The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Erythrocyte vesiculation: a self‐protective mechanism?
Abstract
Summary: Previous studies demonstrated that 20% of haemoglobin is lost from circulating erythrocytes during their total lifespan by vesiculation. To study whether removal molecules other than membrane‐bound haemoglobin were present in erythrocyte‐derived vesicles, flow cytometry and immunoblot analysis were employed to examine the presence of phosphatidylserine (PS) and IgG, and senescent cell antigens respectively. It was demonstrated that 67% of glycophorin A‐positive vesicles exposed PS, and that half of these vesicles also contained IgG. Immunoblot analysis revealed the presence of a breakdown product of band 3 that reacted with antibodies directed against senescent erythrocyte antigen‐associated band 3 sequences. In contrast, only the oldest erythrocytes contained senescent cell antigens and IgG, and only 0·1% of erythrocytes, of all ages, exposed PS. It was concluded that vesiculation constitutes a mechanism for the removal of erythrocyte membrane patches containing removal molecules, thereby postponing the untimely elimination of otherwise healthy erythrocytes. Consequently, these same removal molecules mediate the rapid removal of erythrocyte‐derived vesicles from the circulation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fcγ Receptors: Old Friends and New Family Members
Nimmerjahn, F., & Ravetch, J. V. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.010 · Cited by 1,072
Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation
Nieuwland, R., Böing, A., Romijn, F., Hack, C. E., Sturk, A., & Berckmans, R. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615646 · Cited by 651
Shet, A. S., Aras, O., Gupta, K., Hass, M. J., Rausch, D. J., Saba, N., Koopmeiners, L., Key, N. S., & Hebbel, R. P. (2003) · Blood · doi:10.1182/blood-2003-03-0693 · Cited by 539
The Role of Hemoglobin Denaturation and Band 3 Clustering in Red Blood Cell Aging
Low, P. S., Waugh, S. M., Zinke, K., & Drenckhahn, D. (1985) · Science · doi:10.1126/science.2578228 · Cited by 395
Mechanism of removal of senescent cells by human macrophages in situ.
Kay, M. M. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3521 · Cited by 346
Phosphatidylserine recognition by phagocytes: a view to a kill
Wu, Y., Tibrewal, N., & Birge, R. B. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.02.003 · Cited by 341
Hron, G., Kollars, M., Weber, H., Sagaster, V., Quehenberger, P., Eichinger, S., Kyrle, P. A., & Weltermann, A. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-03-0141 · Cited by 296
Connor, J., Pak, C. C., & Schroit, A. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41959-4 · Cited by 289
Willekens, F. L. A., Werre, J. M., Kruijt, J. K., Roerdinkholder-Stoelwinder, B., Groenen-Döpp, Y. A. M., van den Bos, A. G., Bosman, G. J. C. G. M., & van Berkel, T. J. C. (2005) · Blood · doi:10.1182/blood-2004-04-1578 · Cited by 280
Self-citationMohandas, N., Kim, Y., Tycko, D., Orlik, J., Wyatt, J., & Groner, W. (1986) · Blood · doi:10.1182/blood.v68.2.506.506 · Cited by 190
Cited by
Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging
Mohanty, J. G., Nagababu, E., & Rifkind, J. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00084 · Cited by 595
“Membrane micro-vesiculation is a process that accelerates in the formation of older cells (Willekens et al., 2008) (see above).”
BackgroundAnaemia in kidney disease: harnessing hypoxia responses for therapy
Koury, M. J., & Haase, V. H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.82 · Cited by 313
Biomarkers for prediction of venous thromboembolism in cancer
Pabinger, I., Thaler, J., & Ay, C. (2013) · Blood · doi:10.1182/blood-2013-04-460147 · Cited by 256
Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes
Haschka, D., Petzer, V., Kocher, F., Tschurtschenthaler, C., Schaefer, B., Seifert, M., Sopper, S., Sonnweber, T., Feistritzer, C., Arvedson, T. L., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.98867 · Cited by 34
Extracellular vesicles and lipoproteins – Smart messengers of blood cells in the circulation
Nguyen, P. H. D., Le, A. H., Pek, J. S. Q., Pham, T. T., Jayasinghe, M. K., Do, D. V., Phung, C. D., & Le, M. T. N. (2022) · Journal of Extracellular Biology · doi:10.1002/jex2.49 · Cited by 31
Metadata
- Authors
- Willekens, F. L. A., Werre, J. M., Groenen‐Döpp, Y. A. M., Roerdinkholder‐Stoelwinder, B., De Pauw, B., & Bosman, G. J. C. G. M.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2008-04-16
- Volume
- 141
- Issue
- 4
- Pages
- 549-556
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W1984380276
- Cited by
- 271
- References
- 27
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Erythrocyte vesiculation: a self‐protective mechanism? https://app.cochat.ai/papers/10.1111/j.1365-2141.2008.07055.x
- The paper
- Willekens, F. L. A., Werre, J. M., Groenen‐Döpp, Y. A. M., Roerdinkholder‐Stoelwinder, B., De Pauw, B., & Bosman, G. J. C. G. M. (2008). Erythrocyte vesiculation: a self‐protective mechanism? British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.2008.07055.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
