Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis?
Open accessAbstract
Summary: The resolution of inflammation is central to the maintenance of good health and immune homeostasis. Recently, several intracellular stress proteins have been described as having extracellular properties that are anti-inflammatory or favour the resolution of inflammation. We propose that these molecules should be defined as resolution-associated molecular patterns (RAMPs). RAMPs are released at times of cellular stress and help to counterbalance the inflammatory effects of pathogen-associated (PAMPs) and damage-associated (DAMPs) molecular patterns. We propose that heat shock protein 10 (HSP10), αB-crystallin (αBC), HSP27 and binding immunoglobulin protein (BiP) should be considered founding members of the RAMP family. A greater understanding of RAMP biology may herald the development of novel immunotherapies.
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When sleep is diminished for longer than one night, plasma levels of IL-6 or CRP mostly increase, likely reflecting a systemic, unspecific inflammatory response to prolonged sleep loss.
“More consistent findings are observed if sleep is diminished for longer than one night: plasma levels of IL-6 or CRP (which is produced by the liver in response to IL-6 secretion) mostly increase in such conditions, likely reflecting a systemic, unspecific inflammatory response to prolonged sleep loss (223, 506, 556, 564) (see also sect. IV).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [506]
Prolonged total sleep deprivation of four consecutive nights increases levels of soluble TNF receptor I, which may reflect a homeostatic response to increased TNF production by leukocytes.
“In contrast, prolonged total sleep deprivation of four consecutive nights increased levels of the soluble TNF receptor I (506), which may reflect a homeostatic response to increased TNF production by leukocytes; this, however, was not investigated in the study.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [506]
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
- Authors
- Shields, A. M., Panayi, G. S., & Corrigall, V. M.
- Affiliations
- King's College London (GB)
- ORCID
- Shields, A M
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-14
- Volume
- 165
- Issue
- 3
- Pages
- 292-300
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- PMC
- PMC3170978
- OpenAlex
- W1594493382
- Cited by
- 90
- References
- 81
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 10 · 2019: 2 · 2018: 1 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 11
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical & Experimental Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Versus Arthritis (18152)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- inflammation resolution, immune homeostasis, pathogen-associated molecular patterns, damage-associated molecular patterns, Hsp10, alphaB-crystallin, HSP27, GRP78, anti-inflammatory molecules, immunotherapy
- MeSH terms
- Animals, Heat-Shock Proteins, Homeostasis, Humans, Inflammation, Inflammation Mediators
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