The effect of antiepileptic drugs on thyroid hormonal function: causes and implications

The Colorado Thyroid Disease Prevalence Study

Canaris, G. J., Manowitz, N. R., Mayor, G., & Ridgway, E. C. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.526 · Cited by 2,824 · see citing works

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics

Burtis, E. B. C. A., Ashwood, E. R., & Bruns, D. E. (2011) · Medical Entomology and Zoology · Cited by 2,190 · see citing works

Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline

DeGroot, L. J., Abalovich, M., Alexander, E. K., Amino, N., Barbour, L. A., Cobin, R. H., Eastman, C. J., Lazarus, J. H., Luton, D., Mandel, S. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2803 · Cited by 1,862 · see citing works

Epilepsy: A Comprehensive Textbook

Vaughn, B. V. (1998) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199805000-00039 · Cited by 1,390 · see citing works

Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3‐year follow‐up study

Pop, V. J., Brouwers, E. P. M., Vader, H. L., Vulsma, T., van Baar, A. L., & de Vijlder, J. J. M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01822.x · Cited by 731 · see citing works

American Thyroid Association guidelines for detection of thyroid dysfunction.

Ladenson, P., Singer, P., Ain, K., Bagchi, N., Bigos, S., Levy, E., Smith, S. A., Daniels, G., & Cohen, H. D. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.11.1573 · Cited by 658 · see citing works

Timing and Magnitude of Increases in Levothyroxine Requirements during Pregnancy in Women with Hypothyroidism

Alexander, E. K., Marqusee, E., Lawrence, J., Jarolim, P., Fischer, G. A., & Larsen, P. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040079 · Cited by 633 · see citing works

Mechanisms behind the non-thyroidal illness syndrome: an update

Warner, M., & Beckett, G. J. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0412 · Cited by 433 · see citing works

Effect of Thyroxine Therapy on Serum Lipoproteins in Patients with Mild Thyroid Failure: A Quantitative Review of the Literature

Danese, M. D., Ladenson, P. W., Meinert, C. L., & Powe, N. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.9.2993 · Cited by 423 · see citing works

The Beneficial Effect of<scp>l</scp>-Thyroxine on Cardiovascular Risk Factors, Endothelial Function, and Quality of Life in Subclinical Hypothyroidism: Randomized, Crossover Trial

Razvi, S., Ingoe, L., Keeka, G., Oates, C., McMillan, C., & Weaver, J. U. (2007) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2006-1869 · Cited by 389 · see citing works

Incidence and prevalence

Forsgren, L. (2004) · CRC Press eBooks · doi:10.1201/b13560-9 · Cited by 352 · see citing works

Mortality in epilepsy in the first 11 to 14 years after diagnosis: Multivariate analysis of a long-term, prospective, population-based cohort

Lhatoo, S. D., Johnson, A. L., Goodridge, D. M., MacDonald, B. K., Sander, J. W. A. S., & Shorvon, S. D. (2001) · Annals of Neurology · doi:10.1002/ana.70 · Cited by 342 · see citing works

Effect of Thyroxine Therapy on Serum Lipoproteins in Patients with Mild Thyroid Failure: A Quantitative Review of the Literature*

Danese, M. D., Ladenson, P. W., Meinert, C. L., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6841 · Cited by 308 · see citing works

Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure

Rodondi, N., Bauer, D. C., Cappola, A. R., Cornuz, J., Robbins, J., Fried, L. P., Ladenson, P. W., Vittinghoff, E., Gottdiener, J. S., & Newman, A. B. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.009 · Cited by 273 · see citing works

TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects

Garduño-Garcia, J. D. J., Alvirde-Garcia, U., López-Carrasco, G., Padilla Mendoza, M. E., Mehta, R., Arellano-Campos, O., Choza, R., Sauque, L., Garay-Sevilla, M. E., Malacara, J. M., et al. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0312 · Cited by 268 · see citing works

Effects of antiepileptic drugs on lipids, homocysteine, and C‐reactive protein

Mintzer, S., Skidmore, C. T., Abidin, C. J., Morales, M. C., Chervoneva, I., Capuzzi, D. M., & Sperling, M. R. (2009) · Annals of Neurology · doi:10.1002/ana.21615 · Cited by 220 · see citing works

Blood Levels of Trace Elements, Electrolytes, and Oxidative Stress/Antioxidant Systems in Epileptic Patients

Hamed, S. A., Abdellah, M. M., & El-Melegy, N. T. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fpj04032x · Cited by 179 · see citing works

Thyroid Function in Girls with Epilepsy with Carbamazepine, Oxcarbazepine, or Valproate Monotherapy and after Withdrawal of Medication

Vainionpää, L. K., Mikkonen, K. H., Rättyä, J., Knip, M., Pakarinen, A., Myllylä, V. V., & Isojärvi, J. I. T. (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.26003.x · Cited by 145 · see citing works

Etiology as a risk factor for medically refractory epilepsy

Engel, J. (1998) · Neurology · doi:10.1212/wnl.51.5.1243 · Cited by 139 · see citing works

Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy

Hamed, S. A., Hamed, E. A., Hamdy, R., & Nabeshima, T. (2007) · Epilepsy Research · doi:10.1016/j.eplepsyres.2007.03.010 · Cited by 129 · see citing works

Thyroid Function in Men Taking Carbamazepine, Oxcarbazepine, or Valproate for Epilepsy

Isojärvi, J. I. T., Turkka, J. T., Pakarinen, A., Kotila, M., Rättyä, J., & Myllylä, V. V. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.042007930.x · Cited by 125 · see citing works

Possible Interaction Between Oxcarbazepine and an Oral Contraceptive

Jensen, P. K., Saano, V., Haring, P., Svenstrup, B., & Menge, G. P. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb01773.x · Cited by 125 · see citing works

Lack of enzyme induction with oxcarbazepine (600 mg daily) in healthy subjects.

Larkin, J., McKee, P., Forrest, G., Beastall, G. H., Park, B., Lowrie, J. I., Lloyd, P. M., & Brodie, M. J. (1991) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1991.tb03858.x · Cited by 119 · see citing works

Serum Free Thyroxine in Thyroidal and Nonthyroidal Illnesses: A Comparison of Measurements by Radioimmunoassay, Equilibrium Dialysis, and Free Thyroxine Index*

CHOPRA, I. J., Herle, A. J. V., TECO, G. N. C., & NGUYEN, A. H. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-1-135 · Cited by 114 · see citing works

Long‐Term Treatment of Children with Epilepsy with Valproate or Carbamazepine May Cause Subclinical Hypothyroidism

Eirís‐Puñal, J., Río‐Garma, M. D., del Río-Garma, M. C., Rocamonde, S. A. L., Rodríguez, I. N., & Gago, M. C. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb01595.x · Cited by 112 · see citing works

The effect of long-term antiepileptic treatment on serum cholesterol (TC, HDL, LDL) and triglyceride levels in adult epileptic patients on monotherapy.

Nikolaos, T., Stylianos, G., Nikolaou, C., Irini, P., Christos, M., Dimitrios, T., Konstantinos, P., & Antonis, T. (2004) · PubMed · Cited by 92 · see citing works

Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction

Benedetti, M. S., Whomsley, R., Baltes, E., & Tonner, F. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0056-0 · Cited by 91 · see citing works

Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate

Verrotti, A., Laus, M., Scardapane, A., Franzonı, E., & Chiarelli, F. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0325 · Cited by 91 · see citing works

Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital

Calandre, E. P., Rodriguez-lopez, C. M., Blazquez, A., & Cano, D. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04691.x · Cited by 90 · see citing works

Serum thyroid hormones and blood folic acid during monotherapy with carbamazepine or valproate

Bentsen, K. D., Gram, L., & Veje, A. (1983) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1983.tb04569.x · Cited by 85 · see citing works

Thyroid hormones in epileptic children receiving carbamazepine and valproic acid

Verrotti, A., Basciani, F., Morresi, S., Morgese, G., & Chiarelli, F. (2001) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00279-x · Cited by 83 · see citing works

Thyroid Function with Antiepileptic Drugs

Isojärvi, J. I. T., Pakarinen, A., & Myllylä, V. V. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb02297.x · Cited by 82 · see citing works

Subclinical Thyroid Dysfunction: A Joint Statement on Management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society

Gharib, H., Tuttle, R. M., Baskin, H. J., Fish, L. H., SINGER, P. A., & McDermott, M. T. (2004) · Endocrine Practice · doi:10.4158/ep.10.6.497 · Cited by 79 · see citing works

The effect of antiepileptic drugs on thyroid function in children

Yılmaz, Ü., Yılmaz, T. S., Akıncı, G., Korkmaz, H. A., & Tekgül, H. (2013) · Seizure · doi:10.1016/j.seizure.2013.09.006 · Cited by 78 · see citing works

Thyroid Function in Epileptic Patients Treated With Carbamazepine

Isojärvi, J. I. T., Pakarinen, A., & Myllylä, V. V. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520470029021 · Cited by 73 · see citing works

Trace Elements and Electrolytes Homeostasis and Their Relation to Antioxidant Enzyme Activity in Brain Hyperexcitability of Epileptic Patients

Hamed, S. A., & Abdellah, M. M. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj04004x · Cited by 72 · see citing works

Subclinical Hypothyroidism and Cardiovascular Risk

Palmieri, E. A., Fazio, S., Lombardi, G., & Biondi, B. (2004) · Treatments in Endocrinology · doi:10.2165/00024677-200403040-00005 · Cited by 68 · see citing works

Atherosclerosis in epilepsy: Its causes and implications

Hamed, S. A. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.07.003 · Cited by 63 · see citing works

Risk Factors for Development of Subclinical Hypothyroidism during Valproic Acid Therapy

Mikati, M. A., Tarabay, H., Khalil, A., Rahi, A. C., Banna, D. E., & Najjar, S. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.02.046 · Cited by 62 · see citing works

Antiepileptic drugs influences on body weight in people with epilepsy

Hamed, S. A. (2014) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2015.991716 · Cited by 62 · see citing works

