The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
A role for T cell-derived interleukin 22 in psoriatic skin inflammation
Open accessAbstract
Summary: Interleukin (IL)-22 is a T cell-derived cytokine that has been reported recently to induce cutaneous inflammation in an experimental murine model of psoriasis, and to induce in vitro an inflammatory-like phenotype. In the present study, we assessed the presence of IL-22 and the IL-22 receptor 1 (IL-22R1) in skin lesions, skin-derived T cells, as well as IL-22 levels in sera from patients with psoriasis. IL-22R1 and IL-10R2 transcripts are expressed at a similar level in psoriatic and healthy skin. In contrast, IL-22 mRNA expression was up-regulated in psoriatic skin lesions compared to normal skin, whereas IL-22 mRNA levels in peripheral blood mononuclear cells from psoriatic patients and normal subjects were similar. Circulating IL-22 levels were significantly higher in psoriatic patients than in normal subjects. T cells isolated from psoriatic skin produced higher levels of IL-22 in comparison to peripheral T cells isolated from the same patients. IL-10 was expressed at similar levels in skin biopsies and peripheral blood mononuclear cells of psoriatic patients and normal subjects. Finally, we show here that supernatants of lesional psoriatic skin-infiltrating T cells induce an inflammatory response by normal human epidermal keratinocytes, resembling that observed in psoriatic lesions. Taken together, the results reported in this study indicate that IL-22 is a cytokine produced by skin-infiltrating lymphocytes that is potentially involved in initiation and/or maintenance of the pathogenesis of psoriasis.
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Development, cytokine profile and function of human interleukin 17-producing helper T cells
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Self-citationInterleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
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IL-22 Increases the Innate Immunity of Tissues
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Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?
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Cited by
Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
Ouyang, W., Rutz, S., Crellin, N. K., Valdez, P. A., & Hymowitz, S. G. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101312 · Cited by 1,925
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1767 · Cited by 1,079
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
Eyerich, S., Eyerich, K., Pennino, D., Carbone, T., Nasorri, F., Pallotta, S., Cianfarani, F., Odorisio, T., Traidl-Hoffmann, C., Behrendt, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci40202 · Cited by 1,052
Sonnenberg, G. F., Fouser, L. A., & Artis, D. (2011) · Nature Immunology · doi:10.1038/ni.2025 · Cited by 1,044
Trifari, S., Kaplan, C. D., Tran, E. H., Crellin, N. K., & Spits, H. (2009) · Nature Immunology · doi:10.1038/ni.1770 · Cited by 1,021
Metadata
- Authors
- Boniface, K., Guignouard, E., Pedretti, N., Garcia, M., Delwail, A., Bernard, F.-X., Nau, F., Guillet, G., Dagregorio, G., Yssel, H., Lecron, J.-C., & Morel, F.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09-27
- Volume
- 150
- Issue
- 3
- Pages
- 407-415
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W1507781793
- Cited by
- 290
- References
- 39
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Boniface, K., Guignouard, E., Pedretti, N., Garcia, M., Delwail, A., Bernard, F.-X., Nau, F., Guillet, G., Dagregorio, G., Yssel, H., Lecron, J.-C., & Morel, F. (2007). A role for T cell-derived interleukin 22 in psoriatic skin inflammation. Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.2007.03511.x
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