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Cited by 92Sexual Differentiation and DisordersAdrenal Hormones and DisordersHormonal Regulation and Hypertension

Unfavourable trends in cardiovascular and metabolic risk in paediatric and adult patients with congenital adrenal hyperplasia?

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Mooij, Christiaan F., Kroese, Jeanne Margot, Claahsen‐van der Grinten, Hedi L., Tack, Cees J., Hermus, Ad R.M.M.·2010·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2009.03690.x
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Abstract

Summary: Context As a result of the introduction of treatment with glucocorticoids and mineralocorticoids, now 60 years ago, congenital adrenal hyperplasia has become a lifelong chronic disease. Whether long‐term treatment of the disease leads to long‐term side effects remains unknown. In this respect, especially cardiovascular risk seems to be important. Evidence synthesis We reviewed the reported prevalence of conventional cardiovascular risk factors, i.e. obesity, insulin resistance, high blood pressure and dyslipidaemia in patients with congenital adrenal hyperplasia. Overall, the studies suggest a tendency towards an increased body mass index and fat mass, the presence of insulin resistance and hypertension, although data are relatively scarce and obtained in heterogeneous populations. Conclusions Our findings suggest that adult CAH patients tend to have a cluster of metabolic risk factors, which are consistent with the metabolic syndrome. This notion may have consequences for the care for this group of patients.

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Crossref · 10.1111/j.1365-2265.2009.03690.x

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14 of 14 references verified0 citation errors · 0 not checkable

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  • A systematic review and meta-analysis showed slight but significantly greater carotid intima thickness (WMD 0.08 mm; 95% CI 0.01-0.15) in CAH patients.

    “A systematic review and meta-analysis showed slight but significantly greater carotid intima thickness (WMD 0.08 mm; 95% CI 0.01-0.15mm) (674).”

    From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [674]

  • The authors of the systematic review were unable to draw conclusions regarding the effects of sex, glucocorticoid type and dose, fludrocortisone dose, and genotype, and bias in the individual reports was moderate to high.

    “The authors were unable to draw conclusions regarding the effects of several important variables such as sex, glucocorticoid type and dose, fludrocortisone dose, and genotype, and bias in the individual reports was moderate to high.”

    From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [674]

  • In the same meta-analysis, no differences were noted in fasting blood glucose, insulin level, glucose or insulin level after 2-hour glucose load, or serum lipids between individuals with CAH and controls.

    “however, no differences were noted in fasting blood glucose, insulin level, glucose or insulin level after 2-hour glucose load, or serum lipids.”

    From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [674]

  • In the meta-analysis (416 patients, 14 months-63 years old), compared to controls, individuals with CAH had increased HOMA-IR (WMD 0.49; 95% CI 0.02-0.96).

    “In the meta-analysis (416 patients, 14 months-63 years old), compared to controls, individuals with CAH had increased values for the homeostatic model assessment of insulin resistance (HOMA-IR; weighted mean difference [WMD] 0.49; 95% CI 0.02-0.96),”

    From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [674]

  • The systematic review and metaanalysis found that individuals with CAH had modestly increased systolic blood pressure (WMD 4.44 mm Hg; 95% CI 3.26-5.63) and diastolic blood pressure (WMD 2.35 mm Hg; 95% CI 0.49-4.20).

    “The systematic review and metaanalysis (674) found that individuals with CAH had modestly increased systolic blood pressure (WMD 4.44 mm Hg; 95% CI 3.26-5.63mm Hg) and diastolic blood pressure (WMD 2.35 mm Hg; 95% CI 0.49-4.20 mm Hg).”

    From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [674]

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Authors
Mooij, C. F., Kroese, J. M., Claahsen‐van der Grinten, H. L., Tack, C. J., & Hermus, A. R. M. M.
Affiliations
Radboud University Nijmegen (NL)
Corresponding author
Mooij, Christiaan F.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2010-07-21
Volume
73
Issue
2
Pages
137-146
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2009.03690.x
OpenAlex
W2159149117
Cited by
92
References
14
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 8 · 2012: 5
FWCI
1.34
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
congenital adrenal hyperplasia, cardiovascular risk, metabolic risk, metabolic syndrome, obesity, insulin resistance, hypertension, dyslipidemia, glucocorticoid therapy, mineralocorticoid therapy, long-term treatment side effects, body mass index, fat mass, pediatric patients, adult patients
MeSH terms
Adrenal Hyperplasia, Congenital, Adult, Cardiovascular Diseases, Child, Glucocorticoids, Humans, Long-Term Care, Metabolic Diseases, Risk Factors, Time Factors, Disease Progression

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