States of serum leptin and insulin in children with epilepsy: Risk predictors of weight gain

Hamed, S. A., Fida, N. M., & Hamed, E. A. (2008) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2008.05.005 · Cited by 60 · see citing works

The High Atherosclerotic Risk Among Epileptics: the Atheroprotective Role of Multivitamins

Hamed, S. A., & Nabeshima, T. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05003x · Cited by 60 · see citing works

Serum thyroid hormone balance and lipid profile in patients with epilepsy

Hamed, S. A., Hamed, E. A., Kandil, M. R., El-Shereef, H. K., Abdellah, M. M., & Omar, H. (2005) · Epilepsy Research · doi:10.1016/j.eplepsyres.2005.08.004 · Cited by 59 · see citing works

Novel Clinical Evidence of an Association between Homocysteine and Insulin Resistance in Patients with Hypothyroidism or Subclinical Hypothyroidism

Yang, N., Yao, Z. J., Li, M., Liu, J., Gao, X., Fan, H. J., Hu, Y., Zhang, H., Xu, Y., Qu, A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125922 · Cited by 58 · see citing works

Thyroid and Myocardial Function After Replacement of Carbamazepine by Oxcarbazepine

Isojärvi, J. I. T., Airaksinen, J. K. E., Mustonen, J. N., Pakarinen, A., Rautio, A., Pelkonen, O., & Myllylä, V. V. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb01619.x · Cited by 53 · see citing works

Neuroendocrine Hormonal Conditions in Epilepsy

Hamed, S. A. (2008) · The Neurologist · doi:10.1097/nrl.0b013e3181618ada · Cited by 53 · see citing works

Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate

Hırfanoğlu, T., Serdaroğlu, A., Camurdan, O. M., Cansu, A., Bıdecı, A., Cınaz, P., & Gücüyener, K. (2007) · Pediatrics International · doi:10.1111/j.1442-200x.2007.02456.x · Cited by 53 · see citing works

INCREASED FREQUENCY OF GOITRE IN EPILEPTIC PATIENTS ON LONG‐TERM PHENYTOIN OR CARBAMAZEPINE TREATMENT

Hegedűs, L. D., Hansen, J., Lühdorf, K., Perrild, H., Feldt‐Rasmussen, U., & Kampmann, J. P. (1985) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1985.tb01100.x · Cited by 52 · see citing works

Changes in thyroid function tests induced by 2 month carbamazepine treatment in L-thyroxine-substituted hypothyroid children

De Luca, F., Arrigo, T., Pandullo, E., Siracusano, M. F., Benvenga, S., & Trimarchi, F. (1986) · European Journal of Pediatrics · doi:10.1007/bf00441860 · Cited by 51 · see citing works

Leptin and insulin homeostasis in epilepsy: Relation to weight adverse conditions

Hamed, S. A. (2007) · Epilepsy Research · doi:10.1016/j.eplepsyres.2007.04.001 · Cited by 49 · see citing works

Thyroid hormones, mitochondrial bioenergetics and lipid handling

Cioffi, F., Lanni, A., & Goglia, F. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32833cf354 · Cited by 49 · see citing works

Subclinical Hypothyroidism during Valproic Acid Therapy in Children and Adolescents with Epilepsy

Kim, S. H., Chung, H. R., Kim, S. U., Kim, H., Lim, B. C., Chae, J., Kim, K., Hwang, Y., & Hwang, H. Y. (2012) · Neuropediatrics · doi:10.1055/s-0032-1313913 · Cited by 48 · see citing works

Use of antiepileptic drugs and risk of hypothyroidism

Lai, E. C., Yang, Y. K., Lin, S., & Hsieh, C. (2013) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3498 · Cited by 44 · see citing works

Evolution of Subclinical Hypothyroidism in Children Treated With Antiepileptic Drugs

Gago, M. C., Novo-Rodríguez, M. I., Gómez‐Lado, C., Rodríguez, J., Rodríguez‐Segade, S., & Puñal, J. M. E. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.07.003 · Cited by 43 · see citing works

Central Hypothyroidism With Oxcarbazepine Therapy

Miller, J. L., & Carney, P. R. (2006) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.08.032 · Cited by 42 · see citing works

Thyroid Function in Children with Long-Term Anticonvulsant Treatment

Tanaka, K., Kodama, S., Yokoyama, S., Komatsu, M., Konishi, H., Momota, K., & Matsuo, T. (1987) · Pediatric Neurosurgery · doi:10.1159/000120309 · Cited by 42 · see citing works

Reversible effects of antiepileptic drugs on thyroid hormones in men and women with epilepsy: A prospective randomized double-blind withdrawal study

Lossius, M. I., Taubøll, E., Mowinckel, P., & Gjerstad, L. (2009) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2009.07.014 · Cited by 42 · see citing works

Comparative stroke risk of antiepileptic drugs in patients with epilepsy

Hsieh, C., Lai, E. C., Yang, Y. K., & Lin, S. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03693.x · Cited by 41 · see citing works

Carbamazepine and risk of hypothyroidism: a prospective study

Simko, J., & Horáček, J. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00883.x · Cited by 40 · see citing works

Phenytoin-folic acid interaction: a lesson to be learned.

