) · Allergy · doi:10.1111/all.13824 · Cited by 60 · see citing works
In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Accelerated Terminal Differentiation in Fetal Mouse Skin
Loertscher, J. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.2.465 · Cited by 59 · see citing works
Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1
Hashimoto‐Hachiya, A., Tsuji, G., Murai, M., Yan, X., & Furue, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061654 · Cited by 58 · see citing works
Self-citation
Dual Oxidase 1 Induced by Th2 Cytokines Promotes STAT6 Phosphorylation via Oxidative Inactivation of Protein Tyrosine Phosphatase 1B in Human Epidermal Keratinocytes
Hirakawa, S., Saito, R., Ohara, H., Okuyama, R., & Aiba, S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000791 · Cited by 57 · see citing works
Full Sequencing of the FLG Gene in Italian Patients with Atopic Eczema: Evidence of New Mutations, but Lack of an Association
Cascella, R., Cuzzola, V. F., Lepre, T., Galli, E., Moschese, V., Chini, L., Mazzanti, C., Fortugno, P., Novelli, G., & Giardina, E. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.398 · Cited by 57 · see citing works
Additive Effects of Ultraviolet B and Crude Coal Tar on Cutaneous Carcinogen Metabolism: Possible Relevance to the Tumorigenicity of the Goeckerman Regimen
Mukhtar, H., DelTito, B. J., Matgouranis, P. M., Das, M., Asokan, P., & Bickers, D. R. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12524446 · Cited by 56 · see citing works
Skin-infiltrating, interleukin-22–producing T cells differentiate pediatric psoriasis from adult psoriasis
Cordoro, K. M., Hitraya‐Low, M., Taravati, K., Sandoval, P. M., Kim, E., Sugarman, J., Pauli, M. L., Liao, W. J., & Rosenblum, M. D. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.05.017 · Cited by 56 · see citing works
Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells
Tanaka, G., Kanaji, S., Hirano, A., Arima, K., Shinagawa, A., Goda, C., Yasunaga, S., Ikizawa, K., Yanagihara, Y., Kubo, M., et al. (2005) · International Immunology · doi:10.1093/intimm/dxh260 · Cited by 53 · see citing works
Protective role of 6-formylindolo[3,2-b]carbazole (FICZ), an endogenous ligand for arylhydrocarbon receptor, in chronic mite-induced dermatitis
Mari, O. D. A., Uchi, H., Morino‐Koga, S., & Furue, M. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.02.014 · Cited by 53 · see citing works
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C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin
House, J. S., Zhu, S., Ranjan, R., Linder, K. E., & Smart, R. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009837 · Cited by 52 · see citing works
Significant correlation of serum IL-22 levels with CCL17 levels in atopic dermatitis
Hayashida, S., Uchi, H., Takeuchi, S., Esaki, H., Moroi, Y., & Furue, M. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.08.013 · Cited by 52 · see citing works
Self-citation
The Interleukin-20 Cytokines in Intestinal Diseases
Niess, J. H., Hruz, P. L., & Kaymak, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01373 · Cited by 51 · see citing works
Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells
Park, B., Lim, J. W., & Kim, H. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.07.010 · Cited by 51 · see citing works
Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate
Sasaki, T., Furusyo, N., Shiohama, A., Takeuchi, S., Nakahara, T., Uchi, H., Hirota, T., Tamari, M., Shimizu, N., Ebihara, T., et al. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.06.004 · Cited by 50 · see citing works
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Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes
Nakahara, T., Mitoma, C., Hashimoto-Hachiya, A., Takahara, M., Tsuji, G., Uchi, H., Yan, X., Hachisuka, J., Chiba, T., Esaki, H., et al. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3396 · Cited by 49 · see citing works
Self-citation
Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A
Mohamad, J., Sarig, O., Godsel, L. M., Peled, A., Malchin, N., Bochner, R., Vodo, D., Rabinowitz, T., Pavlovsky, M., Taiber, S., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.04.032 · Cited by 49 · see citing works
Chloracne and Hyperpigmentation Caused by Exposure to Hazardous Aryl Hydrocarbon Receptor Ligands
Furue, M., & Tsuji, G. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16234864 · Cited by 49 · see citing works
Self-citation
The S100 proteins in epidermis: Topology and function
Leśniak, W., & Graczyk‐Jarzynka, A. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.09.015 · Cited by 48 · see citing works
Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway
Hirano, A., Goto, M., Mitsui, T., Hashimoto-Hachiya, A., Tsuji, G., & Furue, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091948 · Cited by 48 · see citing works
Self-citation
Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells
Schiering, C., Vonk, A., Das, S., Stockinger, B., & Wincent, E. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.02.031 · Cited by 48 · see citing works
MAP17 is associated with the T‐helper cell cytokine‐induced down‐regulation of filaggrin transcription in human keratinocytes
Noh, M., Yeo, H., Ko, J., Kim, H. K., & Lee, C. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00902.x · Cited by 47 · see citing works
Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression
Sun, D., Yeh, C., So, E. C., Wang, L.-Y., Wei, T.-S., Chang, M., & Hsing, C. (2013) · Cytokine · doi:10.1016/j.cyto.2013.03.017 · Cited by 46 · see citing works
Galactomyces fermentation filtrate prevents T helper 2‐mediated reduction of filaggrin in an aryl hydrocarbon receptor‐dependent manner
Takei, K., Mitoma, C., Hashimoto‐Hachiya, A., Takahara, M., Tsuji, G., Nakahara, T., & Furue, M. (2015) · Clinical and Experimental Dermatology · doi:10.1111/ced.12635 · Cited by 45 · see citing works
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Genetic Variants of the IL22 Promoter Associate to Onset of Psoriasis before Puberty and Increased IL-22 Production in T Cells
Nikamo, P., Cheuk, S., Lysell, J., Enerbäck, C., Bergh, K., Xu, N., Eidsmo, L., & Ståhle, M. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.5 · Cited by 44 · see citing works
Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes
Karim, N., Phinney, B. S., Salemi, M., Wu, P., Naeem, M., & Rice, R. H. (2019) · Experimental Dermatology · doi:10.1111/exd.13925 · Cited by 44 · see citing works
IL‐22‐producing CD4+ T cells: Middle‐men between the immune system and its environment
Trifari, S., & Spits, H. (2010) · European Journal of Immunology · doi:10.1002/eji.201040848 · Cited by 43 · see citing works
Potential role of the OVOL1–OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma
Ito, T., Tsuji, G., Ohno, F., Nakahara, T., Uchi, H., & Furue, M. (2017) · Modern Pathology · doi:10.1038/modpathol.2016.169 · Cited by 43 · see citing works
Self-citation
Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis
Furue, M., Hashimoto‐Hachiya, A., & Tsuji, G. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-3003 · Cited by 43 · see citing works
Self-citation
The Distal and Proximal Regulatory Regions of the Involucrin Gene Promoter have Distinct Functions and Are Required for In Vivo Involucrin Expression
Crish, J. F., Gopalakrishnan, R., Bone, F., Gilliam, A. C., & Eckert, R. L. (2005) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700019 · Cited by 42 · see citing works
Alteration of keratinocyte differentiation and senescence by the tumor promoter dioxin⋆
Ray, S. S. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00277-1 · Cited by 42 · see citing works
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Regulates Epidermal Keratinization under Psoriatic Skin Inflammation
Ogawa, T., Ishitsuka, Y., Inoue, S., Nakamura, Y., Saito, A., Okiyama, N., Fujisawa, Y., Furuta, J., Watanabe, R., & Fujimoto, M. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.10.022 · Cited by 42 · see citing works
Systemic Pharmacokinetics, Safety, and Preliminary Efficacy of Topical AhR Agonist Tapinarof: Results of a Phase 1 Study
Bissonnette, R., Vasist, L., Bullman, J., Collingwood, T. S., Chen, G., & Maeda‐Chubachi, T. (2018) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.439 · Cited by 41 · see citing works
Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes
Ulzii, D., Kido‐Nakahara, M., Nakahara, T., Tsuji, G., Furue, K., Hashimoto‐Hachiya, A., & Furue, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133324 · Cited by 41 · see citing works
Self-citation
Tussilagonone Ameliorates Psoriatic Features in Keratinocytes and Imiquimod-Induced Psoriasis-Like Lesions in Mice via NRF2 Activation
Lee, J., Song, K., Hiebert, P., Werner, S., Kim, T., & Kim, Y. S. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.12.008 · Cited by 41 · see citing works
NRF2 Activation Inhibits Both TGF‐ β 1‐ and IL‐13‐Mediated Periostin Expression in Fibroblasts: Benefit of Cinnamaldehyde for Antifibrotic Treatment
Mitamura, Y., Murai, M., Mitoma, C., & Furue, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2475047 · Cited by 40 · see citing works
Self-citation
Skin barrier damage after exposure to paraphenylenediamine
Meisser, S. S., Altunbulakli, C., Bandier, J., Opstrup, M. S., Castro-Giner, F., Akdiş, M., Bonefeld, C. M., Johansen, J. D., & Akdiş, C. A. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.11.023 · Cited by 40 · see citing works
Implications of IL-13Rα2 in atopic skin inflammation
Furue, M., Ulzii, D., Nakahara, T., Tsuji, G., Furue, K., Hashimoto‐Hachiya, A., & Kido‐Nakahara, M. (2020) · Allergology International · doi:10.1016/j.alit.2020.01.005 · Cited by 40 · see citing works
Self-citation
Role of nuclear factor E2-related factor 2 (Nrf2) in epidermal differentiation
Lee, Y., Shin, J., Jang, S., Choi, D.-K., Seo, M.-S., Kim, H.-R., Sohn, K., Im, M., Seo, Y., Lee, J., et al. (2014) · Archives of Dermatological Research · doi:10.1007/s00403-014-1470-x · Cited by 36 · see citing works
Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis
Takemura, M., Nakahara, T., Hashimoto‐Hachiya, A., Furue, M., & Tsuji, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041169 · Cited by 36 · see citing works
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Health‐care resource use and current treatment of adult atopic dermatitis patients in Japan: A retrospective claims database analysis
Igarashi, A., Fujita, H., Arima, K., Inoue, T., Dorey, J., Fukushima, A., & Taguchi, Y. (2019) · The Journal of Dermatology · doi:10.1111/1346-8138.14947 · Cited by 35 · see citing works
A Novel Role of the NRF2 Transcription Factor in the Regulation of Arsenite-Mediated Keratin 16 Gene Expression in Human Keratinocytes
Endo, H., Sugioka, Y., Nakagi, Y., Saijo, Y., & Yoshida, T. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10696 · Cited by 34 · see citing works
Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype
Trzeciak, M., Sakowicz‐Burkiewicz, M., Wesserling, M., Dobaczewska, D., Gleń, J., Nowicki, R. J., & Pawełczyk, T. (2016) · Acta Dermato Venereologica · doi:10.2340/00015555-2482 · Cited by 33 · see citing works
Phenotypes of atopic dermatitis identified by cluster analysis in early childhood
Seo, E., Yoon, J., Jung, S., Lee, J., Lee, B. H., & Yu, J. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14714 · Cited by 33 · see citing works
IL-17 promotes keratinocyte proliferation via the downregulation of C/EBPα
Ma, W., JIA, K., & Zhang, Y. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2939 · Cited by 32 · see citing works
Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma
Ito, T., Tsuji, G., Ohno, F., Uchi, H., Nakahara, T., Hashimoto‐Hachiya, A., Yoshida, Y., Yamamoto, O., Oda, Y., & Furue, M. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.12.013 · Cited by 31 · see citing works
Self-citation
Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne
Furue, M., Fuyuno, Y., Mitoma, C., Uchi, H., & Tsuji, G. (2018) · Antioxidants · doi:10.3390/antiox7070090 · Cited by 30 · see citing works
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IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway
Lai, X., Li, X., Chang, L., Chen, X., Huang, Z., Bao, H., Huang, J., Yang, L., Wu, X., Wang, Z., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01682 · Cited by 30 · see citing works
Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling
