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Cited by 71Circadian rhythm and melatoninSchizophrenia research and treatmentStress Responses and Cortisol

Depressed nocturnal plasma melatonin levels in drug-free paranoid schizophrenics

Monteleone, Palmiero, Maj, Mario, Fusco, Mario, Kemali, Dargut, Reiter, Russel J.·1992·Schizophrenia Research
DOI 10.1016/0920-9964(92)90077-i
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Abstract

The 24-h profiles of plasma melatonin and cortisol were evaluated in 7 drug-free male paranoid schizophrenics and in 7 healthy subjects matched to the patients for age, sex, body weight, height and season of testing. Blood samples were obtained at 20.00, 22.00, 24.00, 01.00, 02.00, 06.00, 08.00 and 12.00 h. Light was turned off from 21.00 to 07.00 h. Compared with that of the normal controls, the circadian rhythm of plasma melatonin was absent in paranoid schizophrenics (F7.84 = 7.30, p less than 0.0001; two-way ANOVA with repeated measures) whereas the 24-h profile of plasma cortisol was preserved, although at a slightly higher level (F1.12 = 26.810, p less than 0.0002). The melatonin/cortisol ratio was significantly higher in healthy subjects than in the schizophrenic patients. A functional relationship between disturbances in the melatonin rhythm especially and schizophrenia may be proposed, although the significance of this relationship remains to be elucidated.

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Crossref · 10.1016/0920-9964(92)90077-i

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  • Studies of individuals with schizophrenia who were not currently taking medication have revealed alterations in several aspects of the melatonin rhythm, including reduced nighttime melatonin concentrations, blunted rhythmic amplitude, and phase advance of the typical melatonin acrophase.

    “Studies of individuals with SZ who were not currently taking medication have revealed alterations in several aspects of the melatonin rhythm, including reduced nighttime melatonin concentrations149–151, blunted rhythmic amplitude149,150, and phase advance of the typical melatonin acrophase152.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [150]

  • In contrast to melatonin, the cortisol circadian rhythm appears to remain more or less intact in schizophrenia, although concentrations are often elevated relative to healthy controls.

    “In contrast to melatonin, the cortisol circadian rhythm appears to remain more or less intact in SZ150–152, although concentrations are often elevated relative to healthy controls156,157.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [150]

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Authors
Monteleone, P., Maj, M., Fusco, M., Kemali, D., & Reiter, R. J.
Affiliations
  • University of Naples Federico II (IT)
  • The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Reiter, Russel J.
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
1992-04
Volume
7
Issue
1
Pages
77-84
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/0920-9964(92)90077-i
OpenAlex
W2011180659
Cited by
71
References
42
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 6
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
paranoid schizophrenia, plasma melatonin
MeSH terms
Adult, Circadian Rhythm, Depressive Disorder, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Melatonin, Pineal Gland, Pituitary-Adrenal System, Psychiatric Status Rating Scales, Schizophrenia, Paranoid

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