REDUCED NOCTURNAL MELATONIN SECRETION IN CHRONIC SCHIZOPHRENIA: RELATIONSHIP TO BODY WEIGHT
Abstract
SUMMARY: Melatonin was estimated by RIA in samples taken at 24.00 h and 08.00 h from twenty‐one male chronic schizophrenics and twelve age‐sex matched controls and subsequently in more frequent nocturnal samples from nine of the chronic schizophrenics. The 24.00 h melatonin level and the 24.00/08.00 h melatonin ratio were significantly reduced in the chronic schizophrenic patients. Similar results, with no evidence of subsidiary peaks of melatonin secretion, were obtained in those patients who were retested. No relationships between melatonin secretion and age or anterior pituitary hormone secretion were demonstrated, but an effect of body weight was noted which accounted, in part, for the difference between schizophrenics and controls. These results suggest that the low levels of melatonin noted in studies on depressed patients may not be specific and that body weight must be controlled in subsequent studies of melatonin secretion in patients with psychiatric disease.
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Studies of individuals with schizophrenia who were not currently taking medication have revealed alterations in several aspects of the melatonin rhythm, including reduced nighttime melatonin concentrations, blunted rhythmic amplitude, and phase advance of the typical melatonin acrophase.
“Studies of individuals with SZ who were not currently taking medication have revealed alterations in several aspects of the melatonin rhythm, including reduced nighttime melatonin concentrations149–151, blunted rhythmic amplitude149,150, and phase advance of the typical melatonin acrophase152.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [149]
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Circadian rhythm disruption and mental health
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- Authors
- FERRIER, I. N., ARENDT, J., JOHNSTONE, E. C., & CROW, T. J.
- Affiliations
- University of Surrey (GB)
- Corresponding author
- FERRIER, I. N.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1982-08
- Volume
- 17
- Issue
- 2
- Pages
- 181-187
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2125955673
- Cited by
- 118
- References
- 21
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2013: 3 · 2012: 3
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- melatonin, chronic schizophrenia, nocturnal melatonin secretion, body weight, melatonin rhythm, anterior pituitary hormones, circadian rhythm
- MeSH terms
- Adult, Aged, Body Weight, Chronic Disease, Circadian Rhythm, Humans, Male, Melatonin, Middle Aged, Schizophrenia
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