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Cited by 23Electrolyte and hormonal disordersDialysis and Renal Disease ManagementCardiovascular, Neuropeptides, and Oxidative Stress Research

Metabolic clearance rate of immunoreactive vasopressin in man

BENMANSOUR, MUSTAPHA, RAINFRAY, MURIEL, PAILLARD, FRANÇOISE, ARDAILLOU, RAYMOND·1982·European Journal of Clinical Investigation
DOI 10.1111/j.1365-2362.1982.tb02228.x
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Abstract

Abstract. Metabolic clearance of synthetic arginine vasopressin (AVP) has been measured in sixteen healthy subjects and ten uraemic patients on maintenance haemodialysis. Plasma AVP was measured using a specific radioimmunoassay at different intervals after a single injection of 2 μg AVP. The theoretical curve which fitted best with the disappearance curve was the sum of two exponentials in twenty‐two subjects and of three exponentials in the other four. Metabolic clearance rate and the volume of fast initial distribution were 287·1 ml min‐1 (m 2)‐1 and 219·3 ml/kg b.w., respectively, in normal subjects. Metabolic clearance rate was considerably lower in the uraemic group. This emphasizes the role of kidneys in the degradation of AVP and may account, at least in part, for the higher basal plasma value of this hormone observed in uraemic patients.

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Crossref · 10.1111/j.1365-2362.1982.tb02228.x

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  • Later radioimmunoassay studies indicated that vasopressin disappeared from the circulation with a bi-exponential decay: the fast phase had a half-life of 5.4 min and a distribution volume close to the plasma volume, and the slower phase had a half-life of 78 min with a distribution volume close to the extracellular fluid volume.

    “Later studies using radioimmunoassay indicated that vasopressin disappeared from the circulation with a bi‐exponential decay 107. The fast phase had a half‐life of 5.4 min and a distribution volume close to the plasma volume; the slower phase had a half‐life of 78 min with a distribution volume close to the extracellular fluid volume.”

    From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [107]

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Authors
BENMANSOUR, M., RAINFRAY, M., PAILLARD, F., & ARDAILLOU, R.
Affiliations
Inserm (FR)
Corresponding author
ARDAILLOU, RAYMOND
ORCID
RAINFRAY, MURIEL
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
1982-12
Volume
12
Issue
6
Pages
475-480
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
DOI
10.1111/j.1365-2362.1982.tb02228.x
OpenAlex
W2121365479
Cited by
23
References
18
Citations by year
2024: 1 · 2020: 1 · 2017: 1 · 2016: 2
FWCI
1.24
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9241 d)
Locations
  • European Journal of Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords
vasopressin, metabolic clearance rate, uremia, hemodialysis, plasma vasopressin, volume of distribution, renal function
MeSH terms
Adult, Arginine Vasopressin, Blood Pressure, Creatinine, Female, Renal Dialysis, Humans, Kidney, Kidney Failure, Chronic, Male, Metabolic Clearance Rate, Middle Aged, Radioimmunoassay

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