Cited by 194Psoriasis: Treatment and PathogenesisMicroRNA in disease regulationDermatology and Skin Diseases

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MicroRNAs: novel regulators in skin inflammation

Sonkoly, E., Ståhle, M., Pivarcsi, A.·2008·Clinical and Experimental Dermatology

DOI 10.1111/j.1365-2230.2008.02804.x

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Abstract

Compelling evidence indicates that microRNAs (miRNAs), short, non-protein coding RNAs, are critical for the development and survival of multicellular organisms. Recently, miRNAs were implicated in the pathogenesis of psoriasis and atopic eczema (AE), the two most common chronic inflammatory disorders in skin. In particular, miR-203, the first skin-specific miRNA, showing an intriguing expression profile being confined to skin epithelium, is specifically overexpressed in psoriasis. MiR-146a, another miRNA showing specific upregulation in psoriasis, is involved in the regulation of innate immune responses and the tumour necrosis factor (TNF)-alpha pathway. Interestingly, miR-125b, another miRNA involved in the TNF-alpha pathway, is also deregulated in psoriasis and AE. As skin inflammation may serve as a model for chronic inflammatory disorders, it is likely that miRNAs involved in skin inflammation will eventually emerge in other inflammatory or autoimmune disorders, and some of these may become disease markers and therapeutic targets. In this review we present an overview of what is currently known about the roles of miRNAs in chronic inflammatory skin disorders.

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“miRNAs might potentially have an enormous impact in the regulation of immunological and inflammatory disorders as well as growth development [16,22,23,24].”
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MicroRNA Cross-Involvement in Autism Spectrum Disorders and Atopic Dermatitis: A Literature Review
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Association of miR-146aC>G, miR-196a2T>C, and miR-499A>G Polymorphisms With Risk of Premature Ovarian Failure in Korean Women
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miR-125b inhibits keratinocyte proliferation and promotes keratinocyte apoptosis in oral lichen planus by targeting MMP-2 expression through PI3 K/Akt/mTOR pathway
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Increased expression of microRNA‐155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activity
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Targeting microRNA for improved skin health
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MicroRNA signatures in the pathogenesis and therapy of inflammatory bowel disease
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Pivarcsi, A., Ståhle, M., & Sonkoly, E. (2014) · Experimental Dermatology · doi:10.1111/exd.12469 · Cited by 35
Self-citation
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MicroRNA-146a and miR-99a are potential biomarkers for disease activity and clinical efficacy assessment in psoriasis patients treated with traditional Chinese medicine
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Retracted

Authors: Sonkoly, E., Ståhle, M., & Pivarcsi, A.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Pivarcsi, A.
ORCID: Sonkoly, E.
Ståhle, M.
Pivarcsi, A.
Venue: Clinical and Experimental Dermatology
Publisher: Oxford University Press (OUP)
Published: 2008-05
Volume: 33
Issue: 3
Pages: 312-315
ISSN: 0307-6938 (ISSN-L)
1365-2230
DOI: 10.1111/j.1365-2230.2008.02804.x
OpenAlex: W2138201174
Semantic Scholar: 4f0a9c7636f8905753e42022dc0507190c837a15
Cited by: 194
References: 34
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 12 · 2016: 14 · 2015: 15 · 2014: 19 · 2013: 15 · 2012: 10
FWCI: 1.23
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2679 d)
Locations: Clinical and Experimental Dermatology (publishedVersion)
PubMed (publishedVersion)
Funders: National Psoriasis Foundation
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: microRNA, skin inflammation, psoriasis, atopic dermatitis, miR-203, miR-146a, miR-125b, TNF signaling, innate immune regulation, skin epithelium, disease biomarkers, therapeutic target
MeSH terms: Dermatitis, Gene Expression Regulation, Humans, Psoriasis, Skin, Keratinocytes, Up-Regulation, Cytokines, MicroRNAs

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MicroRNAs: novel regulators in skin inflammation

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