Hypothyroidism induced by anti-epileptic therapy
Abstract
Two patients on long-term anti-epileptic treatment, one with both phenytoin and carbamazepine, the other with carbamazepine, developed clinical hypothyroidism. Laboratory assays verified the diagnosis. Both patients became euthyroid and the thyroid hormone assays were normal after withdrawal of the drugs.
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Other case reports describe the development of hypothyroidism in patients treated with LT4 who were prescribed phenytoin.
“Other case reports also describe the development of hypothyroidism in patients treated with LT4, who were prescribed phenytoin (179,180).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [179]
Cites
DEPRESSION OF THE SERUM PROTEIN-BOUND IODINE LEVEL BY DIPHENYLHYDANTOIN*
Oppenheimer, J. H., FISHER, L. V., Nelson, K., et al. (1961) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-21-3-252 · Cited by 113 · see citing works
THYROID FUNCTION TESTS IN PATIENTS ON LONG‐TERM TREATMENT WITH VARIOUS ANTICONVULSANT DRUGS
Liewendahl, K., Majuri, H., & Helenius, T. (1978) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1978.tb01493.x · Cited by 112 · see citing works
Rootwelt, K., Ganes, T., & Johannessen, S. I. (1978) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517809104880 · Cited by 103 · see citing works
Effects of Anticonvulsant Drugs on Thyroid Hormones in Epileptic Children
Fichsel, H., & Knöpfle, G. (1978) · Epilepsia · doi:10.1111/j.1528-1157.1978.tb04498.x · Cited by 77 · see citing works
Anticonvulsants and thyroid function.
Yeo, P. P., Bates, D. E., Howe, J. G., RATCLIFFE, W. A., Schardt, C. W., Heath, A., & Evered, D. C. (1978) · BMJ · doi:10.1136/bmj.1.6127.1581 · Cited by 72 · see citing works
Oppenheimer, J. H., & Tavernetti, R. R. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104680 · Cited by 66 · see citing works
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works
“Other case reports also describe the development of hypothyroidism in patients treated with LT4, who were prescribed phenytoin (179,180).”
De Luca, F., Arrigo, T., Pandullo, E., Siracusano, M. F., Benvenga, S., & Trimarchi, F. (1986) · European Journal of Pediatrics · doi:10.1007/bf00441860 · Cited by 51 · see citing works
ISLEY, W. L. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-517 · Cited by 46 · see citing works
Thyroxine Replacement Requirements in Hypothyroid Patients Receiving Phenytoin
BLACKSHEAR, J. L., SCHULTZ, A. L., NAPIER, J. S., & STUART, D. D. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-3-341 · Cited by 41 · see citing works
AANDERUD, S., MYKING, O. L., & STRANDJORD, R. E. (1981) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1981.tb00662.x · Cited by 33 · see citing works
Self-citation
- Authors
- Aanderud, S., & Strandjord, R. E.
- Affiliations
- Haukeland University Hospital (NO)
- Corresponding author
- Strandjord, R. E.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Hindawi Limited
- Published
- 2009-01-29
- Volume
- 61
- Issue
- 5
- Pages
- 330-332
- ISSN
- 0001-6314 (ISSN-L)
- 1600-0404
- OpenAlex
- W2076804820
- Cited by
- 57
- References
- 6
- Citations by year
- 2025: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Neurologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- drug-induced hypothyroidism, antiepileptic drugs, phenytoin, carbamazepine, drug-induced thyroid dysfunction, drug withdrawal, thyroid function tests
- MeSH terms
- Aged, Carbamazepine, Female, Humans, Hypothyroidism, Middle Aged, Phenytoin
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