Seligmann, H., Potasman, I., Weller, B., Schwartz, M., & Prokocimer, M. (1999) · PubMed · Cited by 38 · see citing works

Thyroglobulin and Thyroid Hormones in Patients on Long‐Term Treatment with Phenytoin, Carbamazepine, and Valproic Acid

Ericsson, U.-B. C., Bjerre, I., Forsgren, M., & Ivarsson, S. A. (1985) · Epilepsia · doi:10.1111/j.1528-1157.1985.tb05697.x · Cited by 38 · see citing works

Valproic Acid and CEBPα-Mediated Regulation of Adipokine Gene Expression in Hypothalamic Neurons and 3T3-L1 Adipocytes

Brown, R., Imran, S. A., Ur, E., & Wilkinson, M. (2008) · Neuroendocrinology · doi:10.1159/000113927 · Cited by 34 · see citing works

The reproductive conditions and lipid profile in females with epilepsy

Hamed, S. A., Hamed, E. A., Shokry, M., Omar, H. F., & Abdellah, M. M. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00740.x · Cited by 34 · see citing works

THE INFLUENCE OF CARBAMAZEPINE ON THYROID HORMONES AND THYROXINE BINDING GLOBULIN IN HYPOTHYROID PATIENTS SUBSTITUTED WITH THYROXINE

AANDERUD, S., MYKING, O. L., & STRANDJORD, R. E. (1981) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1981.tb00662.x · Cited by 33 · see citing works

Evaluation of Subclinical Hypothyroidism in Ambulatory Children With Controlled Epilepsy on Valproate Monotherapy

Sahu, J. K., Gulati, S., Kabra, M., Arya, R., Sharma, R., Gupta, N., Kaleekal, T., Reeta, K. H., & Gupta, Y. K. (2011) · Journal of Child Neurology · doi:10.1177/0883073811421985 · Cited by 32 · see citing works

Plasma High-Density Lipoprotein Cholesterol in Epileptics Treated with Various Anticonvulsants

Luoma, P. V., Myllylä, V. V., Sotaniemi, E. A., Lehtinen, I. A., & Hokkanen, E. (2008) · European Neurology · doi:10.1159/000115130 · Cited by 32 · see citing works

Thyroid Hormones in Children on Antiepileptic Therapy

Aygün, F., Ekici, B., Aydınli̇, N., Aydın, B. K., Baş, F., & Tatlı, B. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.627486 · Cited by 32 · see citing works

An Examination of the Mutual Effects of Valproic Acid, Carbamazepine, and Phenobarbital on 25-Hydroxyvitamin D Levels and Thyroid Function Tests

Çayır, A., Özden, Ö., Tan, H., & Turan, M. (2013) · Neuropediatrics · doi:10.1055/s-0033-1349226 · Cited by 30 · see citing works

Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long‐term study

Garoufi, A., Koemtzidou, E., Katsarou, E., Dinopoulos, A., Kalimeraki, I., Fotinou, A., Drakatos, A., & Attilakos, A. (2013) · European Journal of Neurology · doi:10.1111/ene.12262 · Cited by 30 · see citing works

The effects of carbamazepine on the thyrotropin response to thyrotropin-releasing hormone

Joffe, R. T., Gold, P. W., Uhde, T. W., & Post, R. M. (1984) · Psychiatry Research · doi:10.1016/0165-1781(84)90016-7 · Cited by 29 · see citing works

Epilepsy, Atherosclerosis, Myocardial Infarction, and Carbamazepine

de Chadarévian, J., Legido, A., Miles, D. K., & Katsetos, C. D. (2003) · Journal of Child Neurology · doi:10.1177/08830738030180021301 · Cited by 27 · see citing works

Thyroid Function in Children With Epilepsy Treated With Sodium Valproate Monotherapy

Attilakos, A., Katsarou, E., Prassouli, A., Mastroyianni, S. D., Voudris, K. A., Fotinou, A., & Garoufi, A. (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e318166cbcd · Cited by 27 · see citing works

Endocrine effects of valproic acid therapy in girls with epilepsy: A prospective study

Goldberg‐Stern, H., Yaacobi, E., Phillip, M., & de Vries, L. (2014) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2014.07.004 · Cited by 26 · see citing works

Serum thyroid hormones and pituitary response to thyrotropin‐releasing hormone in epileptic children receiving anti‐epileptic medication

Yüksel, A., Kartal, A., Cenani, A., & Yalçın, E. (1993) · Pediatrics International · doi:10.1111/j.1442-200x.1993.tb03018.x · Cited by 24 · see citing works

Treatment of hypopituitarism in patients receiving antiepileptic drugs

Paragliola, R. M., Prete, A., Kaplan, P. W., Corsello, S. M., & Salvatori, R. (2015) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(14)70081-6 · Cited by 22 · see citing works

