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Effects of testosterone on sexual function in men: results of a meta‐analysis
Abstract
Summary: Objectives The role of androgen decline in the sexual activity of adult males is controversial. To clarify whether sexual function would benefit from testosterone (T) treatment in men with partially or severely reduced serum T levels, we conducted a systematic review and meta‐analysis of placebo‐controlled studies published in the past 30 years. The aim of this study was to assess and compare the effects of T on the different domains of sexual life. Data source A comprehensive search of all published randomized clinical trials was performed in MEDLINE, the Cochrane Library, EMBASE and Current Contents databases. Review methods Guided by prespecified criteria, software‐assisted data abstraction and quality assessed by two independent reviewers, a total of 17 randomized placebo‐controlled trials were found to be eligible. For each domain of sexual function we calculated the standardized mean difference relative to T and reported the results of pooled estimates of T treatment using the random effect model of meta‐analysis. Heterogeneity, reproducibility and consistency of the findings across studies were explored using sensitivity and meta‐regression analysis. Results Overall, 656 subjects were evaluated: 284 were randomized to T, 284 to placebo (P) and 88 treated in cross‐over. The median study length was 3 months (range 1–36 months). Our meta‐analysis showed that in men with an average T level at baseline below 12 nmol/l, T treatment moderately improved the number of nocturnal erections, sexual thoughts and motivation, number of successful intercourses, scores of erectile function and overall sexual satisfaction, whereas T had no effect on erectile function in eugonadal men compared to placebo. Heterogeneity was explored by grouping studies according to the characteristics of the study population. A cut‐off value of 10 nmol/l for the mean T of the study population failed to predict the effect of treatment, whereas the presence of risk factors for vasculogenic erectile dysfunction (ED), comorbidities and shorter evaluation periods were associated with greater treatment effects in the studies performed in hypogonadal, but not in eugonadal, men. Meta‐regression analysis showed that the effects of T on erectile function, but not libido, were inversely related to the mean baseline T concentration. The meta‐analysis of available studies indicates that T treatment might be useful for improving vasculogenic ED in selected subjects with low or low‐normal T levels. The evidence for a beneficial effect of T treatment on erectile function should be tempered with the caveats that the effect tends to decline over time, is progressively smaller with increasing baseline T levels, and long‐term safety data are not available. The present meta‐analysis highlights the need, and pitfalls, for large‐scale, long‐term, randomized controlled trials to formally investigate the efficacy of T replacement in symptomatic middle‐aged and elderly men with reduced T levels and ED.
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“Several studies have previously reported that testosterone levels are linked to a variety of conditions and diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, obesity, stroke and osteoporosis. 1-7”
From Cigarette smoking has a positive and independent effect on testosterone levels (2013) · cites this paper as [4]
In the citing paper
“Testosterone therapy may be justifiable in patients with some of these conditions, such as men receiving opioids, who may suffer from opioid-induced suppression of testosterone levels 32 and sexual dysfunction, 33 osteoporosis, and/or muscle atrophy.34”
From Who Gets Testosterone? Patient Characteristics Associated with Testosterone Prescribing in the Veteran Affairs System: a Cross-Sectional Study (2017) · cites this paper as [33]
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Items 101–200 of 491
Which Is First? The Controversial Issue of Precedence in the Treatment of Male Sexual Dysfunctions
Jannini, E. A., Isidori, A. M., Aversa, A., Lenzi, A., & Althof, S. E. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12315 · Cited by 72
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“For example, the administration of T to hypogonadal men causes increased libido and improved sexual functioning (e.g. Shah and Montoya, 2007), and broadly, T levels are positively associated with male sexual functioning (e.g. Halpern et al., 1998; see Isidori et al., 2005 for review).”
Translational Perspective on the Role of Testosterone in Sexual Function and Dysfunction
Podlasek, C. A., Mulhall, J. P., Davies, K. P., Wingard, C. J., Hannan, J. L., Bivalacqua, T. J., Musicki, B., Khera, M., González-Cadavid, N. F., & Burnett, A. L. “. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.06.004 · Cited by 74
“Rigorously performed meta-analytic studies have disputably supported the positive impact of testosterone therapy.(10,11) In one recent analysis comprising 29 randomized controlled trials, testosterone therapy was found to improve several aspects of male sexual function in confirmed testosterone-deficient patients such…”
Santoro, N. F., Braunstein, G. D., Butts, C. L., Martin, K. A., McDermott, M., & Pinkerton, J. V. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1271 · Cited by 75
“A metaanalysis of 8 RCTs of DHEA treatment in elderly men found no improvement in lumbar or femoral neck BMD, nor in markers of bone formation or resorption (155).”
