Actinic keratosis in the en-face and slice imaging mode of high-definition optical coherence tomography and comparison with histology: Actinic keratosis in high-definition optical coherence tomography
Abstract
BACKGROUND: Optical coherence tomography (OCT) allows real-time, in vivo examination of nonmelanoma skin cancer. An innovative high-definition (HD)-OCT with a horizontal (en-face) and vertical (slice) imaging mode offers additional information in the diagnosis of actinic keratosis (AK) and may potentially replace invasive diagnostic biopsies. OBJECTIVES: To define the characteristic morphological features of AK by using HD-OCT in the two imaging modes compared with histopathology as gold standard. METHODS: In total, 20 AKs were examined by HD-OCT in the en-face and slice imaging modes and characteristic features were described and evaluated in comparison with the histopathological findings. Furthermore, the HD-OCT images of a subgroup of AKs were compared with those of the clinically normal adjacent skin. RESULTS: The preoperative in vivo diagnostics showed the following features in the en-face imaging mode of HD-OCT: disruption of stratum corneum, architectural disarray, cellular/nuclear polymorphism in the stratum granulosum/stratum spinosum, and bright irregular bundles in the superficial dermis. In the vertical slice imaging mode the following characteristics were found: irregular entrance signal, destruction of layering, white streaks and dots, and grey areas. In contrast, the clinically healthy adjacent skin showed mainly a regular epidermal 'honeycomb' pattern in the en-face mode and distinct layering of the skin in the slice mode. CONCLUSIONS: HD-OCT with both the en-face and slice imaging modes offers additional information in the diagnosis of AK compared with conventional OCT and might enhance the possibility of the noninvasive diagnosis of AK prior to treatment procedures and possibly in the monitoring of noninvasive treatment strategies.
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OCT has been shown to accurately image the development of actinic keratosis (AK) in patients of FST I-III.
“Although OCT has been shown to accurately image the development of actinic keratosis (AK), a precursor to squamous cell carcinoma (SCC), in patients of FST I–III”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [104]
The majority of studies on OCT imaging of AK do not mention skin color, likely due to the perception that AK only affects people with light skin.
“the majority of studies do not mention skin color and this is likely due to the perception that AK only affects people with light skin.99–104”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [104]
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- Authors
- Maier, T., Braun-Falco, M., Laubender, R. P., Ruzicka, T., & Berking, C.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Maier, T.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10-05
- Volume
- 168
- Issue
- 1
- Pages
- 120-128
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W2104944775
- Cited by
- 57
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 14 · 2014: 8 · 2013: 6 · 2012: 2
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Keywords
- actinic keratosis, high-definition optical coherence tomography, en face imaging, slice imaging, non-melanoma skin cancer, non-invasive diagnosis, histopathological correlation, stratum corneum disruption
- MeSH terms
- Aged, Aged, 80 and over, Biopsy, Face, Facial Neoplasms, Female, Humans, Male, Middle Aged, Tomography, Optical Coherence, Keratosis, Actinic
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