Serum thyroid hormone profile and trace elements in children receiving valproic acid therapy: A longitudinal and controlled study

Döneray, H., Kara, İ. S., Karakoç, A., Tan, H., & Orbak, Z. (2012) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2012.03.001 · Cited by 21 · see citing works

Pattern Of Epilepsy In Childhood And Adolescence : A Hospital-Based Study

Kandil, M. R., Ahmed, W., Sayed, A. S., & Hamed, S. A. (2008) · African Journal of Neurological Sciences · doi:10.4314/ajns.v26i1.7592 · Cited by 20 · see citing works

Noninvasive screening for preclinical atherosclerosis in children on phenytoin or carbamazepine monotherapy: A cross sectional study

Sankhyan, N., Gulati, S., Hari, S., Kabra, M., Ramakrishnan, L., & Kalra, V. (2013) · Epilepsy Research · doi:10.1016/j.eplepsyres.2013.08.011 · Cited by 20 · see citing works

Evaluation of Thyroid Hormones in Children Receiving Carbamazepine or Valproate

Kafadar, İ., Kılıç, B. A., Arapoğlu, M., Yalçın, K., & Dalgıç, N. (2014) · Journal of Child Neurology · doi:10.1177/0883073814529822 · Cited by 16 · see citing works

Study of cognitive functions in newly diagnosed cases of subclinical and clinical hypothyroidism

Behera, J., Sood, S., Rajput, R., Satpal, Praveen, P., & Sharma, K. M. T. K. (2014) · Journal of Natural Science Biology and Medicine · doi:10.4103/0976-9668.127290 · Cited by 14 · see citing works

Phenytoin toxicity and thyroid dysfunction.

Betteridge, T., & Fink, J. (2009) · PubMed · Cited by 13 · see citing works

Serum cathepsin B activity during regression of Morris hepatoma 5123 D.

Fedorowski, A., Steciwko, A., & Rabczyński, J. (2004) · PubMed · Cited by 13 · see citing works

Thyroid function during B-vitamin supplementation of patients on antiepileptic drugs

Apeland, T., Kristensen, O., Strandjord, R. E., & Mansoor, M. A. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.01.007 · Cited by 12 · see citing works

Effects Of Carbamazepine On The Hypothalamic-Pituitary-Thyroid Axis

Bongu, D., Sachdev, J., & Kabadi, U. M. (1999) · Endocrine Practice · doi:10.4158/ep.5.5.239 · Cited by 11 · see citing works

Effects of anticonvulsant drugs on thyroid hormones in epileptic children.

Deda, G., Akıncı, A., Teziç, T., & Karagöl, U. (1992) · PubMed · Cited by 8 · see citing works

Effect of antiepileptic drugs on the thyroid gland in children with epilepsy (preliminary report).

Chakova, L., Karakhanian, E., Dimitrov, H. K., & Lutakova, E. (1998) · PubMed · Cited by 8 · see citing works

[Subclinical hypothyroidism and cardiovascular risk].

Rubio, M. A. L., López, P. J. T., Montes, J. A. R., López, M. D. C. F., Albero, J. S., & López, P. B. (2015) · PubMed · doi:10.3305/nh.2015.31.5.8740 · Cited by 6 · see citing works

[The effect of primidone treatment of thyroid hormones in epileptic children and adolescents (author's transl)].

Fichsel, H., & Knöpfle, G. (1977) · PubMed · Cited by 2 · see citing works

Thyroid Gland Volume in Adults with Epilepsy: Relationship to Thyroid hormonal function

Hamed, S. A. (2015) · Neurology and Neuroscience · doi:10.3823/349 · Cited by 2 · see citing works

Thyroid dysfunction and kidney disease: An update

Iglesias, P., Bajo, M. A., Selgas, R., & Díez, J. J. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9395-7 · Cited by 247 · see citing works

The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects

Gu, Y., Li, H., Bao, X., Zhang, Q., Liu, L., Meng, G., Wu, H., Du, H., Shi, H., Xia, Y., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2965 · Cited by 122 · see citing works

The effect of epilepsy and antiepileptic drugs on sexual, reproductive and gonadal health of adults with epilepsy

Hamed, S. A. (2016) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2016.1160777 · Cited by 73 · see citing works

Comorbid thyroid disease in patients with major depressive disorder - results from the European Group for the Study of Resistant Depression (GSRD)

Fugger, G., Dold, M., Bartova, L., Kautzky, A., Souery, D., Mendlewicz, J., Serretti, A., Zohar, J., Montgomery, S., Frey, R., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.03.011 · Cited by 69 · see citing works

Maternal carbamazepine alters fetal neuroendocrine-cytokines axis

Ahmed, R. G., & El‐Gareib, A. W. (2017) · Toxicology · doi:10.1016/j.tox.2017.03.002 · Cited by 60 · see citing works

Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions

Sawicka-Gutaj, N., Zawalna, N., Gut, P., & Ruchała, M. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00377-w · Cited by 57 · see citing works

Decompensated hypothyroidism: A review for the emergency clinician

Bridwell, R. E., Willis, G. C., Gottlieb, M. A., Koyfman, A., & Long, B. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.09.062 · Cited by 48 · see citing works

Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction

Iqubal, A., Sharma, S., Sharma, K., Bhavsar, A., Hussain, I., Iqubal, M. K., & Kumar, R. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.025 · Cited by 43 · see citing works

Hypothyroidism risk compared among nine common bipolar disorder therapies in a large US cohort

Lambert, C. G., Mazurie, A., Lauve, N., Hurwitz, N. G., Young, S. S., Obenchain, R. L., Hengartner, N., Perkins, D. J., Tohen, M. F., & Kerner, B. (2016) · Bipolar Disorders · doi:10.1111/bdi.12391 · Cited by 39 · see citing works

Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny – part I: which parameters from human studies are most relevant for toxicological assessments?

Sauer, U. G., Asiimwe, A., Botham, P. A., Charlton, A., Hallmark, N., Jacobi, S., Marty, S., Melching‐Kollmuss, S., Palha, J. A., Strauss, V., et al. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1839380 · Cited by 25 · see citing works

Bone Health and Endocrine Comorbidities in Pediatric Epilepsy

McNamara, N., Romanowski, E. F., Olson, D. P., & Shellhaas, R. A. (2017) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2017.10.005 · Cited by 25 · see citing works

The effect of levetiracetam and oxcarbazepine monotherapy on thyroid hormones and bone metabolism in children with epilepsy: A prospective study

Shi, K., Guo, J., Zhao, H., Han, H., Yang, C., Wu, Y., & Du, L.-J. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107555 · Cited by 24 · see citing works

The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital

Güngör, O., Özkaya, A. K., & Temiz, F. (2018) · Acta Neurologica Belgica · doi:10.1007/s13760-018-0908-x · Cited by 23 · see citing works

Effect of levetiracetam monotherapy on lipid profiles and thyroid hormones in children with epilepsy: A prospective study

Attilakos, A., Dinopoulos, A., Tsirouda, M., Paschalidou, M., Prassouli, A., Stamati, A., Parasxou, N., & Garoufi, A. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.106162 · Cited by 23 · see citing works

Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis

Han, Y., Yang, J., Zhong, R., Guo, X., Cai, M., & Lin, W. (2022) · Neurological Sciences · doi:10.1007/s10072-022-06120-w · Cited by 22 · see citing works

Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?

Chapela, S. P., Simancas-Racines, A., Ceriani, F., Martinuzzi, A. L. N., Russo, M. P., Zambrano, A. K., Simancas‐Racines, D., Verde, L., Muscogiuri, G., Katsanos, C. S., et al. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00528-w · Cited by 21 · see citing works

Drug interactions in users of tablet vs. oral liquid levothyroxine formulations: a real-world evidence study in primary care

Guglielmi, V., Bellia, A., Bianchini, E., Medea, G., Cricelli, I., Sbraccia, P., Lauro, D., Cricelli, C. A., & Lapi, F. (2017) · Endocrine · doi:10.1007/s12020-017-1412-4 · Cited by 20 · see citing works

Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (Part I): Liver carcinogenesis

Strupp, C., Quesnot, N., Richert, L., Moore, J., Bomann, W. H., & Singh, P. (2020) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2020.104758 · Cited by 20 · see citing works

Hormonal Changes in Women with Epilepsy

Li, Q., Zhang, Z., & Fang, J. (2024) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s453532 · Cited by 19 · see citing works

Effects of modified Atkins diet on thyroid function in adult patients with pharmacoresistant epilepsy

Molteberg, E., Thorsby, P. M., Kverneland, M., Iversen, P. O., Selmer, K. K., Nakken, K. O., & Taubøll, E. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107285 · Cited by 18 · see citing works

Levothyroxine pseudo-malabsorption: testing and treatment in the outpatient setting

Rdzak, G. M., Whitman, L. M., & Inzucchi, S. E. (2018) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018818771433 · Cited by 14 · see citing works

L-T4 therapy in the presence of pharmacological interferents

Benvenga, S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.607446 · Cited by 13 · see citing works

Weight of Evidence and Human Relevance Evaluation of the Benfluralin Mode of Action in Rats (Part II): Thyroid carcinogenesis

Strupp, C., Quesnot, N., Weber-Parmentier, C., Richert, L., Bomann, W. H., & Singh, P. (2020) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2020.104736 · Cited by 13 · see citing works

Association between subclinical hypothyroidism and psychotic features in Chinese young adults with first-episode and untreated major depressive disorder

Dai, W., Liu, J., Xie, H., Teng, Z., Luo, W., Yuan, H., Chen, J., Liu, M., & Zhang, X. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.067 · Cited by 13 · see citing works

Hypothyroidism induced by phenytoin and gabapentin

Miyake, Z., Ishii, K., & Tamaoka, A. (2018) · Medicine · doi:10.1097/md.0000000000012938 · Cited by 11 · see citing works

The ‘collateral side’ of mood stabilizers: safety and evidence-based strategies for managing side effects

Orsolini, L., Pompili, S., & Volpe, U. (2020) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2020.1820984 · Cited by 12 · see citing works