BackgroundInfluentialJordan, K., Fromberger, P., Stolpmann, G., & Müller, J. L. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02394.x · Cited by 74
Erectile Dysfunction and Testosterone Deficiency
Blute, M., Hakimian, P., Kashanian, J. A., Shteynshluyger, A., Lee, M., & Shabsigh, R. (2008) · Frontiers of hormone research · doi:10.1159/000176048 · Cited by 71
Sexual Dysfunction in Men with COPD: Impact on Quality of Life and Survival
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“Bearing in mind the high prevalence of hypogonadism in men with COPD [19] and the mechanistic links between testosterone and sexual function [10, 18], it would appear possible to predict a link between gonadal state and sexual dysfunction, including erectile dysfunction (ED), in men with COPD.”
BackgroundInfluentialBobjer, J., Naumovska, M., Giwercman, Y. L., & Giwercman, A. (2012) · International Journal of Andrology · doi:10.1111/j.1365-2605.2012.01277.x · Cited by 68
“…of the reproductive organs including spermatogenesis (Welsh et al., 2009), prostate (Thomas et al., 2008) and sexual function (Aversa et al., 2003; Isidori et al., 2005); but also non-reproductive organs are androgen dependent for proper bone mineralization (Devogelaer et al., 1992; Murphy et…”
BackgroundKołodziejczak, K., Rosada, A., Drewelies, J., Düzel, S., Eibich, P., Tegeler, C., Wagner, G. G., Beier, K. M., Ram, N., Demuth, I., et al. (2019) · Psychology and Aging · doi:10.1037/pag0000347 · Cited by 78
Quality of life, self‐esteem, fatigue, and sexual function in young men after cancer
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Sexual and reproductive dysfunction associated with antiepileptic drug use in men with epilepsy
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Exogenous testosterone increases men’s perceptions of their own physical dominance
Welling, L. L. M., Moreau, B. J. P., Bird, B. M., Hansen, S., & Carré, J. M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.016 · Cited by 66
“A previous meta-analysis found that the effects of testosterone on erectile function and, to a lesser extent, libido depend on basal testosterone concentrations (Isidori et al., 2005).”
Aging and Erectile Dysfunction
Tirado, L. C. E., Ferrer, J., & Herrera, A. M. (2016) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2015.10.011 · Cited by 70
Impact of anabolic androgenic steroids on sexual function
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“Potential benefits of T supplementation in men with low T have been widely reported, with meta-analyses of randomized controlled trials (RCTs) demonstrating modest improvements in libido, AM erections, sexual thoughts, and erectile function (7,8).”
MethodAllan, C. A., Forbes, E. A., Strauss, B. J., & McLachlan, R. I. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.22 · Cited by 64
Aghazadeh, Y., Zirkin, B. R., & Papadopoulos, V. (2015) · Vitamins and hormones · doi:10.1016/bs.vh.2014.12.006 · Cited by 65
Metabolic syndrome and sexual dysfunction
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Gettler, L. T., McDade, T. W., Agustin, S. S., Feranil, A. B., & Kuzawa, C. W. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.08.019 · Cited by 63
“T is necessary for the initiation andmaintenance of sexual behavior in many non-human species (Hull and Rodriguez-Manzo, 2009), and hypogonadalmen generally report reduced sexual desire and sexual activity, compared to males with normal-functioning reproductive physiology (Isidori et al., 2005).”
Prevalence and predictors of sexual problems in men aged 75-95 years: a population-based study.
Hyde, Z., Flicker, L., Hankey, G., Almeida, O., McCaul, K., Chubb, S. A. P., & Yeap, B. (2012) · Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02565.x · Cited by 64
Testosterone treatment in the aging male: myth or reality?
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“Meta-analyses of randomized, placebo-controlled trials of TRT in men with sexual dysfunction and varying TT levels demonstrated benefits in some aspects of sexual desire, erectile function and performance [83] (Level 2a, Grade A).”
