THE INFLUENCE OF CARBAMAZEPINE ON THYROID HORMONES AND THYROXINE BINDING GLOBULIN IN HYPOTHYROID PATIENTS SUBSTITUTED WITH THYROXINE
Abstract
SUMMARY: Carbamazepine (CBZ) decreases the serum concentration of thyroid hormones. It is proposed that CBZ increases the extra‐thyroidal metabolism of thyroid hormones. In order to test this hypothesis CBZ was given to nine hypothyroid patients substituted with thyroxine (T4). A significant decrease in serum concentrations of T4, calculated free T4 (FT4), triiodothyronine (T3), and calculated free T3 (FT3) was found after 3 weeks of CBZ medication. The serum concentrations of TSH and the T4:T3 ratios were unaltered, while the serum concentrations of T4‐binding globulin (TBG) increased markedly in eight of the nine patients. These findings support the hypothesis of a CBZ induced increase in the extra‐thyroidal metabolism of thyroid hormones.
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Decreased T4 and T3 concentrations without an alteration in TSH were reported in 13 patients without pre-existing hypothyroidism and nine hypothyroid patients after initiation of carbamazepine therapy.
“Decreased T4 and T3 concentrations without an alteration in TSH were reported in 13 patients without pre-existing hypothyroidism (176) and nine hypothyroid patients (181) after initiation of carbamazepine therapy.”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [181]
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“Decreased T4 and T3 concentrations without an alteration in TSH were reported in 13 patients without pre-existing hypothyroidism (176) and nine hypothyroid patients (181) after initiation of carbamazepine therapy.”
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- Authors
- AANDERUD, S., MYKING, O. L., & STRANDJORD, R. E.
- Affiliations
- University of Bergen (NO)
- Corresponding author
- AANDERUD, SYLVI
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1981-09
- Volume
- 15
- Issue
- 3
- Pages
- 247-252
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2041345005
- Cited by
- 33
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2019: 1 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- carbamazepine, hypothyroidism, thyroxine, thyroid hormones, free thyroxine, free triiodothyronine, thyroxine-binding globulin, drug-induced thyroid dysfunction, T4/T3 ratio, thyroid-stimulating hormone
- MeSH terms
- Adult, Carbamazepine, Female, Humans, Hypothyroidism, Male, Middle Aged, Thyrotropin, Thyroxine, Thyroxine-Binding Proteins, Triiodothyronine
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