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Cited by 149Erythropoietin and Anemia TreatmentIron Metabolism and DisordersHematological disorders and diagnostics

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro‐inflammatory markers

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Ferrucci, Luigi, Guralnik, Jack M., Bandinelli, Stefania, Semba, Richard D., Lauretani, Fulvio, Corsi, Annamaria, Ruggiero, Carmelinda, Ershler, William B., Longo, Dan L.·2007·British Journal of Haematology
DOI 10.1111/j.1365-2141.2007.06502.xPMC PMC2669300
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Abstract

Summary: Epidemiological studies report that a third of the cases of anaemia in older persons is unexplained. We compared erythropoietin (EPO), inflammatory markers and major comorbidities between older subjects with normal haemoglobin levels and those with different aetiologic forms of anaemia, including unexplained anaemia. Participants were a representative sample of 964 persons aged ≥65 years, with no evidence of bleeding, complete blood tests, and a complete blood count within 6 h of phlebotomy. Anaemia was defined as haemoglobin <130 g/l in men and 120 g/l in women, and classified as a result of chronic kidney disease, iron deficiency, chronic disease and B12/folate deficiency anaemia, or unexplained anaemia based on standard criteria. Of the 124 anaemic participants, 42 (36·8%) had unexplained anaemia. Participants with anaemia of chronic diseases had significantly higher interleukin‐6 (IL‐6) and C‐reactive protein (CRP) levels, while those with unexplained anaemia had significantly lower CRP than non‐anaemic controls. Iron deficiency anaemia was characterised by significantly higher EPO levels compared with other types of anaemia and normal haemoglobin, B12 and/or folate deficiency. Unexplained anaemia was characterised by unexpectedly low EPO and low lymphocyte count. Unexplained anaemia is associated with reduced kidney EPO response, low levels of pro‐inflammatory markers and low lymphocyte counts.

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Crossref · 10.1111/j.1365-2141.2007.06502.x

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  1. Chaves P.H., 2005, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 729

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Metadata

Authors
Ferrucci, L., Guralnik, J. M., Bandinelli, S., Semba, R. D., Lauretani, F., Corsi, A., Ruggiero, C., Ershler, W. B., & Longo, D. L.
Affiliations
  • National Institute on Aging (US)
  • Associação Saúde da Família (BR)
  • Johns Hopkins University (US)
  • Agenzia Regionale di Sanità della Toscana (IT)
  • University of Florence (IT)
Corresponding author
Ferrucci, Luigi
ORCID
Venue
British Journal of Haematology
Publisher
Wiley
Published
2007-03
Volume
136
Issue
6
Pages
849-855
ISSN
  • 0007-1048 (ISSN-L)
  • 1365-2141
DOI
10.1111/j.1365-2141.2007.06502.x
PMC
PMC2669300
OpenAlex
W2092104238
Cited by
149
References
30
Citations by year
2026: 3 · 2025: 7 · 2023: 11 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 9 · 2016: 7 · 2015: 11 · 2014: 11 · 2013: 3 · 2012: 11
FWCI
8.09
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1 d)
Locations
  • British Journal of Haematology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Ministero della Salute (263 MD 9164 13, ICS 110.1/RS97.71, N01-AG-916413, 263 MD 821336, N01-AG-821336, 263 MD 9164, 110.1|RS97.71)
  • National Institutes of Health (Z99 AG999999)
  • National Institute on Aging (263 MD 9164, N01AG-821336, 263-MD-9164-13, 821336, N01[AG]916413, 263MD821336, R01AG027012)
  • National Institute on Minority Health and Health Disparities (263-MD-916413, 263MD 821336, R01MD009164)
Topics
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Hematology › Hematological disorders and diagnostics
Keywords
older adults, erythropoietin, pro-inflammatory markers, C-reactive protein, interleukin-6, iron deficiency anemia, anemia of chronic disease, chronic kidney disease, lymphocyte count, comorbidities
MeSH terms
Aged, Aging, Anemia, C-Reactive Protein, Cardiovascular Diseases, Diabetes Mellitus, Erythropoietin, Female, Health Surveys, Humans, Italy, Kidney Diseases, Male, Osteoarthritis, Parkinson Disease, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Case-Control Studies, Lymphocyte Count, Inflammation Mediators, Stroke

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