Is the prevalence of thyroid disease higher in children receiving antiepileptic medication? A systematic review and meta-analysis

Ilia, T. S., Dragoumi, P., Papanikolopoulou, S., Goulis, D. G., Pavlou, E., & Zafeiriou, D. (2021) · Seizure · doi:10.1016/j.seizure.2021.11.010 · Cited by 12 · see citing works

Costus Root Extract Preserves Thyroid Hormones Levels, Thyroglobulin Expression and Thyroid Tissues in Rats Receiving Valproate Sodium

Mahmoud, M. S. (2020) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v12i4.1145 · Cited by 8 · see citing works

Fatty liver in adults receiving antiepileptic medications: relationship to the metabolic risks

Hamed, S. A., Abd-Elaal, R. F., Radwan, M. E. M., & Abdellah, M. M. (2015) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2016.1131123 · Cited by 9 · see citing works

Thyroid hormones, Sertoli cell proliferation and differentiation in progenies from carbamazepine‐treated rat dams during pregnancy and lactation

de Oliva, S. U., Andretta, R. R., Simas, J. N., Tesser, R. B., Paccola, C. C., & Miraglia, S. M. (2021) · Andrologia · doi:10.1111/and.13969 · Cited by 6 · see citing works

The longitudinal effect of oxcarbazepine on thyroid function in children and adolescents with epilepsy

Park, H., Heo, J., Kim, M., Lee, J., Kim, M., Jin, D., Kim, T. H., Chung, J. H., Cho, S. Y., & Kim, S. W. (2022) · Epilepsia · doi:10.1111/epi.17407 · Cited by 7 · see citing works

Notes for the general paediatrician: managing thyrotoxicosis in children and young people

Vidouris, M., Worth, C., Patel, L., Date, A., Jasser, A., Hird, B., Tetlow, L. J., & Banerjee, I. (2022) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2022-001582 · Cited by 5 · see citing works

Thyroid Functions in Children on Levetiracetam or Valproic Acid Therapy

Karatoprak, E., & Paksoy, S. (2020) · Journal of Pediatric Epilepsy · doi:10.1055/s-0040-1716916 · Cited by 5 · see citing works

Predictive Value of Thyroid Hormones for Incident Hyperuricemia in Euthyroid Subjects: The Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study

Gu, Y., Meng, G., Zhang, Q., Liu, L., Wu, H., Zhang, S., Wang, Y., Zhang, T., Wang, X., Sun, S., et al. (2021) · Endocrine Practice · doi:10.1016/j.eprac.2020.10.009 · Cited by 5 · see citing works

Association between valproate treatment for acute phase schizophrenia and risk of new onset hypothyroidism

Zhao, Y. Y., Wen, S. W., Qin, Y., Liu, Y., Gao, Y., Retnakaran, R. R., Zhang, R., & Zhai, D. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.07.011 · Cited by 5 · see citing works

Effect of antiepileptic drug monotherapy on endogenous sex hormonal profile in men and women with epilepsy

Kanojia, N., Guin, D., Machahary, N., Thakran, S., Kukal, S., Thakur, J., Panda, B., Singh, P., Srivastava, A., Singh, P., et al. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.110220 · Cited by 4 · see citing works

Laboratory policies and practices for thyroid function tests in Croatia: survey on behalf of Working Group for Laboratory Endocrinology of the Croatian Society of Medical Biochemistry and Laboratory Medicine

Kuprešanin, M. S., Đuras, A., Krleža, J. L., Pezo, A., Lukić, I., Bokulić, A., Zec, I., Goreta, S., Gabaj, N. N., Kocijančić, M., et al. (2022) · Biochemia Medica · doi:10.11613/bm.2022.030702 · Cited by 4 · see citing works

Thyroid functions as a parameter in monitoring of antiepileptic drugs

Comert, E., Celebi, U., Cinar, B. P., Acikgoz, M., DEMİREL, E. A., & Atasoy, H. T. (2022) · Neurological Research · doi:10.1080/01616412.2021.2025317 · Cited by 3 · see citing works

Effect of Sodium Valproate and Levetiracetam on Thyroid Hormones in Pediatric Patients with Epilepsy

Dwajani, S. (2020) · Advances in Pharmacology & Clinical Trials · doi:10.23880/apct-16000182 · Cited by 3 · see citing works

Efficacy and safety of levetiracetam vs. oxcarbazepine in the treatment of children with epilepsy: a systematic review and meta-analysis

Liu, Y., Wang, Y.-X., Li, X., & Wu, X. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1336744 · Cited by 2 · see citing works

Effect of Antiepileptic Drug Treatment on Thyroid Hormone Levels in Epilepsy Patients

Mutlu, A. (2019) · Medical Bulletin of Haseki · doi:10.4274/haseki.galenos.2019.4922 · Cited by 2 · see citing works

The association between longitudinal trends of thyroid hormones levels and incident hypertension in a euthyroid population