Dao, T. T. P., Song, K., Kim, J. Y., & Kim, Y. S. (2020) · Inflammation Research · doi:10.1007/s00011-020-01322-4 · Cited by 30 · see citing works
Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System
Tanaka, Y., Ito, T., Tsuji, G., & Furue, M. (2020) · Antioxidants · doi:10.3390/antiox9060507 · Cited by 30 · see citing works
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Filaggrin loss‐of‐function mutations and levels of filaggrin degradation products in adult patients with atopic dermatitis in Croatia
Tončić, R. J., Kežić, S., Jakaša, I., Hadžavdić, S. L., Balić, A., Petković, M., Pavičić, B., Zuzul, K., & Marinović, B. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16232 · Cited by 29 · see citing works
Non-invasive evaluation of atopic dermatitis based on redox status using in vivo dynamic nuclear polarization magnetic resonance imaging
Eto, H., Tsuji, G., Chiba, T., Furue, M., & Hyodo, F. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.043 · Cited by 28 · see citing works
Self-citation
Long‐term clinical efficacy and safety of secukinumab for Japanese patients with psoriasis: A single‐center experience
Momose, M., Asahina, A., Umezawa, Y., & Nakagawa, H. (2017) · The Journal of Dermatology · doi:10.1111/1346-8138.14145 · Cited by 28 · see citing works
Recent Positive Selection in Genes of the Mammalian Epidermal Differentiation Complex Locus
Goodwin, Z. A., & Strong, C. D. G. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2016.00227 · Cited by 27 · see citing works
Microbiome analysis of forehead skin in patients with atopic dermatitis and healthy subjects: Implication of Staphylococcus and Corynebacterium
Furue, M., Iida, K., Imaji, M., & Nakahara, T. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14486 · Cited by 27 · see citing works
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Measurement of trihydroxy-linoleic acids in stratum corneum by tape-stripping: Possible biomarker of barrier function in atopic dermatitis
Chiba, T., Nakahara, T., Kohda, F., Ichiki, T., Manabe, M., & Furue, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210013 · Cited by 27 · see citing works
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Current skin symptoms of Yusho patients exposed to high levels of 2,3,4,7,8-pentachlorinated dibenzofuran and polychlorinated biphenyls in 1968
Mitoma, C., Mine, Y., Utani, A., Imafuku, S., Muto, M., Akimoto, T., Kanekura, T., Furue, M., & Uchi, H. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.03.070 · Cited by 25 · see citing works
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Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis
Fang, Z., Pan, T., Li, L., Wang, H., Zhu, J., Zhang, H., Zhao, J., Chen, W., & Lu, W. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2044723 · Cited by 273 · see citing works
Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review
Fang, Z., Li, L., Zhang, H., Zhao, J., Lu, W., & Chen, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720393 · Cited by 200 · see citing works
Particulate matter causes skin barrier dysfunction.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., et al. (2021) · JCI insight · doi:10.1172/jci.insight.145185 · Cited by 173 · see citing works
“barrier proteins such as FLG and LOR (42, 56).”
BackgroundInfluential
Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13/IL-4‒JAK‒STAT6/STAT3 Axis: Pathogenic and Therapeutic Implications in Atopic Dermatitis
Furue, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113741 · Cited by 157 · see citing works
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miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation
Jiao, P., Wang, X.-P., Luoreng, Z.-M., Yang, J., Jia, L., Ma, Y., & Wei, D.-W. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59876 · Cited by 151 · see citing works
Basics and recent advances in the pathophysiology of atopic dermatitis
Nakahara, T., Kido‐Nakahara, M., Tsuji, G., & Furue, M. (2020) · The Journal of Dermatology · doi:10.1111/1346-8138.15664 · Cited by 135 · see citing works
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Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation
Fernández‐Gallego, N., Sánchez‐Madrid, F., & Cibrián, D. (2021) · Cells · doi:10.3390/cells10113176 · Cited by 135 · see citing works
Multiple roles for cytokines in atopic dermatitis: from pathogenic mediators to endotype-specific biomarkers to therapeutic targets
Fania, L., Moretta, G., Antonelli, F., Scala, E., Abeni, D., Albanesi, C., & Madonna, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052684 · Cited by 128 · see citing works
Basic mechanisms of itch
Misery, L., Pierre, O., Gall‐Ianotto, C. L., Lebonvallet, N., Chernyshov, P. V., Garrec, R. L., & Talagas, M. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.05.004 · Cited by 121 · see citing works
Environmental Air Pollutants Affecting Skin Functions with Systemic Implications
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310502 · Cited by 94 · see citing works
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Phelps, C. M., Willis, N. B., Duan, T., Lee, A. H., Zhang, Y., Rodriguez J, D. M., Pandey, S. P., Laughlin, C. R., Rosen, A. B. I., McPherson, A. C., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.018 · Cited by 91 · see citing works
Current and Emerging Strategies to Inhibit Type 2 Inflammation in Atopic Dermatitis
Haddad, E., Cyr, S. L., Arima, K., McDonald, R. A., Levit, N. A., & Nestle, F. O. (2022) · Dermatology and Therapy · doi:10.1007/s13555-022-00737-7 · Cited by 91 · see citing works
An Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis Human Skin Equivalent Model by a Skin-On-A-Chip
Kim, K., Kim, H., & Sung, G. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042116 · Cited by 77 · see citing works
Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis
Humeau, M., Boniface, K., & Bodet, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.801579 · Cited by 75 · see citing works
Interplay of cytokines in the pathophysiology of atopic dermatitis: insights from Murin models and human
Yamamura, Y., Nakashima, C., & Otsuka, A. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1342176 · Cited by 73 · see citing works
What’s New in Topicals for Atopic Dermatitis?