MethodYeap, B. B., Almeida, O. P., Hyde, Z., Chubb, S. A. P., Hankey, G. J., Jamrozik, K., & Flicker, L. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03055.x · Cited by 65
Significance of hypogonadism in erectile dysfunction
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“T level have only a mild or moderate hypogonadism, while the magnitude of the eVect of T therapy on erectile function is inversely related to the baseline T concentration [ 65 ].”
BackgroundMethodInfluentialHydrogen Sulphide Is Involved in Testosterone Vascular Effect
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Testosterone deficiency in adults and corresponding treatment patterns across the globe
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“Although it is clear that the clinical burden of TD is significant, and its treatment has the potential to improve QOL, many questions remain surrounding testosterone prescribing patterns around the world.”
BackgroundCurrent topics in testosterone replacement of hypogonadal men
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Sexuality in Men and Women With Epilepsy
Harden, C. L. (2006) · CNS Spectrums · doi:10.1017/s1092852900026717 · Cited by 54
“Furthermore, information about the safety of long-term testosterone supplementation (eg, potential to promote benign prostatic hypertrophy), is not available.(6)”
BackgroundDo low testosterone levels contribute to ill-health during male ageing?
Yeap, B. B., de Araújo, A. B., & Wittert, G. (2012) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2012.725461 · Cited by 53
Standard Operational Procedures for Low Sexual Desire in Men
Aurioles, E. R., & Bivalacqua, T. J. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02778.x · Cited by 53
Salivary Testosterone Levels in Men at a U.S. Sex Club
Escasa-Dorne, M. J., Casey, J. F., & Gray, P. B. (2010) · Archives of Sexual Behavior · doi:10.1007/s10508-010-9711-3 · Cited by 53
“While many studies have clarified the effects of testosterone administration on sexual function in men (for review, see Isidori et al., 2005), studies investigating the influence of sexual stimuli on testosterone levels have included relatively small sample sizes, few naturalistic studies (in favor…”
BackgroundSexual function in men with epilepsy
Talbot, J. A., Sheldrick, R., Caswell, H. L., & Duncan, S. (2008) · Neurology · doi:10.1212/01.wnl.0000311242.51618.b7 · Cited by 53
Heany, S. J., van Honk, J., Stein, D. J., & Brooks, S. J. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9692-y · Cited by 54
“Testosterone has been associated with aggression, violence, and sexually motivated behavior (Dabbs et al. 1987; Isidori et al. 2005;Montoya et al. 2012), perhaps by reducing impulse control (Struber et al.”
Testosterone Replacement Therapy for Sexual Symptoms
Rastrelli, G., Guaraldi, F., Reismann, Y., Sforza, A., Isidori, A. M., Maggi, M., & Corona, G. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.11.005 · Cited by 55
Self-citationAndrogen Physiology, Pharmacology, and Abuse
Handelsman, D. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00138-4 · Cited by 54
Amiaz, R., Pope, H. G., Mahne, T., Kelly, J. F., Brennan, B. P., Kanayama, G., Weiser, M., Hudson, J. I., & Seidman, S. N. (2011) · Journal of Sex & Marital Therapy · doi:10.1080/0092623x.2011.582425 · Cited by 52
“Testosterone replacement is associated with an improvement in sexual function, particularly nocturnal erections, sexual thoughts and motivation, and overall sexual satisfaction in such men (Isidori et al., 2005).”
BackgroundPharmacologically Induced Hypogonadism and Sexual Function in Healthy Young Women and Men
Schmidt, P. J., Steinberg, E. M., Negro, P. P., Haq, N., Gibson, C. J., & Rubinow, D. R. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.24 · Cited by 53
Dinsmore, W. W., & Wyllie, M. G. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2011.10837.x · Cited by 51
In silico and in vitro pharmacogenetic analysis in mice
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Foresta, C., Caretta, N., Corona, G., Fabbri, A., Francavilla, S., Jannini, E. A., Maggi, M., Bettocchi, C., & Lenzi, A. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00932.x · Cited by 49
Self-citationNational Athletic Trainers' Association Position Statement: Anabolic-Androgenic Steroids
Kersey, R. D., Elliot, D. L., Goldberg, L., Kanayama, G., Leone, J. E., Pavlovich, M., & Pope, H. G. (2012) · Journal of Athletic Training · doi:10.4085/1062-6050-47.5.08 · Cited by 73
“Further study is required before definitive statements can be made.(18) Other Medicinal Purposes.”
