CoChat
Sign Up
Cited by 91

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

MicroRNA 155 modulates megakaryopoiesis at progenitor and precursor level by targeting Ets‐1 and Meis1 transcription factors

Romania, Paolo, Lulli, Valentina, Pelosi, Elvira, Biffoni, Mauro, Peschle, Cesare, Marziali, Giovanna·2008·British Journal of Haematology
DOI 10.1111/j.1365-2141.2008.07382.x
Open this paper in CoChat — free account

Abstract

Summary: MicroRNAs (miRNAs) control basic biological functions and are emerging as key regulators of haematopoiesis. This study focused on the functional role of MIRN155 on megakaryocytic (MK) differentiation of human cord blood CD34+ haematopoietic progenitor cells (HPCs). MIRN155, abundantly expressed in early HPCs, decreases sharply during MK differentiation. Functional studies showed that enforced expression of MIRN155 impairs proliferation and differentiation of MK cells. Furthermore, HPCs transfected with MIRN155 showed a significant reduction of their MK clonogenic capacity, suggesting that down‐modulation of this miRNA favours MK progenitor differentiation. Consistent with this observation, MIRN155 down‐regulates, by directly binding to their 3′‐UTR, the expression of Ets‐1 and Meis1, two transcription factors with well‐known functions in MK cells. These results show that the decline of MIRN155 is required for MK proliferation and differentiation at progenitors and precursors level and indicate that sustained expression of MIRN155 inhibits megakaryopoiesis.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1365-2141.2008.07382.x

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • We identified several miRs with previously reported roles in myelopoiesis and/or leukemia as regulated by PU.1.

    “In addition to miRs with thus-far-unknown functions in hematopoietic cells, we identified several miRs with previously reported (partly controversial) roles in myelopoiesis and/or leukemia as regulated by PU.1.10,16,[46][47][48]”

    From Macrophage development from HSCs requires PU.1-coordinated microRNA expression (2011) · cites this paper as [47]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 37

  1. 10.1126/science.1091903 · DOI · Paper page
  2. 10.1128/MCB.9.6.2657 · DOI
  3. 10.1182/blood.V87.11.4678.bloodjournal87114678 · DOI
  4. 10.1073/pnas.0500613102 · DOI
  5. 10.1016/j.cell.2005.09.023 · DOI · Paper page
  6. 10.1073/pnas.0506216102 · DOI · Paper page
  7. 10.1038/ncb1613 · DOI · Paper page
  8. 10.1126/science.2218497 · DOI
  9. 10.1073/pnas.0600587103 · DOI
  10. 10.1073/pnas.0610983104 · DOI
  11. 10.1016/S0008-8749(02)00506-3 · DOI
  12. 10.1038/sj.emboj.7600038 · DOI
  13. 10.1074/jbc.M407489200 · DOI
  14. 10.1182/blood-2007-05-088500 · DOI
  15. 10.1002/path.1825 · DOI
  16. 10.1002/gcc.20273 · DOI
  17. 10.1038/ncb1741 · DOI
  18. 10.1111/j.1365-2141.2007.06611.x · DOI
  19. 10.1016/j.devcel.2008.03.012 · DOI · Paper page
  20. 10.1038/sj.cdd.4401811 · DOI
  21. 10.1002/bies.20406 · DOI
  22. 10.1182/blood.V99.3.888 · DOI
  23. 10.1261/rna.5235104 · DOI
  24. 10.1046/j.1432-1327.1998.2580879.x · DOI
  25. 10.1084/jem.20072108 · DOI · Paper page
  26. 10.1182/blood-2002-02-0380 · DOI
  27. 10.1172/JCI26720 · DOI
  28. 10.1182/blood-2006-04-019760 · DOI
  29. 10.1016/j.leukres.2005.09.001 · DOI
  30. 10.1038/sj.onc.1201502 · DOI
  31. 10.1128/MCB.24.10.4534-4545.2004 · DOI
  32. 10.1634/stemcells.19-5-397 · DOI
  33. 10.1182/blood-2006-01-030015 · DOI
  34. 10.1042/BJ20031166 · DOI
  35. 10.1128/MCB.17.3.1490 · DOI
  36. Testa U., 1996, Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors, Blood, 88, 3391, 10.1182/blood.V88.9.3391.bloodjournal8893391 · DOI
  37. 10.1126/science.1141229 · DOI

Cited by

Sorted by citations

Metadata

Authors
Romania, P., Lulli, V., Pelosi, E., Biffoni, M., Peschle, C., & Marziali, G.
Venue
British Journal of Haematology
Publisher
Wiley
Published
2008-10-22
Volume
143
Issue
4
Pages
570-580
ISSN
  • 0007-1048
  • 1365-2141
DOI
10.1111/j.1365-2141.2008.07382.x
Cited by
91
References
4
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review