The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease
Open accessAbstract
Summary: Inflammatory bowel disease (IBD) may result from exaggerated stimulation of the mucosal immune system by luminal bacterial flora. Bacterial products are recognized by pattern recognition receptors such as Toll-like receptors (TLRs), which are key regulators of the innate immune system. Therefore, the expression of TLR2, TLR3 and TLR4 in colonic biopsy samples taken from children with active IBD were studied and compared to controls. Colonic biopsy samples were collected from macroscopically inflamed and non-inflamed regions of the mucosa of 12 children with freshly diagnosed IBD (fdIBD) and 23 children with relapsed IBD (rIBD). Specimens were also obtained from eight controls. TLR2, TLR3 and TLR4 mRNA expression and protein levels were determined by real-time reverse transcription polymerase chain reaction (RT–PCR) and Western blot. We found higher TLR2 and TLR4 mRNA and protein levels in the inflamed colonic mucosa of children with fdIBD and rIBD compared to controls. In the non-inflamed colonic mucosa of children with fdIBD and rIBD, TLR2 and TLR4 mRNA and protein levels were similar to controls. TLR2 and TLR4 mRNA and protein levels also did not differ between children with fdIBD or rIBD in either inflamed or non-inflamed colonic mucosa. TLR3 mRNA expression and protein levels were similar in all groups studied. Our results of increased levels of TLR2 and TLR4 in the inflamed colonic mucosa of children with IBD confirm the hypothesis that innate immunity has an important role in the pathogenesis of this disease.
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Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
Cited by
Yin, K., Wang, Y., Zhao, H., Wang, D., Guo, M., Mu, M., Liu, Y., Nie, X., Li, B., Li, J., et al. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145758 · Cited by 438
Pulmonary-intestinal cross-talk in mucosal inflammatory disease
Keely, S., Talley, N. J., & Hansbro, P. M. (2012) · Mucosal Immunology · doi:10.1038/mi.2011.55 · Cited by 386
Toll-Like Receptors: Regulators of the Immune Response in the Human Gut
Hug, H., Mohajeri, M., & La Fata, G. (2018) · Nutrients · doi:10.3390/nu10020203 · Cited by 217
Differential Expression of Toll-Like Receptors in Patients With Irritable Bowel Syndrome
Brint, E. K., MacSharry, J., Fanning, A., Shanahan, F., & Quigley, E. M. M. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.438 · Cited by 205
Ungaro, R., Fukata, M., Hsu, D., Hernandez, Y., Breglio, K., Chen, A., Xu, R., Sotolongo, J., Espana, C., Zaias, J., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90496.2008 · Cited by 159
Metadata
- Authors
- Szebeni, B., Veres, G., Dezsõfi, A., Rusai, K., Vannay, Á., Mraz, M., Majorova, E., & Arató, A.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-07
- Volume
- 151
- Issue
- 1
- Pages
- 34-41
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W1821112440
- Cited by
- 194
- References
- 2
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. https://app.cochat.ai/papers/10.1111/j.1365-2249.2007.03531.x
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- Szebeni, B., Veres, G., Dezsõfi, A., Rusai, K., Vannay, Á., Mraz, M., Majorova, E., & Arató, A. (2007). Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.2007.03531.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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