BackgroundInfluentialSleep, Sex Steroid Hormones, Sexual Activities, and Aging in Asian Men
Goh, V. H. ‐., & Tong, T. Y. ‐. (2010) · Journal of Andrology · doi:10.2164/jandrol.109.007856 · Cited by 47
Hypogonadotropic Hypogonadism in Men with Type 2 Diabetes
Dandona, P., Dhindsa, S., Chandel, A., & Chaudhuri, A. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.05.2001 · Cited by 47
Moon, D. G., Park, M. G., Lee, S. W., Park, K., Park, J. K., Kim, S. W., Park, N. C., Ahn, T. Y., Paick, J. S., Seo, J. T., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01765.x · Cited by 46
Androgens and male sexual function
Corona, G., Rastrelli, G., Vignozzi, L., & Maggi, M. (2022) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2022.101615 · Cited by 53
Xiao, Y., Zhao, L., Li, W., Wang, X., Ma, T., Yang, L., Gao, L., Li, C., Zhang, M., Yang, D., et al. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30334 · Cited by 46
“development and postnatally for the maintenance of male secondary sex characteristics and spermatogenesis (Isidori et al., 2005; Sinclair et al., 2015).”
BackgroundAndropause: A Quality-of-Life Issue in Older Males
Haren, M. T., Kim, M. J., Tariq, S. H., Wittert, G., & Morley, J. E. (2006) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.06.001 · Cited by 49
Erectile function, sexual desire, and psychological well-being in men with epilepsy
Duncan, S., Talbot, A., Sheldrick, R., & Caswell, H. L. (2009) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2009.04.028 · Cited by 46
“This reflects the fact that there is no linear relationship between testosterone and sexual interest in men [22].”
BackgroundResultKonaka, H., Sugimoto, K., Orikasa, H., Iwamoto, T., Takamura, T., Takeda, Y., Shigehara, K., Iijima, M., Koh, E., Namiki, M., et al. (2015) · Asian Journal of Andrology · doi:10.4103/1008-682x.148720 · Cited by 45
An update on male hypogonadism therapy
Surampudi, P. N., Swerdloff, R. S., & Wang, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.913022 · Cited by 46
“Testosterone replacement therapy improves sexual function (libido and erectile function) when testosterone levels are restored to the normal range in younger hypogonadal men [31-33].”
Jasuja, G. K., Bhasin, S., Reisman, J. I., Hanlon, J. T., Miller, D. R., Morreale, A. P., Pogach, L. M., Cunningham, F. E., Park, A., Berlowitz, D. R., et al. (2017) · Journal of General Internal Medicine · doi:10.1007/s11606-016-3940-7 · Cited by 44
Androgen Deprivation Therapy in Prostate Cancer: Focusing on Sexual Side Effects
Corona, G., Gacci, M., Baldi, E., Mancina, R., Forti, G., & Maggi, M. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02590.x · Cited by 46
Neuroendocrinological aspects of epilepsy: Important issues and trends in future research
Pack, A. M., Reddy, D. S., Duncan, S., & Herzog, A. G. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.02.009 · Cited by 44
“[48–50] and have not explained why both normal and diminished sexual function can be reported in the same low-normal range of”
BackgroundHormonal and reproductive disturbances in epileptic male patients: Emerging issues
Verrotti, A., Loiacono, G., Laus, M., Coppola, G., Chiarelli, F., & Tiboni, G. M. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.02.002 · Cited by 44
Pharmacological management of late-onset hypogonadism
Rastrelli, G., Maggi, M., & Corona, G. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1445969 · Cited by 46
“All meta-analyses reported outcomes on erectile function and libido, whereas two [83,85] investigated the effect of TTh on morning erections and sexual satisfaction and only our study evaluated”
MethodThe Facial Width-to-Height Ratio Predicts Sex Drive, Sociosexuality, and Intended Infidelity
Arnocky, S. A., Carré, J. M., Bird, B. M., Moreau, B. J. P., Vaillancourt, T., Ortiz, T. L., & Marley, N. (2017) · Archives of Sexual Behavior · doi:10.1007/s10508-017-1070-x · Cited by 47
