Serum TSH related to measures of body mass: longitudinal data from the HUNT Study, Norway: Serum TSH and body mass
Abstract
OBJECTIVE: Thyroid function and body mass are related, but the causal relationship remains unclear. Our objective was to investigate the longitudinal relationship between thyroid stimulating hormone (TSH) and body mass measures [body weight, body mass index (BMI), waist circumference (WC) and waist-hip-ratio (WHR)]. DESIGN: We used data from two waves of a population-based study: HUNT 2 (1995-1997) and 3 (2006-2008). Average follow-up time was 10·5 years. Multivariable general linear and logistic regression models were used to assess the relation between TSH and the body mass measures. PARTICIPANTS: In total 9954 women and 5066 men without self-reported thyroid disease and TSH within the reference range (0·5-3·5 mU/l) at baseline and <10 mU/l at follow-up. RESULTS: For each mU/l increase in TSH among women, weight increased 0·9 kg (95% CI 0·8, 1·1), BMI 0·3 kg/m(2) (95% CI 0·3, 0·4) and WC 0·6 cm (95% CI 0·3, 0·8). In men, the corresponding figures were 0·8 kg (95% CI 0·5, 1·0), 0·2 kg/m(2) (95% CI 0·2, 0·3) and 0·5 cm (95% CI 0·2, 0·8). In line with this, a weight gain of more than 5 kg was associated with a TSH increase of 0·08 mU/l (95% CI 0·06, 0·11) in women and 0·15 mU/l (95% CI 0·12, 0·18) in men. Women who lost more than 5 kg decreased their TSH by 0·12 mU/l (95% CI 0·09, 0·16) and men by 0·03 mU/l (95% CI -0.02, 0·09). CONCLUSION: Weight gain is accompanied by increasing TSH, and weight loss in women is related to decreasing TSH.
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Higher TSH levels were associated with increased BMI, and in longitudinal studies, individuals with rising TSH levels over time exhibited greater weight gain.
“Higher TSH levels were associated with increased BMI [65, 66], and in longitudinal studies, individuals with rising TSH levels over time exhibited greater weight gain [67, 68].”
From Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice (2023) · cites this paper as [68]
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- Authors
- Svare, A., Nilsen, T. I. L., Bjøro, T., Åsvold, B. O., & Langhammer, A.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Oslo University Hospital (NO)
- Corresponding author
- Svare, Anders
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2011-05-06
- Volume
- 74
- Issue
- 6
- Pages
- 769-775
- ISSN
- 0300-0664 (ISSN-L)
- OpenAlex
- W1535519742
- Cited by
- 113
- References
- 35
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 11 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 11 · 2015: 5 · 2014: 8 · 2013: 14 · 2012: 5
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- thyroid-stimulating hormone, body mass index, body weight, waist circumference, waist-to-hip ratio, weight gain, weight loss, sex differences, thyroid function, obesity
- MeSH terms
- Adult, Body Weight, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Norway, Surveys and Questionnaires, Thyroid Diseases, Thyrotropin, Weight Gain, Weight Loss, Body Mass Index, Linear Models, Logistic Models, Waist-Hip Ratio, Waist Circumference, Young Adult
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