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Cited by 163

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Long‐term outcome results of the first tandem autotransplant trial for multiple myeloma

Barlogie, Bart, Tricot, Guido J., Van Rhee, Frits, Angtuaco, Edguardo, Walker, Ron, Epstein, Joshua, Shaughnessy, John D., Jagannath, Sundar, Bolejack, Vanessa, Gurley, Jennifer, Hoering, Antje, Vesole, David, Desikan, Raman, Siegel, David, Mehta, Jayesh, Singhal, Seema, Munshi, Nikhil C., Dhodapkar, Madhav, Jenkins, Bonnie, Attal, Michel, Harousseau, Jean‐Luc, Crowley, John·2006·British Journal of Haematology
DOI 10.1111/j.1365-2141.2006.06271.x
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Abstract

Summary: Total Therapy 1, the first tandem autotransplant trial for newly diagnosed patients with multiple myeloma, was designed to increase the frequency of complete response (CR) and thereby extend survival. With a median follow‐up of 12 years, 62 of 231 initially enrolled patients are alive (17% at 15 years); 31 remain event free (7% at 15 years) including 16 of 94 (41%) that initially achieved CR. Currently alive patients less frequently had cytogenetic abnormalities (CAs) at baseline (P = 0·002), postenrolment (P < 0·001) and at relapse (P = 0·004); elevations of serum C‐reactive protein (CRP) (P = 0·003) and lactate dehydrogenase (P = 0·029), anaemia (P = 0·029) and they more often completed two transplants within 12 months (P = 0·019). Postenrolment overall survival (OS) and event‐free survival (EFS) were superior in the absence of CA of the hypodiploidy or deletion 13 variety (P < 0·001 and 0·037 respectively) and in the presence of low CRP at baseline (P = 0·001 and 0·017 respectively). Postrelapse survival was longer in the absence of CA at relapse (P < 0·001), IgA isotype (P = 0·002), International Staging System stage 3 (P = 0·014), and when patients had two protocol transplants prior to relapse (P = 0·038). Ten‐year EFS and OS could be accomplished in 15% and 33% of patients, respectively, when all agents available in 1989, especially high‐dose melphalan, were applied together upfront for the management of myeloma.

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Metadata

Authors
Barlogie, B., Tricot, G. J., Van Rhee, F., Angtuaco, E., Walker, R., Epstein, J., Shaughnessy, J. D., Jagannath, S., Bolejack, V., Gurley, J., Hoering, A., Vesole, D., Desikan, R., Siegel, D., Mehta, J., Singhal, S., Munshi, N. C., Dhodapkar, M., Jenkins, B., Attal, M., Harousseau, J., & Crowley, J.
Venue
British Journal of Haematology
Publisher
Wiley
Published
2006-09-18
Volume
135
Issue
2
Pages
158-164
ISSN
  • 0007-1048 (ISSN-L)
  • 1365-2141
DOI
10.1111/j.1365-2141.2006.06271.x
OpenAlex
W1970074537
Cited by
163
References
4
FWCI
11.53
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Long‐term outcome results of the first tandem autotransplant trial for multiple myeloma. https://app.cochat.ai/papers/10.1111/j.1365-2141.2006.06271.x
The paper
Barlogie, B., Tricot, G. J., Van Rhee, F., Angtuaco, E., Walker, R., Epstein, J., Shaughnessy, J. D., Jagannath, S., Bolejack, V., Gurley, J., Hoering, A., Vesole, D., Desikan, R., Siegel, D., Mehta, J., Singhal, S., Munshi, N. C., Dhodapkar, M., Jenkins, B., . . . Crowley, J. (2006). Long‐term outcome results of the first tandem autotransplant trial for multiple myeloma. British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.2006.06271.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.