COMPARISON OF METHIMAZOLE, METHIMAZOLE AND SODIUM IPODATE, AND METHIMAZOLE AND SATURATED SOLUTION OF POTASSIUM IODIDE IN THE EARLY TREATMENT OF HYPERTHYROID GRAVES’DISEASE
Abstract
SUMMARY: We have evaluated three regimens for the rapid control (10 days’therapy) of thyrotoxicosis in hyperthyroid Graves’disease: methimazole (MMI, 40 mg/ day), MMI and sodium ipodate (MMI + Na Ipodate, 1 g/day and MMI and saturated solution of potassium iodide (MMI + SSKI, 6 drops twice daily). When serum T4 and T3 concentrations were analysed as the percent change from pre‐treatment values, the following results were observed. Serum T4 concentration decreased in the three treatment groups and the decrease was similar in the MMI and MMI + SSKI groups but significantly lower than in the MMI + Na ipodate group. The serum T3 concentration decreased to the normal range in all seven MMI + Na Ipodate treated patients by the fourth day of treatment and the per cent decrease in serum T3 from pre‐treatment values was significantly greater than in the MMI and MMI + SSKI treated patients. The decrease in serum T3 was similar in the latter two groups. Heart rate decreased in all three groups, but the decrease was significantly more in the MMI+Na ipodate treated patients. The present findings suggest that the rapid control of hyperthyroid Graves’disease is similar in patients treated with MMI and MMI + SSKI and that the combination of MMI + Na Ipodate is more efficacious since the decrease in serum T3 concentrations and heart rate was significantly greater in the MMI + Na ipodate‐treated patients.
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The use of potassium iodide as a beneficial adjunct to ATD therapy for Graves' disease has been investigated in previous studies.
“The use of potassium iodide (KI) as a beneficial adjunct to ATD therapy for GD has been investigated in previous studies (120).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [120]
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“The use of potassium iodide (KI) as a beneficial adjunct to ATD therapy for GD has been investigated in previous studies (120).”
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- Authors
- ROTI, E., ROBUSCHI, G., GARDINI, E., MONTERMINI, M., SALVI, M., MANFREDI, A., GNUDI, A., & BRAVERMAN, L. E.
- Affiliations
- University of Parma (IT)
- Corresponding author
- BRAVERMAN, L. E.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1988-03
- Volume
- 28
- Issue
- 3
- Pages
- 305-314
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2130246688
- Cited by
- 57
- References
- 29
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am018919-11)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- Graves' disease, hyperthyroidism, methimazole, potassium iodide, thyrotoxicosis, serum thyroxine, serum T3, heart rate, early treatment
- MeSH terms
- Adult, Blood Pressure, Drug Evaluation, Drug Therapy, Combination, Female, Graves Disease, Heart Rate, Humans, Ipodate, Male, Methimazole, Middle Aged, Potassium Iodide, Thyroxine, Triiodothyronine, Triiodothyronine, Reverse
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