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Ng Tang Fui, M., Hoermann, R., Prendergast, L. A., Zajac, J. D., & Grossmann, M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2016.242 · Cited by 40
The Potential Impact of Metabolic Syndrome on Erectile Dysfunction in Aging Taiwanese Males
Lee, Y., Liu, C., Huang, C., Li, W., Wu, W., Yeh, H., Wang, C., Huang, C., & Huang, S. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01852.x · Cited by 40
Korean Society for Sexual Medicine and Andrology (KSSMA) Guideline on Erectile Dysfunction
Ryu, J., Cho, K. S., Kim, S. J., Oh, K. J., Kam, S. C., Seo, K. K., Shin, H. S., & Kim, S. W. (2013) · The World Journal of Men s Health · doi:10.5534/wjmh.2013.31.2.83 · Cited by 39
“In a meta-analysis of 17 randomized studies that were conducted on ED patients to investigate the effect of testosterone replacement treatment, the result showed that EF was further improved by testosterone replacement when the testosterone level before treatment was lower.(48)”
MethodRichardson, D., Goldmeier, D., Frize, G., Lamba, H., Souza, C. D., Kocsis, Á., & Scullard, G. H. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00451.x · Cited by 39
The Relationship of Testosterone to Prostate-Specific Antigen in Men with Sexual Dysfunction
Corona, G., Boddi, V., Lotti, F., Gacci, M., Carini, M., Vita, G. D., Sforza, A., Forti, G., Mannucci, E., & Maggi, M. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01549.x · Cited by 39
Epidemiology and pathophysiology of male sexual dysfunction
Kaminetsky, J. C. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.16 · Cited by 39
Shao, N., Yu, X., Yu, Y.-M., Li, B., Pan, J., Wu, W.-H., Zhang, H.-J., Ma, X., Hao, M., & Kuang, H. (2018) · Andrologia · doi:10.1111/and.13039 · Cited by 39
Trait Sexual Motivation Questionnaire: Concept and Validation
Stark, R. M., Kagerer, S., Walter, B., Vaitl, D., Klucken, T., & Wehrum‐Osinsky, S. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.12843 · Cited by 36
Brooke, J. C., Walter, D., Kapoor, D., Marsh, H., Muraleedharan, V., & Jones, T. H. (2014) · Andrology · doi:10.1111/j.2047-2927.2013.00177.x · Cited by 37
“This is in keeping with a meta-analysis that concluded that testosterone improves sexual thoughts, motivation, successful intercourse, erectile function scores and sexual satisfaction (Isidori et al., 2005).”
ResultTestosterone Replacement Therapy in Hypogonadal Men: Assessing Benefits, Risks, and Best Practices
Miner, M. M., Canty, D. J., & Shabsigh, R. (2008) · Postgraduate Medicine · doi:10.3810/pgm.2008.09.1914 · Cited by 35
Nian, Y., Ding, M., Hu, S., He, H., Cheng, S., Yi, L., Li, Y., & Wang, Y. (2016) · Andrologia · doi:10.1111/and.12630 · Cited by 36
“Isidori et al. (2005) performed a meta- analysis and revealed that TRT could improve patients’ overall sexual satisfaction while Bolona et al.(2007) reached the opposite conclusion.”
MethodKaminetsky, J. C., Moclair, B., Hemani, M. L., & Sand, M. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02196.x · Cited by 35
Zang, Z., Tang, H., Tuo, Y., Xing, W., Ji, S., Gao, Y., & Deng, C. (2015) · Asian Journal of Andrology · doi:10.4103/1008-682x.166435 · Cited by 35
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“While other studies have concluded that endocrinal causes are responsible only in a small number of cases of sexual dysfunction in the general population [30], it is unclear whether decreases in testosterone concentration contributes to sexual dysfunction among men in MMT [15,31].”
BackgroundTestosterone Is Associated with Erectile Dysfunction: A Cross-Sectional Study in Chinese Men
Liao, M., Huang, X., Gao, Y., Tan, A., Lu, Z., Wu, C., Zhang, Y., Yang, X., Zhang, H., Qin, X. Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039234 · Cited by 34
“This finding was consistent with the evidence from the animal trials that androgen requirement for sexual behavior was less than the amount normally present [40,41] Moreover, evidences from a meta-analysis also suggested that such a testosterone threshold on sexual function might exist in men [42].”
