The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
MicroRNAs: novel regulators in skin inflammation
Abstract
Compelling evidence indicates that microRNAs (miRNAs), short, non-protein coding RNAs, are critical for the development and survival of multicellular organisms. Recently, miRNAs were implicated in the pathogenesis of psoriasis and atopic eczema (AE), the two most common chronic inflammatory disorders in skin. In particular, miR-203, the first skin-specific miRNA, showing an intriguing expression profile being confined to skin epithelium, is specifically overexpressed in psoriasis. MiR-146a, another miRNA showing specific upregulation in psoriasis, is involved in the regulation of innate immune responses and the tumour necrosis factor (TNF)-alpha pathway. Interestingly, miR-125b, another miRNA involved in the TNF-alpha pathway, is also deregulated in psoriasis and AE. As skin inflammation may serve as a model for chronic inflammatory disorders, it is likely that miRNAs involved in skin inflammation will eventually emerge in other inflammatory or autoimmune disorders, and some of these may become disease markers and therapeutic targets. In this review we present an overview of what is currently known about the roles of miRNAs in chronic inflammatory skin disorders.
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In the citing paper
“miR-203 is also increased in psoriasis and its targets include p63, suppressor of cytokine signaling 3 (SOCS3), and IL-8,89”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [89]
Citations
Cites
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
MicroRNAs: small RNAs with a big role in gene regulation
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
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Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chen, C.-Z., Li, L., Lodish, H. F., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1091903 · Cited by 3,257
Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978
Pathogenesis and therapy of psoriasis
Lowes, M. A., Bowcock, A. M., & Krueger, J. G. (2007) · Nature · doi:10.1038/nature05663 · Cited by 1,819
Dicer is essential for mouse development
Bernstein, E., Kim, S. Y., Carmell, M. A., Murchison, E. P., Alcorn, H., Li, M. Z., Mills, A. A., Elledge, S. J., Anderson, K. V., & Hannon, G. J. (2003) · Nature Genetics · doi:10.1038/ng1253 · Cited by 1,627
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MicroRNA functions in animal development and human disease
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Cited by
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Sonkoly, E., Janson, P., Majuri, M., Savinko, T., Fyhrquist, N., Eidsmo, L., Xu, N., Meisgen, F., Wei, T., Bradley, M., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.05.045 · Cited by 322
“In our study we aimed to explore the role of miRNAs in the pathogenesis of atopic dermatitis, extending our former investigation in this field.(9,10) We identified novel differentially expressed miRNAs in lesional skin of patients with atopic dermatitis.”
Self-citationTargeting inflammation by modulating the Jun/AP-1 pathway
Schönthaler, H. B., Guinea‐Viniegra, J., & Wagner, E. F. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.140533 · Cited by 302
The Innate Immune System in Acute and Chronic Wounds
MacLeod, A. S., & Mansbridge, J. N. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0608 · Cited by 289
Fasseu, M., Tréton, X., Guichard, C., Pédruzzi, E., Cazals-Hatem, D. L., Richard, C., Aparicio, T., Bleiberg-Daniel, F., Soulé, J., Moreau, R., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013160 · Cited by 286
“miRNAs are regulators of early development, cell fate determination, differentiation, proliferation, apoptosis [37–39] and dysregulation of their expression has been involved in various human diseases such as cancer [40–44], developmental abnormalities [45], muscular disorders [46] and inflammatory diseases [47–51].”
Long non-coding RNAs: Mechanism of action and functional utility
Bhat, S. A., Ahmad, S. M., Mumtaz, P. T., Malik, A. A., Dar, M. A., Urwat, U., Shah, R. A., & Ganai, N. A. (2016) · Non-coding RNA Research · doi:10.1016/j.ncrna.2016.11.002 · Cited by 289
“Many lncRNAs were also found to be up-regulated in macrophages exposed to Toll-like receptor 2 (TLR2) ligands [110].”
Background
Metadata
- Authors
- Sonkoly, E., Ståhle, M., & Pivarcsi, A.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Pivarcsi, A.
- Venue
- Clinical and Experimental Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05
- Volume
- 33
- Issue
- 3
- Pages
- 312-315
- ISSN
- 0307-6938 (ISSN-L)
- 1365-2230
- OpenAlex
- W2138201174
- Semantic Scholar
- 4f0a9c7636f8905753e42022dc0507190c837a15
- Cited by
- 194
- References
- 34
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 12 · 2016: 14 · 2015: 15 · 2014: 19 · 2013: 15 · 2012: 10
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Psoriasis Foundation
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- microRNA, skin inflammation, psoriasis, atopic dermatitis, miR-203, miR-146a, miR-125b, TNF signaling, innate immune regulation, skin epithelium, disease biomarkers, therapeutic target
- MeSH terms
- Dermatitis, Gene Expression Regulation, Humans, Psoriasis, Skin, Keratinocytes, Up-Regulation, Cytokines, MicroRNAs
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