Kleinman, E. P., Laborada, J., Metterle, L., & Eichenfield, L. F. (2022) · American Journal of Clinical Dermatology · doi:10.1007/s40257-022-00712-0 · Cited by 72 · see citing works
Nano intervention in topical delivery of corticosteroid for psoriasis and atopic dermatitis—a systematic review
Shetty, K., & Sherje, A. P. (2021) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-021-06558-y · Cited by 65 · see citing works
Role of Basophils in a Broad Spectrum of Disorders
Miyake, K., Ito, J., & Karasuyama, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.902494 · Cited by 65 · see citing works
Limosilactobacillus reuteri Attenuates Atopic Dermatitis via Changes in Gut Bacteria and Indole Derivatives from Tryptophan Metabolism
Fang, Z., Pan, T., Wang, H., Zhu, J., Zhang, H., Zhao, J., Chen, W., & Lu, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147735 · Cited by 65 · see citing works
Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives
Borgia, F., Pomi, F. L., Vaccaro, M., Alessandrello, C., Papa, V., & Gangemi, S. (2022) · Biomolecules · doi:10.3390/biom12121904 · Cited by 63 · see citing works
Immunopathogenesis of Atopic Dermatitis: Focus on Interleukins as Disease Drivers and Therapeutic Targets for Novel Treatments
Makowska, K., Nowaczyk, J., Blicharz, L., Waśkiel-Burnat, A., Czuwara, J., Olszewska, M., & Rudnicka, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010781 · Cited by 63 · see citing works
Oxidative stress affects the beginning of the growth of cancer cells through a variety of routes
Saleh, E. A. M., Al-dolaimy, F., Almajidi, Y. Q., Baymakov, S. R., Mohammed Abdul Kader, M., Ullah, M. I., Abbas, A., Khlewee, I. H., Bisht, Y. S., & Alsaalamy, A. H. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154664 · Cited by 61 · see citing works
Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases
Napolitano, M., Fabbrocini, G., Martora, F., Picone, V., Morelli, P., & Patruno, C. (2021) · Cells · doi:10.3390/cells10123559 · Cited by 58 · see citing works
Cytokines and Epidermal Lipid Abnormalities in Atopic Dermatitis: A Systematic Review
Upadhyay, P. R., Seminario‐Vidal, L., Abe, B. T., Ghobadi, C., & Sims, J. T. (2023) · Cells · doi:10.3390/cells12242793 · Cited by 58 · see citing works
TSLP Impairs Epidermal Barrier Integrity by Stimulating the Formation of Nuclear IL-33/Phosphorylated STAT3 Complex in Human Keratinocytes
Dai, X., Muto, J., Shiraishi, K., Utsunomiya, R., Mori, H., Murakami, M., & Sayama, K. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.01.005 · Cited by 53 · see citing works
Keratinocytes: new perspectives in inflammatory skin diseases
Ye, J., & Lai, Y. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.03.012 · Cited by 53 · see citing works
Novel pathogenesis of atopic dermatitis from the view of cytokines in mice and humans
Nakajima, S., Tie, D., Nomura, T., & Kabashima, K. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155664 · Cited by 52 · see citing works
New Treatments for Atopic Dermatitis Targeting Skin Barrier Repair via the Regulation of FLG Expression
Dębińska, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112506 · Cited by 52 · see citing works
Age of onset defines two distinct profiles of atopic dermatitis in adults
Facheris, P., da Rosa, J. C., Pagan, A. D., Angelov, M., DUCA, E. D., Rabinowitz, G., Gómez‐Arias, P. J., Rothenberg‐Lausell, C., Estrada, Y. D., Bose, S. N., et al. (2023) · Allergy · doi:10.1111/all.15741 · Cited by 51 · see citing works
Immunological Aspects of Skin Aging in Atopic Dermatitis
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115729 · Cited by 50 · see citing works
“Outside-to-inside,” “inside-to-outside,” and “intrinsic” endogenous pathogenic mechanisms in atopic dermatitis: keratinocytes as the key functional cells involved in both permeability barrier dysfunction and immunological alterations
Hatano, Y., & Elias, P. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1239251 · Cited by 50 · see citing works
Skin as the target for allergy prevention and treatment
Marques‐Mejias, A., Bartha, I., Ciaccio, C. E., Chinthrajah, R. S., Chan, S., Hershey, G. K. K., Hui-Beckman, J. W., Kost, L. E., Lack, G., Layhadi, J. A., et al. (2024) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.12.030 · Cited by 50 · see citing works
Recent advances on application of polysaccharides in cosmetics
Wu, Q., Cheng, N., Fang, D., Wang, H., Rahman, F., Hao, H., & Zhang, Y. (2024) · Journal of Dermatologic Science and Cosmetic Technology · doi:10.1016/j.jdsct.2024.100004 · Cited by 49 · see citing works
Skin barrier-inflammatory pathway is a driver of the psoriasis-atopic dermatitis transition
Dong, S., Li, D., & Shi, D. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1335551 · Cited by 49 · see citing works
The evolving landscape of biologic therapies for atopic dermatitis: Present and future perspective
David, E., Ungar, B., Renert‐Yuval, Y., Facheris, P., DUCA, E. D., & Guttman‐Yassky, E. (2023) · Clinical & Experimental Allergy · doi:10.1111/cea.14263 · Cited by 48 · see citing works
Staphylococcus epidermidis isolates from atopic or healthy skin have opposite effect on skin cells: potential implication of the AHR pathway modulation
Landemaine, L., Costa, G. D., Fissier, E., Francis, C., Morand, S. C., Verbeke, J., Michel, M., Briandet, R., Sokol, H., Guéniche, A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098160 · Cited by 48 · see citing works
Gut microbiota and skin pathologies: Mechanism of the gut-skin axis in atopic dermatitis and psoriasis
Chen, M., Wang, R., & Wang, T. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112658 · Cited by 48 · see citing works
Aryl hydrocarbon receptor/nuclear factor E2‐related factor 2 (AHR/NRF2) signalling: A novel therapeutic target for atopic dermatitis