Wang, Y., Gu, Y., Zhang, Q., Liu, L., Meng, G., Wu, H., Zhang, S., Zhang, T., Wang, X., Sun, S., et al. (2021) · Journal of Human Hypertension · doi:10.1038/s41371-020-00474-4 · Cited by 2 · see citing works

DIFFERENT PROGNOSTIC PATTERNS IN EPILEPSIES AND CONSIDERATIONS ABOUT THE DENOTATIONS OF ATYPICAL PATTERNS

Atalar, A. Ç., & Baykan, B. B. (2021) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.27976 · Cited by 2 · see citing works

Carbamazepine drug effect simulating biochemical central hypothyroidism in a patient with Bardet-Biedl syndrome

Kishlyansky, D., & Kline, G. A. (2021) · BMJ Case Reports · doi:10.1136/bcr-2021-245018 · Cited by 2 · see citing works

The Effect of Levetiracetam Therapy on Lipid Profile in Epileptic Children

Çetin, İ. D., & Demiral, M. (2023) · The Anatolian Journal of General Medical Research · doi:10.4274/anatoljmed.2022.49765 · Cited by 1 · see citing works

A Prospective Cohort Study on the Effect of Antiseizure Medications on Thyroid Function in Children Aged 6 Months to 12 Years with Epilepsy

Mohankumar, S. P., Rameshkumar, R., Selvan, T., Nandeesha, H., & Delhikumar, C. G. (2024) · Sultan Qaboos University medical journal · doi:10.18295/squmj.11.2024.075 · Cited by 1 · see citing works

THE PREDICTORS OF EARLY ATHEROSCLEROSIS IN YOUNG ADULT EPILEPTIC PATIENTS

Soliman, A. M., Yousef, S. A. A., Fattah, D., & Mohamed, N. (2016) · Zagazig University Medical Journal · doi:10.21608/zumj.2016.4637 · Cited by 1 · see citing works

Subclinical Hypothyroidism With Overt Symptoms in Patient With Well-Controlled Epilepsy on Valproate Therapy: A Case Report

Doshi, S. P., Denhard, K. A., & Xixis, K. (2025) · Journal of Child Neurology · doi:10.1177/08830738251366864 · Cited by 1 · see citing works

Central hypothyroidism after chemotherapy in childhood cancer survivors: a single centre series

Wanaguru, A., Tait, D. J., Cohn, R. J., Johnston, K. A., & Neville, K. A. (2022) · Acta Oncologica · doi:10.1080/0284186x.2022.2156812 · Cited by 1 · see citing works

Bridging the gap between thyroidology & pediatric oncology

Lebbink, C. A. (2023) · doi:10.33540/1724

Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients

Bal, N. Ç. Ç., Doğan, E. A., & Senol, Y. Y. (2023) · Archives of Epilepsy · doi:10.4274/archepilepsy.2023.221021

Antiseizure Medication in the Setting of Systemic Illness: A Focused Review

Menon, B., Menon, M. P. K., Yadav, P. K., & Bardhan, M. (2025) · International Journal of Epilepsy · doi:10.1055/s-0045-1802582

Side Effects of Anti-seizure Medication

Zhang, L., Chung, W., Xu, X., Xu, Z., Liu, S., Li, L., Xiao, F., Wang, Z., Hong, Z., Wang, Y., et al. (2025) · Springer eBooks · doi:10.1007/978-981-96-8520-2_8

Pharmacological Interactions of Levothyroxine in Multiple-Treated Patients

Marco, F. D., & Cusini, C. (2025) · Springer eBooks · doi:10.1007/978-3-032-01700-0_14

Epilepsy secondary to intracranial calcification cause by hypothyroidism and chronic hypocalcaemia: a case report

Hamed, S. A. (2026) · Iberoamerican Journal of Medicine · doi:10.53986/ibjm.2026.0005

Impact of Antiseizure Medication on Thyroid Function in Children With Epilepsy: A Case-Control Study

Kumar, N., Singh, P., Singh, V. K., & Singh, S. (2026) · Cureus · doi:10.7759/cureus.112345

Antiepileptic Drugs and Thyroid Hormone Homeostasis: Literature Review and Practical Guideline

Rochtus, A. M., Herijgers, D., Jansen, K., & Decallonne, B. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab048.1679

Anti-epileptic Drugs and Thyroid Function

Verrotti, A., Scardapane, A., Manco, R., & Chiarelli, F. (2008) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2008.21.5.401 · Cited by 45 · see citing works

Effects of antiepileptic drug on thyroid hormones in patients with epilepsy: A meta-analysis

Zhang, Y., Shen, C., Lai, Q., Fang, G., Ming, W., Lu, R., & Ding, M. (2016) · Seizure · doi:10.1016/j.seizure.2016.01.010 · Cited by 48 · see citing works

Impact of antiepileptic drugs therapy on thyroid profile in epileptic patients of Punjab origin

Singh, K., & Kaur, H. (2019) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20195280

The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital

Güngör, O., Özkaya, A. K., & Temiz, F. (2018) · Acta Neurologica Belgica · doi:10.1007/s13760-018-0908-x · Cited by 23 · see citing works