BackgroundResultFatherhood in Tall Men Treated with High-Dose Sex Steroids during Adolescence
Hendriks, E., Boellaard, W. P. A., van Casteren, N. J., Romijn, J. C., de Jong, F. H., Boot, A. M., & Drop, S. L. S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0435 · Cited by 34
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Measurement of testosterone in the diagnosis of hypogonadism in the ageing male
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Male hormones and men's quality of life
Khera, M. (2016) · Current Opinion in Urology · doi:10.1097/mou.0000000000000256 · Cited by 33
“[21] found no improvements in erectile function among men with testosterone levels higher than 12 nmol/l (346 ng/dl).”
BackgroundSexual problems in people with refractory epilepsy
Henning, O. J., Nakken, K. O., Træen, B., Mowinckel, P., & Lossius, M. I. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.05.038 · Cited by 32
Influence of Androgens on Circulating Adiponectin in Male and Female Rodents
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“density (BMD) [43], and sexual function [46,47,48], and slight”
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Early Effect of Bariatric Surgery on Urogenital Function in Morbidly Obese Men
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Review of health risks of low testosterone and testosterone administration
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Hypogonadism, Erectile Dysfunction, and Type 2 Diabetes Mellitus: What the Clinician Needs to Know
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New horizons in testosterone and the ageing male
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Effects of Cypermethrin on Sexual Behaviour and Plasma Concentrations of Pituitary-Gonadal Hormones
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Mäkinen, J. I., & Huhtaniemi, I. T. (2010) · Gerontology · doi:10.1159/000319635 · Cited by 30
“Although androgen treatment of ED is a common practice, it still has to be considered empirical, based on personal experience and uncontrolled evidence.There are ample experimental data on beneficial effects of T on various aspects of penile function. Animal experiments have shown vasodilatory effects of T treatment a…”
Nutalapati, S., Ghagane, S. C., Nerli, R. B., Jali, M. V., & Dixit, N. S. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.04.039 · Cited by 29
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“Although it is a known predictor of sexual function in older men (7), most men in our study were eugonadal, therefore perhaps changes in T within a normal range were less likely to affect sexual”
BackgroundCarr, D., Murphy, L. F., Batson, H. D., & Springer, K. W. (2013) · Men and Masculinities · doi:10.1177/1097184x13502651 · Cited by 29
“2010), reduced testosterone levels (Isidori et al. 2005), and elevated risk of chronic conditions like cardiovascular disease and diabetes (Bhasin et al.”
InfluentialHormones, Metabolism, Aging and Men's Health
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Sexual Function and Mortality in Older Men: The Concord Health and Ageing in Men Project
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“There is evidence to suggest that aging men might benefit from exogenous supplementation of T in terms of overall sexual satisfaction, well-being and cognitive senescence [4, 5] .”
Testosterone deficiency: myth, facts, and controversy.
Miner, M. M., Barkin, J., & Rosenberg, M. T. (2014) · PubMed · Cited by 27
Androgen deficiency and type 2 diabetes mellitus
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Association of Major Depression With Sexual Dysfunction in Men
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Endocrine and psychological aspects of sexual dysfunction in Klinefelter patients
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“This result confirms that also in KS, low testosterone represents one of the major causes of low libido, and is in agreement with the positive effects of T treatment in other hypogonadal populations (Isidori et al., 2005).”
Result
Metadata
- Authors
- Isidori, A. M., Giannetta, E., Gianfrilli, D., Greco, E. A., Bonifacio, V., Aversa, A., Isidori, A., Fabbri, A., & Lenzi, A.
- Affiliations
- Sapienza University of Rome (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Isidori, Andrea M.
- ORCID
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2005-09-03
- Volume
- 63
- Issue
- 4
- Pages
- 381-394
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2138141643
- Cited by
- 492
- References
- 99
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 22 · 2022: 17 · 2021: 12 · 2020: 16 · 2019: 15 · 2018: 26 · 2017: 22 · 2016: 27 · 2015: 25 · 2014: 37 · 2013: 41 · 2012: 31
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testosterone replacement therapy, male sexual function, hypogonadism, androgen deficiency, erectile function, vasculogenic erectile dysfunction, sexual desire, nocturnal erections, sexual satisfaction, eugonadal men, treatment effects over time, comorbidities, risk factors for erectile dysfunction, meta-regression, heterogeneity
- MeSH terms
- Adult, Aged, Aging, Data Interpretation, Statistical, Humans, Male, Middle Aged, Placebos, Sexual Dysfunction, Physiological, Testosterone, Randomized Controlled Trials as Topic, Treatment Outcome
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