Hwang, J., Newton, E. M., Hsiao, J. L., & Shi, V. Y. (2022) · Experimental Dermatology · doi:10.1111/exd.14541 · Cited by 47 · see citing works
Skin Care Product Rich in Antioxidants and Anti-Inflammatory Natural Compounds Reduces Itching and Inflammation in the Skin of Atopic Dermatitis Patients
Zhang, Y., Heinemann, N., Rademacher, F., Darvin, M. E., Raab, C., Keck, C. M., Vollert, H., Fluhr, J. W., Gläser, R., Harder, J., et al. (2022) · Antioxidants · doi:10.3390/antiox11061071 · Cited by 46 · see citing works
Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis
Koch, M., Kockmann, T., Rodríguez, E., Wehkamp, U., Hiebert, P., Greenwald, M. B., Stölzl, D., Beer, H., Tschachler, E., Weidinger, S., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.08.048 · Cited by 42 · see citing works
Tapinarof for psoriasis and atopic dermatitis: 15 years of clinical research
Bissonnette, R., Proulx, É. S., Jack, C. S., & Maari, C. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18925 · Cited by 41 · see citing works
The role of NRF2 transcription factor in inflammatory skin diseases
Salman, S., Paulet, V., Hardonnière, K., & Kerdine‐Römer, S. (2025) · BioFactors · doi:10.1002/biof.70013 · Cited by 37 · see citing works
Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin
Konger, R. L., Derr-Yellin, E. C., Zimmers, T. A., Katona, T. M., Xuei, X., Liu, Y., Zhou, H., Simpson, E. R., & Turner, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168634 · Cited by 36 · see citing works
Immunosenescence and Skin: A State of Art of Its Etiopathogenetic Role and Crucial Watershed for Systemic Implications
Papa, V., Pomi, F. L., Borgia, F., Vaccaro, M., Pioggia, G., & Gangemi, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097956 · Cited by 36 · see citing works
Exploring the potential of Halomonas levan and its derivatives as active ingredients in cosmeceutical and skin regenerating formulations
Erginer, M., Gökalsın, B., Tornacı, S., Sesal, C., & Öner, E. T. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124418 · Cited by 35 · see citing works
Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients
Lang, C. C. V., Renert‐Yuval, Y., DUCA, E. D., Pavel, A. B., Wu, J., Zhang, N., Dubin, C., Obi, A., Chowdhoury, M., Kim, M., et al. (2021) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2021.04.023 · Cited by 35 · see citing works
Mesenchymal Stem Cells and Extracellular Vesicles Derived from Canine Adipose Tissue Ameliorates Inflammation, Skin Barrier Function and Pruritus by Reducing JAK/STAT Signaling in Atopic Dermatitis
Kim, S. Y., Yoon, T. H., Na, J., Yi, S. J., Jin, Y., Kim, M., Oh, T., & Chung, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094868 · Cited by 34 · see citing works
Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis
Tanei, R., & Hasegawa, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126682 · Cited by 33 · see citing works
Benvitimod Inhibits IL-4– and IL-13–Induced Tight Junction Impairment by Activating AHR/ARNT Pathway and Inhibiting STAT6 Phosphorylation in Human Keratinocytes
Wang, X., Mao, D., Jia, J., & Zhang, J. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.07.027 · Cited by 33 · see citing works
Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress–activated NF-κB pathway
Wang, P., Hu, G., Zhao, W., Du, J., You, M., Xv, M., Yang, H. Y., Zhang, M., Yan, F., Huang, M., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01308-w · Cited by 33 · see citing works
Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
Focken, J., Scheurer, J., Jäger, A., Schürch, C. M., Kämereit, S., Riel, S., Schaller, M., Weigelin, B., & Schittek, B. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113148 · Cited by 32 · see citing works
Cutaneous Components Leading to Pruritus, Pain, and Neurosensitivity in Atopic Dermatitis: A Narrative Review
Ständer, S., Luger, T. A., Kim, B., Lerner, E. A., Metz, M., Adiri, R., Canosa, J. M., Cha, A., & Yosipovitch, G. (2024) · Dermatology and Therapy · doi:10.1007/s13555-023-01081-0 · Cited by 31 · see citing works
Fermented blueberry and black rice containing Lactobacillus plantarum MG4221: a novel functional food for particulate matter (PM 2.5 )/dinitrochlorobenzene (DNCB)-induced atopic dermatitis
Hong, S. M., Kang, M. C., Jin, M., Lee, T. H., Lim, B. O., & Kim, S. Y. (2021) · Food & Function · doi:10.1039/d0fo02966a · Cited by 31 · see citing works
Managing Atopic Dermatitis with Lebrikizumab – The Evidence to Date
Labib, A., Ju, T., & Yosipovitch, G. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s295672 · Cited by 31 · see citing works
Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair—Facts and Challenges
Dębińska, A., & Sozańska, B. (2023) · Nutrients · doi:10.3390/nu15051070 · Cited by 31 · see citing works
Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis
Xiao, S., Lu, Z., Steinhoff, M. S., Li, Y., Buhl, T., Fischer, M. J. M., Chen, W., Cheng, W., Zhu, R., Yan, X., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.211 · Cited by 30 · see citing works
Crosstalk between keratinocytes and immune cells in inflammatory skin diseases
Ni, X., & Lai, Y. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00028 · Cited by 30 · see citing works
Novel Therapeutic Targets for the Treatment of Atopic Dermatitis
Tsuji, G., Yamamura, K., Kawamura, K., Kido‐Nakahara, M., Ito, T., & Nakahara, T. (2023) · Biomedicines · doi:10.3390/biomedicines11051303 · Cited by 30 · see citing works
New Perspectives in the Management of Chronic Hand Eczema: Lessons from Pathogenesis
Tancredi, V., Buononato, D., Caccavale, S., Brizzi, E. V. D., Caprio, R. D., Argenziano, G., & Balato, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010362 · Cited by 29 · see citing works
Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models.
