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Cited by 165Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Increasing prevalence and incidence of thyroid disease in Tayside, Scotland: the Thyroid Epidemiology Audit and Research Study (TEARS)

Leese, G. P., Flynn, R. V., Jung, R. T., MacDonald, T. M., Murphy, M. J., Morris, A. D.·2008·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2007.03051.x
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Abstract

Summary: Objective We aimed to describe the changing incidence of thyroid disease in a population‐based study in Tayside, Scotland (population 390 000) between 1994 and 2001. Design A retrospective, data‐linkage, population‐based study measuring the incidence and prevalence of thyroid disease. Patients All patients with newly diagnosed, treated and stable thyroid disease in Tayside were identified by electronic linkage of six datasets, including all regional biochemistry data, hospital admissions, deaths and a thyroid follow‐up register. Results The overall prevalence of thyroid dysfunction has increased from 2·3% to 3·8% (1994–2001). The prevalence of ever having had hyperthyroidism increased from 0·86% to 1·26% in females and 0·17% to 0·24% in males (P < 0·0001 for both). The standardized incidence of hyperthyroidism increased from 0·68 to 0·87 per 1000 females/year, representing a 6·3% annual increase (P < 0·0001). The prevalence of primary hypothyroidism increased from 3·12% to 5·14% in females and 0·51% to 0·88% in males (P < 0·0001 for both). The standardized incidence of primary hypothyroidism did not change and varied between 3·90 and 4·89 per 1000 females/year over the 8 years. Incidence of hypothyroidism in males increased from 0·65 to 1·01 per 1000 males/year (P = 0·0017). Mean age at diagnosis of primary hypothyroidism declined in females from 1994 to 2001. Conclusions The prevalence of primary hypothyroidism and previous hyperthyroidism has increased in Tayside, Scotland. This is partly due to an increasing incidence of disease, increased ascertainment and earlier diagnosis of disease. This will result in an increased workload for endocrinologists and general practitioners.

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Crossref · 10.1111/j.1365-2265.2007.03051.x

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Metadata

Authors
Leese, G. P., Flynn, R. V., Jung, R. T., MacDonald, T. M., Murphy, M. J., & Morris, A. D.
Affiliations
University of Dundee (GB)
Corresponding author
Leese, G. P.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2007-09-03
Volume
68
Issue
2
Pages
311-316
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2007.03051.x
OpenAlex
W2028530739
Cited by
165
References
25
Citations by year
2026: 3 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 5 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 8 · 2014: 9 · 2013: 14 · 2012: 8
FWCI
4.88
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion)
Funders
University of Dundee
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
thyroid dysfunction, hyperthyroidism, primary hypothyroidism, incidence, prevalence, temporal trends, age at diagnosis, sex differences, Tayside
MeSH terms
Adult, Female, Humans, Hyperthyroidism, Male, Middle Aged, Retrospective Studies, Scotland, Thyroid Diseases, Age Distribution, Sex Distribution, Young Adult

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