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Cited by 49Asthma and respiratory diseasesFatty Acid Research and HealthChronic Obstructive Pulmonary Disease (COPD) Research

Conjugated linoleic acid improves airway hyper-reactivity in overweight mild asthmatics

MacRedmond, R., Singhera, G., Attridge, S., Bahzad, M., Fava, C., Lai, Y., Hallstrand, T. S., Dorscheid, D. R.·2010·Clinical & Experimental Allergy
DOI 10.1111/j.1365-2222.2010.03531.x
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Abstract

BACKGROUND: Conjugated linoleic acids (CLA) are naturally occurring fatty acids that have multiple biological properties including the regulation of metabolic, proliferative and immune processes. OBJECTIVE: The aim of this study was to investigate the efficacy and safety of CLA as a dietary supplement in mild asthma. METHODS: This was a prospective, randomized, double-blind, placebo-controlled study. Twenty-eight adult subjects (aged 19-40 years) with mild asthma (FEV(1)>70% predicted) were randomized to CLA 4.5 g/day or placebo for 12 weeks in addition to usual treatment. On average, subjects were overweight with a mean body mass index (BMI) of 27.9 kg/m(2). RESULTS: Subjects in the CLA group had a significant improvement in airway hyperresponsiveness (AHR) at week 12 compared with week 0 [PC(20) 6.6 (2.1) mg/mL vs. 2.2 (0.7) mg/mL; P<0.05]. The CLA group had a significant reduction in weight and BMI compared with placebo and this was associated with a reduction in leptin/adiponectin ratio. There were no differences in systemic cytokine levels, induced sputum cell counts, quality-of-life scores or adverse events. CONCLUSIONS: CLA treatment as an adjunct to usual care in overweight mild asthmatics was well tolerated and was associated with improvements in AHR and BMI.

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Crossref · 10.1111/j.1365-2222.2010.03531.x

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  • The consumption of cLA is linked with beneficial clinical responses, including the reduction of obesity-related body mass index, improved insulin sensitivity and attenuation of airway hyperactivity.

    “The consumption of cLA is linked with beneficial clinical responses, including the reduction of obesity-related body mass index, improved insulin sensitivity and attenuation of airway hyperactivity, all of which we propose are due in part to the formation and signaling actions of NO2-cLA [29–32].”

    From Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes (2015) · cites this paper as [31]

  • The beneficial clinical responses linked with cLA consumption are due in part to the formation and signaling actions of NO2-cLA.

    “The consumption of cLA is linked with beneficial clinical responses, including the reduction of obesity-related body mass index, improved insulin sensitivity and attenuation of airway hyperactivity, all of which we propose are due in part to the formation and signaling actions of NO2-cLA [29–32].”

    From Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes (2015) · cites this paper as [31]

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Authors
MacRedmond, R., Singhera, G., Attridge, S., Bahzad, M., Fava, C., Lai, Y., Hallstrand, T. S., & Dorscheid, D. R.
Affiliations
University of British Columbia (CA)
Corresponding author
MacRedmond, R.
ORCID
Venue
Clinical & Experimental Allergy
Publisher
Wiley
Published
2010-06-10
Volume
40
Issue
7
Pages
1071-1078
ISSN
  • 0954-7894 (ISSN-L)
  • 1365-2222
DOI
10.1111/j.1365-2222.2010.03531.x
OpenAlex
W2124652560
Cited by
49
References
44
Citations by year
2026: 1 · 2025: 1 · 2023: 7 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 1
FWCI
1.95
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical & Experimental Allergy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
conjugated linoleic acid, mild asthma, airway hyperresponsiveness, overweight, dietary supplements, body mass index, weight loss, leptin/adiponectin ratio, cytokines, induced sputum, adjunctive therapy
MeSH terms
Adult, Asthma, Double-Blind Method, Female, Humans, Male, Anti-Asthmatic Agents, Dietary Supplements, Linoleic Acids, Conjugated, Overweight

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