Kim, E., Hong, S., Kim, J., Kim, M. S., Lee, Y., Sohn, Y., & Jung, H. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114453 · Cited by 29 · see citing works
Bifidobacterium infantis strain YLGB ‐1496 possesses excellent antioxidant and skin barrier‐enhancing efficacy in vitro
Ma, X., Pan, Y., Zhao, W. H., Sun, P., Zhao, J., Yan, S., Wang, R., Han, Y., Liu, W., Tan, S., et al. (2022) · Experimental Dermatology · doi:10.1111/exd.14583 · Cited by 29 · see citing works
Wound healing activity of aqueous dispersion of fullerene C60 produced by “green technology”
Shershakova, N. N., Михайлович, А. С., Tomchuk, A. A., Makarova, E., Nikonova, A. A., Turetskiy, E. A., Андреевна, П. О., Kamyshnikov, O., Ivankov, O. I., Kyzyma, O. A., et al. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102619 · Cited by 29 · see citing works
Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling
Brusilovsky, M., Rochman, M., Shoda, T., Kotliar, M., Caldwell, J. M., Mack, L. E., Besse, J. A., Chen, X., Weirauch, M. T., Barski, A., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327276 · Cited by 28 · see citing works
Atopic Dermatitis and Psoriasis: Similarities and Differences in Metabolism and Microbiome
Chen, Y., Peng, C., Zhu, L., Wang, J., Cao, Q., Chen, X., & Li, J. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08995-3 · Cited by 27 · see citing works
Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dinitrochlorobenzene-Induced NC/Nga Mice
Oh, J.-S., Lee, S.-J., & Choung, S. (2021) · Nutrients · doi:10.3390/nu13093209 · Cited by 27 · see citing works
A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside
Radi, G., Campanati, A., Diotallevi, F., Martina, E., Marani, A., & Offidani, A. (2022) · Biomedicines · doi:10.3390/biomedicines10112700 · Cited by 27 · see citing works
Polycyclic aromatic hydrocarbons in bone homeostasis
Ye, Q., Xi, X., Fan, D., Cao, X., Wang, Q., Wang, X., Zhang, M., Wang, B., Tao, Q., & Xiao, C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112547 · Cited by 26 · see citing works
Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions
Gu, Q., Lin, J., Lü, X., Chen, T., Yunyang, W., & Yang, Y. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115428 · Cited by 26 · see citing works
NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products
Frantz, M., Rozot, R., & Marrot, L. (2022) · BioFactors · doi:10.1002/biof.1907 · Cited by 26 · see citing works
Interactions between Malassezia and New Therapeutic Agents in Atopic Dermatitis Affecting Skin Barrier and Inflammation in Recombinant Human Epidermis Model
Lee, Y. J., Yassa, C., Park, S.-H., Song, S. W., Jung, W. H., Lee, Y. W., Kang, H., & Kim, J. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076171 · Cited by 26 · see citing works
MiR-1294 suppresses ROS-dependent inflammatory response in atopic dermatitis via restraining STAT3/NF-κB pathway
Yan, C., Ying, J., Wang, L., Changzhi, Y., Qian, Q., Jingzhu, M., Dongjie, S., & Tingting, Z. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104452 · Cited by 26 · see citing works
Targeting mitochondrial dysfunction in atopic dermatitis with trilinolein: A triacylglycerol from the medicinal plant Cannabis fructus
Wang, Y., Lu, H., Cheng, L., Guo, W., Hu, Y., Du, X., Liu, X., Xu, M., Liu, Y., Zhang, Y., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155856 · Cited by 25 · see citing works
3-Bromo-4,5-dihydroxybenzaldehyde Isolated from Polysiphonia morrowii Suppresses TNF-α/IFN-γ-Stimulated Inflammation and Deterioration of Skin Barrier in HaCaT Keratinocytes
Jayasinghe, A. M. K., Han, E. J., Kirindage, K. G. I. S., Fernando, I. P. S., Kim, E.-A. L., Kim, J., Jung, K., Kim, K., Heo, S., & Ahn, G. (2022) · Marine Drugs · doi:10.3390/md20090563 · Cited by 25 · see citing works
Dupilumab Alters Both the Bacterial and Fungal Skin Microbiomes of Patients with Atopic Dermatitis
Umemoto, N., Kakurai, M., Matsumoto, T., Mizuno, K., Cho, O., Sugita, T., & Demitsu, T. (2024) · Microorganisms · doi:10.3390/microorganisms12010224 · Cited by 24 · see citing works
Deacetylasperulosidic Acid Ameliorates Pruritus, Immune Imbalance, and Skin Barrier Dysfunction in 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis NC/Nga Mice
Oh, J.-S., Seong, G.-S., Kim, Y. D., & Choung, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010226 · Cited by 24 · see citing works
Biologic and small-molecule therapy for treating moderate to severe atopic dermatitis: Mechanistic considerations
Rothenberg‐Lausell, C., Bar, J., Dahabreh, D., Renert‐Yuval, Y., DUCA, E. D., & Guttman‐Yassky, E. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.04.009 · Cited by 24 · see citing works
The Central Role of Th2 Immune Response in Inflammatory Dermatoses: From Pathogenesis to Targeted Therapies
