Management of anemia of inflammation in the elderly
Open accessAbstract
Anemia of any degree is recognized as a significant independent contributor to morbidity, mortality, and frailty in elderly patients. Among the broad types of anemia in the elderly a peculiar role seems to be played by the anemia associated with chronic inflammation, which remains the most complex form of anemia to treat. The origin of this nonspecific inflammation in the elderly has not yet been clarified. It seems more plausible that the oxidative stress that accompanies ageing is the real cause of chronic inflammation of the elderly and that the same oxidative stress is actually a major cause of this anemia. The erythropoietic agents have the potential to play a therapeutic role in this patient population. Despite some promising results, rHuEPO does not have a specific indication for the treatment of anemia in the elderly. Moreover, concerns about their side effects have spurred the search for alternatives. Considering the etiopathogenetic mechanisms of anemia of inflammation in the elderly population, an integrated nutritional/dietetic approach with nutraceuticals that can manipulate oxidative stress and related inflammation may prevent the onset of this anemia and its negative impact on patients' performance and quality of life.
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Some authors suggest that the use of spirulina dietary supplements may ameliorate anemia.
“Therefore, some authors suggest that the use of spirulina dietary supplements may ameliorate anemia [117,118].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [118]
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- Authors
- Macciò, A., & Madeddu, C.
- Affiliations
- Ospedaliero Sirai (IT)
- University of Cagliari (IT)
- Corresponding author
- Macciò, Antonio
- Venue
- Anemia
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-20
- ISSN
- 2090-1267 (ISSN-L)
- 2090-1275
- PMC
- PMC3471391
- OpenAlex
- W2129652900
- Cited by
- 60
- References
- 124
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 12 · 2019: 5 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Anemia (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Associazione Sarda per la ricerca in Oncologia Ginecologica-ONLUS
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- anemia of chronic disease, older adults, chronic inflammation, oxidative stress, aging, erythropoietin, recombinant human erythropoietin, frailty, dietary intervention, nutraceuticals, quality of life
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