Pala, V., Rosset, F., Mastorino, L., Sciamarrelli, N., Boskovic, S., Borriello, S., Bongiovanni, E., Crespi, O., Ribero, S., & Quaglino, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110720 · Cited by 23 · see citing works
Expression of barrier proteins in the skin lesions and inflammatory cytokines in peripheral blood mononuclear cells of atopic dogs
Kanwal, S., Singh, S. K., Soman, S. P., Choudhury, S., Kumari, P., Ram, P. K., & Garg, S. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-90992-z · Cited by 23 · see citing works
Huanglian ointment alleviates eczema by maintaining the balance of c-Jun and JunB and inhibiting AGE-RAGE-mediated pro-inflammation signaling pathway
Wang, S., Wang, Y., Han, B., Chen, Y., Bai, X., Yu, S., & Liu, M. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154372 · Cited by 23 · see citing works
Potential Therapeutic Skin Microbiomes Suppressing Staphylococcus aureus-Derived Immune Responses and Upregulating Skin Barrier Function-Related Genes via the AhR Signaling Pathway
Lee, E., Min, K., Ahn, H., Jeon, B., Park, S., Yun, C., Jeon, H., Yeon, J.-S., Kim, H., & Park, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179551 · Cited by 23 · see citing works
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Lie, E., Choi, M., Wang, S., & Eichenfield, L. F. (2023) · Pediatric Drugs · doi:10.1007/s40272-023-00592-9 · Cited by 23 · see citing works
Electrical Impedance Spectroscopy Quantifies Skin Barrier Function in Organotypic In Vitro Epidermis Models
van den Brink, N. J. M., Pardow, F., Meesters, L. D., van Vlijmen‐Willems, I. M. J. J., Rodijk‐Olthuis, D., Niehues, H., Jansen, P. A. M., Roelofs, S. H., Brewer, M. G., van den Bogaard, E. H. J., et al. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.03.038 · Cited by 22 · see citing works
Staphylococcus Infection: Relapsing Atopic Dermatitis and Microbial Restoration
Hulme, J. (2023) · Antibiotics · doi:10.3390/antibiotics12020222 · Cited by 22 · see citing works
The impact of dupilumab on skin barrier function: A systematic review
Montero‐Vílchez, T., la Torre, R. S.-D., Sánchez‐Díaz, M., Ureña‐Paniego, C., Molina‐Leyva, A., & Arias‐Santiago, S. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19081 · Cited by 22 · see citing works
Regulatory mechanism of the IL-33-IL-37 axis via aryl hydrocarbon receptor in atopic dermatitis and psoriasis
Tsuji, G., Yamamura, K., Kawamura, K., Kido-Nakahara, M., Ito, T., & Nakahara, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914633 · Cited by 21 · see citing works
Gamma‐delta ( γδ ) T cell‐derived cytokines ( IL ‐4, IL ‐17, IFN ‐γ and IL ‐10) and their possible implications for atopic dermatitis development
Fagundes, B. O., de Sousa, T. R., & Victor, J. R. (2022) · International Journal of Dermatology · doi:10.1111/ijd.16364 · Cited by 21 · see citing works
Secretome of human umbilical cord mesenchymal stem cell maintains skin homeostasis by regulating multiple skin physiological function
Wang, X., Wang, Q., Yin, P., Chen, L., Zhao, X., Wen, D., & Tan, Y. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03697-8 · Cited by 21 · see citing works
Cell-Based Model Systems for Validation of Various Efficacy-Based Claims for Cosmetic Ingredients
Singh, P., Bhat, S. S., Singh, N. K., Venkanna, B. U., Rafiq, M., & Rao, R. P. (2022) · Cosmetics · doi:10.3390/cosmetics9050107 · Cited by 21 · see citing works
Effects of Dupilumab on Itch-Related Events in Atopic Dermatitis: Implications for Assessing Treatment Efficacy in Clinical Practice
Kishi, R., Toyama, S., Tominaga, M., Kamata, Y., Komiya, E., Kaneko, T., Suga, Y., & Takamori, K. (2023) · Cells · doi:10.3390/cells12020239 · Cited by 21 · see citing works
Exosomes derived from human dermal fibroblasts ( HDFn‐Ex ) alleviate DNCB ‐induced atopic dermatitis (AD) via PPARα
Jang, Y. N., Lee, J. O., Lee, J. M., Park, A. Y., Kim, Y. J., Kim, S., Seok, J., Yoo, K. H., & Kim, B. J. (2023) · Experimental Dermatology · doi:10.1111/exd.14970 · Cited by 21 · see citing works
Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection
Janjetović, Z., & Slominski, A. T. (2024) · Cosmetics · doi:10.3390/cosmetics11020037 · Cited by 21 · see citing works
Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes
Yan, X., Tsuji, G., Hashimoto-Hachiya, A., & Furue, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216338 · Cited by 20 · see citing works
Self-citation
Mast cell–neuron axis as a core mechanism in chronic pruritus of atopic dermatitis: from mechanistic insights to therapeutic targets
Li, D., Han, Y., Zhou, J., Yang, H., Chen, J., Tey, H. L., & Tan, T. T. Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1645095 · Cited by 20 · see citing works
Anti-Inflammatory Effects of Metabolites from Antarctic Fungal Strain Pleosporales sp. SF-7343 in HaCaT Human Keratinocytes
Dong, L., Kim, H. J., Cao, T. Q., Liu, Z., Lee, H., Ko, W., Kim, Y., Sohn, J. H., Kim, T. K., Yim, J. H., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189674 · Cited by 20 · see citing works
Identification of Potential Key Biomarkers and Immune Infiltration in Oral Lichen Planus
Geng, L., Zhang, X., Tang, Y., & Gu, W. (2022) · Disease Markers · doi:10.1155/2022/7386895 · Cited by 20 · see citing works
The contribution of mouse models to understanding atopic dermatitis
Sanjel, B., & Shim, W. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115177 · Cited by 20 · see citing works
Screening and Research on Skin Barrier Damage Protective Efficacy of Different Mannosylerythritol Lipids
Jing, C., Guo, J., Li, Z., Xu, X., Wang, J., Zhai, L., Liu, J., Sun, G. W., Wang, F., Xu, Y., et al. (2022) · Molecules · doi:10.3390/molecules27144648 · Cited by 20 · see citing works
Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis
Huang, Y., Chen, L., Liu, F., Xiong, X., Ouyang, Y., & Deng, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1300378 · Cited by 20 · see citing works
Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic Dermatitis
Chiocchetti, R., Silva, M. D., Aspidi, F., Cunha, R. Z., Gobbo, F., Tagliavia, C., Sarli, G., & Morini, M. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.915896 · Cited by 20 · see citing works
From Gut Dysbiosis to Skin Inflammation in Atopic Dermatitis: Probiotics and the Gut–Skin Axis—Clinical Outcomes and Microbiome Implications
Micu, A. E., Popescu, I. A., Halip, I. A., Mocanu, M., Vâță, D., Hulubencu, A. L., Gheuca-Solovastru, D. F., & Solovăstru, L. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010365 · Cited by 19 · see citing works

Regulation of Skin Barrier Function via Competition between AHR Axis versus IL-13/IL-4‒JAK‒STAT6/STAT3 Axis: Pathogenic and Therapeutic Implications in Atopic Dermatitis
Furue, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113741 · Cited by 157 · see citing works
Self-citation
Crosstalk between Aryl Hydrocarbon Receptor (AHR) Pathway and IL-13 Signaling in Human Keratinocytes and Implications for Atopic Dermatitis
Proper, S. A., Appiagyei, A., Dwyer, A. T., Felton, J. M., Morgenstern, N. B.-B., Marlman, J. M., Kotliar, M., Barski, A., Troutman, T. D., Rothenberg, M. E., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.12.600 · Cited by 1 · see citing works
Reversine enhances skin barrier functions by suppressing the IL-4- and IL-13-mediated STAT6 pathway
Park, Y., Jung, J., Jeong, S., van Ee, A., Garza, L. A., Jang, M., Kim, D., & Park, J. (2023) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2023.06.006 · Cited by 4 · see citing works
Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis
Proper, S. P., Dwyer, A. T., Appiagyei, A., Felton, J. M., Morgenstern, N. B.-B., Marlman, J. M., Kotliar, M., Barski, A., Troutman, T. D., Rothenberg, M. E., et al. (2024) · Frontiers in Allergy · doi:10.3389/falgy.2024.1323405 · Cited by 17 · see citing works
IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis
Vu, Y. H., Hashimoto‐Hachiya, A., Takemura, M., Yumine, A., Mitamura, Y., Nakahara, T., Furue, M., & Tsuji, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249412 · Cited by 51 · see citing works
Self-citation

Authors: Furue, M.
Affiliations: Kyushu University (JP)
Corresponding author: Furue, Masutaka
ORCID: Furue, Masutaka
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2020-07-29
Volume: 21
Issue: 15
Pages: 5382
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms21155382
PMC: PMC7432778
OpenAlex: W3046068546
Cited by: 419
References: 231
Citations by year: 2026: 83 · 2025: 82 · 2024: 81 · 2023: 74 · 2022: 64 · 2021: 32 · 2020: 2
FWCI: 7.19
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Ministry of Health, Labour and Welfare (H30-Shokuhin-Shitei-005)
Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (C, FAG0K08692)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords: atopic dermatitis, filaggrin, loricrin, involucrin, skin barrier dysfunction, IL-4, IL-13, IL-17A, IL-22, aryl hydrocarbon receptor, Nrf2, STAT6, STAT3, oxidative stress, coal tar, tapinarof, AhR agonists
MeSH terms: Filaggrin Proteins, Interleukin-22, Antioxidants, Coal Tar, Dermatitis, Atopic, Gene Expression Regulation, Humans, Interleukins, Membrane Proteins, S100 Proteins, Protein Precursors, Resorcinols, Skin, Stilbenes, Tars, Signal Transduction, Interleukin-4, Receptors, Aryl Hydrocarbon, Oxidative Stress, Interleukin-13, Interleukin-17, STAT3 Transcription Factor, STAT6 Transcription Factor, NF-E2-Related Factor 2, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins

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Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

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